METHYLPYRROLOPYRIMIDINECARBOXAMIDES

Title:

METHYLPYRROLOPYRIMIDINECARBOXAMIDES

Document Type and Number:

WIPO Patent Application WO/2011/023693

Kind Code:

Abstract:

The compounds of formula (I) wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

Inventors:

STADLWIESER JOSEF (DE)
SCHMIDT BEATE (DE)
BERNSMANN HEIKO (DE)
DUNKERN TORSTEN (DE)
BENEDIKTUS EWALD (DE)
PAHL ANDREAS (DE)
HUSSONG RAGNA (DE)
NIMZ OLAF (DE)
MUELLER MATTHIAS (DE)
VIERTELHAUS MARTIN (DE)

Application Number:

PCT/EP2010/062329

Publication Date:

March 03, 2011

Filing Date:

August 24, 2010

Export Citation:

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Assignee:

NYCOMED GMBH (DE)
STADLWIESER JOSEF (DE)
SCHMIDT BEATE (DE)
BERNSMANN HEIKO (DE)
DUNKERN TORSTEN (DE)
BENEDIKTUS EWALD (DE)
PAHL ANDREAS (DE)
HUSSONG RAGNA (DE)
NIMZ OLAF (DE)
MUELLER MATTHIAS (DE)
VIERTELHAUS MARTIN (DE)

International Classes:

C07D487/04; A61K31/519; A61P11/00

Domestic Patent References:

WO2009106531A1	2009-09-03
WO2001094350A1	2001-12-13
WO2009106531A1	2009-09-03
WO2001094350A1	2001-12-13
WO2008030119A1	2008-03-13
WO2006049952A1	2006-05-11

Foreign References:

EP1634883A1	2006-03-15
EP1634883A1	2006-03-15
US20050124623A1	2005-06-09

Other References:

GANGJEE, A.; LI, W.; YANG, J.; KISLIUK, R. L., J. MED. CHEM., vol. 51, 2008, pages 68
VENUGOPALAN, B.; DESAI, P. D.; SOUZA, N. J., J. HETEROCYCLIC CHEM., vol. 25, 1988, pages 1633
MUCHOWSKI, J.M.; SOLAS, D. R., J. ORG:CHEM., vol. 49, 1984, pages 203
COREY, E. J.; GILMAN, N. W.; GANEM, B. E., J. AM. CHEM. SOC., vol. 90, 1968, pages 5616
YAMAMOTO, Y.; HATTORI, K.; ISHII, J.-I.; NISHIYAMA, H., TETRAHEDRON, vol. 62, 2006, pages 4294
HWU, J.R.; WETZEL, J.M., J. ORG. CHEM., vol. 50, 1985, pages 3946
MURATA ET AL., J ORG CHEM, vol. 65, 2000, pages 164
J ORG CHEM, vol. 62, 1997, pages 6458
MUCHOWSKI, J.M.; SOLAS, D. R, J. ORG:CHEM., vol. 49, 1984, pages 203
GASSMAN, P.G.; SCHENK, W.N., J. ORG. CHEM., vol. 42, 1977, pages 918
ZHAO, S.; GHOSH, A.; D'ANDREA, S.V.; FREEMAN, P.; VONVOIGTLANDER, P.F.; CARTER, D.B.; SMITH, M.W., HETEROCYCLES, vol. 39, 1994, pages 163
ERICKSON, S.D.; BANNER, B.; BERTHEL, S.; CONDE-KNAPE, K.; FALICIONI, F.; HAKIMI, I.; HENNESSY, B.; KESTER, R.F.; KIM, K..; MA, CH., BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 1402
GANGJEE A.; LI W.; YANG J.; KISLIUK R. L., J. MED. CHEM., vol. 51, 2008, pages 68
FREEDMAN, J.; STEWART, K.T., J. HETEROCYCL. CHEM., vol. 26, 1989, pages 1547 - 1554
BELANGER, P.C.; LAU, C.K.; WILLIAMS, H.W.R.; DUFRESNE, C.; SCHEIGETZ, J. CAN. J. CHEM., vol. 66, 1988, pages 1479 - 1482
ERICKSON, S.D.; BANNER, B.; BERTHEL, S.; CONDE-KNAPE, K.; FALICIONI, F.; ORZECHOWSKI, L.; QIAN, Y.; SALARI, H.; TENGI, J.; THAKKAR, BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 1402
OKAMURA, W.H.; ELNAGAR, H.Y.; RUTHER, M.; DOBREFF, S, J. ORG. CHEM., vol. 58, 1993, pages 600
SNIDER, B.B.; LIU, T., J. ORG. CHEM., vol. 65, 2000, pages 8490
MILNE, D.; MURPHY, P.J., J. CHEM. SOC. CHEMICAL COMMUNICATION, 1993, pages 884

Attorney, Agent or Firm:

WILD, Robert et al. (P.O. Box 100310, Konstanz, DE)

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Claims:

Claims

1 . Compou nd of formu la (I )

wherein

R1 is -CH₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(0)-1-4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH₂-O-,

R24 is hydrogen,

Y is -(CH₂)_n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

-C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then R5 is 1 -4C-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 'MC-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -N H-C(O)-R7, -C(O)-NR8R9, halogen, hydroxy or NH₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

R8 i s h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is^•MC-alkoxy or hydroxy,

R92 is^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

2. Compound according to claim 1 , wherein

R1 is -CH₂-3^4C-cycloalkyl or 2-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(O)-1-4C- alkyl or 1 -4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH₂-O-,

R24 is hydrogen,

Y is -(CH₂)_n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43, R41 is 1-4C-alkoxy or hydroxy,

R42 is 1-4C-alkoxy or hydroxy,

R43 is 1-4C-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 1-4C-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71, 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1-4C-alkoxy or hydroxy,

R72 is 1-4C-alkoxy or hydroxy,

R73 is 1-4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

3. Compound according to claim 1 to 2, wherein

R1 i s - C H₂-3^C-cycloalkyl or 2-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1- 4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy or 1-4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH₂J_n-,

n is 0,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy, if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or^•MC-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -N H-C(O)-R7, halogen , hyd roxy or N H₂,

R61 is halogen , 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

4. Com pou nd accord i ng to clai m 1 to 3, wherei n

R1 i s - C H₂-3^C-cycloalkyl,

R2 is hydrogen or methyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -2C-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -2C-alkyl or 1 - 2C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH₂-O-,

R23 is hydrogen, halogen, 1 -2C-alkoxy,

R24 is hydrogen,

Y is -(CH₂J_n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one or two substituents R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is fluoro, methyl, or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from fluoro or methyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, fluoro, hydroxy or NH₂,

R61 is fluoro, methyl or hydroxy,

R7 is ^•MC-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy, a salt thereof, or a stereoisomer of the compound or a salt thereof.

5. Compound according to claim 1 selected from the group consisting of

N-(1-Acetylpiperidin^4-yl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-N-[1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; Ethyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cyjpyrimidin-y-yljcarbonyljaminolpiperidine-i-carboxylate; N-(trans-4-acetamidocyclohexyl)-4-[5- (cyclopropylmethoxy)-i ,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-tf]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N- {trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-acetamidocyclohexyl)-4-[5-

[(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-N-[(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R^*,4R^*)-4-hydroxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-{trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyπmidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)- 4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-[(3R)-1- acetylpyrrolidin-3-yl]^4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-1- propanoylpyrrolidin-3-yl]-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[(3R)-1-(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[(3R*,4R*)-4-hydroxy-1 -propanoylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hydroxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-[(3S*,4S*)- 1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cydopropylmethoxy)-4-fluorophenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3- hydroxy-1 -propanoylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluorophenyl]-N-[(3S*,4S*)-3-hydroxy-1-(methoxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxylic acid (1-acetyl-piperidin-4-yl)-amide; 4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-(1-propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid [1-(2-methoxy-acetyl)-piperidin^4-yl]-amide; Ethyl 4-[({4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-acetamidocyclohexyl)-4-[2-

(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N- [(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-1- propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R)-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin-4-yl]-6-methyl-5H-pyrrolo[3,2- cyipyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hydroxy-1- (methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-(2-ethoxy-5-fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-6-methyl-N-(1-propanoylpiperidin^4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1-(methoxyacetyl)piperidin-4-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-(1-propionylpiperidin^4-yl)-5H-pyrrolo[3,2- c(]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[1-

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-(trans-4- acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(3R)-1 -acetylpyrrolidin-3- yl]-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)-1 -propionylpyrrolidin- 3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N- [(3R)-1-(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-methoxyphenyl]- N-[(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- 6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{cis-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(3R)-1- acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)-1- propionylpyrroNdin-3-yl]-5H-pyrrolo[3,2-tf]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyll-N-^SRj-i ^methoxyacetyljpyrrolidin-S-yll-e-methyl-SH-pyrrolop^-cyipyrimidine-?- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)- 5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy- 1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(1 - propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-5- methylphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexy[]^4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-{trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[cis-4-(acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[trans^4-(propanoylamino)cyclohexyl]- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[cis^4-(acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis^4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2-ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-Ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-N-(1-propanoylpiperidin^4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)piperidin-4-yl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl-N-(1-propionylpiperidin-4-yl)-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- [1-(methoxyacetyl)piperidin^-yl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; Ethyl 4-[({4- [2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-Acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-N-[trans-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-Acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{cis^4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]- 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1- propionylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1-

Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(cis-4-Acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl-N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{cis^4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; Ethyl {cis^4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-[(3R*,4R*)-1-Acetyl-3-hydroxypiperidin-4-yl]^4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1- propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- ethylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- SH-pyrrolop^-c^pyrimidine-y-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propanoylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydroxy-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-[1- (methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[trans-4- (Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N- {trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[cis^4-(Acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{cis- 4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(1-acetylpiperidin-4-yl)-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-N-[1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-

(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-2,6-dimethyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]- 2,6-dimethyl-N-(1-propanoylpiperidin^4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6-dimethyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxyj-S-methylphenyll-N-Ii ^methoxyacetyljpiperidin^-yl^.e-dimethyl-SH- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- N-(1-propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4- yl)-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(3R)-1-Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-N-[(3R)-1 -propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; Ethyl (3R)-3- [({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1-carboxylate; N-[(3R*,4R*)-1-Acetyl^4-hydroxypyrrolidin-3-yl]-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- (methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrroloIS^-dlpyrimidine^-carboxamide; N-[(3R)-1- Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-N-[(3R)-1-propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)-1-(methoxyacetyl)pyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]- 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- (methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrroloIS^-dJpyrimidine^-carboxamide; N-[(3R*,4R*)- 1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-4-hydroxy-1- (methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrroloIS^-dlpyrimidine^-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(trans- 4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[cis-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol- 4-yl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R)-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6- methyl-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-N-[(3R*,4R*)-1 -glycoloyl-4-hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R,4R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrroNdin-3-yl}-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxamide; 4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3S,4S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(trans-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[cis^4-(glycoloylamino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(cis-4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1-(hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-N-{(3R)-1-[(2S)- 2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)^4-hydroxy-1-(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide and 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3S,4S)-4-hydroxy- 1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hydroxy-1-(hydroxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3R,4R)-3-hydroxy-1- [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-(2- Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxylic acid [1-(2- hydroxy-acetyl)-piperidin-4-yl]-amide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxylic acid [1-((S)-2-hydroxy-propionyl)-piperidin^4-yl]-amide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(trans-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R)-1-(hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R)-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R*,4R*)-3-hydroxy-1-(hydroxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-N-{(3S,4S)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin- 4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5- fluorophenyl)-N-{1-[(2S)-2-hydroxypropanoyl]piperidin^4-yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-(1-glycoloylpiperidin-4-yl)-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{1- [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-(trans^4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- methoxyphenyl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3R)-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-[(3R*,4R*)-1-glycoloyl-4-hydroxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]- N-{(3R,4R)^-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3S,4S)-4-hydroxy- 1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(1-glycoloylpiperidin^4-yl)-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[trans^4-(glycoloylamino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[cis^4-(glycoloylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-(cis-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3R)-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1-(hydroxyacetyl)piperidin^4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3S,4S)- 3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(cis-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-[1-(hydroxyacetyl)piperidin-4-yl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{trans-4-[(hydroxyacetyl)amino]cyclohexyl}- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N- {cis^4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(cis^4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- Ethoxy-5-(trifluoromethyl)phenyl]-N-[1 -(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(1-glycoloylpiperidin-4-yl)-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[cis-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)-1-glycoloyl-3-hydroxypiperidin-4-yl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-{(rac.-3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {(rac.-3S,4S)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*,4S*)-1- glycoloyl-4-hydroxypiperidin-3-yl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimid ine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-{(rac.-3S,4S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(rac.-3R,4R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[1 -(hydroxyacetyl)piperidin^4-yl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{1 - [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^4-[(hydroxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-(trans^4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-{cis-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4R*)-3-hydroxy-1 -(hydroxyacetyl)piperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-(1- glycoloylpiperidin-4-yl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide4-[2-

(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{1-[(2S)-2-hydroxypropanoyl]piperidin^4-yl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-(trans-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[cis-4-(glycoloylamino)cyclohexyl]-6-methyl- 5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]- N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{(3S,4S)-3-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[1-(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(cis^4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydroxy-1 -(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-{(3S,4S)-4-hydroxy-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-[1-(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[5-Acetyl- 2-(cyclopropylmethoxy)phenyl]-N-{trans^4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-

{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacetyl)piperidin-4-yl]-2,6-dimethyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{1-[(2S)-2-hydroxypropanoyl]piperidin^4-yl}-2,6- dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-[1 -(hydroxyacetyl)piperidin-4-yl]-2,6-dimethyl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2R)-2- hydroxycyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)-1- glycoloylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3- yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-[(3R*,4R*)-1 -glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R*,4R*)-4- hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide ; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)-1-glycoloylpyrrolidin- S-yll-e-methyl-SH-pyrrolop^-dlpyrimidine-y-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*,4R*)-1- glycoloyM-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R*,4R*)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-1-glycoloyl-4-hydroxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- N-{(3R*,4R*)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; tert-Butyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate; tert-Butyl {trans-4- [({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxoM-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]-4-hydroxypyrrolidine-1-carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)^4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin- 7-yl}carbonyl)amino]cyclohexyl}carbamate; Tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert- Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; Tert-butyl (3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1 -carboxylate; tert-Butyl 4-({1-[4- (2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl]-methanoyl}- amino)-piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4- [2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1-carboxylate; tert-Butyl (3R^*,4R^*)-4-[({4-[2-(cycloprOpylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carboxylate; tert-Butyl 4-({[4-(2-ethoxy-5- fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl]carbonyl}amino)piperidine-1-carboxylate; tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2- cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}carbonyl)arnino]cyclohexyl}carbarnate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]- 3-hydroxypiperidine-1 -carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4- [({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)arnino]cyclohexyl}carbamate; tert- Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin- 7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carboxylate; tert-Butyl (3S*,4S*)-3-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2- c^pyrimidin^-yljcarbonyljamino^-hydroxypiperidine-i-carboxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)arnino]cyclohexyl}carbamate; tert- Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carboxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-5-fluoro-4-rnethoxyphenyl]-6-rnethyl-5/-/-pyrrolo[3,2-d]pyrimidin-7- ylJcarbonyOaminolpiperidine-i -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carboxylate; tert-butyl 4-[({4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7- ylJcarbonyOaminolpiperidine-i -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert- butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}carbonyl)arnino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/-/- pyrrolop^-cdpyrimidin^-yljcarbonyljaminojpiperidine-i-carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-c(]pyrirnidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]- 2, 6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl 4- [({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}carbonyl)arnino]piperidine-1- carboxylate; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-N-(1 -propanoylpiperidin^4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[1 -(methoxyacetyl)piperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4- [2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[trans-4- (propanoylamino)cyclohexyl]-5/-/ -pyrrolo[3,2-^d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{trans^4-[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-[(3S,5S)-1-Acetyl-5-methylpyrrolidin-3-yl]-4- [2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(3S,5S)-5-methyl- 1-propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)- 5-(difluoromethyl)phenyl]-N-[(3S,5S)-1-(methoxyacetyl)-5-methylpyrrolidin-3-yl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(1 S,3S)-3-(Acetylamino)cyclopentyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1 S,3S)-3- (propanoylamino)cyclopentyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S,3S)-3-[(methoxyacetyl)amino]cyclopentyl}- 6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(1 R*,2R*,4R*)-4-(Acetylamino)-2- fluorocyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N- [(1 R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclopentyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2-fluoro-4- [(methoxyacetyl)amino]cyclopentyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N- [(1 S*,2S*,4S*)-4-(Acetylamino)-2-methylcyclohexyl]-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1 S*,2S*,4S*)-2-methyl-4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2S*,4S*)^4-[(methoxyacetyl)amino]-2- methylcyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(1 R*,2R*,4R*H- (Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]- N-[(1 R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2-fluoro-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N- [(1 S*,3S*,4S*)-4-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1 S*,3S*,4S*)-3-methyl-4- (propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-cf]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)^4-[(methoxyacetyl)amino]-3- methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-cf]pyrimidine-7-carboxamide; N-[(1 S*,3S*,4S*)-4- (Acetylamino)-3-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]- N-[(1 S*,3S*,4S*)-3-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)-3-fluoro^- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; N- [(1 R*,3S*,4S*)-3-(Acetylamino)^-methylcyclopentyl]-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1 R*,3S*,4S*)-3-methyl-4- (propanoylamino)cyclopentyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,3S*,4S*)-3-[(methoxyacetyl)amino]^4- methylcyclopentyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(1 R*,2R*,4S*H-

(acetylamino)-2-methylcyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6- rnethyl-N-[(1 R*,2R*,4S*)-2-rnethyl-4-(propanoylamino)cyclopentyl]-5H-pyrrolo[3,2-d]pyrirnidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4S*)-4- [(methoxyacetyl)amino]-2-methylcyclopentyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[(1 S*,3S*,4S*)-3-(Acetylamino)^-fluorocyclopentyl]^-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,3S*,4S*)-3-fluoro-4- (propanoylamino)cyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)-3-fluoro-4-

[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5 H -pyrrolo[3,2-d]pyrimidine-7-carboxamide; N- [(1 S*,2R*,4S*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4S*)-2-fluoro-4- (propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4S*)-2-fluoro-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide;

a salt thereof, or a stereoisomer of the compound or a salt thereof. 6. Compound, pharmaceutically acceptable salt thereof or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5 for the treatment or prophylaxis of diseases.

7. Compound, pharmaceutically acceptable salt thereof or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5 for the treatment or prophylaxis of an acute or chronic airway disease. 8. Pharmaceutical composition comprising at least one of the compounds, pharmaceutically acceptable salts thereof, stereoisomers of the compounds and the pharmaceutically acceptable salts thereof according to any of claims 1 to 5 together with at least one pharmaceutically acceptable auxiliary. 9. Pharmaceutical composition according to claim 8 further comprising at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanylyl cyclase activators/stimulators, pirfenidone, antidepressants and antibiotics.

10. Use of a compound, pharmaceutically acceptable salt thereof or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5 in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease.

1 1. Use according to claim 10, wherein the acute or chronic airway disease is selected from pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease. 12. Use of a compound, pharmaceutically acceptable salt thereof or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5 in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of portal hypertension, nephritis, liver cirrhosis, toxic liver damage, hepatitis, non-alcoholic steatohepatitis or liver fibrosis.

13. Method for treating or preventing an acute or chronic airway disease comprising administering to a patient in need thereof a therapeutically effective amount of a compound, pharmaceutically acceptable salt thereof or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5.

14. Method for treating or preventing an acute or chronic airway disease according to claim 13, in which the acute or chronic airway disease is selected from the group consisting of pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease.

15. Method of treating or preventing portal hypertension, nephritis, liver cirrhosis, toxic liver damage, hepatitis, non-alcoholic steatohepatitis or liver fibrosis comprising administering to a patient in need thereof a therapeutically effective amount of a compound, pharmaceutically acceptable salt thereof, or stereoisomer of the compound or the pharmaceutically acceptable salt thereof according to any of claims 1 to 5.

Description:

Description

Methyl pyrrolopyrimidinecarboxamides Field of application of the present subject matter

The present subject matter relates to methylpyrrolopyrimidinecarboxamide compounds, processes for their preparation, pharmaceutical compositions comprising said compounds and the use thereof in the treatment or prophylaxis of diseases.

Background of the Invention

Pyrrolopyrimidinecarboxamides are described in WO2009/106531. EP1634883 disclose 2- substituted phenyl-5,7-dihydrocarbyl-3,7-dihydropyrrolo[2,3-d]pyrimidin^ 4-one derivatives and their use for treatment and/or prevention of sexual dysfunction and other diseases related to phospholipase 5. WO01/94350 disclose 6-phenylpyrrolopyrimidine derivatives as selective cyclic GMP specific phosphodiesterase (PDE 5) inhibitors.

Description of the present subject matter

It has now been found that the methylpyrrolopyrimidinecarboxamide compounds, which are described in detail below, have surprising and advantageous properties.

The present subject matter relates to compounds of formula (I)

wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 'MC-alkoxy or hydroxy, R2 is hyd rogen or 1 -4C-alkyl

R21 is hydrogen or f I uoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hyd rogen ,

Y is -(CHz) _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

-C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is 'MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1-4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73, R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 'MC-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. 1-4C-Alkyl is a straight-chain or branched alkyl group having 1 to 4 carbon atoms. Examples are methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl and tert-butyl. 2-4C-Alkyl is a straight-chain or branched alkyl group having 2 to 4 carbon atoms. Examples are ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl and tert-butyl.

1-4C-Fluoroalkyl is a straight-chain or branched alkyl moiety having 1 to 4 carbon atoms, wherein one or more of the hydrogen atoms of the alkyl moiety are replaced by fluorine. Examples include, but are not limited to, a trifluoromethyl, difluoromethyl, fluoromethyl, perfluoroethyl, 1 ,1 ,1 -trif luoro-2- fluoroethyl, 1 ,1 ,1 -trifluoroethyl, 1 ,1-difluoro-2,2-difluoroethyl, 1 ,1-difluoro-2-fluoroethyl, 1 ,1 - difluoroethyl, 1-fluoro-2,2-difluoroethyl, 1 -fluoro-2-fluoroethyl, 1-fluoroethyl, 2,2-difluoroethyl, 2- fluoroethyl, n-perfluoropropyl, and n-perfluorobutyl group. 1-2C-Fluoroalkyl is a straight-chain or branched alkyl moiety having 1 to 2 carbon atoms, wherein one or more of the hydrogen atoms of the alkyl moiety are replaced by fluorine. Examples include, but are not limited to, a trifluoromethyl, difluoromethyl, fluoromethyl, perfluoroethyl, 1 ,1 ,1 -trif luoro-2- fluoroethyl, 1 ,1 ,1 -trifluoroethyl, 1 ,1-difluoro-2,2-difluoroethyl, 1 ,1-difluoro-2-fluoroethyl, 1 ,1 - difluoroethyl, 1-fluoro-2,2-difluoroethyl, 1-fluoro-2-fluoroethyl, 1 -fluoroethyl, 2,2-difluoroethyl and 2- fluoroethyl group.

Halogen includes fluorine, chlorine, bromine and iodine. In case of R22 and/or R23 and/or R5 and/or R6 and/or R61 being halogen, fluorine is preferred. 3-6C-Cycloalkyl is a cycloalkyl group having 3 to 6 carbon atoms, examples of which include the cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl group. In case of R3 being 3-6C-cycloalkyl, cyclohexyl and cyclopentyl are preferred.

3-4C-Cycloalkyl is a cycloalkyl group having 3 to 4 carbon atoms, examples of which include the cyclopropyl and cyclobutyl group.

5-6C-Cycloalkyl is a cycloalkyl group having 5 to 6 carbon atoms, examples of which include the cyclopentyl and cyclohexyl group. 1-4C-Alkoxy represents a group which, in addition to the oxygen atom, contains a straight-chain or branched alkyl moiety having 1 to 4 carbon atoms. Examples are methoxy, ethoxy, n-propoxy, iso- propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy. 1-2C-Alkoxy represents a group which, in addition to the oxygen atom, contains a straight-chain alkyl moiety having 1 to 2 carbon atoms. Examples are methoxy and ethoxy,

1-4C-Fluoroalkoxy represents a group which, in addition to the oxygen atom, contains a straight- chain or branched alkyl moiety having 1 to 4 carbon atoms, wherein one or more of the hydrogen atoms of the alkyl moiety are replaced by fluorine. Examples include, but are not limited to, a trifluo- romethoxy, difluoromethoxy, fluoromethoxy, perfluoroethoxy, 1 ,1 ,1-trifluoro-2-fluoroethoxy, 1 ,1 ,1- trifluoroethoxy, 1 ,1-difluoro-2,2-difluoroethoxy, 1 ,1-difluoro-2-fluoroethoxy, 1 ,1 -difluoroethoxy, 1- fluoro-2,2-difluoroethoxy, 1 -fluoro-2-fluoroethoxy, 1-fluoroethoxy, 2,2-difluoroethoxy, 2- fluoroethoxy, n-perfluoropropoxy, and n-perfluorobutoxy group.

The group -C(O)-I -4C-alkyl represents a group which, in addition to the carbonyl group -C(O)-, contains a straight-chain or branched alkyl moiety having 1 to 4 carbon atoms. Examples are methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, iso-propylcarbonyl, n-butylcarbonyl,

iso-butylcarbonyl, sec-butylcarbonyl and tert-butylcarbonyl.

The group -C(O)-I -2C-alkyl represents a group which, in addition to the carbonyl group -C(O)-, contains a straight-chain or branched alkyl moiety having 1 to 2 carbon atoms. Examples are methylcarbonyl and ethylcarbonyl.

The group -C(O)-3-6C-cycloalkyl represents a group which, in addition to the carbonyl group -C(O)-, contains a cycloalkyl group having 3 to 6 carbon atoms. Examples are cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl and cyclohexylcarbonyl. The group -C(O)-O-I -4C-alkyl represents a group which, in addition to the oxycarbonyl group

-C(O)-O-, contains a straight-chain or branched alkyl moiety having 1 to 4 carbon atoms. Examples are methyloxycarbonyl, ethyloxycarbonyl, n-propyloxycarbonyl, iso-propyloxycarbonyl, n- butyloxycarbonyl, iso-butyloxycarbonyl, sec-butyloxycarbonyl and tert-butyloxycarbonyl. The 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom includes, but is not limited to, azetidinyl, oxazetidinyl, pyrrolidinyl, oxazolidinyl, piperidinyl, morpholinyl, azepanyl and oxazepanyl, in particular azetidinyl, 1 ,3-oxazetidinyl, pyrrolidinyl, 1 ,3-oxazolidinyl, piperidinyl, morpholinyl, azepanyl and 1 ,3-oxazepanyl, preferably azetidin-3-yl, pyrrolidin-3-yl, morpholin-2-yl, piperidin-3-yl and piperidin-4-yl.

The 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom includes, but is not limited to, azetidinyl, oxazetidinyl, pyrrolidinyl, oxazolidinyl, piperidinyl and morpholinyl, in particular azetidinyl, 1 ,3-oxazetidinyl, pyrrolidinyl, 1 ,3-oxazolidinyl, piperidinyl, morpholinyl, preferably azetidin-3-yl, pyrrolidin-3-yl, morpholin-2-yl, piperidin-3-yl and piperidin-4-yl.

The 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom includes, but is not limited to, pyrrolidinyl, oxazolidinyl, piperidinyl and morpholinyl, in particular pyrrolidinyl, 1 ,3-oxazolidinyl, piperidinyl, morpholinyl, preferably pyrrolidin-3-yl, morpholin- 2-yl, piperidin-3-yl and piperidin-4-yl.

