Title:
METHODS FOR TREATING FUNCTIONAL BOWEL DISORDERS USING alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS
Document Type and Number:
WIPO Patent Application WO2004084881
Kind Code:
B1
Abstract:
A method is provided for using alpha2delta subunit calcium channel modulators or other compounds that interact with the alpha2delta calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat functional bowel disorders in patients in need of treatment. According to the present invention, alpha2delta subunit calcium channel modulators include GABA analogs including gabapentin and pregabalin, fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, beta3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Inventors:
FRASER MATTHEW OLIVER (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)
Application Number:
PCT/US2004/008701
Publication Date:
December 23, 2004
Filing Date:
March 22, 2004
Export Citation:
Assignee:
DYNOGEN PHARMACEUTICALS INC (US)
FRASER MATTHEW OLIVER (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)
FRASER MATTHEW OLIVER (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)
International Classes:
A61K31/195; A61K31/197; A61K31/216; A61K45/06; (IPC1-7): A61K31/195; A61K31/197; A61K31/216
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