Title:
METHODS OF TREATING SUBSTANCE USE DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/028519
Kind Code:
A3
Abstract:
In some embodiments provided herein are methods of treating substance use disorder in a patient in need thereof, the methods comprising administering to the patient the compound of Formula (I), or a pharmaceutically acceptable salt thereof, in an amount that is effective in treating the substance use disorder and that does not cause respiratory depression in the patient.
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Inventors:
BLAHUNKA PAUL (US)
MAREK GERARD (US)
ITO MOTOTSUGU (US)
MAREK GERARD (US)
ITO MOTOTSUGU (US)
Application Number:
PCT/US2022/075393
Publication Date:
April 20, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
ASTELLAS PHARMA GLOBAL DEV INC (US)
International Classes:
A61K31/54; A61P25/36
Foreign References:
| US20150111876A1 | 2015-04-23 |
Other References:
ANONYMOUS: "A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants - ClinicalTrials.gov", CLINICALTRIALS.GOV, 26 June 2020 (2020-06-26), Internet, XP093004859, Retrieved from the Internet [retrieved on 20221205]
LOBINA CARLA ET AL: "Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse", BEHAVIOURAL BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 400, 9 December 2020 (2020-12-09), XP086456143, ISSN: 0166-4328, [retrieved on 20201209], DOI: 10.1016/J.BBR.2020.113045
HAILE COLIN N ET AL: "The GABAB receptor positive allosteric modulator ASP8062 reduces operant alcohol self-administration in male and female Sprague Dawley rats", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 238, no. 9, 6 July 2021 (2021-07-06), pages 2587 - 2600, XP037541837, ISSN: 0033-3158, [retrieved on 20210706], DOI: 10.1007/S00213-021-05881-0
ANONYMOUS: "A Study to Assess the Safety and Efficacy of ASP8062 as an Add-on Therapy to Buprenorphine/Naloxone in Participants With Opioid Use Disorder - NCT05062577", CLINICALTRIALS.GOV, 30 September 2021 (2021-09-30), Internet, XP093004856, Retrieved from the Internet [retrieved on 20221205]
ANONYMOUS: "Human Laboratory Study of ASP8062 for Alcohol Use Disorder - NCT05096117", CLINICALTRIALS.GOV, 27 October 2021 (2021-10-27), Internet, XP093004725, Retrieved from the Internet [retrieved on 20221205]
ITO MOTOTSUGU ET AL: "A phase 1 study to assess potential interaction between ASP8062 and alcohol in healthy adult subjects", JOURNAL OF PSYCHOPHARMACOLOGY, 7 January 2022 (2022-01-07), XP055913074, Retrieved from the Internet DOI: https://doi.org/10.1177%2F02698811211058967
LOBINA CARLA ET AL: "Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse", BEHAVIOURAL BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 400, 9 December 2020 (2020-12-09), XP086456143, ISSN: 0166-4328, [retrieved on 20201209], DOI: 10.1016/J.BBR.2020.113045
HAILE COLIN N ET AL: "The GABAB receptor positive allosteric modulator ASP8062 reduces operant alcohol self-administration in male and female Sprague Dawley rats", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 238, no. 9, 6 July 2021 (2021-07-06), pages 2587 - 2600, XP037541837, ISSN: 0033-3158, [retrieved on 20210706], DOI: 10.1007/S00213-021-05881-0
ANONYMOUS: "A Study to Assess the Safety and Efficacy of ASP8062 as an Add-on Therapy to Buprenorphine/Naloxone in Participants With Opioid Use Disorder - NCT05062577", CLINICALTRIALS.GOV, 30 September 2021 (2021-09-30), Internet, XP093004856, Retrieved from the Internet
ANONYMOUS: "Human Laboratory Study of ASP8062 for Alcohol Use Disorder - NCT05096117", CLINICALTRIALS.GOV, 27 October 2021 (2021-10-27), Internet, XP093004725, Retrieved from the Internet
ITO MOTOTSUGU ET AL: "A phase 1 study to assess potential interaction between ASP8062 and alcohol in healthy adult subjects", JOURNAL OF PSYCHOPHARMACOLOGY, 7 January 2022 (2022-01-07), XP055913074, Retrieved from the Internet
Attorney, Agent or Firm:
DORIGO, Andrea et al. (US)
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