In one embodiment, the present subject matter relates to compounds of formula (I), wherein R 1 i s - C H ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R72 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

R8 is hydrogen, R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is 1 -4C-al koxy or hyd roxy,

R92 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In one embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl or 2-4C-alkyl which is optionally substituted by R1 1 ,

R1 1 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1 -4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1 -4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R41 is 'MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In one embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl or 2-4C-alkyl which is optionally substituted by R1 1 ,

R1 1 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1 -4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1 -4C-fluoroalkyl,

or R21 and R22 combine to form a group -O-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R72 is 'MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein R 1 i s - C H ₂-3^C-cycloalkyl or 2-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1- 4C-fluoroalkyl,

or R21 and R22 combine to form a group -O-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy or 1-4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl or 2-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1-

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-, R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy or 1 -4C-fluoroalkoxy,

R24 is hyd rogen ,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is 'MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl or 2-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1-

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy or 1-4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then R5 is 1 -4C-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, halogen, hyd roxy or N H ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl or 2-4C-alkyl,

R2 is hydrogen or 1 -4C-alkyl

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 - 4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy or 1 -4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy, halogen or NH ₂,

R7 is ^•MC-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen or methyl R21 is hyd rogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -2C-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -2C-alkyl or 1 -

2C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -2C-alkoxy,

R24 is hyd rogen ,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is fluoro, methyl, or hydroxy,

if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from fluoro or methyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, fluoro, hydroxy or NH ₂,

R61 is fluoro, methyl or hydroxy,

R7 is ^•MC-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-2C-alkoxy 1-4C-fluoroalkoxy, -C(O)-I -2C-alkyl or 1-2C- fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-2C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is 1 -4C-alkoxy or hydroxy,

R6 is -N H-C(O)-R7or hyd roxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, fluoro, methy, ethyl, isopropyl, methoxy, -C(O)-methyl, fluoromethyl,

difluoromethyl or trifluoromethyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, fluoro, or methoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(0)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl, R21 is hyd rogen ,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or by one substituent R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1 -4C-alkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen or 1 -4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one substituent R5, or a 5- 6C-cycloalkyl group substituted by R6 and optionally substituted by R61 , R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1 -4C-alkyl,

R41 is 1 -4C-alkoxy or hydroxy,

R5 is halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R61 is halogen or 1-4C-alkyl,

R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or 1-4C-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen or 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or by one substituent R5, or a 5- 6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

R41 is 'MC-alkoxy or hydroxy,

R5 is halogen, hydroxy or 1 -4C-alkyl,

R6 is -NH-C(0)-R7,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen, R22 is hydrogen, fluoro, methyl, methoxy, -C(O)-methyl, difluoromethyl or trifluoromethyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, fluoro or methoxy,

R24 is hyd rogen ,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

R5 is fluoro, hydroxy or methyl,

R6 is -NH-C(0)-R7,

R61 is fluoro or methyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl, methoxy, -C(O)-methyl, difluoromethyl or trifluoromethyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, fluoro or methoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , R41 is methoxy or hydroxy,

R5 is fluoro, hydroxy or methyl,

R6 is -NH-C(O)-R7,

R61 is fluoro or methyl, R7 is methyl or ethyl, which are optionally substituted by R71 , or ethoxy,

R71 is methoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C Hz-S-ΘC-cycloalkyl or 'MC-alkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy, 1 -4C-fluoroalkoxy, -C(O)-1 -4C- alkyl or 1 -4C-fluoroalkyl,

or R21 and R22 combine to form a group -O-CH ₂-O-,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R41 is 'MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy, R8 is h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is 'MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 -

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is 'MC-alkoxy or hydroxy, R73 is 1 -4C-al koxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 - 4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or halogen,

R22 is hydrogen, halogen, 1 -4C-alkyl or ^•MC-fluoroalkyl,

R23 is hydrogen, R24 is hyd rogen ,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1-4C-alkyl or ^•MC-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is 1 -4C-alkoxy or hydroxy,

R43 is 1 -4C-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is methoxy, fluoro, methyl or hydroxy,

if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from fluoro or methyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -N H-C(O)-R7, fluoro, hydroxy or N H ₂,

R61 is fluoro, methyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl or ^•MC-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is methoxy, fluoro, methyl or hydroxy,

R6 is -NH-C(O)-R7, fluoro, hydroxy or NH ₂, R61 is fluoro, methyl or hyd roxy,

R7 is hyd rogen , 1 -4C-alkyl , wh ich is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen or fluoro,

R22 is hydrogen, halogen, 1 -4C-alkyl or 'MC-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl, ethyl, isopropyl, fluoromethyl, difluoromethyl or trifluoromethyl, R23 is hydrogen, R24 is hyd rogen ,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and otionally substituted by one or two substituents R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is methoxy, fluoro, methyl or hydroxy,

if two substituents R5 are present, these are identical and binding at the same carbon atom and are selected from fluoro or methyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, fluoro, hydroxy or NH ₂,

R61 is fluoro, methyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is halogen, 1 -4C-alkyl or 1 -4C-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or by one substituent R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 , R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 1 -4C-alkoxy or hydroxy,

R42 is 1 -4C-alkoxy or hydroxy,

R43 is 1 -4C-alkoxy or hydroxy,

R5 is 1 -4C-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, halogen, hydroxy or N H ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is halogen, 1-4C-alkyl or ^•MC-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is 'MC-alkoxy or hydroxy,

R5 is halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R61 is halogen or 'MC-alkyl,

R7 is ^•MC-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is halogen, 1 -4C-alkyl or 1 -4C-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro, methyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a 5-6C-cycloalkyl group substituted by

R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R5 is halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro, methyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

R41 is 'MC-alkoxy or hydroxy,

R5 is halogen or 1 -4C-alkyl,

R6 is -NH-C(O)-R7,

R61 is halogen or 1-4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro, methyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , R41 is 1 -4C-al koxy,

R5 is fluoro or methyl,

R6 is -NH-C(0)-R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71 , or ethoxy,

R71 is methoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C Hz-S-ΘC-cycloalkyl or 'MC-alkyl,

R2 is hydrogen or 'MC-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(0)-1-4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy, hydroxy or 'MC-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy, R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

R8 i s h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1-

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy, hydroxy or ^•MC-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂, R61 is halogen , 1 -4C-alkyl or hydroxy,

R7 is hyd rogen , 1 -4C-alkyl , wh ich is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 -

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkoxy, hydroxy or ^•MC-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43, R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 'MC-alkyl, R21 is hyd rogen ,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen or 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH^S-ΘC-cycloalkyl,

R2 is hydrogen or 'MC-alkyl,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl, ethyl, isopropyl, methoxy, ethoxy, -C(O)-1-2C-alkyl,

fluoromethyl, difluoromethyl or trifluoromethyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is 1-4C-alkoxy or hydroxy,

R43 is 1-4C-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1-4C-alkoxy or hydroxy,

R73 is 1-4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkylor1-4C-alkyl,

R2 is hydrogen or 'MC-alkyl,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CH ₂) _n-,

n isOori,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71, 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is ^•MC-alkyl, which is optionally substituted by R91, or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy, a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or methyl,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R43 is ^•MC-alkoxy or hydroxy,

R5 is methoxy, fluoro, methyl or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen or methyl,

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CH ₂J _n-,

R4 is -C(O)-I -4C-alkyl , wherei n the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is 1 -4C-al koxy or hyd roxy,

R43 is 1 -4C-alkoxy or hyd roxy,

R6 is -N H-C(0)-R7 , hyd roxy or N H ₂,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-4C-cycloalkyl,

R2 is hydrogen

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one or two substituents R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is fluoro, methyl or hydroxy,

R6 is -NH-C(0)-R7, fluoro, hydroxy or NH ₂,

R61 is fluoro, methyl or hydroxy, R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 1 -4C-al koxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R5 is fluoro, methyl or hydroxy,

R6 is -NH-C(0)-R7, fluoro, hydroxy or NH ₂,

R61 is fluoro, methyl or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen

R21 is hydrogen,

R22 is hydrogen, fluoro, methyl or methoxy,

R23 is hydrogen, fluoro or methoxy

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl,

R41 is 1 -4C-alkoxy or hydroxy,

R5 is fluoro, methyl or hydroxy,

R6 is -N H-C (0)-R7 ,

R61 is fluoro or methyl,

R7 is 'MC-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 'MC-alkyl,

R21 is hydrogen,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

-C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy, R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

R8 i s h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen or methyl, R21 is hyd rogen ,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, fluoro, hydroxy or NH ₂,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, fluoro, hydroxy or NH ₂, R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y Is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 ,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen,

R23 is fluoro

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and said heterocyclic ring being optionally substituted by R5, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , R41 is 1 -4C-alkoxy or hydroxy,

R5 i s h yd roxy ,

R6 is -NH-C(0)-R7,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 ,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is fluoro

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R41 is ^•MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy, R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

R8 i s h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is fluoro

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R21 is hydrogen,

R2 is hydrogen or 1-4C-alkyl,

R22 is fluoro

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is 1 -4C-alkoxy or hydroxy,

R6 is -N H-C(0)-R7 or hyd roxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and said heterocyclic ring being optionally substituted by R5, or a cyclohexyl or cyclopentyl group substituted by R6, R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is 'MC-alkoxy or hydroxy,

R5 is hydroxy,

R6 is -NH-C(O)-R7,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen, R22 is methoxy

R23 is fluoro,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43, R41 is ^•MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, hydroxy or NH ₂,

R72 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is methoxy

R23 is fluoro,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0, R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 1 -4C-alkoxy or hydroxy,

R43 is 1 -4C-alkoxy or hydroxy,

R5 is 1 -4C-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -N H-C(0)-R7, hydroxy or N H ₂,

R7 is hydrogen, 'MC-alkyl, which is optionally substituted by R71 , or 'MC-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is methoxy

R23 is fluoro,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy, a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is methoxy

R23 is fluoro,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, or -C(O)-O-I -4C-alkyl,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is methyl,

R23 is fluoro,

R24 is hydrogen,

Y is -(CHz) _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R42 is 1 -4C-alkoxy or hydroxy,

R43 is 1 -4C-alkoxy or hydroxy,

R5 is 1 -4C-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, -C(O)-N R8R9, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R72 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

R8 is h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is methyl,

R23 is fluoro,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is methyl,

R23 is fluoro,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is methyl,

R23 is fluoro,

R23 is hydrogen,

R24 is hydrogen, Y i s - ( C H ₂J _n-,

n is 0,

R3 is a 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 ,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is fluoro,

R23 is methoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R41 is ^•MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, -C(O)-NR8R9, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy, R8 is h yd rog e n ,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is fluoro,

R23 is methoxy,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or R5, or a 3-6C-cycloalkyl group substituted by R6,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is fluoro, R23 is methoxy,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoro,

R23 is methoxy,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, R71 is 1 -4C-al koxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is ^•MC-alkyl

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 ,

-C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R42 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is 'MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R72 is 'MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is ^•MC-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92, R91 is 1 -4C-al koxy or hyd roxy,

R92 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is methyl, ethyl or isopropyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43, R41 is 'MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl, R21 is hyd rogen ,

R22 is methyl, ethyl or isopropyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is methyl, ethyl or isopropyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 and/or R5 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is 'MC-alkoxy or hydroxy, R5 is methoxy, fluoro, methyl or hydroxy,

R6 is -N H-C(O)-R7 or hyd roxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is ^•MC-alkyl,

R23 is hydrogen,

R24 is hydrogen,

Y Is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and said heterocyclic ring being optionally substituted by R5, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is methyl, ethyl or isopropyl,

R23 is hydrogen,

R24 is hydrogen, Y i s - ( C H ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and said heterocyclic ring being optionally substituted by R5, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is methyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and said heterocyclic ring being optionally substituted by R5, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is ^•MC-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R41 is 'MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(O)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 'MC-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is fluoromethyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0 or 1 ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R41 is 'MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is fluoromethyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, or a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is methoxy, fluoro, methyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is fluoro, methyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is fluoromethyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen, R23 is hyd rogen ,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy, a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is 1 -4C-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is 'MC-alkoxy or hydroxy,

R5 is halogen, 1-4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is fluoromethyl, difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

O-1 -4C-alkyl,

R41 is 1 -4C-alkoxy or hydroxy,

R5 is halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(0)-R7, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R5 is halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl, R23 is hyd rogen ,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R41 is ^•MC-alkoxy,

R5 is halogen or 1-4C-alkyl,

R6 is -NH-C(O)-R7,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 ,

R41 is ^•MC-alkoxy,

R5 is fluoro or methyl,

R6 is -NH-C(O)-R7,

R61 is fluoro or methyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 1 -4C-alkoxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y Is -(CHz) _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 ,

R41 is 1 -4C-alkoxy,

R5 is fluoro or methyl,

R6 is -NH-C(O)-R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71 , or ethoxy,

R71 is methoxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is 1 -4C-fluoroalkyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(O)-R7,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 ,

R71 is ^•MC-alkoxy or hydroxy, a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a cyclohexyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(O)-R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71 ,

R71 is methoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a cyclohexyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(O)-R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71 ,

R71 is methoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein R 1 i s - C H ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0 or 1 ,

R3 is a 4- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R42 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(O)-I -4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen, Y i s - ( C H ₂J _n-,

n is O or i ,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being optionally substituted by R4 and/or by one or two substituents R5, R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is methoxy, fluoro, 1-4C-alkyl or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, 1-4C-fluoroalkoxy, -C(0)-1-4C- alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom,

R43 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl, R2 is h yd rog e n ,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1-

4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy or 1-4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom,

R43 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CHz) _n-,

n is O,

R3 is a 5-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and/or R5,

R4 is -C(O)-H, -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is 'MC-alkoxy or hydroxy,

R43 is 'MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1-4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CHz-S-ΘC-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and/or said heterocyclic ring being optionally substituted by R5,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1-4C-alkyl or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , or -C(O)-

O-1-4C-alkyl,

R41 is 'MC-alkoxy or hydroxy,

R5 is halogen or 1 -4C-alkyl,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom and/or said heterocyclic ring being optionally substituted by R5,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl,

R41 is ^•MC-alkoxy or hydroxy,

R5 is halogen or 1 -4C-alkyl, a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, ^•MC-fluoroalkoxy or -C(O)-I -4C- alkyl, 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy, or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is O or i ,

R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is 'MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 'MC-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is ^•MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is ^•MC-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen, R22 is hydrogen, halogen, 1-4C-alkyl, 1 -4C-alkoxy, hydroxy, 1 -4C-fluoroalkoxy or -C(O)-I -4C- alkyl, 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy, or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hyd rogen ,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R6 is -NH-C(0)-R7, -C(O)-NR8R9, halogen, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is ^•MC-alkoxy or hydroxy,

R72 is ^•MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

R8 is hydrogen,

R9 is 1 -4C-alkyl, which is optionally substituted by R91 , or 3-6C-cycloalkyl, which is optionally substituted by R92,

R91 is 'MC-alkoxy or hydroxy,

R92 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, ^•MC-fluoroalkoxy or -C(O)-I -4C- alkyl, 1 -4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CHz) _n-,

n is 0,

R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 ,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy, R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy, 1-4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1- 4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 'MC-alkoxy or 1-4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0,

R3 is a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R6 is -NH-C(O)-R7, hydroxy or NH ₂,

R61 is halogen, 1-4C-alkyl or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0, R3 is a 3-6C-cycloalkyl group substituted by R6,

R6 is -N H-C(0)-R7 or hyd roxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 'MC-alkoxy, which is optionally substituted by R73,

R71 is 1 -4C-alkoxy or hydroxy,

R73 is 1 -4C-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is 0,

R3 is a cyclohexyl or cyclopentyl group substituted by R6,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, which is optionally substituted by R73,

R71 is 'MC-alkoxy or hydroxy,

R73 is ^•MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3^C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I -4C-alkyl or ^•MC-fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is 0, R3 is a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R6 is -N H-C(O)-R7 ,

R61 is halogen or 1 -4C-alkyl,

R7 is 1 -4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is ^•MC-alkoxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl which is optionally substituted by R1 1 ,

R11 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1-4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy, ^•MC-fluoroalkoxy or -C(O)-I -4C- alkyl, 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, hydroxy or 1 -4C-fluoroalkoxy,

or R22 and R23 combine to form a group -0-CH ₂-O-,

R24 is hydrogen,

Y is -(CH ₂J _n-,

n is O or i ,

R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 , or -C(O)- O-1 -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43,

R41 is ^•MC-alkoxy or hydroxy,

R43 is ^•MC-alkoxy or hydroxy,

if only one substituent R5 is present then

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

if two su bstituents R5 are present, these are identical and binding at the same carbon atom and are selected from halogen or 1 -4C-alkyl or together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring,

R6 is -NH-C(0)-R7, halogen, hydroxy or NH ₂,

R61 is halogen, 1 -4C-alkyl or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy, which is optionally substituted by R73, R71 is 1 -4C-al koxy or hyd roxy,

R73 is 1 -4C-alkoxy or hyd roxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof. In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R 1 i s - C H ₂-3-6C-cycloalkyl or 1 -4C-alkyl which is optionally substituted by R1 1 ,

R1 1 is 1 -4C-alkoxy or hydroxy,

R2 is hydrogen or 1 -4C-alkyl,

R21 is hydrogen,

R22 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 - 4C-fluoroalkyl,

or R21 and R22 combine to form a group -O-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy or 1 -4C-fluoroalkoxy,

R24 is hydrogen,

Y is -(CH ₂) _n-,

n is O or i ,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or R5, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R41 ,

R41 is ^•MC-alkoxy or hydroxy,

R5 is ^•MC-alkoxy, halogen, 1 -4C-alkyl or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is hydrogen, 1 -4C-alkyl, which is optionally substituted by R71 , or 1 -4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), wherein

R1 is -CH ₂-3-6C-cycloalkyl or 1 -4C-alkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1 -4C-alkyl, 'MC-alkoxy, 1 -4C-fluoroalkoxy, -C(O)-I -4C-alkyl or 1 - 4C-fluoroalkyl,

or R21 and R22 combine to form a group -0-CH ₂-O-,

R23 is hydrogen, halogen, 1 -4C-alkyl, 1 -4C-alkoxy,

R24 is hydrogen, Y i s - ( C H ₂J _n-,

n is 0,

R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said

heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6,

R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R41 is ^•MC-alkoxy or hydroxy,

R6 is -NH-C(O)-R7 or hydroxy,

R7 is hydrogen, 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy,

R71 is 'MC-alkoxy or hydroxy,

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-6C-cycloalkyl or 1-4C-alkyl, R2, R21 , R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-6C-cycloalkyl, R2, R21 , R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3^C-cycloalkyl, R2, R21 , R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R2 is hydrogen, R1 , R21 , R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R2 is methyl, R1 , R21 , R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R21 is hydrogen, R1 , R2, R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R21 is fluoro, R1 , R2, R22, R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, -C(O)-I ^C-alkyl, 1-4C- fluoroalkyl, or R21 and R22 combine to form a group -0-CH ₂-O-, R1 , R11 , R2, R21 , R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R22 is hydrogen, fluoro, methy, ethyl, isopropyl, methoxy, -C(O)-methyl, fluoromethyl, difluoromethyl, trifluoromethyl, or R21 and R22 combine to form a group -0-CH ₂-O-, R1 , R11 , R2, R21 , R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R22 is is fluoro, methyl, difluoromethyl or trifluoromethyl, R1 , R11 , R2, R21 , R23, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R23 is hydrogen, halogen, or 1-4C-alkoxy, R1 , R11 , R2, R21 , R22, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R23 is hydrogen, fluoro, or methoxy, R1 , R11 , R2, R21 , R22, R24, Y, n, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein n is 0, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R1 , R1 1 , R2, R21 , R22, R23, R24, Y, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6, R1 , R11 , R2, R21 , R22, R23, R24, Y, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R3 is piperidine substituted by R4 at the nitrogen atom and optionally substituted by one or two substituents R5 at said piperidine ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R1 , R11 , R2, R21 , R22, R23, R24, Y, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R3 is piperidine substituted by R4 at the nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6, R1 , R11 , R2, R21 , R22, R23, R24, Y, R4, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R41 , R42, R43, R5, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is hydroxy, R1 , R1 1 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is fluoro, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is hydroxy or fluoro, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is methyl, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein two substituents R5 are present, these are identical and binding at the same carbon atom and are fluoro, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein two substituents R5 are present, these are identical and binding at the same carbon atom and are methyl, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein two substituents R5 are present and together with the carbon atom, to which they are bonded, form a spiro-linked cyclopropane ring, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is halogen or 1-4C-alkyl, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R5 is fluoro or methyl, R1 , R1 1 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R6, R61 , R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is -NH-C(O)-R7, halogen, hydroxy or NH ₂, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R61 , R7, R71 , R72 and R73 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is -NH-C(O)-R7, hydroxy or NH ₂, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R61 , R7, R71 , R72 and R73 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is -NH-C(O)-R7 or NH ₂, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R61 , R7, R71 , R72 and R73 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is -NH-C(O)-R7 or hydroxy, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R61 , R7, R71 , R72 and R73 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is -NH-C(O)-R7, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R61 , R7, R71 , R72 and R73 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is hydroxy, R1 , R1 1 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5 and R61 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R6 is halogen R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, and R61 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is halogen R1 , R1 1 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is fluoro R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below. In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is 1-4C-alkyl R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is methyl R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is halogen or 1-4C-alkyl, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R61 is fluoro or methyl, R1 , R11 , R2, R21 , R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R7, R71 , R72, R73, R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 'MC-alkoxy, R1 , R11 , R21 , R2, R22, R23, R24, Y, R3, R4, R41 , R42, R43, R5, R6, R61 , R71 , R8, R9, R91 and R92 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-4C-cycloalkyl, n is 0, R2 is hydrogen, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one or two substituents R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R4 is -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R6 is -NH-C(O)-R7 or hydoxy, R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, R21 , R22, R23, R24, Y, R41 R5, R61 and R71 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-4C-cycloalkyl, n is 0, R2 is hydrogen, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom and optionally substituted by one substituent R5 at said heterocyclic ring, or a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61 , R4 is - C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R6 is -NH-C(0)-R7, R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, R21 , R22, R23, R24, Y, R41 R5, R61 and R71 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-4C-cycloalkyl, n is 0, R2 is hydrogen, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6, R4 is -C(O)-I -4C- alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R6 is -NH-C(O)-R7 or hydoxy, R7 is 1-4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, R21 , R22, R23, R24, Y, R41 and R71 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I) or salts thereof, wherein R1 is -CH ₂-3-4C-cycloalkyl, n is 0, R2 is hydrogen, R3 is a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being substituted by R4 at said nitrogen atom, or a cyclohexyl or cyclopentyl group substituted by R6, R4 is -C(O)-I -4C- alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , R6 is -NH-C(O)-R7, R7 is 1- 4C-alkyl, which is optionally substituted by R71 , or 1-4C-alkoxy, R21 , R22, R23, R24, Y, R41 and R71 are as described above or below.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), selected from

N-(1-Acetylpiperidin^4-yl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-N-[1-(methoxyacetyl)piperidin^4-yl]-6-meth yl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; Ethyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-acetamidocyclohexyl)-4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine- 7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-[trans-4-(propionylamino)cyc lohexyl]- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N- {trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyr rolo[3,2-c(]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-acetamidocyclohexyl)-4-[5-

(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine- 7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[cis^4-(propionylamino)cyclo hexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide; Ethyl {cis- 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin- 7- yl}carbonyl)amino]cyclohexyl}carbamate; N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine- 7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-[(3R)-1 -propionylpyrrolidin-3-yl]-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R)- 1-(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[5-(cyclopro pylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-N-[(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-met hyl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[(3R*,4R*)^4-hydroxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluorophen yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7- carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-{trans^4-[(methoxyace tyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)- 4-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]- 5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N-[(3R)-1- acetylpyrrolidin-3-yl]^4-[2-(cyclopropylmethoxy)^4-fluorophe nyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-1 - propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[(3R)-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7- carboxamide; N-[(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[2-(cyclop ropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carb oxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[(3R*,4R*)-4-hydroxy-1 -propanoylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-[(3S*,4S*)- 1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cydopropylmethoxy)-4 -fluorophenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3- hydroxy-1 -propanoylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluorophenyl]-N-[(3S*,4S*)-3-hydroxy- 1-(methoxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxylic acid (1-acetyl-piperidin-4-yl)-amide; 4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-(1-propionyl piperidin-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo [3,2- c^pyrimidine^-carboxylic acid [1-(2-methoxy-acetyl)-piperidin^4-yl]-amide; Ethyl 4-[({4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-acetamidocyclohexyl)-4-[2- (cyclopropylmethoxyj-S-fluorophenyll-e-methyl-SH-pyrrolop^-d lpyrimidine-y-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[trans-4-(pr opionylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-5H-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; N- [(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-f luorophenyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-1 - propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-c arboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R)-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopr opylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin-4- yl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxy-1- (methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-(2-ethoxy-5-fluorophenyl)-6-methyl-5 /-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-6-methyl-N-(1-propanoylpiperidin ^4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1-(methoxyacetyl)piperidin-4- yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-(1-propiony lpiperidin^4-yl)-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[1-

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide; N-(trans-4- acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-methoxyphen yl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[(3R)-1 -acetylpyrrolidin-3- yl]-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- 1 -propionylpyrrolidin- 3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N- [(3R)-1-(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrol o[3,2-c(]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopro pylmethoxy)^4-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-methoxyphenyl]- N-[(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methoxyphe nyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7- carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- 6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo [3,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-{trans-4-[(methoxyac etyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[cis-4-(pro pionylamino)cyclohexyl]-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N-[(3R)-1- acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-methoxyph enyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- 1- propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyll-N-^SRj-i ^methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrrolop^-cyipy πmidine^- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopr opylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)- 5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin -4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxy- 1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methylphen yl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(1 - propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-5- methylphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexy[]^4-[2-(cyclopropylmethoxy )-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-{trans^4-[(methoxyace tyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[cis-4-(acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[cis-4-(prop anoylamino)cyclohexyl]-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(trifluoro methyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)piperidin-4-yl] -6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[ trans^4-(propanoylamino)cyclohexyl]- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-p yrrolo[3,2-c(]pyrirnidine-7-carboxarnide; N-[cis^-(acetylamino)cyclohexyl]^4-[2-(cyclopropylrnethoxy)- 5-(trifluoromethyl)phenyl]-6-rnethyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis^4-[(m ethoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2-ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide; 4-[2-Ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-N-(1-propanoylpiperidin^4- yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)p iperidin-4-yl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl-N-(1 -propionylpiperidin-4-yl)-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- [1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; Ethyl 4-[({4- [2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5 /-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-Acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-[trans-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{trans-4-[( methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-Acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{cis^4-[(me thoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]- 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- propionylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 3-hydroxy-1- (methoxyacetyl)piperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyr imidine-7 -carboxamide; N-[(3S*,4S*)-1- Acetyl-4-hydroxypiperidin-3-yl]-4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- [(3S*,4S*)-4-hydroxy-1-propionylpiperidin-3-yl]-6-methyl-5/- /-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4-hydroxy-1- (methoxyacetyl)piperidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyr imidine-7-carboxamide; N-(1-

Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluoro- 5-methylphenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7- carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )^4-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-6-methyl-N-[trans^4-(propanoylamino)c yclohexyl]-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^ 4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; N-[cis-4- (Acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)-4-fluoro- 5-methylphenyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6- methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{cis-4-[(met hoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]- 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-6-methyl- 5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxy-1 - propanoylpiperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4R*)-3 -hydroxy-1-(methoxyacetyl)piperidin- 4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine- 7-carboxamide; Ethyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-m ethyl-5H- pyrrolop^-cyjpyrimidin^-yljcarbonyljaminolpiperidine-i-carbo xylate; N-(trans^4-

