METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS

WIPO Patent Application WO2004084880

B1

A method is provided for using alpha2delta subunit calcium channel modulators or other compounds that interact with the alpha2delta calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat pain. According to the present invention, alpha2delta subunit calcium channel modulators include GABA analogs (e.g., gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, beta3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.

JPS6027660	[Title of the Invention] Glutamine derivative
JP5064609	Compositions and Usages Containing β-Hydroxy-β-Methylbutyric Acid and At least One Amino Acid
WO/2005/089742	MEDICINE FOR PREVENTION OR TREATMENT OF FREQUENT URINATION OR URINARY INCONTINENCE

FRASER MATTHEW OLIVER (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)

PCT/US2004/008700

December 29, 2004

March 22, 2004

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DYNOGEN PHARMACEUTICALS INC (US)
FRASER MATTHEW OLIVER (US)
THOR KARL BRUCE (US)
BURGARD EDWARD C (US)
BRETTMAN LEE R (US)
LANDAU STEVEN B (US)
RICCA DANIEL J (US)

A61K31/195; A61K31/197; A61K31/216; A61K45/06; (IPC1-7): A61K31/195; A61K31/216; A61K31/197

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