(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{cis^4-[ (methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; Ethyl {cis^4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-[(3R*,4R*)-1-Acetyl-3-hydroxypiperidin-4-yl]^4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-rnethyl-5/- /-pyrrolo[3,2-d]pyrirnidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)- 3-hydroxy-1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-ethylpheny l]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- ethylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7- carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5-ethylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans^4-[(methoxyacet yl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5/-/-pyrrolo[3, 2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[cis-4-(propa noylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopro pylmethoxy)-5-ethylphenyl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propanoylpyrrolidin-3-yl]-6-methyl-5/ -/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxy-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7 -carboxamide; N-[trans-4- (Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(propan -2-yl)phenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N- {trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyr rolo[3,2-c(]pyrimidine-7 -carboxamide; N-[cis^4-(Acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)- 5-(propan-2-yl)phenyl]-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{cis- 4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2- c^pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(1-acetylpiperidin-4- yl)-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-N-[1-(methoxyacetyl)piperidin^4- yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7-carboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-N-[trans-4-(propanoylam ino)cyclohexyl]-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-2,6-dimethyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]- 2,6-dimethyl-N-(1-propanoylpiperidin^4-yl)-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-4-fluoro-5-m ethoxyphenyl]-2,6-dimethyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-2,6-dimethyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- N-(1-propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine -7-carboxamide; N-(1-Acetylpiperidin-4- yl)-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5 /-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(3R)-1-Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-4 -fluoro-5-methoxyphenyl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-N-[(3R)-1-propionylpyrrolidin-3-yl]- 5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)- 1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]py rimidine-7 -carboxamide; Ethyl (3R)-3- [({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-met hyl-5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1-carboxylate; N-[(3R*,4R*)-1-Acetyl^4-hydroxypyrrolidin-3-yl]-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-p yrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 4-hydroxy-1- (methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrroloIS^-dJpy rimidine^-carboxamide; N-[(3R)-1- Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-fluoro^4- methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-N-[(3R)-1-propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d] pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)-1-(me thoxyacetyl)pyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]- 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)- 4-hydroxy-1-

(methoxyacetyljpyrroNdin-S-yll-θ-methyl-SH-pyrroloβ^-dl pyrimidine^-carboxamide; N-[(3R*,4R*)- 1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy) -5-methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl-5H -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyljpyrroNdin-S-yll-θ-methyl-SH-pyrroloβ^-dlpyr imidine^-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[trans-4-(glycoloylamino)cyclohexyl]- 6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(trans- 4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-py rrolo[3,2-d]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[cis-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7 -carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(cis-4-{[(2S)-2-hydroxypropanoyl]amin o}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol- 4-yl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl-5/-/-pyrr olo[3,2-cy]pyrimidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R)-1-[(2S)-2-hydroxypropanoyl]pyrr olidin-3-yl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-N-[(3R*,4R*)-1 -glycoloyl-4-hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R,4R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3S,4S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[trans-4-(glycoloylam ino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(trans-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[cis^4-(glycoloy lamino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(cis-4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1-(hydroxyacety l)pyrrolidin-3-yl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyπmidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-N-{(3R)-1-[(2S)- 2-hydroxypropanoyl]pyrroNdin-3-yl}-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)^4-hydroxy- 1-(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3S,4S)-4-hydro xy-1- [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hydro xy-1-(hydroxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3R,4R)-3-hydro xy-1 - [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-c(]pyrimidine-7-carboxamide; 4-(2- Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo[3, 2-cy]pyrimidine-7-carboxylic acid [1-(2- hydroxy-acetyl)-piperidin-4-yl]-amide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxylic acid [1-((S)-2-hydroxy-propionyl)-piperidin^4-yl]-amide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-[trans-4-(glycoloylam ino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(trans-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R)-1-(hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrol o[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R)-1-[(2S)-2-hydro xypropanoyl]pyrrolidin-3-yl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R*,4R*)-3-hydroxy-1-(hydroxyacetyl)piperidin^4-yl]-6-meth yl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R,4R)-3-hydro xy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-N-{(3S,4S)-3-hydroxy-1- [(2S)-2-hydroxypropanoyl]piperidin- 4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7 -carboxamide; 4-(2-Ethoxy-5- fluorophenyl)-N-{1-[(2S)-2-hydroxypropanoyl]piperidin^4-yl}- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-(1-glycoloylpip eridin-4-yl)-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{1- [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-(trans^4-{[(2S)-2-hy droxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- methoxyphenyl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3R)-1-[(2S)-2 - hydroxypropanoyl]pyrroNdin-3-yl}-6-methyl-5H-pyrrolo[3,2-c^p yrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-[(3R*,4R*)-1-glycolo yl-4-hydroxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]- N-{(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3 -yl}-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3S,4S)^4-hydr oxy-1- [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(1-glycoloylpiper idin^4-yl)-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[trans^4-(glycoloyla mino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[cis^4-(glycolo ylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-(cis-4- {^S^-hydroxypropanoyllaminoJcyclohexylj-e-methyl-SH-pyrroloI S^-dlpyrimidine^-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R)-1-glycolo ylpyrrolidin-3-yl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3R)-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrol o[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydr oxy-1-(hydroxyacetyl)piperidin^4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropano yl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3S,4S)- 3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacety l)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-py rrolo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4-[(hydroxy acetyl)arnino]cyclohexyl}-6-rnethyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4-[(hydroxy acetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(cis-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-[1-(h ydroxyacetyl)piperidin-4-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{tran s-4-[(hydroxyacetyl)amino]cyclohexyl}- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoy l]amino}cyclohexyl)-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide; ^^-(Cyclopropylmethoxyj-S-^rifluoromethyljphenyll-N- {cis^4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(cis^4-{[( 2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- Ethoxy-5-(trifluoromethyl)phenyl]-N-[1 -(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-6-methyl-5H-pyrrolo[3,2-d]p yrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(1-glycoloy lpiperidin-4-yl)-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-py rrolo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[trans-4 -(glycoloylamino)cyclohexyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cy clohexyl)-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[cis-4 - (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(cis-4-{[(2 S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 1-glycoloyl-3-hydroxypiperidin-4-yl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-{(rac.-3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypr opanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {(rac.-3S,4S)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin -4-yl}-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-1- glycoloyl-4-hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-{(rac.-3S,4 S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(rac.-3R,4 R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[1 -(hydroxyacetyl)piperidin^4-yl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{1 - [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^4-[(h ydroxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-(trans^4-{[(2S)-2-hydroxypropanoyl]amino}cyc lohexyl)-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-{cis-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-(cis-4-{[(2S )-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4R*)-3 -hydroxy-1 -(hydroxyacetyl)piperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoy l]piperidin-4-yl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-(1- glycoloylpiperidin-4-yl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-meth yl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-(trans -4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[cis-4-(gly coloylamino)cyclohexyl]-6-methyl- 5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]- N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methy l-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R,4R)-3-h ydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{(3S,4S)-3- hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[1-(hydroxyacetyl)pipe ridin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4-[(hydroxyacet yl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4-[(hydroxya cetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(cis^4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydroxy-1 -(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-{(3S,4S)-4-hydrox y-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cycloh exyl)-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-(cis-4-{[ (2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-[1-(hydroxyacetyl)pip eridin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[5-Acetyl- 2-(cyclopropylmethoxy)phenyl]-N-{trans^4-[(hydroxyacetyl)ami no]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrr olo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacety l)piperidin-4-yl]-2,6-dimethyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6- dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyll-N-Ii ^hydroxyacetyOpiperidin^-yll^.e-dimethyl-SH-pyrrolop^-cyipyr imidine^- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{1-[(2 S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2R)-2- hydroxycyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine- 7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)- 1- glycoloylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3- yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-[(3R*,4R*)-1 -glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2 - d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R*, 4R*)-4- hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl -5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)- 1-glycoloylpyrrolidin-3- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrro lo[3,2- d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-1- glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- d]pyrimid ine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R*,4R*)-4 -hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-1-glycolo yl-4-hydroxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- N-{(3R*,4R*)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin -3-yl}-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; tert-Butyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl {trans-4- [({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin- 7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-y l}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)arnino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7 - yl}carbonyl)amino]-4-hydroxypyrrolidine-1-carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)^4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}ca rbonyl)amino]piperidine-1-carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-meth yl-5/-/-pyrrolo[3,2-c(]pyrimidin- 7-yl}carbonyl)amino]cyclohexyl}carbamate; Tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}c arbonyl)arnino]cyclohexyl}carbarnate; tert- Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5H-pyrrolo[3,2-cy]pyrimidin-7- ylJcarbonyOaminolpyrrolidine-i -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}ca rbonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; Tert-butyl (3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5/-/- pyrrolop^-cyjpyrimidin^-ylJcarbonyljaminol-S-hydroxypiperidi ne-i -carboxylate; tert-Butyl 4-({1-[4- (2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo [3,2-c(]pyrirnidin-7-yl]-rnethanoyl}- amino)-piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate; tert-Butyl {cis-4-[({4- [2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrol o[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}ca rbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-m ethyl-5H-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1 -carboxylate; tert-Butyl 4-({[4-(2-ethoxy-5- fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl]ca rbonyl}amino)piperidine-1 -carboxylate; tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methy l-5/-/-pyrrolo[3,2- cf]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl} carbonyl)arnino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2- cy]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5H-pyrrolo[3,2- c^pyrimidin^-yljcarbonyljaminolpyrrolidine-i -carboxylate; tert-Butyl (3R*,4R*)^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-d]pyrirnidin-7-yl}carbonyl)arnino]- 3-hydroxypiperidine-i-carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl {trans-4- [({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-p yrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}car bonyl)amino]cyclohexyl}carbamate; tert- Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- rnethyl-5/-/-pyrrolo[3,2-c(]pyrirnidin- 7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi din-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi din-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyp henyl]-6-methyl-5/-/- pyrrolop^-cyjpyrimidin^-ylJcarbonyljaminol-S-hydroxypiperidi ne-i-carboxylate; tert-Butyl (3S*,4S*)-3-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methoxyph enyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypiperidine-1-carb oxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7 - yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}car bonyl)amino]cyclohexyl}carbamate; tert- Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methylphe nyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carb oxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-5-fluoro-4-rnethoxyphenyl]-6-rnethyl-5/ -/-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyp henyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperi dine-1 -carboxylate; tert-butyl 4-[({4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}car bonyl)amino]cyclohexyl}carbamate; tert- butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}car bonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl-5/-/- pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/-/-py rrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}carb onyl)arnino]cyclohexyl}carbarnate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidi n-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]- 2, 6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino ]piperidine-1 -carboxylate; tert-Butyl 4- [({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6-d imethyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7 -yl}carbonyl)arnino]piperidine-1- carboxylate;

a salt thereof, or a stereoisomer of the compound or a salt thereof.

In an alternative embodiment, the present subject matter relates to compounds of formula (I), se- lected from N-(1-Acetylpiperidin-4-yl)-4-[5-(cydopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- N-(1-propionylpiperidin^4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine -7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; Ethyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]p iperidine-1 -carboxylate; N-(trans^4- acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-[trans-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{trans^4-[(methoxyacetyl)amino]cycloh exyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-y l}carbonyl)amino]cyclohexyl}carbamate; N-(cis-4-acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- N-[cis^4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyr imidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{cis-4-[(methoxyacetyl)amino]cyclohex yl}-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide; Ethyl {cis^4-[({4-[5-(cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-y l}carbonyl)amino]cyclohexyl}carbamate; N-[(3R)-1-acetylpyrrolidin-3-yl]^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- N-[(3R)-1-propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyri midine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[(3R)-1-(methoxyacetyl)pyrrolidin-3-y l]-6-methyl-5/-/- pyrrolop^-cyjpyrimidine-y-carboxamide; N-[(3R*,4R*)-1-acetyl-4-hydroxypyrrolidin-3-yl]-4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine- 7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxy-1-propionylpyrro lidin-3-yl]- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol- 4-yl]-N-[(3R*,4R*)-4-hydroxy-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluor ophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-N-(1-propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[1-(methoxyacetyl)pip eridin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-N-[trans^4-(propionylamino)cyclohexyl ]-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)^4-fluorophenyl]-N-{trans-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; N-(cis-4- acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluoropheny l]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-

(Cyclopropylmethoxy)-4-fluorophenyl]-N-{cis^4-[(methoxyac etyl)arnino]cyclohexyl}-6-rnethyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 4-fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-N-[(3R)-1-propanoylpyrrolidin-3-yl]-5 /-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1-(methoxy acetyl)pyrrolidin-3-yl]- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1-acetyl-4-hydroxypyrrolidin-3- yl]-4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)^4-hyd roxy-1-propanoylpyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- [(3R*,4R*)-4-hydroxy-1-(methoxyacetyl)pyrrolidin-3-yl]-6-met hyl-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; N-[(3S*,4S*)-1-acetyl-3-hydroxypiperidin^4-yl]^4-[2-(cyclopr opylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carb oxamide; 4-[2-(Cyclopropylmethoxy)-4- fluorophenyl]-N-[(3S*,4S*)-3-hydroxy-1-propanoylpiperidin-4- yl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hyd roxy-1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide; 4-(2- Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo[3,2- c^pyrimidine-7-carboxylic acid (1 - acetyl-piperidin-4-yl)-amide; 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-(2-Cyclopropylmethoxy-5- fluoro-phenyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxylic acid [1 -(2-methoxy-acetyl)- piperidin-4-yl]-amide; Ethyl 4-[({4-[2-(cydopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/- pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans^4-acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2 -d]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[trans-4-(pr opionylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-5H-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; N- [(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-f luorophenyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-1 - propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-c arboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R)-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopr opylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carb oxamide; 4-[2-(Cyclopropylmethoxy)-5- fluorophenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin-4- yl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxy-1- (methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-(2-ethoxy-5-fluorophenyl)-6-methyl-5 /-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-6-methyl-N-(1-propanoylpiperidin ^4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1-(methoxyacetyl)piperidin-4- yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-(1-propiony lpiperidin^4-yl)-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7 -carboxamide; N-(trans-4- acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-methoxyphen yl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(3R)-1 -acetylpyrrolidin-3- yl]-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- 1 -propionylpyrrolidin- 3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N- [(3R)-1-(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrol o[3,2-cy]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-acetyl^4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopro pylmethoxy)^4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-methoxyphenyl]- N-[(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-(1- acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methoxyphe nyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrirnidine-7- carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- 6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo [3,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-{trans-4-[(methoxyac etyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-

(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[cis-4-(pro pionylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N-[(3R)-1- acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-methoxyph enyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- 1- propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyll-N-^SRj-i ^methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrrolop^-cyipy πmidine^- carboxamide; N-[(3R*,4R*)-1-acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopr opylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)- 5-methoxyphenyl]-N-[(3R*,4R*)-3-hydroxy-1-propanoylpiperidin -4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxy- 1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methylphen yl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(1 - propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-5- methylphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexy[]^4-[2-(cyclopropylmethoxy )-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-{trans^4-[(methoxyace tyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[cis-4-(acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[cis-4-(prop anoylamino)cyclohexyl]-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(trifluoro methyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)piperidin-4-yl] -6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[ trans^4-(propanoylamino)cyclohexyl]- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-p yrrolo[3,2-c(]pyrirnidine-7-carboxarnide; N-[cis^-(acetylamino)cyclohexyl]^4-[2-(cyclopropylrnethoxy)- 5-(trifluoromethyl)phenyl]-6-rnethyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis^4-[(m ethoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(1-acetylpiperidin-4-yl)-4-[2-ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide; 4-[2-Ethoxy-5- (trifluoromethyl)phenyl]-6-methyl-N-(1-propanoylpiperidin^4- yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-[1-(methoxyacetyl)p iperidin-4-yl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl-N-(1 -propionylpiperidin-4-yl)-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- [1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; Ethyl 4-[({4- [2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5 /-/-pyrrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]piperidine-1-carboxylate; N-(trans-4-Acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-[trans-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-

(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{trans-4 -[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis^4-Acetamidocyclohexyl)^4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{cis^4-[(me thoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]- 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- propionylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 3-hydroxy-1-

(methoxyacetyl)piperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7 -carboxamide; N-[(3S*,4S*)-1- Acetyl-4-hydroxypiperidin-3-yl]-4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- [(3S*,4S*)-4-hydroxy-1-propionylpiperidin-3-yl]-6-methyl-5/- /-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4-hydroxy-1- (methoxyacetyl)piperidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyr imidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5-m ethylphenyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7- carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )^4-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-6-methyl-N-[trans^4-(propanoylamino)c yclohexyl]-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^ 4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; N-[cis-4- (Acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)-4-fluoro- 5-methylphenyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6- methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{cis-4-[(met hoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]- 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-6-methyl- 5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxy-1 - propanoylpiperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4R*)-3 -hydroxy-1-(methoxyacetyl)piperidin- 4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide; 4-[2-(Cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine- 7-carboxamide; Ethyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-m ethyl-5H- pyrrolop^-cyjpyrimidin^-yljcarbonyljaminolpiperidine-i-carbo xylate; N-(trans^4- Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4-me thoxyphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-N-[trans-4-(propionylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{trans-4-[( methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; N-(cis-4-Acetamidocyclohexyl)-4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5/-/ -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{cis^4-[(me thoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; Ethyl {cis^4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; N-[(3R*,4R*)-1-Acetyl-3-hydroxypiperidin-4-yl]^4-[2- (cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-rnethyl-5/- /-pyrrolo[3,2-d]pyrirnidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)- 3-hydroxy-1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide; N-(1- Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-ethylpheny l]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- ethylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7- carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5-ethylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans^4-[(methoxyacet yl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5/-/-pyrrolo[3, 2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[cis-4-(propa noylamino)cyclohexyl]-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; N- [(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopro pylmethoxy)-5-ethylphenyl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propanoylpyrrolidin-3-yl]-6-methyl-5/ -/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxy-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-[1-

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide; N-[trans-4- (Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(propan -2-yl)phenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N- {trans^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyr rolo[3,2-cy]pyrimidine-7-carboxamide; N-[cis^4-(Acetylamino)cyclohexyl]^4-[2-(cyclopropylmethoxy)- 5-(propan-2-yl)phenyl]-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{cis- 4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3, 2-c(]pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(1-acetylpiperidin-4- yl)-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-N-[1-(methoxyacetyl)piperidin^4- yl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide; 4-[5-Acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-N-[trans-4-(propanoylam ino)cyclohexyl]-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[1 -(methoxyacetyl)piperidin^4-yl]-2,6-dimethyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]- 2,6-dimethyl-N-(1-propanoylpiperidin^4-yl)-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; N-(1- Acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-4-fluoro-5-m ethoxyphenyl]-2,6-dimethyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5- fluoro^4-methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]-2,6-dimethyl-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- N-(1-propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine -7-carboxamide; N-(1-Acetylpiperidin-4- yl)-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5 /-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(3R)-1-Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-4 -fluoro-5-methoxyphenyl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-N-[(3R)-1 -propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)- 1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]py rimidine-7 -carboxamide; Ethyl (3R)-3- [({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-met hyl-5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1-carboxylate; N-[(3R*,4R*)-1-Acetyl^4-hydroxypyrrolidin-3-yl]-4-[2- (cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-p yrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 4-hydroxy-1- (methoxyacetyljpyrrolidin-S-yll-θ-methyl-SH-pyrroloIS^-dlpy rimidine^-carboxamide; N-[(3R)-1- Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5-fluoro^4- methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-N-[(3R)-1-propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d] pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)-1-(me thoxyacetyl)pyrrolidin-3-yl]-6- methyl-SH-pyrroloβ^-dlpyrimidine^-carboxamide; N-[(3R*,4R*)-1-Acetyl-4-hydroxypyrrolidin-3-yl]- 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-4-hydroxy-1- propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*,4R*)- 4-hydroxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]py rimidine-7-carboxamide; N-[(3R*,4R*)- 1-Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy) -5-methoxyphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N- [(3R*,4R*)-4-hydroxy-1-propionylpyrrolidin-3-yl]-6-methyl-5H -pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyljpyrroNdin-S-yll-θ-methyl-SH-pyrroloβ^-dlpyr imidine^-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[5-

(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[trans-4-(glycoloylamino)cyclohexyl]- 6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(trans- 4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-py rrolo[3,2-d]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[cis-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7 -carboxamide; 4-[5-

(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(cis-4-{[(2S)-2-hydroxypropanoyl]amin o}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol- 4-yl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl-5/-/-pyrr olo[3,2-cy]pyrimidine-7-carboxamide; 4-[5- (Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R)-1-[(2S)-2-hydroxypropanoyl]pyrr olidin-3-yl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-N-[(3R*,4R*)-1 -glycoloyl-4-hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7- carboxamide; 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R,4R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide; 4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3S,4S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-(1 -glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[trans-4-(glycoloylam ino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(trans-4-

{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/ -pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[cis^4-(glycoloy lamino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(cis-4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1-(hydroxyacety l)pyrrolidin-3-yl]-6-methyl-5/-/- pyrrolop^-cyjpyrimidine-y-carboxamide; 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-N-{(3R)-1-[(2S)- 2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3, 2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)^4-hydroxy- 1-(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3S,4S)-4-hydro xy-1- [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hydro xy-1-(hydroxyacetyl)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3R,4R)-3-hydro xy-1 - [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-(2- Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo[3, 2-cy]pyrimidine-7-carboxylic acid [1-(2- hydroxy-acetyl)-piperidin-4-yl]-amide; 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxylic acid [1-((S)-2-hydroxy-propionyl)-piperidin^4-yl]-amide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-[trans-4-(glycoloylam ino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(trans-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R)-1-(hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrol o[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R)-1-[(2S)-2-hydro xypropanoyl]pyrrolidin-3-yl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N- [(3R*,4R*)-3-hydroxy-1-(hydroxyacetyl)piperidin^4-yl]-6-meth yl-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R,4R)-3-hydro xy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-fluorophenyl]-N-{(3S,4S)-3-hydroxy-1- [(2S)-2-hydroxypropanoyl]piperidin- 4-yl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5-fluorophenyl)-N-[1-

(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidine-7 -carboxamide; 4-(2-Ethoxy-5- fluorophenyl)-N-{1-[(2S)-2-hydroxypropanoyl]piperidin^4-yl}- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-(1-glycoloylpip eridin-4-yl)-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{1- [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-(trans^4-{[(2S)-2-hy droxypropanoyl]amino}cyclohexyl)- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4- methoxyphenyl]-N-[(3R)-1-glycoloylpyrrolidin-3-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3R)-1-[(2S)-2 - hydroxypropanoyl]pyrroNdin-3-yl}-6-methyl-5H-pyrrolo[3,2-c^p yrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)^4-methoxyphenyl]-N-[(3R*,4R*)-1-glycolo yl-4-hydroxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]- N-{(3R,4R)^-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3- yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-{(3S,4S)^4-hydr oxy-1- [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(1-glycoloylpiper idin^4-yl)-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[trans^4-(glycoloyla mino)cyclohexyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[cis^4-(glycolo ylamino)cyclohexyl]-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-(cis-4-

{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-p yrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R)-1-glycolo ylpyrrolidin-3-yl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3R)-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrol o[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hydr oxy-1-(hydroxyacetyl)piperidin^4- yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- methoxyphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropano yl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3S,4S)- 3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacety l)piperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-py rrolo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4-[(hydroxy acetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4-[(hydroxy acetyl)amino]cyclohexyl}-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(cis-4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-[1-(h ydroxyacetyl)piperidin-4-yl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]- N-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{tran s-4-[(hydroxyacetyl)amino]cyclohexyl}- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoy l]amino}cyclohexyl)-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide; ^^-(Cyclopropylmethoxyj-S-^rifluoromethyljphenyll-N- {cis^4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(cis^4-{[( 2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- Ethoxy-5-(trifluoromethyl)phenyl]-N-[1 -(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-6-methyl-5H-pyrrolo[3,2-d]p yrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(1-glycoloy lpiperidin-4-yl)-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-py rrolo[3,2-d]pyrimidine-7-carboxamide; 4- [2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[trans-4 -(glycoloylamino)cyclohexyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cy clohexyl)-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[cis-4 - (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(cis-4-{[(2 S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*,4R*)- 1-glycoloyl-3-hydroxypiperidin-4-yl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-{(rac.-3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypr opanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N- {(rac.-3S,4S)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin -4-yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-1- glycoloyl-4-hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-{(rac.-3S,4 S)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(rac.-3R,4 R)-4-hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[1 -(hydroxyacetyl)piperidin^4-yl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{1 - [(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrro lo[3,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^4-[(h ydroxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-(trans^4-{[(2S)-2-hydroxypropanoyl]amino}cyc lohexyl)-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-{cis-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N-(cis-4-{[(2S )-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4R*)-3 -hydroxy-1 -(hydroxyacetyl)piperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoy l]piperidin-4-yl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-(1- glycoloylpiperidin-4-yl)-6-methyl-5H-pyrrolo[3,2-c^pyrimidin e-7-carboxamide4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-[trans-4-(glycoloylamino)cyclohexyl]-6-meth yl-5H-pyrrolo[3,2-c(]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-(trans -4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[cis-4-(gly coloylamino)cyclohexyl]-6-methyl- 5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]- N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methy l-5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[(3R*, 4R*)-3-hydroxy-1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R,4R)-3-h ydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{(3S,4S)-3- hydroxy-1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[1-(hydroxyacetyl)pipe ridin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[2-

(Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4-[(hydroxya cetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4-[(hydroxya cetyl)amino]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(cis^4-{[(2S)- 2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydroxy-1 -(hydroxyacetyl)pyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-{(3S,4S)-4-hydrox y-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7 -carboxamide; 4- [2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cycloh exyl)-6-methyl-5H-pyrrolo[3,2- cf]pyπmidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-(cis-4-{[ (2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide; 4-[5- Acetyl-2-(cyclopropylmethoxy)phenyl]-N-[1-(hydroxyacetyl)pip eridin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide; 4-[5-Acetyl- 2-(cyclopropylmethoxy)phenyl]-N-{trans^4-[(hydroxyacetyl)ami no]cyclohexyl}-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4- {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrr olo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacety l)piperidin-4-yl]-2,6-dimethyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6- dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyll-N-Ii ^hydroxyacetyOpiperidin^-yll^.e-dimethyl-SH-pyrrolop^-cyipyr imidine^- carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{1-[(2 S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2R)-2- hydroxycyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine- 7 -carboxamide; 4-[2-

(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2-hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2- cf]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)- 1- glycoloylpyrrolidin-S-yll-e-methyl-SH-pyrrolop^-dlpyrimidine ^-carboxamide; 4-[2- (Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3- yl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-[(3R*,4R*)-1 -glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2 - d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R*, 4R*)-4- hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl -5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)- 1-glycoloylpyrrolidin-3- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-N-{(3R)-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrro lo[3,2- d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-1- glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- d]pyrimid ine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{(3R*,4R*)-4 -hydroxy-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-1-glycolo yl-4-hydroxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]- N-{(3R*,4R*)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin -3-yl}-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide; tert-Butyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl {trans-4- [({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin- 7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3- benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7- yl}carbonyl)arnino]cyclohexyl}carbarnate; tert-Butyl (3R)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2- c^pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[5- (cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7 - yl}carbonyl)amino]-4-hydroxypyrrolidine-1-carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)^4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}ca rbonyl)amino]piperidine-1-carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-meth yl-5/-/-pyrrolo[3,2-c(]pyrimidin- 7-yl}carbonyl)amino]cyclohexyl}carbamate; Tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}c arbonyl)arnino]cyclohexyl}carbarnate; tert- Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5H-pyrrolo[3,2-cy]pyrimidin-7- ylJcarbonyOaminolpyrrolidine-i -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}ca rbonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; Tert-butyl (3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5/-/- pyrrolop^-cdpyrimidin^-ylJcarbonyljaminoJ-S-hydroxypiperidin e-i -carboxylate; tert-Butyl 4-({1-[4- (2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrrolo [3,2-c(]pyrirnidin-7-yl]-rnethanoyl}- amino)-piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate; tert-Butyl {cis-4-[({4- [2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5/-/-pyrrol o[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}ca rbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-m ethyl-5H-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1 -carboxylate; tert-Butyl 4-({[4-(2-ethoxy-5- fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl]ca rbonyl}amino)piperidine-1 -carboxylate; tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methy l-5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2- (cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidin-7- yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2- c^pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate; tert-Butyl (3R*,4R*)^4-[({4-[2- (cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[ 3,2-d]pyrirnidin-7-yl}carbonyl)amino]- 3-hydroxypiperidine-i-carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl {trans-4- [({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-p yrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbo nyl)arnino]cyclohexyl}carbamate; tert- Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- rnethyl-5/-/-pyrrolo[3,2-c(]pyrirnidin- 7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi din-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi din-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pip eridine-1-carboxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-rnethoxyphenyl]-6-rnethyl-5/ -/-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyp henyl]-6-methyl-5/-/- pyrrolop^-cdpyrimidin^-ylJcarbonyljaminoJ-S-hydroxypiperidin e-i-carboxylate; tert-Butyl (3S*,4S*)-3-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methoxyph enyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypiperidine-1-carb oxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7- yljcarbonyljaminolpiperidine-i -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4- fluoro-5-methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi n-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}car bonyl)amino]cyclohexyl}carbamate; tert- Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)^-fluoro-5-methylphe nyl]-6-methyl-5H-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiperidine-1-carb oxylate; tert-Butyl 4-[({4-[2- (cyclopropylmethoxy)-5-fluoro-4-rnethoxyphenyl]-6-rnethyl-5/ -/-pyrrolo[3,2-d]pyrimidin-7- ylJcarbonyOaminolpiperidine-i -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- fluoro^-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7 - yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl} carbonyl)arnino]cyclohexyl}carbarnate; tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyp henyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3-hydroxypiper idine-1-carboxylate; tert-butyl 4-[({4-[2- (cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}ca rbonyl)arnino]cyclohexyl}carbarnate; tert- butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}car bonyl)amino]-4-hydroxypyrrolidine-1- carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl {trans^4-[({4-[2- (cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidin-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2- yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7-yl}carb onyl)arnino]cyclohexyl}carbarnate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2- cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carboxylate; tert-Butyl {trans^4-[({4-[2-

(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-cy]pyrimidi n-7- yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]- 2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)ami no]piperidine-1 -carboxylate; tert-Butyl 4- [({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6-d irnethyl-5/-/-pyrrolo[3,2-c(]pyrirnidin-7- yl}carbonyl)amino]piperidine-1 -carboxylate; tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl}carbonyl)amino]piperidine-1- carboxylate; N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(difl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-N-(1 -propanoylpiperidin^4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[1 -(methoxyacetyl)piperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4- [2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-rnethyl- 5/-/-pyrrolo[3,2-c(]pyrirnidine-7- carboxamide;

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-met hyl-N-[trans-4- (propanoylaminojcyclohexyll-S^pyrrolop^-^pyrimidine^-carboxa mide; 4-[2-

(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{trans^4 -[(methoxyacetyl)amino]cyclohexyl}-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide;

N-[(3S,5S)-1-Acetyl-5-methylpyrrolidin-3-yl]-4-[2-(cycloprop ylmethoxy)-5-(difluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-N-[(3S,5S)-5-methyl-1-propa noylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2- cf]pynmidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(3S,5 S)-1 - (methoxyacetyl)-5-methylpyrrolidin-3-yl]-6-methyl-5/-/-pyrro lo[3,2-cy]pyrimidine-7 -carboxamide; N-[(1 S,3S)-3-(Acetylamino)cyclopentyl]^4-[2-(cyclopropylmethoxy)- 5-(difluoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-N-[(1 S,3S)-3-(propanoylamino)cyclopentyl]-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide;

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S,3S)-3-

[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidine-7-carboxamide; N- [(1 R*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclopentyl]^4-[2-(cyclo propylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R*,2R*,4R*)-2-fluoro-4- (propanoylamino)cyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c(]py rimidine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2-fluoro-4- [(methoxyacetyl)amino]cyclopentyl}-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide; N- [(1 S*,2S*,4S*)-4-(Acetylamino)-2-methylcyclohexyl]-4-[2-(cyclop ropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[( 1 S*,2S*,4S*)-2-methyl-4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide;

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2S*,4S*)-4-[(methoxyacetyl)amino]-2- methylcyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; N-[(1 R*,2R*,4R*H- (Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)- 5-(difluoromethyl)phenyl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]- N-[(1 R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl- 5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2-fluoro-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide; N- [(1 S*,3S*,4S*)-4-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclop ropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide; 4-[2-

(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N -[(1 S*,3S*,4S*)-3-methyl-4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)^4-[(methoxyacetyl)amino]-3- methylcyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(1 S*,3S*,4S*)^4- (Acetylamino)-3-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)- 5-(difluoromethyl)phenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]- N-[(1 S*,3S*,4S*)-3-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl- 5H-pyrrolo[3,2-cy]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)-3-fluoro^- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide; N- [(1 R*,3S*,4S*)-3-(Acetylamino)^4-methylcyclopentyl]-4-[2-(cyclo propylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[( 1 R*,3S*,4S*)-3-methyl-4- (propanoylamino)cyclopentyl]-5/-/-pyrrolo[3,2-c(]pyrimidine- 7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,3S*,4S*)-3-[(methoxyacetyl)amino]^4- methylcyclopentyl}-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide; N-[(1 R*,2R*,4S*Η- (acetylamino)-2-methylcyclopentyl]-4-[2-(cyclopropylmethoxy) -5-(difluoromethyl)phenyl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6- methyl-N-[(1 R*,2R*,4S*)-2-methyl-4-(propanoylamino)cyclopentyl]-5H-pyrro lo[3,2-d]pyrimidine-7- carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4S*)-4- [(methoxyacetyl)amino]-2-methylcyclopentyl}-6-methyl-5/-/-py rrolo[3,2-cy]pyrimidine-7-carboxamide; N-[(1 S*,3S*,4S*)-3-(Acetylamino)^-fluorocyclopentyl]^-[2-(cyclopr opylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,3S*,4S*)-3-fluoro-4-

(propanoylamino)cyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide; 4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)-3-fluoro-4- [(methoxyacetyl)amino]cyclopentyl}-6-methyl-5H-pyrrolo[3,2-d ]pyrimidine-7-carboxamide; N- [(1 S*,2R*,4S*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclop ropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4S*)-2-fluoro-4- (propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7 -carboxamide; 4-[2- (Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4S*)-2-fluoro-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide;

a salt thereof, or a stereoisomer of the compound or a salt thereof.

It is to be understood that the present subject matter covers all combinations of substituent groups referred to hereinabove. In particular, the present subject matter covers all combinations of alternative or preferred groups described hereinabove.

Salts of the compounds according to the present subject matter and the stereoisomers thereof include all inorganic and organic acid addition salts and salts with bases, especially all pharmaceutically acceptable inorganic and organic acid addition salts and salts with bases, particularly all pharmaceutically acceptable inorganic and organic acid addition salts and salts with bases customarily used in pharmacy.

Examples of acid addition salts include, but are not limited to, hydrochlorides, hydrobromides, phosphates, nitrates, sulfates, acetates, trifluoroacetates, citrates, gluconates including D- gluconates and L-gluconates, glucuronates including D-glucuronates and L-glucuronates, benzoates, 2-(4-hydroxybenzoyl)benzoates, butyrates, salicylates, subsalicylates, maleates, laurates, malates including L-malates and D-malates, lactates including L-lactates and D-lactates, fumarates, succinates, oxalates, tartarates including L-tartarates, D-tartarates and meso-tartarates, stearates, benzenesulfonates (besilates), toluenesulfonates (tosilates), methanesulfonates (mesilates), laurylsulfonates, 3-hydroxy-2-naphthoates, lactobionates (salts of 4-O-beta-D- galactopyranosyl-D-gluconic acid), galactarates, embonates and ascorbates.

Examples of salts with bases include, but are not limited to, lithium, sodium, potassium, calcium, aluminum, magnesium, titanium, ammonium, meglumine and guanidinium salts.

The salts include water-insoluble and, particularly, water-soluble salts.

The compounds according to the present subject matter, the salts thereof, the stereoisomers of the compounds and the salts thereof may contain, e.g. when isolated in crystalline form, varying amounts of solvents. Included within the scope of the present subject matter are, therefore, all solvates of the compounds of formula (I), the salts thereof, the stereoisomers of the compounds and the salts thereof. Hydrates are a preferred example of said solvates. Some of the compounds of formula 1 , salts thereof, stereoisomers thereof or salts of the latter may exist in different crystalline forms (polymorphs), which are within the scope of the invention. The obtained solids of the compounds of formula 1 , salts thereof, stereoisomers thereof or salts of the latter are re-crystal ised in different crystalline forms (polymorphs) with solvents or mixtures of the solvents selected from water, methanol, ethanol, isopropanol, n-butanol, dichloromethane, tert- butylmethylether, acetonitril, dioxan, methylethylketon, aceton, glycole, ethylene glycol, methyl isobutylketon,

The compounds according to the present subject matter and the salts thereof include stereoisomers.

Examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6. Stereoisomers of one exemplified compound of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6 are shown below (cis/trans stereoisomers), wherein the trans stereoisomer (S1 ) is preferred:

Furthermore the present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S ₁R)- isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

(S7) (S8) (S9) (S10)

Y = -(CH ₂) ₀- ^or -( ^CH2>- Examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61. Stereoisomers of one exemplified compound of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 includes the pure (S,S,S)-isomers, (S,S,R)-isomers, (S,R,S)-isomers and (S,R,R)-isomers, (R,R,R)-isomers, (R,R,S)-isomers, (R,S,S)-isomers and (R,S,R)-isomers and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S1 1 ), (S13), (S15) and (S18) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

Furthermore examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61.

Stereoisomers of one exemplified compound of formula (I) wherein R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 includes the pure (S,S,S)-isomers, (S, S, R)- isomers, (S,R,S)-isomers and (S,R,R)-isomers, (R,R,R)-isomers, (R,R,S)-isomers, (R,S,S)-isomers and (R,S,R)-isomers and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S19), (S21 ), (S23) and (S26) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

Y = -(CH ₂V ^or -( ^CH ₂>-

Further examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and wherein said heterocyclic ring contains a stereogenic center. Stereoisomers of an exemplified compound of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and said heterocyclic ring containing a stereogenic center are shown below:

(S27) (S28)

Y = -(CH ₂) ₀- ^or -( ^CH ₂)-

Further examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or by two substituents R5 and wherein said heterocyclic ring contains a stereogenic center. Stereoisomers of an exemplified compound of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or by two substituents R5 and said heterocyclic ring containing a stereogenic center are shown below:

(S29) (S30)

Y = -(CH ₂J ₀- or -(CH ₂)- Further examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by R4 and/or R5 and wherein said heterocyclic ring contains stereogenic centers. The present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S,R)-isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

(S31) (S32) (S33) (S34)

Y = -(CH ₂J ₆- Furthermore the present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S ₁R)- isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Stereoisomers of a further exemplified compound of formula (I) wherein R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom, said heterocyclic ring being optionally substituted by R4 and/or R5 and said heterocyclic ring containing stereogenic centers. The present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S,R)-isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂),,- or -(CH ₂)-

Furthermore, the present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S ₁R)- isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂J ₀-

Y = "(CH ₂)-

Y = -(CH ₂),,- Furthermore, the present subject matter includes the pure (R,R)-isomers, (R,S)-isomers, (S ₁R)- isomers and (S,S)-isomers, and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂)-

Further examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R4 is a group having a stereogenic center, such as a group -C(O)-CH(CHb)-OH. Further examples of stereoisomers include, but are not limited to, compounds of formula (I) wherein R6 is a group having a stereogenic center, such as a group -NH-C(O)-CH(CHa)-OCH ₃.

Each of said stereogenic centers may have the absolute configuration R or the absolute configuration S (according to the rules of Cahn, lngold and Prelog).

The present subject matter relates to the pure stereoisomers and to mixtures of the stereoisomers independent of the ratio, including the racemates. Accordingly, the present subject matter relates to the pure (cis)-isomers, the pure (trans)-isomers, and mixtures thereof, the pure (R)-isomers, the pure (S)-isomers, and mixtures thereof, the pure (RS)-isomers, the pure (SS)-isomers, the pure (SR)-isomers, the pure (RR)-isomers, and mixtures of two or more thereof in any ratio.

Furthermore, the present subject matter includes the pure (trans, R)-isomers, (trans, S)-isomers, (cis,R)-isomers and (cis,S)-isomers, and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S77) and (S78) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

(S77) (trans,S) (S78) (trans.R) (S79) ( _C, _S]S) (S80) (as, R)

Y = -(CH ₂),,- or -(CH ₂)-

Y= -(CH ₂J ₀-

Furthermore, the present subject matter includes the pure (S,R,S)-isomers, (R,R,S)-isomers, (S,R,R)-isomers, (R,R,R)-isomers, (S,S,S)-isomers, (R,S,S)-isomers and (S,S,R)-isomers, (R,S,R)- isomers and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y= -(CH ₂) ₀- or -(CH ₂)- ₁ = 1 or 2 Furthermore, the present subject matter includes the pure (S,R,S)-isomers, (R,R,S)-isomers, (S,R,R)-isomers, (R,R,R)-isomers, (S,S,S)-isomers, (R,S,S)-isomers and (S,S,R)-isomers, (R,S,R)- isomers and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂J ₆- Furthermore, the present subject matter includes the pure (S,R,S)-isomers, (R,R,S)-isomers, (S,R,R)-isomers, (R,R,R)-isomers, (S,S,S)-isomers, (R,S,S)-isomers and (S,S,R)-isomers, (R,S,R)- isomers and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂)- Furthermore, the present subject matter includes the pure (S,R,S)-isomers, (R,R,S)-isomers, (S,R,R)-isomers, (R,R,R)-isomers, (S,S,S)-isomers, (R,S,S)-isomers and (S,S,R)-isomers, (R,S,R)- isomers and mixtures of two or more thereof in any ratio. An example of said isomers is shown below:

Y = -(CH ₂J ₀-

Y = -(CH ₂)-

Y = -(CH ₂),,-

Y = -(CH ₂)- Furthermore, the present subject matter includes the pure (S,S,S,S)-isomers, (S,S,S,R)-isomers, (R,S,S,S)-isomers and (R,S,S,R)-isomers, (S,RS,S)-isomers, (S,R,S,R)-isomers, (R ₁R ₁S ₁S)- isomers, (R,R,S,R)-isomers, (S,S,R,S)-isomers, (S,S,R,R)-isomers, (R,S,R,S)-isomers, (R,S,R,R)- isomers, (S,R,R,S)-isomers, (S,R,R,R)-isomers, (R,R,R,S)-isomers and (R,R,R,R)-isomers and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S161 ), (S162), (S165), (S166), (S171 ), (S172), (S175) and (S176) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

(S161) (S,S,S,S) (S162) (S,S,S,R) (S163) (R,S,S,S) (S164) (R,S,S,R)

(S165) (S,R,S,S) (S166) (S,R,S,R) (S167) (R,R,S,S) (S168) (R,R,S,R)

(S169) (S,S,R,S) (S170) (S,S,R,R) (S171) (R,S,R,S) (S172) (R,S,R,R)

(S173) (S,R,R,S) (S174) (S,R,R,R) (S175) (R,R,R,S) (S176) (R,R,R,R)

Y = -(CH ₂J ₀- Furthermore, the present subject matter includes the pure (S,S,S,S)-isomers, (S,S,S,R)-isomers, (R,S,S,S)-isomers and (R,S,S,R)-isomers, (S,RS,S)-isomers, (S,R,S,R)-isomers, (R ₁R ₁S ₁S)- isomers, (R,R,S,R)-isomers, (S,S,R,S)-isomers, (S,S,R,R)-isomers, (R,S,R,S)-isomers, (R ₁S ₁R ₁R)- isomers, (S,R,R,S)-isomers, (S,R,R,R)-isomers, (R,R,R,S)-isomers and (R,R,R,R)-isomers and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S177), (S178), (S181 ), (S182), (S187), (S188), (S191 ) and (S192) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

(S177) (R,S,S,S) (S178) (R,S,S,R) (S179) (S,S,S,S) (S180) (S,S,S,R)

(S181) (R,R,S,S) (S182) (R,R,S,R) (S183) (S,R,S,S) (S184) (S,R,S,R)

(S185) (R,s,R,S) (S186) (R,S,R,R) (S187) (S,S,R,S) (S188) (S,S,R,R)

(S189) (R,R,R,S) (S190) (R,R,R,R) (S191 ) (S,R,R,S) (S192) (S,R,R,R)

Y = -(CH ₂)-

Furthermore, the present subject matter includes the pure (S,S,S,S)-isomers, (S,S,S,R)-isomers, (R,S,S,S)-isomers and (R,S,S,R)-isomers, (S,RS,S)-isomers, (S,R,S,R)-isomers, (R,R,S,S)- isomers, (R,R,S,R)-isomers, (S,S,R,S)-isomers, (S,S,R,R)-isomers, (R,S,R,S)-isomers, (R,S,R,R)- isomers, (S,R,R,S)-isomers, (S,R,R,R)-isomers, (R,R,R,S)-isomers and (R,R,R,R)-isomers and mixtures of two or more thereof in any ratio, wherein the stereoisomers (S193), (S194), (S197), (S198), (S203), (S204), (S207) and (S208) and mixtures of two or more thereof in any ratio are preferred. An example of said isomers is shown below:

(S193) (SRSS) (S194) (SRSR) (S195) (RRSS) (S196) (RRSR)

(S197) (SSSS) (S198) (SSSR) (S199) (RSSS) (S200) (RSSR)

(S201) (S,R,R,S) (S202) (S,R,R,R) (S203) (R.R.R.S) (S204) (R.R.R.R)

(S205) (S.S.R.S) (S206) (S,S,R,R) (S207) (R,S,R,S) (S208) (R,S,R,R)

Y= -(CH ₂I ₀- or -(CH ₂)- Furthermore, derivatives of the compounds according to the present subject matter, the salts thereof, the stereoisomers of the compounds and the salts thereof which are converted into compounds according to the present subject matter, the salts thereof, the stereoisomers of the compounds or the salts thereof in a biological system (bioprecursors or pro-drugs) are covered by the present subject matter. Said biological system is e.g. a mammalian organism, particularly a human subject. The bioprecursor is, for example, converted into the compounds according to the present subject matter, the salts thereof, the stereoisomers of the compounds or the salts thereof by metabolic processes. The compounds according to the invention can be prepared as follows.

(4) (5) (6)

Reaction scheme 1

The compound of formula (6) wherein R2 is hydrogen can be obtained as shown in reaction scheme 1 according to the procedures described in US 2005/0124623A1.

(17) (19) (20)

(21) (22) (23)

(24) (25)

Reaction scheme 2

As shown in reaction scheme 2 synthesis of the compound of formula (25), wherein R2 is methyl may start from the literature known compound of formula (17) [Gangjee, A.; Li, W.; Yang, J.;

Kisliuk, R. L; J. Med. Chem. 2008, 51 , 68] by reaction with a nitril of formula (18) in the presence of an acid (prferentially hydrochloric acid) under anhydrous conditions and cyclization of the obtained compound of formula (19) or its salt to the compound of formula (20) wherein R2 is methyl according to the procedures as for example described in Venugopalan, B.; Desai, P. D.; Souza, N. J.; J. Heterocyclic Chem. 1988, 25, 1633. Subsequent reaction of the compound of formula (20) with either neat POCI ₃ or a solution of POCI ₃ in an inert organic solvent (preferentially acetonitril) at reflux temperature for 2h to 24h and reaction of the obtained compound of formula (21 ) with for example bromine or N-bromosuccinimide in an organic solvent such as dichloromethane (DCM) at a temperature of from -40 to 20 ⁰C for 0.5 to 4 h gives the compounds of formula (22). The compound of formula (22) thus obtained can then be protected by reaction with a base such as sodium hydride and (2-chloromethoxy-ethyl)-trimethyl-silane in a organic solvent such as dimethoxyethane, dimethylformamide or dimethylsulfoxide at a temperature of from 0 ⁰C to 25°C for 1 h to 24h as for example described in Muchowski, J. M.; Solas, D. R.; J. Org:Chem. 1984, 49, 203 to a compound of formula (23).

In an additional step a solution of the compound of formula (23) in an organic solvent, such as tetrahydrofurane can be reacted with n-BuLi (n-butyl lithium) in an organic solvent, such as hexane, at a temperature of -78°C for 0.5 to 3 h. Subsequently, dimethylformamide (DMF) is added and the reaction is performed at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h, as for example described in

WO2008/30119 to yield the compound of formula (24).

Finally a solution of the compound of formula (24) in methanol is treated with MnQ in the presence of potassium cyanide at ambient temperature for 4h to 24h as for example idescribed in Corey, E.

J.; Gilman, N. W.; Ganem, B. E.; J. Am. Chem. Soc. 1968, 90, 5616 to give the compound of formula (25).

Reaction scheme 3

As shown in reaction scheme 3, synthesis of a boronic acid derivative of formula (9) may start from phenols of formula (7) wherein R21 , R22, R23 and R24 have the above defined meanings. The phenols of formula (7) are commercially available or can be prepared by methods known to a person skilled in the art. In a first step R1, which has the above defined meaning, may be introduced by alkylation. The alkylation is for example carried out by suspending sodium hydride in an organic solvent, such as dimethylethane (DME) or dimethylsulfoxide (DMSO) or a mixture thereof, adding a solution of compound (7) in an organic solvent, such as DME, at a temperature in the range of from 0 to 40 ⁰C, then adding a compound R1-halogen, preferably RI-Br or R1-I, and reacting the mixture at a temperature of from 20 to 80 ⁰C for 1 to 48 h to give a compound of formula (8). In a second step, directed ortho-metalation followed by reaction with a boron electrophile leads to the compounds of formula (9) wherein R1 , R21 , R22, R23 and R24 have the above defined meanings, and Ra and Rb represent 1-4C-alkyl or hydrogen, preferably Ra and Rb combine to form a straight-chain or branched alkylene group having 2 to 8 carbon atoms, for example without limitation -C(CH ₃) ₂-C(CH ₃) ₂-. In particular, a solution of compound (8) in an organic solvent, such as tetrahydrofuran (THF), can be reacted with n-butyl lithium (n-BuLi) in an organic solvent, such as hexane, at a temperature of from -78 to 0 ⁰C for 0.5 to 4 h. Subsequently, for example commercially available 2-iso-propoxy-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane is added and the reaction is performed at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h to yield a compound of formula (9).

(7) (10) (11)

(9)

Reaction scheme 4 An alternative preparation of compounds of formula (9) is shown in reaction scheme 4. The preparation may start from phenols of formula (7), wherein R21 , R22, R23 and R24 have the above or below defined meanings and which are commercially available or can be prepared by methods known to a person skilled in the art or as for example described in Yamamoto, Y.; Hattori, K.; Ishii, J. -I.; Nishiyama, H. Tetrahedron, 2006, 62, 4294. The phenols of formula (7) are for example reacted with bromine or N-bromosuccinimide in an organic solvent such as dichloromethane (DCM) at a temperature of from -40 to 20 ⁰C for 0.5 to 4 h to give compounds of formula (10). In a second step R1 , which has the above defined meaning, may be introduced by alkylation. The alkylation is for example carried out by suspending sodium hydride in an organic solvent, such as

dimethylethane (DME) or dimethylsulfoxide (DMSO) or a mixture thereof, adding a solution of compound (10) in an organic solvent, such as DME, at a temperature in the range of from 0 to

40 ⁰C, then adding a compound R1 -halogen, preferably RI-Br or R1 -I, and reacting the mixture at a temperature of from 20 to 80 ⁰C for 1 to 48 h leading to compounds of formula (11 ). In case R22 is difluoromethyl a compound of formula 1 1 , wherein R21 , R23, R24 and R1 have the above defined meanings and R22 is CH=O is reacted in an additional step with a fluorinating agent, such as tris(2- methoxyethyl)aminosulfurtrifluoride, in an organic solvent, such as dichloromethane, at elevated temperatures preferably under microwave heating. In a next step, halogen-lithium exchange followed by reaction with a boron electrophile yields the compounds of formula (9), wherein R1 , R21 , R22, R23 and R24 have the above defined meanings, and Ra and Rb represent 1-4C-alkyl or hydrogen, preferably Ra and Rb combine to form a straight-chain or branched alkylene group having 2 to 8 carbon atoms, for example without limitation -C(CH ₃) ₂-C(CH ₃) ₂-. In particular, a solution of compound (11 ) in an organic solvent, such as tert-butylmethylether, can be reacted with n-BuLi (n-butyl lithium) in an organic solvent, such as hexane, at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h. Subsequently, for example commercially available 2-iso-propoxy-4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane is added and the reaction is performed at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h to yield a compound of formula (9). Compounds of formula (9), wherein R22 is 1-4C- alkyl-1 ,3-dioxolane and R1 , R21 , R23, R24, Ra and Rb have the above defined meanings can be also prepared starting from phenols of formula (7), wherein R22 is -C(O)-I -4C-alkyl and R1 , R21 , R23 and R24 have the above defined meanings, by acetalisation of compound (1 1 ), wherein R22 is -C(O)-I -4C-alkyl and R1 , R21 , R23 and R24 have the above defined meanings before the halogen- lithium exchange reaction as described above is followed. The acetalisation can be performed by methods known to a person skilled in the art for example by reacting compound (11 ) in an organic solvent, such as dichloromethane with 1 ,2-bis (trimethylsilyloxy)-ethane in the presence of a catalytic amount of trimethylsilyl trifluoro-methane sulfonate at a temperature of from 0 ⁰C to 25°C for 1 to 4 h as for example described in Hwu, J. R.; Wetzel, J. M.; J. Org. Chem. 1985, 50, 3946.

Reaction scheme 5

According to a further alternative preparation method shown in reaction scheme 5, synthesis of boronic acid derivatives of formula (9) may start from phenols of formula (7) wherein R21 , R22, R23 and R24 have the above defined meanings and which are commercially available or can be prepared by methods known to a person skilled in the art. In a first step R1 , which has the above defined meaning, is introduced by alkylation. The alkylation is for example carried out by suspending sodium hydride in an organic solvent, such as dimethylethane (DME) or

dimethylsulfoxide (DMSO) or a mixture thereof, adding a solution of compound (7) in an organic solvent, such as DME, at a temperature in the range of from 0 to 40 ⁰C, then adding a compound R1-halogen, preferably RI-Br or R1-I, and reacting the mixture at a temperature of from 20 to 80 ⁰C for 1 to 48 h to give a compound of formula (12). In a second step, compound (11 ) may be prepared for example from compound (12) by reaction with N-bromosuccinimide in an organic solvent, such as dimethylformamide, at a temperature of from 0 to 60 ⁰C for 0.5 to 5 h. In a third step, halogen-lithium exchange followed by reaction with a boron electrophile yields the compounds of formula (9), wherein R1 , R21 , R22, R23 and R24 have the above defined meanings, and Ra and Rb represent 1-4C-alkyl or hydrogen, preferably Ra and Rb combine to form a straight- chain or branched alkylene group having 2 to 8 carbon atoms, for example without limitation -C(CH ₃) ₂-C(CH ₃) ₂-. In particular, a solution of compound (1 1 ) in an organic solvent, such as tert- butylmethylether, can be reacted with n-BuLi (n-butyl lithium) in an organic solvent, such as hexane, at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h. Subsequently, for example commercially available 2-iso-propoxy-4, 4,5, 5-tetramethyl-[1 , 3, 2]dioxaborolane is added and the reaction is performed at a temperature of from -78 to 0 ⁰C for 0.5 to 3 h to yield a compound of formula (9). Alternatively, compounds of formula (9) may be synthesized from compounds of formula (11 ) and an appropriate boron compound, such as bis(pinacolato)diboron, in the presence of a Pd catalyst, such as 1 ,1 '-bis(diphenyl-phosphino)ferrocene palladium-(ll)-chloride, and a base, such as potassium acetate, in an organic solvent, such as dioxane, at a temperature of from 20 to 100 ⁰C for 1 to 24 h. The Pd catalyzed preparation of boronic acid derivatives is, for example, described in Murata et al, J Org Chem 2000, 65, 164 and J Org Chem 1997, 62, 6458.

(6) (9) (13)

(14) (15)

Reaction scheme 6 Reaction scheme 6 illustrates the synthesis of compounds of formula (15) wherein R2 is hydrogen and R1 , R21 , R22, R23 and R24 have the above defined meanings. In a first step, compound (6) prepared according to reaction scheme 1 can be reacted with a compound of formula (9) prepared according to any of reaction schemes 3, 4 or 5, wherein R1 , R21 , R22, R23, R24, Ra and Rb have the above defined meanings, to obtain a compound of formula (13). In particular, the compound of formula (6), a base, such as K ₂CO ₃, CS ₂CO ₃ or K ₃PO ₄, a solvent, such as dimethoxyethane, dioxane or dimethylformamide, a compound of formula (9) and a Pd catalyst, such as PdCI ₂(PCy _S) ₂ (Cy = cyclohexyl), are preferably heated at a temperature in the range of from 60 to 120 ⁰C for 1 to 16 h. The compound of formula (13) thus obtained can then be protected by reaction with a base such as sodium hydride and (2-chloromethoxy-ethyl)-trimethyl-silane in a organic solvent such as dimethoxyethane, dimethylformamide or dimethylsulfoxide at a temperature of from 0 ⁰C to 25°C for 1 h to 24h as for example described in Muchowski, J. M.; Solas, D. R.; J. Org:Chem. 1984, 49, 203 to a compound of formula (14). The compound of formula (14) is reacted with an alkali hydroxide, such as LiOH, in a solvent, preferably a mixture of an organic solvent, such as dioxane, and water, at a temperature in the range of from 20 to 100 ⁰C for 1 to 48 h to yield a compound of formula (15).

(25) (9) (26)

(15)

Reaction scheme 7 Reaction scheme 7 illustrates the synthesis of compounds of formula (15) wherein R2 is methyl and R1 , R2, R21 , R22, R23 and R24 have the above defined meanings. In a first step, compound (25) prepared according to reaction scheme 2 can be reacted with a compound of formula (9) prepared according to any of reaction schemes 3, 4 or 5, wherein R1 , R21 , R22, R23, R24, Ra and Rb have the above defined meanings, to obtain a compound of formula (26). In particular, the compound of formula (25), a base, such as K ₂CO ₃, Cs ₂CO ₃ or K ₃PO ₄, a solvent, such as dimethoxyethane, dioxane or dimethylformamide, a compound of formula (9) and a Pd catalyst, such as PdCI ₂(PCy ₃) ₂ (Cy = cyclohexyl), are preferably heated at a temperature in the range of from 60 to 120 ⁰C for 1 to 16 h. The compound of formula (26) thus obtained is reacted with an alkali hydroxide, such as LiOH, in a solvent, preferably a mixture of an organic solvent, such as dioxane, and water, at a temperature in the range of from 20 to 100 ⁰C for 1 to 48 h to yield a compound of formula (15).

(15) (1-1 )

Reaction scheme 8 As shown in reaction scheme 8, starting from compounds of formula (15) prepared according to any of reaction schemes 6 or 7, compounds of formula (1-1 ), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1 ^4C-alkyl group is optionally substituted by R43, with R41 , R42 and R43 having the above defined meanings, can be prepared by reaction with compounds of formula (16-1 ), wherein Y has the above defined meaning and R3 is a 4- to 7- membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-I -4C-alkyl, wherein the 1 ^4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3- 6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1^4C-alkyl group is optionally substituted by R43, with R41 , R42 and R43 having the above defined meanings, under standard amide bond forming conditions. The compounds of formula (16-1 ) are commercially available or can be prepared by methods known to a person skilled in the art or as described in reaction scheme 16. In particular, a dehydrating agent, such as 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride, a base, such as triethylamine, and a catalyst, such as 1- hydroxybenzotriazole, can be added to a compound of formula (15) which is preferably dissolved or suspended in an organic solvent, e.g. dichloromethane. After stirring the mixture e.g. for 0.3 to 2 h, preferably at ambient temperature (e.g. 20 to 25°C), a compound of formula (16-1 ) can be added and the reaction is preferably performed at ambient temperature (e.g. 20 to 25°C) for 1 to 48 h to yield the compound of formula (1-1 ).

(15) (I-2)

Reaction scheme 9

As shown in reaction scheme 9, compounds of formula (I-2), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 , with R6 being -NH-C(O)-R7 and R7 being 1-4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1 ^4C- alkoxy, which is optionally substituted by R73, with R61 , R71 , R72 and R73 having the above defined meanings can be synthesized by reaction of compounds of formula (15) prepared according to any of reaction schemes 6 or 7, with compounds of formula (16-2), wherein Y has the above defined meaning and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 , with R6 being -NH-C(O)-R7 and R7 being 1-4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or 1-4C-alkoxy, which is optionally substituted by R73, with R61 , R71 , R72 and R73 having the above defined meanings. The compounds of formula (16-2) are commercially available or can be prepared by methods known to a person skilled in the art or can be prepared by methods described in the experimental part (see C1 1 , CC22, C33 and C44). In particular, a dehydrating agent, such as 1-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, a base, such as triethylamine, and a catalyst, such as 1-hydroxybenzotriazole, can be added to a compound of formula (15) which is preferably dissolved or suspended in an organic solvent, such as dichloromethane. After stirring the mixture e.g. for 0.3 to 2 h preferably at ambient temperature (e.g. 20 to 25°C), a compound of formula (16-2) can be added and the reaction is preferably performed at ambient temperature (e.g. 20 to 25°C) for 1 to 48 h to yield the compound of formula (I-2).

(1-1 ) (I-3)

(I-4)

Reaction scheme 10

Compounds of formula (1-1 ), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-O-C(CH ₃) ₃, prepared according to reaction scheme 8 can be deprotected and converted into compounds of formula (I-4), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning. In particular, compounds of formula (1-1 ) are deprotected by methods known to a person skilled in the art for example by reaction with tetrabutylammonium fluoride and 1 ,2-diamino-ethane in an organic solvent like tetrahydrofurane as for example described in Muchowski, J. M.; Solas, D. R.; J.

Org:Chem. 1984, 49, 203.

In the following step HCI preferably dissolved in an organic solvent, such as dioxane, can be added to the compound of formula (I-3) which is preferably dissolved in an organic solvent, such as an alcohol, e.g. 2-propanol. The reaction mixture is then preferably heated at 40 to 80 ⁰C for 1 to 4 h to yield the hydrochloride of the compound of formula (I-4). The compound of formula (I-4) can be prepared from said hydrochloride as known to a person skilled in the art, such as by treatment with a base, e.g. aqueous potassium carbonate or aqueous ammonia.

(I-2) (I-5)

(I-6)

Reaction scheme 1 1 Compounds of formula (I-2), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being -NH-C(O)-R7 and R7 being -0-C(CHb) ₃ and R61 has the above defined meaning prepared according to reaction scheme 9 can be deprotected and converted into compounds of formula (I-6), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being - NH ₂ as shown in reaction scheme 11 and R61 has the above defined meaning. In particular, compounds of formula (I-2) are deprotected by methods known to a person skilled in the art for example by reaction with tetrabutylammonium fluoride and 1 ,2-diamino-ethane in an organic solvent like tetrahydrofurane as for example described in Muchowski, J. M.; Solas, D. R.; J.

Org:Chem. 1984, 49, 203.

In the following step HCI preferably dissolved in an organic solvent, such as dioxane, can be added to the compound of formula (I-5) which is preferably dissolved in an organic solvent, such as an alcohol, e.g. 2-propanol. The reaction mixture is then preferably heated at 40 to 8O ⁰C for 1 to 4 h to yield the hydrochloride of the compound of formula (I-6). The compound of formula (I-6) can be prepared from said hydrochloride as known to a person skilled in the art, such as by treatment with a base, e.g. aqueous potassium carbonate or aqueous ammonia.

Compounds of formula (I-2), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being hydroxy and R61 has the above defined meaning, prepared according to reaction scheme 9 can be deprotected and converted into compounds of formula (I-5), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being hydroxy as shown in reaction scheme 11 and R61 has the above defined meaning. In particular, compounds of formula (I-2) are deprotected by methods known to a person skilled in the art for example by reaction with tetrabutylammonium fluoride and 1 ,2-diamino-ethane in an organic solvent like tetrahydrofurane as for example described in Muchowski, J. M.; Solas, D. R.; J. Org:Chem. 1984, 49, 203.

H ₂N-Y-R3 N ₃ I

(16-3) J

( 13b) (I-6)

Reaction scheme 11a:

An alternative synthesis of compounds of formula (I-3), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring con- taining one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-O-C(CH ₃) ₃, and compounds of formula (1-5), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being -NH-C(O)-R7 and R7 being -0-C(CHb) ₃ and R61 has the above defined meaning, and compounds of formula (1-6), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being -NH ₂ and R61 has the above defined meaning, is shown in reaction scheme 11a.

A compound of formula (13) prepared according to reaction scheme 6, wherein R1 , R2, R21 , R22, R23 and R24 have the above defined meanings is transformed into a compound of formula (13a) by reacting with an alkali metal hydroxid preferably KOH (generated from potassium fert-butoxyde and water) in an organic solvent preferably fert-BuOH. A comparable reaction is, for example described in Gassman, P.G.; Schenk, W.N. J. Org. Chem. 1977, 42, 918.

A compound of formula (13a) can be reacted with a compound of formula (16-1 ), which are com- mercially available or can be prepared by methods known to a person skilled in the art or as described in reaction scheme 16, a compound of formula (16-2), which are commercially available or can be prepared by methods known to a person skilled in the art or can be prepared by methods described in the experimental part (see C11 , CC22, C33 and C44), or a compound of (16-3), which are commercially available or can be prepared by methods known to a person skilled in the art or can be prepared by methods described in the experimental part (see C12, C23, C34 and C45). In particular, a dehydrating agent, such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, a base, such as triethylamine, and a catalyst, such as 1 -hydroxybenzotriazole, can be added to a compound of formula (13) which is preferably dissolved or suspended in an organic solvent, such as dichloromethane. After stirring the mixture e.g. for 0.3 to 2 h preferably at ambient temperature (e.g. 20 to 25°C), a compound of formula (16-1 ), a compound of formula (16-2) or a compound of formula (16-3) can be added and the reaction is preferably performed at ambient temperature (e.g. 20 to 25°C) for 1 to 48 h to yield a corresponding compound of formula (I-3), a compound of formula (I-5) or a compound of formula (13b). A compound of formula (I-6) can be obtained by pressure hydrogenation, such as 10 to 30 bar, of a compound of formula (13b) pref- erably at ambient temperature, such as 20 to 25°C, in the presence of a catalyst, such as Pd on carbon or Pd(OH) ₂ on carbon, in an organic solvent such as methanol.

Reaction scheme 12 Alternatively, as shown in reaction scheme 12, compounds of formula (1-1 ), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-I -4C-alkyl, wherein the 1-4C-alkyl group is optionally substituted by R41 , -C(O)-3-6C-cycloalkyl, wherein the 3-6C-cycloalkyl group is optionally substituted by R42, or -C(O)-O-I -4C-alkyl, wherein the 1 -4C-alkyl group is optionally substituted by R43, and R41 , R42 and R43 are as defined above, may be prepared from compounds of formula (I-4), wherein R1 , R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning, prepared according to reaction scheme 10. In particular, a compound R4-CI can be added to the compound of formula (I-4) which is preferably dissolved in an organic solvent, such as dichloromethane, in the presence of a base, such as diazabicycloundecene (DBU). The compound of formula R4-CI is commercially available or can be prepared by methods known to a person skilled in the art. The addition is preferably carried out at a temperature of from 0 to 20 ⁰C. After complete addition, the reaction is preferably continued at ambient temperature (e.g. 20 to 25°C) for 1 to 24 h. In case R41 , R42 or R43 represent hydroxy, it is known to a person skilled in the art that the hydroxy group is preferably to be protected by a suitable protecting group, such as an acetate group or a silyl protective group, e.g. a tert-butyl- dimethylsilyl group or a tert-butyl-diphenylsilyl group. Said protective groups can be removed by methods known to a person skilled in the art with or without prior isolation of the protected intermediate (i.e. the compound of formula (1-1 ) in its protected form).

(I-6) (I-2)

Reaction scheme 13

Alternatively, as shown in reaction scheme 13, compounds of formula (I-2), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 , with R6 being -NH-C(O)-R7, with R7 being 1 - 4C-alkyl, which is optionally substituted by R71 , 3-6C-cycloalkyl, which is optionally substituted by R72, or ^•MC-alkoxy, which is optionally substituted by R73, and R61 , R71 , R72 and R73 are as defined above, may be prepared from compounds of formula (I-6), wherein R1 , R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61 with R6 being NH ₂ prepared according to reaction scheme 11 and R61 has the above defined meanings. In particular, a compound R7-C(O)-CI can be added to the compound of formula (I-6) which is preferably dissolved in an organic solvent, such as dichloromethane, in the presence of a base, such as diazabicycloundecene (DBU). The compound of formula R7 -C(O)-CI is commercially available or can be prepared by methods known to a person skilled in the art. The addition is preferably carried out at a temperature of from 0 to 20 ⁰C. After complete addition, the reaction is preferably continued at ambient temperature (e.g. 20 to 25°C) for 1 to 24 h to yield the compound of formula (I-2). In case R71 , R72 or R73 represent hydroxy, it is known to a person skilled in the art that the hydroxy group is preferably to be protected by a suitable protecting group, such as an acetate group or a silyl protective group, e.g. a tert-butyl- dimethylsilyl group or tert-butyl-diphenylsilyl group. Said protective groups can be removed by methods known to a person skilled in the art with or without prior isolation of the protected intermediate (i.e. the compound of formula (I-2) in its protected form).

(I-4) (1-1 )

Reaction scheme 14 As shown in reaction scheme 14, compounds of formula (1-1 ), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7-membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being substituted by R4 and optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning and R4 being -C(O)-H can be prepared from compounds of formula (I-4), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 4- to 7- membered saturated heterocyclic ring containing one nitrogen atom and optionally one oxygen atom, said heterocyclic ring being optionally substituted by one or two substituents R5, wherein R5 has the above defined meaning, prepared according to reaction scheme 10. In particular, the compound R4-O-C(O)-CH ₃, which can be prepared by methods known to a person skilled in the art, can be added to the compound of formula (\-4) which is preferably dissolved in an organic solvent, such as dichloromethane, in the presence of a base, such as diazabicycloundecene (DBU). The addition is preferably carried out at a temperature of from 0 to 20 ⁰C. After completion of addition, the reaction is preferably continued at ambient temperature (e.g. 20 to 25°C) for 1 to 24 h to yield the compound of formula (1-1 ).

As shown in reaction scheme 15, compounds of formula (I-2), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being -NH-C(O)-R7 with R7 being hydrogen and R61 has the above defined meaning can be prepared from compounds of formula (I-6), wherein R1 , R2, R21 , R22, R23, R24 and Y have the above defined meanings and R3 is a 3-6C-cycloalkyl group substituted by R6 and optionally substituted by R61with R6 being -Nhb, obtained according to reaction scheme 11. In particular, the compound R7-C(O)-O-C(O)-Chb with R7 being hydrogen, which can be prepared by methods known to a person skilled in the art, can be added to the compound of formula (I-6) which is preferably dissolved in an organic solvent, such as dichloromethane, in the presence of a base, such as diazabicycloundecene (DBU). The addition is preferably carried out at a temperature of from 0 to 20 ⁰C. After completion of addition, the reaction is preferably continued at ambient temperature (e.g. 20 to 25°C) for 1 to 24 h to yield a compound of formula (I-2).

(17) (18a) (18b)

(16a) (16b)

Reaction scheme 16

As shown in reaction scheme 16, compounds of formula (16a) or (16b) can be prepared from known compounds (18a) or (18b) [Zhao, S.; Ghosh, A.; D'Andrea, S.V.; Freeman, P.;

VonVoigtlander, P. F.; Carter, D.B.; Smith, M. W.; Heterocycles, 1994, 39, 163 and Erickson, S. D.; Banner, B.; Berthel, S.; Conde-Knape, K.; Falicioni, F.; Hakimi, I.; Hennessy, B.; Kester, R.F.; Kim, K..; Ma, Ch.; McComas, W.; Mennona, F.; Mischke, S.; Orzechowski, L.; Qian, Y.; Salari, H.; Tengi, J.; Thakkar, K.; Taub, R.; Tilley, J.W.; Wang, H.; Bioorg. Med. Chem. Lett. 2008, 18, 1402] by methods known to a person skilled in the art for example by catalytic hydrogenation in an organic solvent like ethanol or methanol in the presence of a precious metal catalyst like palladium on carbon or platinum oxide at a temperature of from 20 to 50 ⁰C and at standard atmospheric pressure (101 ,325 kPa) to 1050 kPa for 1 h to 48h.

It is known to the person skilled in the art that, if there are a number of reactive centers on a starting or intermediate compound, it may be necessary to block one or more reactive centers temporarily by protective groups in order to allow a reaction to proceed specifically at the desired reaction center.

The compounds according to the present subject matter are isolated and purified in a manner known per se, e.g. by distilling off the solvent in vacuo and recrystallizing the residue obtained from a suitable solvent or subjecting them to one of the customary purification methods, such as column chromatography on a suitable support material. Salts of the compounds of formula (I) and the stereoisomers thereof can be obtained by dissolving the free compound in a suitable solvent (for example a ketone such as acetone, methylethylketone or methylisobutylketone, an ether such as diethyl ether, tetrahydrofurane or dioxane, a chlorinated hydrocarbon such as methylene chloride or chloroform, a low molecular weight aliphatic alcohol such as methanol, ethanol or isopropanol, a low molecular weight aliphatic ester such as ethyl acetate or isopropyl acetate, or water) which contains the desired acid or base, or to which the desired acid or base is then added. The acid or base can be employed in salt preparation, depending on whether a mono- or polybasic acid or base is concerned and depending on which salt is desired, in an equimolar quantitative ratio or one differing therefrom. The salts are obtained by filtering, reprecipitating, precipitating with a non-solvent for the salt or by evaporating the solvent. Salts obtained can be converted into the free compounds which, in turn, can be converted into salts. In this manner, pharmaceutically unacceptable salts, which can be obtained, for example, as process products in the manufacturing on an industrial scale, can be converted into pharmaceutically acceptable salts by processes known to the person skilled in the art.

Pure diastereomers and pure enantiomers of the compounds of formula (I) and the salts thereof can be obtained e.g. by asymmetric synthesis, by using chiral starting compounds in synthesis and/or by splitting up enantiomeric and diasteriomeric mixtures obtained in synthesis. Preferably, the pure diastereomeric and pure enantiomeric compounds of the present subject matter are obtainable by using chiral starting compounds in synthesis and/or by splitting up enantiomeric and diasteriomeric mixtures obtained in synthesis.

Enantiomeric and diastereomeric mixtures can be split up into the pure enantiomers and pure diastereomers by methods known to a person skilled in the art. Preferably, diastereomeric mixtures are separated by crystallization, in particular fractional crystallization, or chromatography.

Enantiomeric mixtures can be separated e.g. by forming diastereomers with a chiral auxiliary agent, resolving the diastereomers obtained and removing the chiral auxiliary agent. As chiral auxiliary agents, for example, chiral acids can be used to separate enantiomeric bases and chiral bases can be used to separate enantiomeric acids via formation of diastereomeric salts.

Furthermore, diastereomeric derivatives such as diastereomeric esters can be formed from enantiomeric mixtures of alcohols or enantiomeric mixtures of acids, respectively, using chiral acids or chiral alcohols, respectively, as chiral auxiliary agents. Additionally, diastereomeric complexes or diastereomeric clathrates may be used for separating enantiomeric mixtures. Alternatively, enantiomeric mixtures can be split up using chiral separating columns in chromatography. Another suitable method for the isolation of enantiomers is the enzymatic separation.

All patents, patent applications, publications, test methods and other materials cited herein are incorporated by reference in their entireties. The following examples illustrate the present subject matter in greater detail, without restricting it. Further compounds according to the present subject matter, of which the preparation is not explicitly described, can be prepared in an analogous way.

The compounds, salts and stereoisomers which are mentioned in the examples, and the salts of the compounds which are mentioned in the examples, and the stereoisomers of the compounds mentioned in the examples, the stereoisomers of the salts which are mentioned in the examples and the stereoisomers of the salts of the compounds which are mentioned in the examples repre- sent preferred embodiments of the present subject matter.

Examples

The following abbreviations are used: min: minutes, h: hour(s), DCM: dichloromethane, DCE: dichloroethane, THF: tetrahydrofuran, EA: ethyl acetate, sesamol: 3,4-methylenedioxyphenol, brine: saturated sodium chloride solution, DBU: 1 ,8-diazabicyclo[5.4.0]undec-7-en, Huenigs base: N-ethyl-diisopropylamine, mp.: melting point, bp: boiling point, RT: room temperature (20 to 25°C), ambient temperature: 20 to 25°C, TLC: thin layer chromatography, GC-MS (El): gas

chromatography coupled to mass spectrometry with electron impact ionization, MS (ESI): mass spectrometry with electron spray ionization, HR-MM (ESI): high resolution mass spectrometry with electron spray ionization, ¹H-NMR: ¹H nuclear magnetic resonance spectroscopy (chemical shifts are reported as ppm against tetramethylsilane as internal standard, coupling constants J are reported in Hz). Epimers and/or racemates are marked herein with a "*" in the chemical name at the corresponding stereogenic center.

Example A1 : (£/Z)-2-Cyano-3-ethoxy-but-2-enoic acid ethyl ester

A round bottom flask equipped with a magnetic stirring bar, a short Vigreux-Column and a condenser is charged with commercially available triethyl ortho acetate (973.4 g; 6.0 mol), commercially available cyano-acetic acid ethyl ester (452.5 g; 4.0 mol) and commercially available acetic anhydride (816.7 g; 8.0 mol). The stirred reaction mixture is heated to about 100 ⁰C and the formed ethyl acetate is removed by distillation. As the reaction progressed the temperature is gradually raised to 150 ⁰C

The reaction mixture is cooled to ambient temperature. The semisolid crude is distilled in high vacuum. The fraction boiling between 110 ⁰C and 120 ⁰C (4 x 10 ^~3 mbar) is collected and redistilled to yield the title compound as pale yellow solid. GC-MS (El): m/z = 183 (M ⁺); 127 (100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 4.35 (qu, J = 7.0, 2H); 4.15 (qu, J = 7.1 , 2H); 2.63 (s, 3H); 1.29 (t, J

= 7.0, 3H); 1.22 (t, J = 7.1 , 3H). Example A2: 3-Amino-5-methyl-1/-/-pyrrole-2,4-dicarboxylic acid diethyl ester

A reaction flask equipped with a mechanic stirrer, a dropping funnel, a reflux condenser and a nitrogen bubbler is charged with dry EtOH (700 mL), (E/Z)-2-cyano-3-ethoxy-but-2-enoic acid ethyl ester from example 1 (128.25 g; 0.70 mol) and commercially available 2-amino-malonic acid diethyl ester hydrochloride (148.15 g; 0.70 mol). To the well-stirred reaction mixture NaOEt (-21 % solution in EtOH; 1150 mL; -2.45 mol) is added within 15 min (slightly exothermic). After complete addition the reaction mixture is heated to gentle reflux under an atmosphere of nitrogen and mechanical stirring for 18 hours.

The reaction mixture is cooled to ambient temperature and neutralized to pH = 7 by slow addition of a sufficient amount of 1 M citric acid. EtOH is removed under reduced pressure at 50 ⁰C (rotava- pour). The residual solid is distributed between water (1500 mL) and dichloromethane (500 mL). The organic layer is separated. The aqueous layer is extracted with dichloromethane (2 x 500 ml). The combined organic layers are dried over MgSO ₄ in the presence of decolorizing charcoal. The solution is filtered through a plug of neutral alumina (act. 2-3) followed by filtration through a plug of silica. The solvent is removed under reduced pressure until the product starts to precipitate. Pre- cipitation of the product is completed by addition of cyclohexane (1000 ml) and cooling to 0 ⁰C for three hours. The solid is collected by suction filtration, washed with several portions of hexane and dried in vacuum at 50 ⁰C over night to yield the title compound as off-white solid.

MS (ESI): m/z = 241 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.26 (br.s, 1 H, -NH); 5.62 (br.s, 2H, -NH ₂); 4.20 (qu, J = 7.1 , 2H); 4.18 (qu, J = 7.1 , 2H); 2.34 (s, 3H); 1.27 (t, J = 7.1 , 3H); 1.26 (t, J = 7.1 , 3H).

Example A3: Ethyl^4-hydroxy-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxylate A reaction flask equipped with a mechanical stirrer, a reflux condenser and a nitrogen bubbler is charged with EtOH (5000 mL), 3-amino-5-methyl-1/-/-pyrrole-2,4-dicarboxylic acid diethyl ester from example A2 (565.57 g; 2.50 mol) and formamidine acetate (1041.10 g; 10.00 mol). The well-stirred reaction mixture is heated to gentle reflux for five days under an atmosphere of nitrogen.

The reaction mixture is cooled to ambient temperature. The precipitated crude is collected by suction filtration, washed with several small portions of EtOH and sucked dry for one hour. The solid is suspended in water (2500 mL), stirred for two hours at ambient temperature, collected by suction filtration, ished with several small portions of water and sucked dry for one hour. The solid is again suspended in EtOH (2500 mL). The suspension is stirred for three hours at ambient temperature. The solid is collected by suction filtration, washed with several small portions of EtOH, sucked dry for one hour and finally dried in vacuum at 50 ⁰C over night to yield the title compound 7 containing 15 mol % of isomer 8 as off-white solid.

The mixture of 7 and 8 (50.0 g, 0.23 mol) is suspended in EtOH (1000 ml_). The stirred suspension is refluxed for one hour, filtered while still hot and washed with several small portions of boiling EtOH. The remaining solid is resuspended in EtOH (500 ml_). The stirred suspension is refluxed for one hour, filtered while still hot, washed with several small portions of boiling EtOH and dried in vacuum at 50 ⁰C over night to deliver the title compound as colorless solid.

MS (ESI): m/z = 222 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.56 (s, 1 H, -NH); 12.04 (s, 1 H, -OH); 7.88 (s, 1 H); 4.24 (qu, J = 6.9, 2H); 2.55 (s, 3H); 1.28 (t, J = 6.9, 3H).

Pure isomer 8 is obtained as colorless solid from the evaporated filtrates after crystallization from EtOH.

MS (ESI): m/z = 222 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 12.64 (s, 1 H, -NH); 11.41 (s, 1 H, -OH); 7.77 (s, 1 H); 4.28 (qu, J = 7.1 , 2H); 2.56 (s, 3H); 1.30 (t, J = 7.1 , 3H).

Example A4: Ethyl^4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxylate

A reaction flask, equipped with a mechanic stirrer, a reflux condenser and a nitrogen bubbler is charged with POCI ₃ (1200 mL). Ethyl 4-hydroxy-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxyl ate from example A3 (207.19 g; 1.00 mol) is added in several portions. The carefully stirred suspension is heated to gentle reflux for five hours.

The resulting dark solution is cooled to ambient temperature. POCb is removed by distillation under reduced pressure until the precipitated crude product prevented further stirring. Remaining POCI ₃ is removed by repeated co-distillation with dry toluene (3x1000 mL). Finally the resulting solid is suspended in toluene and stirred at ambient temperature under an atmosphere of nitrogen over night. The dark precipitate is collected by suction filtration, ished with several small portions of toluene and diethyl ether, and sucked dry under an atmosphere of nitrogen.

The dry solid is suspended in ice cold water (1000 mL). The pH of the well-stirred suspension is adjusted to 8 by careful addition of 2M KHCO ₃-solution. The suspension is stirred for several hours until pH stayed at 8.0 (from time to time the pH has to be readjusted to 8.0 by addition of 2M KHCO ₃-solution). The product is isolated by suction filtration, washed with several small portions of water and sucked dry for two hours.

For further purification the product is suspended in acetonitrile (1000 mL). The suspension is stirred at 60 ⁰C for one hour and at ambient temperature for one additional hour. The product is collected by suction filtration washed with several small portions of acetonitril and sucked dry for one hour. A second crop of product is obtained from the mother liquor after concentation under reduced pres- sure. The solids are combined and dried in vacuum at 50 ⁰C over night to yield the title compound as off-white solid.

MS (ESI): m/z = 240 (IVlH ⁺); 226 (100 %); 212.

¹H-NMR (300 MHz, DMSO-d ₆): 12.76 (br.s, 1 H, -NH); 8.64 (s, 1 H); 4.29 (qu, J = 7.1 , 2H); 1.32 (t, J = 7.1 , 3H).

Example A.5: Ethyl 3-(ethanimidoylamino)-5-methyl-1/-/-pyrrole-2-carboxylate

hydrochloride

Ethyl-3-amino-5-methyl-1 /-/-pyrrole-2-carboxylate (58.87 g; 0.35 mol) prepared according to literature [Gangjee A.; Li W.; Yang J.; Kisliuk R. L.; J. Med. Chem. 2008, 51 , 68] is suspended in acetonitrile (1750 ml_). To the suspension is added dropwise 4M HCI in dioxane (473 ml_; 1.89 mol) within 15 minutes. After complete addition the reaction mixture is heated to 50 ⁰C for 18 hours. The reaction mixture is cooled to 10 ⁰C, the solid is collected by suction filtration and washed with cold acetonitrile (400 mL). A second crop of product is obtained from the mother liquor after concentra- tion under reduced pressure.The residue is collected with f-butylmethyl-ether. After the suction filtration the solids are combined and dried in vacuum at 50 ⁰C to yield the title compound as off- white solid.

MS (ESI): m/z = 210 (MH ⁺)

1H-NMR (300 MHz, DMSO-d ₆): 11.96 (s, 1 H, -NH); 10.93 (s, 1 H, -NH); 9.45 (s, 1 H, -NH); 8.22 (s, 1 H, -NH); 5.92 (m, 1 H); 4.19 (qu, J = 7.1 , 2H); 2.29 (s, 3H); 2.23 (s, 3H); 1.26 (t, J = 7.1 , 3H).

Example A.6: 2,6-Dimethyl-3,5-dihydro^4/-/-pyrrolo[3,2-cy]pyrimidin^4-one

A reaction flask equipped with a mechanical stirrer and a reflux condenser is charged with EtOH (900 mL), Ethyl-3-(ethanimidoylamino)-5-methyl-1/-/-pyrrole-2-carboxyl ate hydrochloride from ex- ample A5 (82.79 g; 0.34 mol) and 6M NaOH (226 mL; 1.36 mol). The well-stirred reaction mixture is heated to gentle reflux for 4 hours and is cooled to ambient temperature. The resulting solution is diluted with water (1000 mL) and the pH is adjusted to 6.5 by carefully addition of 2M citric acid. The precipitate is collected by suction filtration, washed with several portions of water and dried in vacuum at 50 ⁰C to yield the title compound as off-white solid.

MS (ESI): m/z = 164 (MH ⁺)

¹H-NMR (300 MHz, DMSO-d ₆): 11.63 (s, 1 H, -NH); 11.58 (s, 1 H, -OH); 5.98 (m, 1 H); 2.29 (s, 3H); 2.26 (s, 3H).

Example A.7: 4-Chloro-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine

2,6-Dimethyl-3,5-dihydro^4/-/-pyrrolo[3,2-cy]pyrimidin^4- one from example A6 (87.00 g; 0.53 mol) is suspended in dry acetonitrile (870 mL). After addition of POCb (122 mL; 1.33 mol) the stirred reaction mixture is heated to gentle reflux for 18 hours. The volatiles are removed by destination under reduced pressure. The residue is diluted with ice cold water (1500 mL) and the well-stirred suspension is adjusted to pH = 8 by addition of 5M KOH. The suspension is stirred for several hours until pH stayed at 8.0. (from time to time the pH has to be readjusted to 8.0 by addition of 5M KOH). The solid is isolated by suction filtration, dissolved in dichloromethane, dried over MgSO ₄ and filtered through a plug of neutral alumina (act. 2-3). The solvent is removed under reduced pressure. The product is resuspended in tert-butylmethylether, filtered and dried in vaccum at 50 ⁰C over night to yield the title compound as off-white solid. MS (ESI): m/z = 182 (MH ⁺)

1H-NMR (300 MHz, DMSO-d ₆): 11.99 (s, 1 H, -NH); 6.33 (m, 1 H); 2.57 (s, 3H); 2.48 (s, 3H).

Example A.8: 7-Bromo^4-chloro-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine

4-Chloro-2,6-dimethyl-5H-pyrrolo[3,2-cy]pyrimidine from example A7 (10.90 g; 60.00 mmol) is dissolved in dichloromethane (120 mL). The stirred mixture is cooled to -10 ⁰C. Br ₂ (3.08 mL; 60.00 mmol) dissolved in dichloromethane (20 mL) is added dropwise within 25 minutes. The re- suiting precipitate is collected by suction filtration, suspended in Na ₂SO ₃ (5% solution) (100 mL) and is stirred for 30 minutes at ambient temperature. After filtratrion the product is dissolved in ace- tonitrile (1000 mL), refluxed for one hour and filtered while still hot. The solvent is removed under reduced pressure until the product starts to precipitate. Precipitation of the product is completed by addition of cyclohexane and cooling to 0 ⁰C for several hours. The solid is collected by suction fil- tration, washed with cyclohexane and dried in vaccum at 50 ⁰C over night to yield the title compound as a white solid.

MS (ESI): m/z = 262 (MH ⁺)

1 H-NMR (300 MHz, DMSO-d ₆): 12.61 (s, 1 H, -NH); 2.62 (s, 3H); 2.48 (s, 3H). Example A.9: 7-Bromo-4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]m ethyl}-5/-/- pyrrolo[3,2-c(]pyrimidine

Sodium hydride (1.82 g; 45.60 mmol; 60% in oil, washed with hexane), is suspended in dry DMF (125 mL) and dry DMSO (25 mL). To the stirring suspension 7-Bromo^4-chloro-2,6-dimethyl-5H- pyrrolo[3,2-cf]pyπmidine from example A8 (10.00 g; 38.00 mmol) dissolved in dry DMF (125 mL) is added dropwise within 30 minutes at ambient temperature. After complete addition the reaction mixture is stirred for one hour at ambient temperature. To the resulting solution 2- (trimethylsilyl)ethoxymethylchloride (8.74 mL; 49.40 mmol) is added dropwise and the reaction mixture is stirred for one hour at ambient temperature. After diluting with water / ice and dichloromethane, the organic layer is separated and the aqueous layer is extracted with dichloromethane (2 x 400 mL). The combined organic layers are dried over MgSO ₄ and filtered through a plug of neutral alumina (act. 2-3). The solvent is removed under reduced pressure and the residue is purified by column chromatography on silica gel (cyclohexane:ethylacetate / 9: 1 ) affording the title compound as a white solid. MS (ESI): m/z = 392 (MH ⁺)

¹H-NMR (300 MHz, DMSO-d ₆): 5.81 (s, 2H); 3.57 (t, J = 7.9, 2H); 2.63 (s, 3H); 2.58 (s, 3H); 0.83 (m, 2H); -0.09 (s, 9H). Example A.10: 4-Chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 /-/-pyrrolo[3,2- c(]pyrimidine-7-carbaldehyde

7-Bromo-4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]m ethyl}-5/-/-pyrrolo[3,2-d]pyrimidine from example A9 (12.41 g; 31.76 mmol) is dissolved in dry tetrahydrofurane (100 mL). At -78 ⁰C n- butyllithium (12.7 mL; 31.76 mmol; 2.5M solution in n-hexane) is syringed into the stirred reaction mixture. After 30 min DMF (12.4 mL; 158.80 mmol) is added via syringe and the mixture is stirred for additional 2 hours at -78 ⁰C and for 30 minutes at 0 ⁰C. The rection is quenched by addition of 1 M citric acid (32 mL) and brine (32 mL). After diluting with tert-butylmethylether the aqueous layer is separated and extracted with tert-butylmethylether (3 x 50 mL). The combined organic layers are dried over MgSO ₄ and the solvent is removed under reduced pressure. The residue is purified by column chromatography on silica gel (cyclohexane:ethylacetate / 7:3) affording the title compound as a white solid.

MS (ESI): m/z = 340 (MH ⁺)

¹H-NMR (300 MHz, DMSO-d ₆): 10.35 (s, 1 H); 5.85 (s, 1 H); 3.61 (t. J = 7.9, 2H); 2.87 (s, 3H); 2.67 (s, 3H); 0.85 (m, 2H); -0.08 (s, 9H).

Example A.11: Methyl 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 /-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylate

To a well stirred mixture of 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 H-pyrrolo[3,2- cf]pyπmidine-7-carbaldehyde from example A10 (9.49 g; 27.90 mmol), MeOH (50 mL), KCN (6.00 g; 92.10 mmol) and MnO ₂ (35.60 g, 383.30 mmol) acetic acid (1.68 g; 27.90 mmol) is added at ambient temperature. After 4 hours the dark mixture is filtered through Celite and the solvent is removed under reduced pressure. The residue is purified by column chromatography on silica gel (cyclohexane:ethylacetate / 9:1 ) affording the title compound as an pale yellow oil.

MS (ESI): m/z = 370 (MH ⁺)

1H-NMR (300 MHz, DMSO-d ₆): 5.85 (s, 2H); 3.84 (s, 3H); 3.59 (t, J = 7.9, 2H); 2.84 (s, 3H); 2.64 (s, 3H); 0.84 (m, 2H); -0.09 (s, 9H).

Example B.a1 : 2-Bromo-5-fluoro^4-methoxy-phenol

3-Fluoro-4-methoxy-phenol (21.32 g; 0.15 mol) prepared according to literature [Freedman, J.; Stewart, K.T.; J. Heterocycl. Chem. 1989, 26, 1547-1554] is dissolved in dry dichloromethane (300 mL). The well stirred reaction mixture is cooled to -15°C (ice/salt). A solution of bromine (23.97 g; 0.15 mol) in dry dichloromethane (75 mL) is dropped into the reaction mixture. After complete addition stirring is continued for one hour. Water (150 mL) containing sodium sulfite (3.0 g) is added to the reaction mixture. Stirring is continued at ambient temperature for 30 min. The organic layer is separated, washed with water (100 mL) and dried over MgSO ₄ in the presence of decolorizing charcoal. After filtration the solvent is completely removed under reduced pressure. The residue is crystallized from fert-butylmethylether/hexane to yield the title compound as a colorless solid.

GC-MS (El): m/z = 222, 220 (M ⁺); 207, 205 (M ⁺-CH ₃, 100%); 179, 177.

¹H-NMR (300 MHz, DMSO-d ₆): 10.06 (s, 1 H, -OH); 7.28 (d, J = 9.2, 1 H); 6.81 (d, J = 12.6, 1 H);

3.76 (s, 3H). The following compounds are obtained analogously to the procedure described in above example B.a1.

Example B.a2: 2-Bromo^4-fluoro-5-methoxy-phenol

Starting from 4-fluoro-3-methoxy-phenol prepared according to literature [Belanger, P. C; Lau, C. K.; Williams, H.W.R.; Dufresne, C; Scheigetz, J. Can. J. Chem. 1988, 66, 1479-1482] the title compound is obtained as colorless solid.

GC-MS (El): m/z = 222, 220 (M ⁺, 100%); 207, 205 (M-CH ₃ ⁺); 179, 177.

¹H-NMR (300 MHz, CDCI ₃): 7.16 (d, J = 10.2, 1 H); 6.67 (d, J = 7.7, 1 H); 5.29 (s, 1 H, -OH); 3.85 (s, 3H)

Example B.a3: 2-Bromo-5-fluoro-4-methylphenol

Starting from commercially available 3-fluoro^4-methylphenol the title compound is obtained as colorless solid.

GC-MS (El): m/z = 206, 204 (M ⁺); 125 (100%).

1 H-NMR (300 MHz, DMSO-d ₆): 10.38 (br.s, 1 H, -OH); 7.39 (d, J = 8.2, 1 H); 6.70 (d, J = 1 1 .1 , 1 H); 2.1 1 (s, 3H).

Example B.a4: 1 -(3-Bromo-4-hydroxy-phenyl)-ethanone

Starting from commercially available 1 -(4-hydroxy-phenyl)-ethanone the title compound is obtained as colorless solid.

GC-MS (El): m/z = 214, 212 (M ⁺); 199,197 (100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .19 (s, 1 H, -OH); 8.06 (d, J = 2.2, 1 H); 7.82 (dd, J = 8.4, 2.2, 1 H);

7.03 (d, J = 8.4, 1 H); 2.49 (s, 3H). Example B.a5: 2-Bromo-4-ethyl-phenol

Starting from commercially available 4-ethyl-phenol the title compound is obtained as colorless oil after short path distillation at 10 mbar.

GC-MS (El): m/z = 202, 200 (M ⁺); 187,195 (100%). ¹H-NMR (300 MHz, DMSO-d ₆): 9.88 (s, 1 H, -OH); 7.29 (d, J = 2.0, 1 H); 7.00 (dd, J = 8.2, 2.0, 1 H);

6.85 (d, J = 8.2, 1 H); 2.49 (qu, J = 7.7, 2H); 1.12 (t, J = 7.7, 3H).

Example B.a6: 2-bromo^4-isopropyl-phenol

Starting from commercially available 4-isopropyl-phenol the title compound is obtained as colorless oil after short path distillation at 10 mbar.

GC-MS (El): m/z = 216, 214 (M ⁺); 201 , 199; 120 (100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.88 (s, 1 H, -OH); 7.30 (d, J = 2.2, 1 H); 7.04 (dd, J = 8.4, 2.2, 1 H);

6.86 (d, J = 8.4, 1 H); 2.78 (sept, J = 6.9, 1 H); 1.14 (d, J = 6.9, 6H).

Example B.b1 : 5-Cyclopropylmethoxy-benzo[1 ,3]dioxole

Sodium hydride (60 wt% dispersion in mineral oil; 1 1 .0 g; 275.0 mmol) is freed from oil by washing with hexane (2 x 50 mL) and suspended in dry DME (375 mL) and dry DMSO (37.5 mL).

Under an atmosphere of nitrogen a solution of commercially available sesamol (3,4- methylenedioxy-phenol) (34.53 g; 250.0 mmol) in dry DME (250 mL) is dropped into the well-stirred suspension at a rate to keep the internal temperature below 40 ⁰C. After complete addition stirring is continued at ambient temperature for one hour.

Neat commercially available bromomethyl-cyclopropane (37.13 g; 275.0 mmol) is added in one portion and the reaction mixture is stirred at 80 ⁰C over night. Ice-cold water (125 mL) is drop wise added and the reaction mixture is stirred for 30 min at ambient temperature. After addition of brine

(125 mL) the organic layer is separated and concentrated in vacuo. The aqueous layer is extracted with tert-butylmethylether (3 x 200 mL). All organic phases are combined, washed with brine (200 mL), dried over MgSO ₄ and filtered through a plug of neutral alumina containing 5 wt% of water.

The product is completely eluted with several portions of tert-butylmethylether. The solvent is removed under reduced pressure. The remaining crude product is purified by short path distillation at 3 x 10 ^"3 mbar (1 17°C) to give the title compound as colorless oil that solidifies at ambient temperature.

GC-MS (El): m/z = 192 (M ⁺); 138 (M ⁺-C ₄H ₆, 100 %).

¹ H-NMR (200 MHz, DMSO-d ₆): 6.77 (d, J = 8.5, 1 H); 6.59 (d, J = 2.5, 1 H); 6.32 (dd, J = 8.5, 2.5, 1 H); 5.93 (s, 2H); 3.71 (d, J = 6.9, 2H); 1.15 (m, 1 H); 0.53 (m, 2H); 0.27 (m, 2H).

The following compounds are obtained analogously to the procedure described in above example B.b1 . Example B. b2: 1 -Bromo-2-cyclopropylmethoxy^4-fluoro-benzene

Starting from commercially available 2-bromo-5-fluoro-phenol and commercially available bromomethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar. GC-MS (El): m/z = 244, 246 (M ⁺); 190, 192 (M ⁺-C4H6); 55 (100%). ¹H-NMR (300 MHz, DMSO-d ₆): 7.58 (dd, J = 8.7, 6.4, 1 H); 7.02 (dd, J = 11.2, 2.8, 1 H); 6.75 (ddd, J = 8.7, 2.8, 1 H); 3.93 (d, J = 6.8, 2H); 1.24 (m, 1 H); 0.56 (m, 2H); 0.38 (m, 2H).

Example B.b3: i-Bromo^-cyclopropylmethoxy-δ-fluoro-benzene

Starting from commercially available 2-bromo^4-fluoro-phenol and commercially available bromo- methyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar. GC-MS (El): m/z = 244, 246 (M ⁺); 190, 192; (M ⁺-C ₄H ₆); 55 (100%).

1H-NMR (400 MHz, DMSO-d ₆): 7.52 (dd, J ₁ = 8.2, J ₂ = 3.1 , 1 H); 7.19 (ddd, J ₁ = 9.1 , J ₂ = 8.2, J ₃ =

3.1 , 1 H); 7.10 (dd, J1 = 9.1 , J2 =5.0, 1 H); 3.89 (d, J = 6.8, 2H); 1.22 (m, 2H); 0.57 (m, 2H); 0.35 (m, 2H).

Example B.b5: i -Bromo^-cyclopropylmethoxy^-methoxy-benzene

Starting from commercially available 2-bromo-5-methoxy-phenol and bromomethyl-cyclopropane the title compound is obtained as colorless solid.

GC-MS (El): m/z = 258, 256 (M ⁺).

¹H-NMR (200 MHz, DMSO-d ₆): 7.41 (d, J = 7.9, 1 H); 6.48 (dd, J ₁ = 7.9, J ₂ = 2.2, 1 H); 6.45 (d, J =

2.2, 1 H); 3.87 (d, J = 5.6, 2H); 3.76 (s, 3H); 1.26 (m, 1 H); 0.63 (m, 2H); 0.36 (m, 2H).

Example B.b6: i -Bromo^-cyclopropylmethoxy-δ-methoxy-benzene

Starting from commercially available 2-bromo-4-methoxy-phenol and bromomethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar.

GC-MS (El): m/z = 256, 258 (M ⁺); 202, 204 (100 %).

¹H-NMR (200 MHz, CDCI ₃): 7.11 (d, J = 2.8, 1 H); 6.86 (d, J = 8.9, 1 H); 6.78 (dd, J ₁ = 8.9, J ₂ = 2.8, 1 H); 3.82 (d, J = 6.8, 2H); 3.75 (s, 3H); 1.16 (m, 1 H); 0.51 (m, 2H); 0.44 (m, 2H).

Example B.b7: 2-Bromo-1 -cyclopropylmethoxy-4-methyl-benzene

Starting from commercially available 2-bromo^4-methyl-phenol and bromomethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar.

GC-MS (El): m/z = 242,240 (M ⁺); 188,186 (M ⁺-C ₄H ₆); 107; 80, 78; 55 (100%).

1H-NMR (300 MHz, DMSO-d ₆):.7.38 (dd, J = 2.2, 0.7, 1 H); 7.10 (ddd, J = 8.4, 2.2, 0.7, 1 H); 6.96 (d, J = 8.4, 1 H); 3.86 (d, J = 6.8, 2H); 2.22 (s, 3H); 1.21 (m, 1 H); 0.56 (m, 2H); 0.33 (m, 2H).

Example B.b8: 2-Bromo-1 -cyclopropylmethoxy-4-trifluoromethyl-benzene

Starting from commercially available 2-bromo-4-trifluoromethyl-phenol and bromomethyl- cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar.

GC-MS (El): m/z = 296,294 (M ⁺); 268, 266; 242, 240 (M ⁺-C ₄H ₆); 132; 55 (100%).

1H-NMR (300 MHz, DMSO-d ₆):.7.93 (dd, J = 2.3, 0.5, 1 H); 7.70 (ddd, J = 8.8, 2.3, 0.5, 1 H); 7.26 (d, J = 8.8, 1 H); 4.03 (d, J = 6.9, 2H); 1.27 (m, 1 H); 0.60 (m, 2H); 0.38 (m, 2H). Example B.b9: 2-Bromo-1 -ethoxy-4-trifluoromethyl-benzene

Starting from commercially available 2-bromo^4-trifluoromethyl-phenol and ethyliodide the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar.

GC-MS (El): m/z = 270, 268 (M ⁺); 242, 240 (M ⁺-C ₂H ₄, 100%); 132.

¹H-NMR (300 MHz, DMSO-d ₆):.7.93 (dd, J = 2.3, 0.7, 1 H); 7.71 (ddd, J = 8.8, 2.3, 0.7, 1 H); 7.27 (d, J = 8.8, 1 H); 4.21 (qu, J = 6.9, 2H); 1.38 (t, J = 6.9, 3H).

Example B.b10: i -Bromo^-cyclopropylmethoxy^-fluoro-δ-methoxy-benzene

Starting from 2-bromo-5-fluoro-4-methoxy-phenol (example B.a1 ) and commercially available bro- momethyl-cyclopropane the title compound is obtained as colorless solid.

GC-MS (El): m/z = 276, 274 (M ⁺); 222, 220 (M ⁺-C ₄H ₆, 100%); 206, 204.

¹H-NMR (400 MHz, DMSO-d ₆): 7.38 (d, J = 9.2, 1 H); 7.13 (d, J = 13.1 , 1 H); 3.85 (d, J =6.9, 2H); 3.80 (s, 3H); 1.20 (m, 1 H); 0.57 (m, 2H); 0.33 (m, 2H).

Example B.b11: i -Bromo^-cyclopropylmethoxy^-fluoro-δ-methyl-benzene

Starting from 2-bromo-5-fluoro-4-methyl-phenol (example B.a3) and commercially available bro- momethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5x10 ^"3 mbar.

GC-MS (El): m/z = 260, 258 (M ⁺); 206, 204 (M ⁺-C ₄H ₆); 179; 125; 96; 55 (100%).

¹H-NMR (400 MHz, DMSO-d ₆): 7.49 (d, J = 8.2, 1 H); 6.97 (d, J = 1 1.7, 1 H); 3.89 (d, J =6.9, 2H); 2.14 (d, J = 1.8, 3H); 1.22 (m, 1 H); 0.57 (m, 2H); 0.34 (m, 2H).

Example B.b12: i -Bromo^-cyclopropylmethoxy-δ-fluoro^-methoxy-benzene

Starting from 2-bromo^4-fluoro-5-methoxy-phenol (example B.a2) and commercially available bro- momethyl-cyclopropane the title compound is obtained as colorless solid.

GC-MS (El): m/z = 276, 274 (M ⁺); 222, 220 (M ⁺-C ₄H ₆, 100 %).

¹H-NMR (400 MHz, DMSO-d ₆): 7.48 (d, J = 10.8, 1 H); 6.90 (d, J = 7.9, 1 H); 3.93 (d, J =6.8, 2H); 3.85 (s, 3H); 1.24 (m, 1 H); 0.58 (m, 2H); 0.36 (m, 2H).

Example B.b13: 1 -(3-Bromo^4-cyclopropylmethoxy-phenyl)-ethanone

Starting from 1 -(3-bromo-4-hydroxy-phenyl)-ethanone (example B.a4) and commercially available bromomethyl-cyclopropane the title compound is obtained as colorless solid.

GC-MS (El): m/z = 270, 268 (M ⁺); 242, 240; 216, 214 (M ⁺-C ₄H ₆); 201 , 199; 55 (100%).

1H-NMR (400 MHz, DMSO-d ₆): 8.11 (d, J = 2.1 , 1 H); 7.94 (dd, J = 8.7, 2.1 , 1 H); 7.19 (d, J = 8.7, 1 H); 4.03 (d, J =6.9, 2H); 2.53 (s, 3H); 1.27 (m, 1 H); 0.60 (m, 2H); 0.38 (m, 2H).

Example B.b14: 2-[3-Bromo-4-(cyclopropylmethoxy)phenyl]-2-methyl-1 ,3-dioxolane A solution of 1-(3-bromo^4-cyclopropylmethoxy-phenyl)-ethanone from example B.b13 (14.0 g; 52.0 mmol) in dry dichloromethane (250 mL) was cooled in an ice-bath before addition of trimethyl- silyl trifluoro-methane sulfonate (0.23 g; 1.04 mmol) and dropwise addition of 1 ,2-bis- (trimethylsilyloxy)-ethane (13.15 g; 62.4 mmol). The reaction mixture was stirred for two hours, extracted with 1 M aqueous NaHCO ₃ (100 mL) and dried over MgSO ₄. The crude is purified by column chromatography on silica gel (ethyl acetate / cyclohexane - 9:1 ) to yield the title compound as pale yellow oil.

GC-MS (El): m/z = 314, 314 (M ⁺); 299, 297 (M ⁺-CH ₃, 100 %); 245, 243 (M ⁺-CH ₃, -C ₄H ₆); 201 , 199; 87; 55.

1H-NMR (400 MHz, DMSO-d ₆): 7.53 (d, J = 2.2, 1 H); 7.33 (dd, J = 8.6, 2.2, 1 H); 7.05 (d, J = 8.6, 1 H); 3.96 (m, 2H); 3.91 (d, J =6.9, 2H); 3.69 (m, 2H); 1.53 (s, 3H); 1.23 (m, 1 H); 0.58 (m, 2H); 0.35 (m, 2H).

Example B.b15: i -Bromo^-cyclopropylmethoxy-δ-ethyl-benzene

Starting from 2-bromo-4-ethyl-phenol (example B.a5) and commercially available bromomethyl- cyclopropane the title compound is obtained as colorless oil after distillation at 10 mbar.

GC-MS (El): m/z = 256, 254 (M ⁺); 228, 226 (M ⁺-C ₂H ₄); 202, 200 (M ⁺-C ₄H ₆); 187, 185 (M ⁺-C ₄H ₆, -

CH ₃); 55 (100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 7.39 (d, J = 2.0, 1 H); 7.13 (dd, J = 8.4, 2.0, 1 H); 6.98 (d, J = 8.4, 1 H); 3.87 (d, J =6.8, 2H); 3.53 (qu, J = 7.7, 2H); 1.22 (m, 1 H); 1.13 (t, J = 7.7, 3H); 0.56 (m, 2H);

0.33 (m, 2H).

Example B.b16: 2-Bromo-1-cyclopropylmethoxy-4-(propan-2-yl)benzene

Starting from 2-bromo-4-isopropyl-phenol (example B.a6) and commercially available bromome- thyl-cyclopropane the title compound is obtained as colorless solid after short path distillation at 2x10 ^"3 mbar.

GC-MS (El): m/z = 270, 268 (M ⁺); 201 , 199; 120; 91 ; 55 (100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 7.41 (d, J = 2.2, 1 H); 7.17 (dd, J = 8.4, 2.2, 1 H); 6.99 (d, J = 8.4, 1 H); 3.87 (d, J =6.8, 2H); 2.38 (sept, J = 6.9, 1 H); 1.22 (m, 1 H); 1.16 (d, J = 6.9, 6H); 0.56 (m, 2H); 0.34 (m, 2H).

Example B.b17: 3-Bromo-4-(cyclopropylmethoxy)benzaldehyde

A well stirred mixture of commercially available 3-bromo-4-hydroxy-benzaldehyde (40.2 g; 220 mmol), anhydrous K ₂CO ₃ (30.4 g; 220 mmol) and commercially available bromomethyl- cyclopropane (32.4 g; 240 mmol) in dry DMF (200 mL) is heated to 60 ⁰C over night. The reaction mixture is filtered, concentrated under reduced pressure, diluted with water and extracted with fert. BuOMe . The combined organic extracts are washed with brine, dried over Mg ₂SO ₄ and concen- trated under reduced pressure. The residue is chomatographed on silica gel (cyclohexane/AcOEt : 100:0 to 85:15) to yield 47.5 g of the title compound as pale yellow oil.

¹H-NMR (300 MHz, DMSO-d ₆): 9.85 8s, 1 H); 8.10 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.6, 2.0, 1 H); 7.28 (d, J = 8.6, 1 H); 4.06 (d, J = 6.9, 2H); 1.28 (m, 1 H); 0.61 (m, 2H); 0.39 (m, 2H).

Example B.b18: 2-Bromo-1-(cyclopropylmethoxy)-4-(difluoromethyl)benzene

A pressure vial is charged with dichloromethane (10.0 mL), 3-bromo-4-cyclopropylmethoxy- benzaldehyde (example B.b17; 2.55 g; 10.0 mmol) and commercially available bis(2- methoxyethyl)aminosulfurtrifluoride (5.53 g; 25.0 mmol). After capping the reaction mixture was heated in a microwave oven to 70 ⁰C for 15 min. and slowly poured into a well stirred ice cold 2M NaHCO ₃ solution (50 mL.). After extraction with dichloromethane the combined organic layers are dried over MgSCU and concentrated under reduced pressure. The residue is chromatographed on silica gel (hexane/AcOEt : 90:10 to 80:20) to yield 2.3 g of the title compound as pale yellow oil. ¹H-NMR (300 MHz, DMSO-d ₆): 7.77 (~t, J = 0.9, 1 H); 7.54 (~dt, J = 8.6, 0.9, 1 H); 7.20 (d, J = 8.6, 1 H); 6.95 (t, J = 55.9, 1 H); 3.98 (d, J 0 6.9, 2H); 1.26 (m, 1 H), 0.59 (m, 2H); 0.37 (m, 2H).

Example B.d: 5-Cyclopropylmethoxy-4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)- benzo[1 ,3]dioxole

The reaction is performed in flame-dried glassware under an atmosphere of argon.

A stirred solution of 5-cyclopropylmethoxy-benzo[1 ,3]dioxole from example B.b1 (38.44 g; 200.0 mmol) in dry THF (500 mL) is cooled to -40° C before n-butyl lithium (138.0 mL; 1.6 M solution in hexane; 220 mmol) is slowly added via syringe. After complete addition, stirring is continued at -40° C for two hours. At -78° C neat 2-iso-propoxy-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane (40.95 g; 220.0 mmol) is added via syringe and stirring is continued at -78° C for two hours.

At -15° C the reaction mixture is quenched with saturated NH _tCI-solution (200 mL) and stirred at ambient temperature for 30 min. The organic layer is separated and concentrated under reduced pressure. The aqueous layer is extracted with tert.-butylmethylether (3 x 200 mL). All organic phases are combined, washed with saturated NaCI-solution (200 mL), dried over MgSO ₄ and filtered through a plug of neutral alumina containing 5 wt% of water. The product is completely eluted with several small portions of tert. butylmethylether.

The solvent is removed under reduced pressure. The crude is treated with ice-cold methanol (50 mL) to deliver the title compound as colorless solid.

GC-MS (El): m/z = 318 (M ⁺); 264 (M ⁺-C ₄H ₆); 207; 164 (100 %).

¹H-NMR (200 MHz, DMSO-d ₆): 6.78 (d, J = 8.4, 1 H); 6.29 (d, J = 8.4; 1 H); 5.92 (s, 2H); 3.71 (d, J = 6.3, 2H); 1.29 (s, 12H); 1.14 (m, 1 H); 0.50 (m, 2H); 0.34 (m, 2H).

Example B.c2: 2-(2-Cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)^4,4,5,5-t etramethyl- [1 ,3,2]dioxaborolane The reaction is performed in flame-dried glassware under an atmosphere of argon.

A stirred solution of i-bromo^-cyclopropylmethoxy^-fluoro-δ-methoxy-benzene from example B.b10 (27.51 g; 0.10 mol) in dry tert. butylmethylether (500 mL) is cooled to -20 ⁰C before addition of n-butyl lithium (1.6 M in hexane; 68.8 mL; 0.1 1 mol) via syringe. After complete addition stirring is continued for one hour. Neat 2-iso-propoxy^4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane is added via syringe into the reaction mixture at -40 ⁰C. After 30 min the reaction is quenched with 1 M citric acid (200 mL) at 0 ⁰C and stirred for one hour at ambient temperature. The organic layer is separated. The aqueous layer is extracted with tert.-butylmethylether (100 mL).The combined organic layers are washed with brine (200 mL) dried over MgSO ₄ and filtered through a plug of neutral alumina containing 5 wt% of water. The product is completely eluted with several small portions of tert.- butylmethylether. The solvent is removed under reduced pressure. The crude is purified by short path distillation at 3x10 ^"3 mbar (160 ⁰C) to give the title compound as a colorless oil that solidifies at ambient temperature.

GC-MS (El): m/z = 322 (M ⁺, 100%); 211 , 168.

1H-NMR (300 MHz, DMSO-d ₆): 7.14 (d, J = 10.5, 1 H); 6.91 (d, J = 13.6, 1 H); 3.81 (d, J =6.0, 2H); 3.77 (s, 3H); 1.28 (s, 12H); 1.16 (m, 1 H); 0.48 (m, 2H); 0.38 (m, 2H).

The following compounds are obtained analogously to the procedure described in above example B.c2.

Example B.c3: 2-(2-Cyclopropylmethoxy-4-fluoro-phenyl)-4,4,5,5-tetramethyl - [1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-4-fluoro-benzene (example B.b2) the title compound is obtained as colorless solid after short bath distillation at 3x10 ^"3 mbar (130 ⁰C).

GC-MS (El): m/z = 292 (M ⁺); 181 , 55 (100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 7.48 (dd, J1 = J2 = 8.0, 1 H); 6.80 (dd, J1 = 12.0, J2 = 2.2, 1 H); 6.71 (ddd, J1 = 8.4, J2 = 8.0, J3 = 2.2, 1 H); 3.89 (d, J = 5.8, 2H); 1 .27 (s, 12H); 1 .17 (m, 1 H); 0.51 (m, 2H); 0.46 (m, 2H). Example B.c4: 2-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-4,4,5,5-tetramethyl -

[1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-5-fluoro-benzene (example B.b3) the title compound is obtained as colorless solid after short bath distillation at 3x10 ^"3 mbar (100 ⁰C).

GC-MS (El): m/z = 292 (M+); 181 (100%); 55.

1 H-NMR (300 MHz, DMSO-d ₆): 7.22-7.13 (m, 2H); 6.95 (dd, J1 = 8.9, J2 = 4.2, 1 H); 3.85 (d, J =6.4,

2H); 1.28 (s, 12H); 1 .17 (m, 1 H); 0.52 (m, 2H); 0.46 (m, 2H). Example B.c6: 2-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-4,4,5,5-tetramethy l- [1 ,3,2]dioxaborolane

Starting from i -bromo^-cyclopropylmethoxy^-methoxy-benzene (example B.b5) the title compound is prepared as colorless solid after crystallization from hexane.

GC-MS (El): m/z = 304 (M ⁺); 276 ; 250; 193; 164 (100%); 150.

¹ H-NMR (200 MHz, DMSO-d ₆): 7.41 (d, J = 7.9, 1 H); 6.48 (dd, J ₁ = 7.9, J ₂ = 2.2, 1 H); 6.45 (d, J = 2.2, 1 H); 3.87 (d, J =5.6, 2H); 3.75 (s, 3H); 1.25 (s, 12H); 1 .16 (m, 1 H); 0.49 (m, 2H); 0.44 (m, 2H).

Example B.c7: 2-(2-Cyclopropylmethoxy-5-methoxy-phenyl)-4,4,5,5-tetramethy l- [1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-5-methoxy-benzene (example B.b6) the title compound is obtained as colorless oil after short bath distillation at 3x10 ^"3 mbar (160 ⁰C).

GC-MS (El): m/z = 304 (M ⁺); 276; 250; 193 (100%); 150.

¹ H-NMR (200 MHz, CDCI ₃): 7.15 (d, J = 3.1 , 1 H); 6.90 (dd, J ₁ = 9.0, J ₂ = 3.1 , 1 H); 6.81 (d, J = 9.0, 1 H); 3.80 (d, J =6.3, 2H); 3.78 (s, 3H); 1.35 (s, 12H); 1.17 (m, 1 H); 0.55 (m, 2H); 0.38 (m, 2H).

Example B.c8: 2-(2-Cyclopropylmethoxy-5-methyl-phenyl)-4,4,5,5-tetramethyl - [1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-5-methyl-benzene (example B.b7) the title compound is obtained as colorless solid.

GC-MS (El): m/z = 288 (M ⁺); 177 (100%).

¹ H-NMR 400 MHz, DMSO-d ₆): 7.26 (d, J = 2.1 , 1 H); 7.16 (dd, J = 8.3, 2.1 , 1 H); 6.81 (d, J = 8.3,

1 H); 3.81 (d, J = 5.9, 2H); 2.21 (s, 3H); 1 .27 (s, 12H); 1.15 (m, 1 H); 0.47 (m, 2H); 0.40 (m, 2H). Example B.c9: 2-(2-Cyclopropylmethoxy-5-trifluoromethyl-phenyl)^4,4,5,5-te tramethyl-

[1 ,3,2]dioxaborolane

Starting from 2-bromo-1 -cyclopropylmethoxy-4-trifluoromethyl-benzene (example B.b8) the title compound is obtained as colorless solid.

GC-MS (El): m/z = 342 (M ⁺); 231 (100%).

1 H-NMR 300 MHz, DMSO-d ₆): 7.74 (ddd, J = 8.8, 2.6, 0.7, 1 H); 7.69 (d, J = 2.6, 1 H); 7.12 (d, J =

8.8, 1 H); 3.98 (d, J = 5.8, 2H); 1.30 (s, 12H); 1.20 (m, 1 H); 0.59 (m, 2H); 0.43 (m, 2H).

Example B.d O: 2-(2-Ethoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane

Starting from 2-bromo-1 -ethoxy-4-trifluoromethyl-benzene (example B.b9) the title compound is obtained as colorless solid

GC-MS (El): m/z = 316 (M ⁺); 216 (100%). ¹ H-NMR 300 MHz, DMSO-d ₆): 7.75 (ddd, J = 8.8, 2.4, 0.6, 1 H); 7.70 (d, J = 2.4, 1 H); 7.13 (d, J = 8.8, 1 H); 4.09 (qu, J = 6.9, 2H); 1.33 (t, j = 6.9, 3H); 1.29 (s, 12H).

Example B.d 1 : 2-(2-Cyclopropylmethoxy-4-fluoro-5-methyl-phenyl)^4,4,5,5-te tramethyl- [1 ,3,2]dioxaborolane

Starting from i -bromo^-cyclopropylmethoxy^-fluoro-S-methyl-benzene (example B.b1 1 ) the title compound is obtained as colorless oil.

GC-MS (El): m/z = 306 (M ⁺); 195 (100 %); 55.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.35 (dd, J = 10.0, 0.5, 1 H); 6.76 (d, J = 12.4, 1 H); 3.85 (d, J = 5.8, 2H); 2.13 (d, J = 0.5, 3H); 1 .27 (s, 12H); 1.15 (m, 1 H); 0.49 (m, 2H); 0.41 (m, 2H).

Example B.c12: 2-(2-Cyclopropylmethoxy-5-fluoro^4-methoxy-phenyl)-4,4,5,5-t etramethyl- [1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-5-fluoro-4-methoxy-benzene (example B.b12) the title compound is obtained as colorless solid after crystallization from methanol.

GC-MS (El): m/z = 322 (M ⁺); 21 1 ; 182; 168 (100 %); 55.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.15 (d, J = 1 1 .7, 1 H); 6.73 (d, J = 7.0, 1 H); 3.88 (d, J = 6.0, 2H); 3.85 (s, 3H); 1.26 (s, 12H); 1.16 (m, 1 H); 0.50 (m, 2H); 0.30 (m, 2H). Example B.c13: 2-[2-(Cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-4,4,5,5- tetramethyl-1 ,3,2-dioxaborolane

Starting from 2-[3-bromo^4-(cyclopropylmethoxy)phenyl]-2-methyl-1 ,3-dioxolane (example B.b14) the title compound is obtained as colorless solid.

GC-MS (El): m/z = 360 (M ⁺); 345 (100 %).

1 H-NMR (300 MHz, DMSO-d ₆): 7.49 (d, J = 2.5, 1 H); 7.40 (dd, J = 8.6, 2.5, 1 H); 6.89 (d, J = 8.6,

1 H); 3.95 (m, 2H); 3.86 (d, J =5.7, 2H); 3.67 (m, 2H); 1.50 (s, 3H); 1.28 (s, 12H); 1.17 (m, 1 H); 0.48

(m, 2H); 0.41 (m, 2H).

Example B.c14: 2-(2-Cyclopropylmethoxy-5-ethyl-phenyl)-4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane

Starting from 1 -bromo-2-cyclopropylmethoxy-5-ethyl-benzene (example B.b15) the title compound is obtained as pale yellow oil.

GC-MS (El): m/z = 302 (M ⁺); 274; 191 (100 %); 55.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.27 (d, J = 2.0, 1 H); 7.20 (dd, J = 8.4, 2.0, 1 H); 6.83 (d, J = 8.4, 1 H); 3.82 (d, J =5.8, 2H); 2.50 (qu, J = 7.7, 2H); 1.28 (s, 12H); 1.13 (t, J = 7.7, 3H); 1.12 (m, 1 H);

0.48 (m, 2H); 0.39 (m, 2H). Example B.c15: 2-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenylH,4,5,5-tetra methyl- 1 ,3,2-dioxaborolane

Starting from 2-bromo-1-cyclopropylmethoxy-4-(propan-2-yl)benzene (example B.b16) the title compound is obtained as colorless solid.

GC-MS (El): m/z = 316 (M ⁺); 301 ; 288; 247; 205; 147 (100 %); 103; 83; 55.

¹H-NMR (300 MHz, DMSO-d ₆): 7.29 (d, J = 2.4, 1 H); 7.23 (dd, J = 8.4, 2.2, 1 H); 6.84 (d, J = 8.4, 1 H); 3.82 (d, J =5.9, 2H); 2.81 (sept, J = 6.9, 1 H); 1.28 (s, 12H); 1.15 (d, J = 6.9, 6H & m, 1 H); 0.48 (m, 2H); 0.40 (m, 2H). Example B.c16: 2-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]^4,4,5,5- tetramethyl-

1 ,3,2-dioxaborolane

2-Bromo-1-cyclopropylmethoxy-4-difluoromethyl-benzene (example B.b18; 24.35 g; 87.9 mmol) is dissolved in dry tert. BuOMe (440 ml_). n-BuLi (1.6M in hexane; 60.0 ml_; 96.0 mmol) is slowly syringed into the well stirred reaction mixture at -40 ⁰C. After one hour commercially available 2- isopropoxy-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (17.86 g; 96.0 mmol) is added at -40 ⁰C followed by stirring at 0 ⁰C for one additional hour. The reaction mixture is quenched by addition of 2M aqueous citric acid (90.0 mL). The organic layer is separated, washed with brine, dried over Mg ₂SO ₄ and filtered through a pad of neutral alumina (act.2-3). The solvent is removed under reduced pressure to yield 28.1 g of the title compound as pale yellow oil.

CAUTION:

THE COMPOUND TENDS TO VIGOROUSLY DECOMPOSE WHEN HEATED ABOVE 8O ⁰C. ¹H-NMR (300 MHz, DMSO-d ₆): 7.63 (~t, J = 1.1 , 1 H); 7.58 (~dt, J = 8.4, 1.1 , 1 H); 7.05 (d, J = 8.4, 1 H); 6.95 (t, J = 56.2, 1 H); 3.94 (d, J = 5.8, 2H); 1.29 (s, 12 H); 1.19 (m, 1 H), 0.51 (m, 2H); 0.43 (m, 2H).

Example C1: tert-Butyl-(3R*,4R*)-4-azido-3-hydroxy-piperidine-1-carboxyl ate (23f) and tert-butyl-(3S*,4S*)-3-azido-4-hydroxy-piperidine-1-carboxyl ate (23g)

A mixture of tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (60 g, 0.30 mol), prepared according to literature [Zhao, S.; Ghosh, A.; D'Andrea, S.V.; Freeman, P.; VonVoigtlander, P. F.; Carter, D. B.; Smith, M.W.; Heterocycles, 1994, 39, 163], sodium azide (25,4 g, 0.39 mol) and ammonium chloride (21 g, 0.39 mol) in ethanol (150 mL) and water (150 mL) is heated to gentle reflux overnight. Ethanol is evaporated in vacuo. The residue is distributed between dichloro- methane and water. The aqueous layer is separated and extracted with dichloromethane. The combined organic layer is washed with water and brine, dried over Na ₂SO ₄ and concentrated in vacuo to obtain, 67.3 g of the crude as a 4:1 mixture 23f and 23g according to ¹H-NMR in agreement with literature data [Erickson, S. D.; Banner, B.; Berthel, S.; Conde-Knape, K.; Falicioni, F.; Hakimi, I.; Hennessy, B.; Kester, R.F.; Kim, K.; Ma, Ch.; McComas, W.; Mennona, F.; Mischke, S.; Orzechowski, L.; Qian, Y.; Salari, H.; Tengi, J.; Thakkar, K.; Taub, R.; Tilley, J. W.; Wang, H.; Bio- org. Med. Chem. Lett. 2008, 18, 1402].

Separation by column chromatography on silica gel (heptane:ethyl acetate - 4:1 ) yields faster elut- ing 23f, slower eluting 23g and un-separated 23f and 23g. tert-Butyl-(3R*,4R*)-4-azido-3-hydroxy-piperidine-1-carboxyl ate (23f)

MS (ESI): m/z = 217 (MH ⁺, 100%).

¹H-NMR (400 MHz, CDCI ₃): 4.12 (m, 1 H); 3.95 (br.m, 1 H); 3.50 (m,1 H); 3.38 (m, 1 H); 2.89 (m, 1 H);

2.78 (m, 1 H); 2.71-2.32 (m 1 H); 2.00 (m, 1 H); 1.52 (m, 1 H); 1.44 (s, 9H). tert-Butyl-(3S*,4S*)-3-azido-4-hydroxy-piperidine-1-carboxyl ate (23g)

MS (ESI): m/z = 217 (MH ⁺, 100%).

¹H-NMR (400 MHz, CDCI ₃): 4.23 (m, 1 H); 4.00 (m, 1 H); 3.54 (m, 1 H); 3.30 (m, 1 H); 2.82 (m, 1 H);

2.66 (m, 1 H); 2.24 (m, 1 H); 1.97 (m, 1 H); 1.59 (m, 1 H); 1.46 (s, 9H).

Example C2: tert-Butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1 -carboxylate (21f)

(3S*,4S*)-tert-butyl 4-azido-3-hydroxypiperidine-1 -carboxylate from example C1 (47 g, 194 mmol) is dissolved in methanol (1200 ml_) under nitrogen. Palladium hydroxide (20% on carbon; 4,7 g) is added. The atmosphere is changed to hydrogen and the stirred reaction mixture is hydrogenated at room temperature and 70 psi for 72 hours. The mixture is filtered through celite. The filtrate is evaporated. The residue is recrystallized from CH ₂CI ₂ with a small amount of MeOH to obtain the title compound as a white solid.

HR-MS (ESI): m/z = 217.1539 ([MH] ⁺, C ₁₀H ₂₁N ₂O ₃ ⁺, calc. 217.1547). Example C3: tert-Btyl (3S*,4S*)-3-Amino^4-hydroxy-piperidine-1 -carboxylate (21 g)

Following the procedure outlined in above example C2 starting from (3S*,4S*)-3-azido-4-hydroxy- piperidine-1 -carboxylic acid tert-butyl ester (example C1 ) the title compound is obtained as white solid.

HR-MS (ESI): m/z = 217.1541 ([MH] ⁺, C ₁₀H ₂₁N ₂O ₃ ⁺, calc. 217.1547).

Example C4: (1 R,3S)-3-[(fert-Butoxycarbonyl)amino]cyclopentyl methanesulfonate Methansulfonyl chloride (8.2 g; 72.0 mmol) is slowly added to an ice cold solution of commercially available tert-butyl [(1 S,3R)-3-hydroxycyclopentyl]carbamate (12.1 g; 60.0 mmol) and 2,6-lutidine (9.6 g; 90.0 mmol) in dry dichloromethane (300 ml_). The stirred reaction mixture ia allowed to warm to ambient temperature over night. The reaction mixture is extracted with water, ice cold 1 N HCI, half saturated brine, and dried over MgSO ₄. After filtration through a pad of neural alumina (act. 2-3) the solvent is removed under reduced pressure to yield the crude title compound as yellow oil that is processed without additional purification. Example C5: fert-Butyl [(I S^S^S-azidocyclopentyljcarbamate

Crude product from example C4 is dissolved in dry DMF (180 mL). After addition of sodium azide (11.7 g; 180.0 mmol) the reaction mixture is stirred for three days at 60 ⁰C. After filtration the reac- tion mixture is concentrated under reduced pressure, diluted with dichloromethane, extracted with water, half saturated brine and dried over MgSCv After column chromatography on silica gel (cyclohexane/AcOEt - 9 : 1 ) 11.8 g of the title compound is obtained as pale yellow oil.

1H-NMR (300 MHz, DMSO-d ₆): 6.90 (d, J = 6.2, 1 H, -NH); 4.1 1 (m, 1 H); 3.88 (m, 1 H); 2.08-1.77 (m, 3H); 1.70 (m, 1 H); 1.60-1.31 (m, 2H & s, 9H).

Example C6: fert-Butyl [(1 S,3S)-3-aminocyclopentyl]carbamate hydrochloride

fert-Butyl [(1 S,3S)-3-azidocyclopentyl]carbamate (example C5; 11.3 g; 50.0 mmol) is dissolved in MeOH (250 mL) and pressure hydrogenated over Pd(OH) ₂ (20% on charcoal; 0.45 g) at 20 bar and ambient temperature over night. After filtration through a pad of celite the solvent is removed under reduced pressure. The residue is dissolved in fert.-BuOMe (250 mL) cooled to 0 ⁰C and treated with HCI (4N in dioxane; 13.5 mL). The precipitate is collected by suction filtration, washed with several small portions of fert.-BuOMe and dried under reduced pressure to yield 11.1 g of the title compound as off-white solid.

1H-NMR (300 MHz, DMSO-d ₆): 8.26-7.08 (br.s, 3H, -NH ₃ ⁺); 6,95 (d, J = 6,9, 1 H, -NH); 3,95 (m, 1 H); 3,52 (m, 1 H); 1 ,98 (m, 2H); 1 ,77 (m, 2H); 1 ,43 (m, 2H); 1 ,38 (s, 9H).

Example C7: fert-Butyl [(1 R*,3S*,4R*H-(benzyloxy)-3-methylcyclohexyl]carbamate Known (1 R*,2S*,4R*)-4-azido-2-methylcyclohexyl benzyl ether (12.Og; 48.9 mmol) [Aicher, T.; Chi- carelli, M. J.; Hinklin, R.J.; Tian, H.; Wallace, O. B.; Chen, Z.; Mabry, T.E.; McCowan, J. R.; Snyder, N.J.; Winneroski, L.L.; Allen, J. G.; WO 2006/049952 (2009)] is dissolved in MeOH (500.0 mL) and pressure hydrogenated over Pd (10% on charcoal; 1.2 g) at 20 bar and ambient temperature for two hours. The catalyst is removed by filtration through a pad of celite. The filtrate is concentrated under reduced pressure. The residue is dissolved in dioxane (100 mL). After addition of 2N NaOH (25.0 mL; 50.0 mmol) and di fert-butyl dicarbonate (11.4 g; 51.3 mmol) the mixture is stirred for one hour at ambient temperature and concentrated under reduced pressure. After addition of water and extraction with fert-BuOMe the organic layer is dried over MgSO ₄. The solvent is removed under reduced pressure and the residue is chromatographed on silica gel (cyclohexane/AcOEt - 9:1 ) to yield 14.4 g of the title compound as colourless oil.

1H-NMR (300 MHz, CDCI ₃): 7.35-7.21 (m, 5H); 4.59 (d, J = 12.1 , 1 H); 4.36 (d, J = 12.1 , 1 H & br.s, 1 H, -NH); 3.55-3.35 (m, 2H); 2.08 (m, 1 H); 1.79-1.57 (m, 3H); 1.44 (s, 9H); 1.42-1.21 (m, 3H); 0.99 (d, J = 6.6, 3H).

Example C8: fert-Butyl [(1 R*,3R*,4S*H-hydroxy-3-methylcyclohexyl]carbamate fert-Butyl [(1 R*,3S*,4R*)-4-(benzyloxy)-3-methylcyclohexyl]carbamate (example C7; 14.0 g; 43.8 mmol) dissolved in MeOH (440 mL) is pressure hydrogenated over Pd (10% on charcoal; 1.4 g) at 50 bar and ambient temperature for 72 hours. The catalyst is removed by filtration through a pad of celite. The filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/AcOEt - 70:30 to 50:50) to yield 8.5 g of the tile compound as colourless oil. ¹H-NMR (300 MHz, CDCI ₃): 4.42 (br.s, 1 H ₁ -NH); 3.76 (m, 1 H); 3.46 (m, 1 H); 1.89 (m, 1 H); 1.80- 1.33 (m, 6H); 1.45 (s, 9H); 1.23 (m, 1 H); 0.98 (d, J = 6.8, 3H).

Example C9: (1 S*,2R*,4R*)-4-[(fert-Butoxycarbonyl)amino]-2-methylcyclohexy l methane- sulfonate

Starting from fert-butyl [(1 R*,3R*,4S*H-hydroxy-3-methylcyclohexyl]carbamate (example C8; 10.2 g; 44.3 mmol) and following the procedure as described in example C4 12.3 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohexane/AcOEt - 70:30).

1H-NMR (300 MHz, CDCI ₃): 4.74 (br.s, 1 H); 4.42 (br.s, 1 H, -NH); 3.51 (m, 1 H); 3.01 (s, 3H); 2.24 (m, 1 H); 1.93-1.56 (m, 4H); 1.44 (s, 9H & m, 1 H); 1.20 (m, 1 H); 1.03 (d, J = 6.6, 3H).

Example C10: fert-Butyl [(1 R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate

Starting from (1 S*,2R*,4R*)-4-[(fert-butoxycarbonyl)amino]-2-methylcyclohexy l methanesulfonate (example C9; 2.4 g; 7.8 mmol) and following the procedure as described in example C5 1.4 g of the title compound is obtained as colourless solid after column chromatography on silica gel (cyclohex- ane/AcOEt - 95:05 to 85: 15).

¹H-NMR (300 MHz, CDCI ₃): 4.35 (br.s, 1 H, -NH); 3.46 (m, 1 H); 2.78 2.78 (m, 1 H); 2.18-1.95 (m, 3H); 1.63-1.33 (s, 9H & m, 2H); 1.17 (m, 1 H); 1.03 (d, J = 6.6, 3H); 0.90 (m, 1 H).

Example C11 : fert-Butyl [(1 R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamate fert-Butyl [(1 R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate (example C10; 1.2 g; 4.7 mmol) is dissolved in MeOH (20.0 mL) and pressure hydrogenated over Pd (10% on charcoal; 0.1 g) at 20 bar and ambient temperature over night. After filtration through a pad of celite the solvent is re- moved under reduced pressure to yield 1 .0 g of the title compound as off-white solid.

¹ H-NMR (300 MHz, CDCI ₃, MeOH-d ₄): 3.41 (m, 1 H); 2.20 (m, 1 H); 2.03-1.81 (m, 3H); 1.44 (s, 9H);

1.34-1.07 (m, 3H); 0.98 (d, J = 6.6, 3H); 0.91 (m, 1 H).

HR-MS (ESI): m/z = 229.1899 ([MH] ⁺, C ₁₂H ₂₅N ₂O ₂ ⁺, calc. 229.191 1 ). Example C12: (1 R*,3R*,4R*)-4-Azido-3-methylcyclohexanamine hydrochloride fert-Butyl [(1 R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate (example C10; 2.5 g; 10.0 mmol) is dissolved in THF (25.0 mL). After addition of HCI (4M solution in dioxane; 10.0 mL; 40.0 mmol) the reaction mixture is stirred at ambient temperature over night and gently refluxed for additional 6 hours. fert-BuOMe is added at ambient temperature, the precipitated product is collected by suction filtration, washed with several small portions of tert-BuOMe and dried under reduced pressure to yield 1.8 g of the title compound as colourless solid.

¹H-NMR (400 MHz, MeOH-d ₄): 3.16 (m, 1 H); 2.95 (m, 1 H); 2.19 (m, 1 H); 2.11 (m, 1 H); 2.03 (m, 1 H); 1.60-1.44 (m, 3H); 1.23 (m, 1 H); 1.10 (d, J = 6.5, 3H).

HR-MS (ESI): m/z = 155.1284 ([MH] ⁺, C ₇H ₁₅N ₄ ⁺, calc. 155.1291 ).

Example C13: fert-Butyl(diphenyl)({4-[(trimethylsilyl)oxy]cyclohex-3-en-1 -yl}oxy)silane Trimethylsilyl trifluoromethanesulfonate (45.0 g; 198.8 mmol) is dropped into a solution of known 4{[fert-butyl(diphenyl)silyl]oxy}cyclohexanone [Okamura, W.H.; Elnagar, H. Y.; Ruther, M.; Dobreff, S. J. Org. Chem. 1993, 58, 600] (58.4 g, 165.5 mmol) and triethylamine (55.4 mL; 397.6 mmol) in dichloromethane (500 mL) at -78°C under an atmosphere of nitrogen. After one hour the reaction mixture is allowed to warm to 0 ⁰C and quenched with saturated NaHCOs-solution (120 mL). The organic layer is separated, dried over MgSO ₄ and concentrated under reduced pressure. A 1 :1- mixture of tert-BuOMe and hexane is added to the biphasic residue. The organic layer is separated, washed with saturated NaHCO ₃-solution and dried over MgSO ₄. The solvent is removed under reduced pressure to deliver 69.0 g of the title compound as colourless oil.

1H-NMR (300 MHz, CDCI ₃): 7.64 (m, 4H); 7.45-7.32 (m, 6H); 4.64 (m, 1 H); 3.93 (m, 1 H); 2.23-2.05 (m, 3H); 1.99-1.85 (m, 1 H); 1.81-1.62 (m, 2H); 1.05 (s, 9H); 0.16 (s, 9H).

Example C14: (2S*,4R*)-4-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xanone and (2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xanone

To a stirred solution of fert-butyl(diphenyl)({4-[(trimethylsilyl)oxy]cyclohex-3-en-1 -yl}oxy)silane (example C13; 69.0 g; 162 mmol) in dry acetonitrile (750 mL) Selectfluor ® (68.6 g; 184 mmol) is added in small portions at 5°C. After complete addition the reaction mixture is stirred at ambient temperature over night. Saturated NaHCO ₃-solution (200 mL) is added, the precipitate is removed by filtration and the filtrate is concentrated under reduced pressure. The residue is distributed between fert-BuOMe and saturated NaHCO ₃-solution. The organic layer is separated, washed with brine and dried over MgSO4. The solvent is removed under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/AcOEt - 10:0 to 9:1 ) to deliver 44.9 g of (2S*,4R*)-4- {[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclohexanone as white solid

¹H-NMR (300 MHz, CDCI ₃): 7.67 (m, 4H); 7.50-7.34 (m, 6H); 5.41 (ddd, J = 48.7, 12.2, 6.8, 1 H); 4.33 (m, 1 H); 2.93 (td, J = 13.9, 6.0, 1 H); 2.56-2.34 (m, 2H); 2.05-1.93 (m, 1 H); 1.81 (m, 1 H); 1.69 (tdd, J = 13.9, 4.6, 2.4, 1 H); 1.12 (s, 9H)

and 9.3 g of (2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xanone as white solid

¹H-NMR (300 MHz, CDCI ₃): 7.68 (m, 4H); 7.49-7.36 (m, 6H); 4.68 (ddd, J = 48.0, 12.4, 7.3, 1 H); 4.08 (m, 1 H); 2.54 (m, 1 H); 2.40 (m, 1 H); 2.16-1.96 (m, 3H); 1.89-1.73 (m, 1 H); 1.06 (s, 9H). Example C15: (1 R*,2S*,4R*H-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xanol L-Selectride® (1 M in THF; 69.0 mL; 69.0 mmOI) is dropped into a stirred solution of (2S*,4R*)-4- {[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclohexanone (example C14; 23.3 g; 62.8 mmol) in dry THF (230 mL) at -15°C. The reaction mixture is stirred over night and cooled to 0 ⁰C before careful addi- tion of ice cold water (100 mL), followed by dropwise addition of H ₂O ₂ (30% solution in water; 39.0 mL). After 30 min. saturated Na ₂SO ₃-solution (80 mL) is dropwise added at 0 ⁰C. fert-BuOMe (300 mL) is added, the organic layer is separated and concentrated under reduced pressure. The aqueous layer is extracted with fert-BuOMe. All combined organic phases are washed with brine and dried over MgSO ₄. The solvent is removed under reduced pressure. The residue is chromatogra- phed on silica gel (cyclohexane/AcOEt - 10:0 to 9:1 ) to yield 15.5 g of the title compound as colourless liquid.

¹H-NMR (300 MHz, DMSO-d ₆): 7.59 (m, 4H); 7.44 (m, 6H); 4.77 (d, J = 4.7, 1 H, -OH); 4.70 (tdd, J = 49.5, 7.1 , 2.7, 1 H); 3.97 (m, 1 H); 3.70 (m, 1 H); 1.98 (m, 1 H); 1.75-1.53 (m, 3H); 1.40 (m, 2H); 1.01 (s, 9H).

Example C16: (1 R*,2S*,4R*)-4-[[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl methane sulfonate

Starting from (1 R*,2S*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexanol (example C15; 10.4 g; 27.8 mmol) and following the procedure as described in example C4 12.2 g of the title com- pound is obtained as pale yellow oil after column chromatography on silica gel (cyclohexane/AcOEt - 90: 10 to 80:20).

¹ H-NMR (300 MHz, CDCI ₃): 7.62 (m, 4H); 7.43 (m, 6H); 5.16-4.91 (m, 2H); 4.20 (m, 1 H); 3.02 (s, 3H); 2.17-1.-84 (m, 4H); 1.69 (m, 1 H); 1.49 (m, 1 H); 1 .07 (s, 9H). Example C17: {[(1 R*,3S*,4S*)-4-Azido-3-fluorocyclohexyl]oxy}(fert-butyl)diphe nylsilane

Starting from (1 R*,2S*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl methanes ulfonate (example C16; 12.1 g; 26.8 mmol) and following the procedure as described in example C5, 9.4 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohexane/AcOEt - 95:05).

1 H-NMR (300 MHz, CDCI ₃): 7.63 (m, 4H); 7.39 (m, 6H); 4.84 (dm, J = 50.3, 1 H); 4.15 (m, 1 H); 3.45 (m, 1 H); 2.16 (m, 1 H); 1.99-1.75 (m, 2H); 1.65 (m, 1 H); 1.49 (m, 1 H); 1.33 (m, 1 H); 1.07 (s, 9H).

Example C18: fert-Butyl [(1 S*,2S*,4R*)^-{[tert-butyl(diphenyl)silyl]oxy}-2-fluorocycloh exyl] carbamate

Starting from {[(1 R*,3S*,4S*)-4-azido-3-fluorocyclohexyl]oxy}(fert-butyl)diphe nylsilane (example C17; 9.4 g; 23.6 mmol) and following the procedure as described in example C7, 8.7 g of the title compound is obtained as colourless solid after column chromatography on silica gel (cyclohex- ane/AcOEt - 95:05). ¹H-NMR (300 MHz, DMSO-d ₆): 7.60 (m, 4H); 7.46 (m, 6H); 7.1 1 (d, J = 8.4, 1 H, -NH); 4.73 (tdd, J = 50.4, 10.4, 4.6, 1 H); 4.09 (m, 1 H); 3.44 (m, 1 H); 1.98 (m, 1 H); 1.76 (m, 1 H); 1.67-1.46 (m, 3H); 1.39 (s, 9H & m, 1 H); 1.03 (s, 9H). Example C19: fert-Butyl [(1 S*,2S*,4R*)-2-fluoro^-hydroxycyclohexyl]carbamate

Tetrabutylammoniumfluoride trihydrate (11.9 g; 36.7 mmol) is added to a solution of fert-butyl [(1 S*,2S*,4R*)-4-{[tert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl] carbamate (example C18; 8.7 g; 18.3 mmol). The reaction mixture is stirred over night at ambient temperature. The solvent is removed under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/AcOEt - 60:40 to 40:60) to yield 4.2 g of the title compound as colourless oil.

¹H-NMR (300 MHz, DMSO-d ₆): 6.91 (d, J = 8.0, 1 H, -NH); 4.57 (d, J = 2.7, 1 H, -OH); 4.56 (dm, J = 50.4, 1 H); 3.94 (m, 1 H); 3.41 (m, 1 H); 2.03 (m, 1 H); 1.64-1.50 (m, 4H); 1.50-1.32 (s, 9H & m, 1 H).

Example C20: (1 R*,3S*,4S*H-[(fert-Butoxycarbonyl)amino]-3-fluorocyclohexyl methane sulfonate

Starting from fert-butyl [(1 S*,2S*,4R*)-2-fluoro-4-hydroxycyclohexyl]carbamate (example C19; 5.9 g; 25.5 mmol) and following the procedure as described in example C4, 6.6 g of the title compound is obtained as colourless solid after chromatography on silica gel (cyclohexane/AcOEt - 60:40 to 50:50)

1H-NMR (300 MHz, CDCI ₃): 5.05 (m, 1 H); 4.61 (br.s, 1 H, -NH & dm, J = 48.9, 1 H); 3.72 (m, 1 H); 3.02 (s, 3H); 2.40 (m, 1 H); 2.09 (m, 1 H); 1.96 (m, 2H); 1.79 (m, 1 H); 1.64 (m, 1 H); 1.45 (s, 9H).

Example C21: fert-Butyl [(1 S*,2S*,4S*)-4-azido-2-fluorocyclohexyl]carbamate

Starting from (1 R*,3S*,4S*)-4-[(fert-butoxycarbonyl)amino]-3-fluorocyclohexy l methanesulfonate (example C20; 5.3 g; 17.0 mmol) and following the procedure as described in example C5, 4.0 g of the title compound is obtained as colourless solid after chromatography on silica gel (cyclohex- ane/AcOEt - 60:40).

¹H-NMR (300 MHz, CDCI ₃): 4.45 (br.s, 1 H, -NH); 4.25 (dm, J = 49.7, 1 H); 3.55 (m, 1 H); 3.35 (m, 1 H); 2.46 (m, 1 H); 2.21 (m, 1 H); 1.99 (m, 1 H); 1.64 (m, 1 H); 1.45 (s, 9H & m, 1 H); 1.23 (m, 1 H).

Example C22: fert-Butyl [(1 S*,2S*,4S*)-4-amino-2-fluorocyclohexyl]carbamate

Starting from fert-butyl [(1 S*,2S*,4S*)-4-azido-2-fluorocyclohexyl]carbamate (example C21 ; 2.0 g; 7.7 mmol) and following the procedure as described in example C11 yields 1.7 g of the title compound as colourless solid.

HR-MS (ESI): m/z = 233.1651 ([MH] ⁺, C ₁₁H ₂₂FN ₂O ₂ ⁺, calc. 233.1659).

Example C23: (1 S*,2S*,4S*)-4-Azido-2-fluorocyclohexanamine hydrochloride Starting from fert-butyl [(1 S*,2S*,4S*)-4-azido-2-fluorocyclohexyl]carbamate (example C21 ; 1.9 g; 7.5 mmol) and following the procedure as described in example C12 yields 1.4 g of the title compound as colourless solid.

HR-MS (ESI): m/z = 159.1038 ([MH] ⁺, C ₆H ₁₃FN ₄ ⁺, calc. 159.1040).

Example C24: (1 S*,2S*,4S*)-4-(Benzyloxy)-2-methylcyclopentanol

A stirred suspension of CuCN (8.9 g; 100.0 mmol) in dry THF (100.0 mL) is cooled to -78°C before addition of MeLi (1.6 M solution in Et ₂O; 125.0 mL; 200.0 mmol). The mixture is allowed to warm to ambient temperatute and re-cooled to -78°C before dropwise addition of a solution of known cis-3- (benzyloxy)-6-oxabicyclo[3.1.0]hexane (9.5 g; 50.0 mmol) [Snider, B. B.; Liu, T. J. Org. Chem.

2000, 65, 8490; Milne, D.; Murphy, P.J. J. Chem. Soc. Chemical Communication 1993, 884] in dry THF (100 mL) followed by dropwise addition of BF ₃ etherate (6.8 mL; 55.0 mmol). The cooled reaction mixture is stirred over night, allowed to warm to 0 ⁰C and quenched with saturated NH _tCI- solution containing 10% (v/v) of 25% aqueous NK^OH-solution (250 mL). The organic layer is separated and concentrated under reduced pressure. The aqueous layer is extracted with fert-

BuOMe. All organic phases are combined, washed with brine, dried over MgSO ₄ and concentrated under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/ϊert-BuOMe - 80:20 to 50:50) to yield 7.6 g of the title compound as pale yellow oil.

1H-NMR (300 MHz, DMSO-d ₆): 7.31 (m, 5H); 4.62 (d, J = 5.3, 1 H, -OH); 4.38 (s, 2H); 3.87 (m, 1 H); 3.39 (m, 1 H); 2.26 (m, 1 H); 1.84 (m, 2H); 1.47 (m, 1 H); 1.30 (m, 1 H); 0.93 (d, J = 6.2, 3H).

Example C25: (1 R*,2S*,4S*)-4-(Benzyloxy)-2-methylcyclopentyl 3-nitrobenzoate

To an ice-cold stirred solution of (1 S*,2S*,4S*)^4-(benzyloxy)-2-methylcyclopentanol (example C24; 7.5 g; 36.5 mmol), 3-nirobenzoic acid (18.4 g; 110.0 mmol) and triphenylphoshine (23.0 g; 87.6 mmol) diethyl azodicarboxylate (40% solution in toluene; 38.1 g; 87.6 mmol) is dropwise added. The reaction mixture is stirred at ambient temperature for two hours and concentrated under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/fert-BuOMe - 100: 0 to 80:20) to yield 1 1.5 g of the title compound as pale yellow oil.

1H-NMR (300 MHz, DMSO-d ₆): 8.61 (~s, 1 H); 8.49 (m, 1 H); 8.37 (m, 1 H); 7.84 (t, J = 8.0, 1 H); 7.33 (m, 5H); 5.41 (m, 1 H); 4.44 (d, J = 1.5, 2H); 4.20 (m, 1 H); 2.43 (m, 1 H); 2.18 (m, 2H); 2.00 (m, 1 H); 1.73 (m, 1 H); 1.00 (d, J = 6.7, 3H).

Example C26: (1 R*,2S*,4S*)-4-(Benzyloxy)-2-methylcyclopentanol

To a solution of (1 R*,2S*,4S*)^4-(benzyloxy)-2-methylcyclopentyl 3-nitrobenzoate (example 25; 11.5 g; 32.5 mmol) in THF (80.0 mL) and MeOH (40.0 mL) LiOH (1.17 g; 48.7 mmol) dissolved in water (40.0 mL) is added. The reaction mixture is stirred at ambient temperature for one hour and concentrated under reduced pressure. The residue is diluted with water and extracted with di- chloromethane. The organic layer is dried over MgSO ₄, and concentrated under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/fert-BuOMe - 80: 20 to 50:50) to yield 5.9 g of the title compound as pale yellow oil.

¹H-NMR (300 MHz, DMSO-d ₆): 7.30 (m, 5H); 4.37 (s, 2H); 4.28 (d, J = 4.2, 1 H, -OH); 4.07 (m, 1 H); 3.97 (m, 1 H); 2.08-1.86 (m, 2H); 1.84-1.68 (m, 2H); 1.54 (m, 1 H); 0.90 (d, J = 6.8, 3H).

Example C27: (1 R*,2S*,4S*)-4-(Benzyloxy)-2-methylcyclopentyl methanesulfonate Starting from (1 R*,2S*,4S*)-4-(benzyloxy)-2-methylcyclopentanol (example C26; 5.9 g; 28.4 mmol) and following the procedure as described in example C4, 7.5 g of the title compound is obtained as pale yellow oil after column chromatography on silica gel (cyclohexane/fert-BuOMe - 90: 10 to 65:35).

¹ H-NMR (300 MHz, DMSO-d ₆): 7.32 (m, 5H); 5.02 (m, 1 H); 4.40 (d, J = 2.2, 2H); 4.14 (m, 1 H); 3.14 (s, 3H); 2.39-2.24 (m, 2H); 2.08 (m, 1 H); 1.91 (m, 1 H); 1.52 (m, 1 H); 0.99 (d, J = 6.7, 3H).

Example C28: (1 S*,2S*,4S*)-1 -Azido-4-(benzyloxy)-2-methylcyclopentane

Starting from (1 R*,2S*,4S*)-4-(benzyloxy)-2-methylcyclopentyl methanesulfonate (example C27; 7.4 g; 26.5 mmol) and following the procedure as described in example C5, 5.6 g of the title compound is obtained as pale yellow oil after column chromatography on silica gel (cyclohexane/ϊert- BuOMe - 90: 10 to 65:35).

¹ H-NMR (300 MHz, DMSO-d ₆): 7.32 (m, 5H); 4.41 (s, 2H); 3.97 (m, 1 H); 3.38 (m, 1 H); 2.40 (m, 1 H); 2.1 1 -1.90 (m, 2H); 1.65 (m, 1 H); 1.39 (m, 1 H); 1.02 (d, J = 6.4, 3H).

Example C29: fert-Butyl [(1 S*,2S*,4S*)-4-(benzyloxy)-2-methylcyclopentyl]carbamate Starting from (1 S*,2S*,4S*)-1 -azido-4-(benzyloxy)-2-methylcyclopentane (example C28; 4.9 g; 24.0 mmol) and following the procedure as described in example C7, 5.5 g of the title compound is ob- tained as pale yellow oil after column chromatography on silica gel (cyclohexane/ϊert-BuOMe - 95:05 to 70:30).

¹ H-NMR (300 MHz, DMSO-d ₆): 7.31 (m, 5H); 6.74 (d, J = 8.2, 1 H, -NH); 4.37 (s, 2H); 3.90 (m, 1 H); 3.26 (m, 1 H); 2.27 (m, 1 H); 1.87 (m, 2H); 1.46 (m, 1 H); 1.37 (s, 9H & m, 1 H); 0.90 (d, J = 6.0, 3H). Example C30: fert-Butyl [(1 S*,2S*,4S*)-4-hydroxy-2-methylcyclopentyl]carbamate

Starting from ferf-butyl [(1 S*,2S*,4S*)-4-(benzyloxy)-2-methylcyclopentyl]carbamate (example C29; 5.4 g; 18.1 mmol) and following the procedure as described in example C8, 3.9 g of the title compound is obtained as pale yellow oil.

1 H-NMR (300 MHz, DMSO-d ₆): 6.64 (d, J = 8.0, 1 H, -NH); 4.47 (d, J = 4.0, 1 H, -OH); 4.03 (m, 1 H); 3.21 (m, 1 H); 2.15 (m, 1 H); 1.89 (m, 1 H); 1 .64 (m, 1 H); 1.37 (s, 9H); 1.31 (m, 2H); 0.89 (d, J = 6.6, 3H). Example C31 : (1 S*,3S*,4S*)-3-[(fert-Butoxycarbonyl)aminoH-methylcyclopentyl methanesulfonate

Starting from fert-butyl [(1 S*,2S*,4S*)-4-hydroxy-2-methylcyclopentyl]carbamate (example C30; 3.9 g; 18.0 mmol) and following the procedure as described in example C4, 4.8 g of the title compound is obtained as colourless solid after column chromatography on silica gel (cyclohexane/ϊert-BuOMe - 90: 10 to 60:40).

¹ H-NMR (300 MHz, DMSO-d ₆): 6.89 (d, J = 7.9, 1 H, -NH); 4.99 (m, 1 H); 3.29 (m, 1 H); 3.12 (s, 3H); 2.45 (m, 1 H); 2.09-1.84 (m, 2H); 1.69-1 .50 (m, 2H); 1.38 (s, 9H); 0.93 (d, J = 6.2, 3H). Example C32: fert-Butyl [(1 S*,2S*,4R*)-4-azido-2-methylcyclopentyl]carbamate

Starting from (1 S*,3S*,4S*)-3-[(fert-butoxycarbonyl)amino]-4-methylcyclopent yl methanesulfonate (example C31 ; 4.8 g; 16.0 mmol) and following the procedure as described in example C5, 3.7 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclo- hexane/fert-BuOMe - 90: 10 to 80:20).

1 H-NMR (300 MHz, DMSO-d ₆): 6.82 (d, J = 8.0, 1 H, -NH); 4.03 (m, 1 H); 3.42 (m, 1 H); 2.22 (m, 1 H); 1.87 (m, 1 H); 1.79-1.64 (m, 2H); 1.38 (s, 9H); 1.15 (m, 1 H); 0.96 (d, J = 6.2, 3H).

Example C33: fert-Butyl [(1 S*,2S*,4R*)-4-amino-2-methylcyclopentyl]carbamate

Starting from fert-butyl [(1 S*,2S*,4R*)-4-azido-2-methylcyclopentyl]carbamate (example C32; 1.6 g; 6.8 mmol) and following the procedure as described in example C1 1 , 1.4 g of the title compound is obtained as colourless oil.

¹ H-NMR (300 MHz, DMSO-d ₆): 6.64 (d, J = 7.7, 1 H, -NH); 3.45 (m, 1 H); 3.29 (br.s, 2H, -NH ₂); 3.21 (m, 1 H); 1.99 (m, 1 H); 1.71 -1.50 (m, 3H); 1.37 (s, 9H); 0.93 (d, J = 6.6, 3H); 0.83 (m, 1 H). Example C34: (1 S*,2S*,4R*)-4-Azido-2-methylcyclopentanamine hydrochloride

Starting from fert-butyl [(1 S*,2S*,4R*)-4-azido-2-methylcyclopentyl]carbamate (example C32; 3.6 g;

15.0 mmol) and following the procedure as described in example C12, 2.4 g of the title compound is obtained as colourless solid.

¹ H-NMR (300 MHz, DMSO-d ₆): 8.27 (br.s, 3H, -NH ₃ ⁺); 4.20 (m, 1 H); 3.12 (m, 1 H); 2.29 (m, 1 H); 2.13-1.94 (m, 3H); 1.26 (m, 1 H); 1.10 (d, J = 6.8, 3H).

HR-MS (ESI): m/z = 141.1 136 ([MH] ⁺, C ₆H ₁₃N ₄ ⁺, calc. 141.1 135)

Example C35: (1 S*,2S*,4R*)-4-(Benzyloxy)-2-fluorocyclopentanol

A stirred mixture of known cis-3-(benzyloxy)-6-oxabicyclo[3.1 .0]hexane (6.1 g; 32.1 mmol) [Snider, B.B.; Liu, T. J. Org. Chem. 2000, 65, 8490; Milne, D.; Murphy, P.J. J. Chem. Soc. Chemical Communication 1993, 884] and tetrabutylammonium dihydrogen trifluoride (16.3 g; 54.1 mmol) is heated to 150 ⁰C over night. The mixture is diluted with AcOEt and extracted with sat. NaHCO ₃- solution. The organic layer is dried over MgSO ₄ and concentrated under reduced pressure. The residue is chromatographed on silica gel (cyclohexane/AcOEt - 10:0 to 80:29) to yield 5.5 g of the title compound as pale yellow oil.

¹H-NMR (300 MHz, DMSO-d ₆): 7.32 (m, 5H); 5.13 (d, J = 4.6, 1 H, -OH); 4.81 (dm, J = 53.1 , 1 H); 4.43 (s, 2H); 4.11 -3.93 (m, 2H); 2.32 (m, 1 H); 2.18-1.88 (m, 2H); 1.51 (m, 1 H).

Example C36: (1 S*,2R*,4S*)-4-(Benzyloxy)-2-fluorocyclopentyl 3-nitrobenzoate

Starting from (1 S*,2S*,4R*)-4-(Benzyloxy)-2-fluorocyclopentanol (example C35; 6.5 g; 30.9 mmol) and following the procedure as described in example C25, 7.3 g of the title compound is obtained as pale yellow oil.

1 H-NMR (300 MHz, DMSO-d ₆): 8.63 (m, 1 H); 8.52 (m, 1 H); 8.39 (m, 1 H); 7.86 (t, J = 8.0, 1 H); 7.40- 7.24 (m, 5H); 5.50-5.21 (m, 2H); 4.48 (s, 2H); 4.30 (m, 1 H); 2.46-2.04 (m, 4H).

Example C37: (1 S*,2R*,4S*)-4-(Benzyloxy)-2-fluorocyclopentanol

Starting from (1 S*,2R*,4S*)-4-(Benzyloxy)-2-fluorocyclopentyl 3-nitrobenzoate (example C36; 7.3 g; 20.0 mmol) and following the procedure as described in example C26, 3.8 g of the title compound is obtained as colourless oil.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.31 (m, 5H); 4.91 (d, J = 5.8, 1 H, -OH); 4.83 (dm, J = 54.7, 1 H); 4.39 (s, 2H); 4.18-3.99 (m, 2H); 2.20 (m, 1 H); 2.00-1.75 (m, 3H). Example C38: (1 S*,2R*,4S*)-4-(Benzyloxy)-2-fluorocyclopentyl methanesulfonate

Starting from (1 S*,2R*,4S*)-4-(benzyloxy)-2-fluorocyclopentanol (example C37; 3.8 g; 17.9 mmol) and following the procedure as described in example C4, 5.1 g of the title compound is obtained as pale yellow oil.

1 H-NMR (300 MHz, DMSO-d ₆): 7.33 (m, 5H); 5.32-5.01 (m, 2H); 4.43 (d, J = 1.8, 2H); 4.22 (m, 1 H); 3.24 (s, 3H); 2.40-1.91 (m, 4H).

Example C39: (1 S*,3R*,4R*)-3-Azido-4-fluorocyclopentyl benzyl ether

Starting from (1 S*,2R*,4S*)-4-(Benzyloxy)-2-fluorocyclopentyl methanesulfonate (example C38; 5.1 g; 17.7 mmol) and following the procedure as described in example C5, 3.5 g of the title compound is obtained as colourless oil.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.32 (m, 5H); 5.03 (dm, J = 53.1 , 1 H); 4.44 (s, 2H); 4.22-4.07 (m, 2H); 2.44 (m, 1 H); 2.16 (m, 1 H); 2.08 (m, 1 H); 1 .72 (m, 1 H).

Example C40: fert-Butyl [(1 R*,2R*,4S*H-(benzyloxy)-2-fluorocyclopentyl]carbamate Starting from (1 S*,3R*,4R*)-3-azido-4-fluorocyclopentyl benzyl ether (example C39; 4.5 g; 19.0 mmol) and following the procedure as described in example C7, 5.2 g of the title compound is obtained as colourless solid. ¹ H-NMR (300 MHz, DMSO-d ₆): 7.32 (m, 5H); 6.95 (br.d, J = 6.8, 1 H, -NH); 4.87 (dm, J = 53.3, 1 H); 4.43 (s, 2H); 4.05 (m, 1 H); 3.83 (m, 1 H); 2.32 (m, 1 H); 2.18-1 .89 (m, 2H); 1 .53 (m, 1 H); 1.38 (s, 9H). Example C41 : fert-Butyl [(1 R*,2R*,4S*)-2-fluoro-4-hydroxycyclopentyl]carbamate

Starting from fert-butyl [(1 R*,2R*,4S*)-4-(benzyloxy)-2-fluorocyclopentyl]carbamate (example C40; 5.2 g; 16.9 mmol) and following the procedure as described in example C8, 3.5 g of the title compound is obtained as colourless solid.

¹ H-NMR (300 MHz, DMSO-d ₆): 6.86 (br.d, J = 7.1 , 1 H, -NH); 4.86 (d, J = 3.7, 1 H, -OH); 4.84 (dm; J = 53.1 , 1 H); 4.15 (m, 1 H); 3.79 (m, 1 H); 2.19 (m, 1 H); 2.07-1.71 (m, 2H); 1.38 (s, 9H & m, 1 H).

Example C42: (1 S*,3R*,4R*)-3-[(fert-Butoxycarbonyl)amino]-4-fluorocyclopent yl methane- sulfonate

Starting from fert-butyl [(1 R*,2R*,4S*)-2-fluoro-4-hydroxycyclopentyl]carbamate (example C41 ; 3.5 g; 16.0 mmol) and following the procedure as described in example C4, 4.4 g of the title compound is obtained as colourless solid.

¹ H-NMR (300 MHz, DMSO-d ₆): 7.13 (br.d, J = 6.6, 1 H, -NH); 5.09 (m, 1 H); 4.93 (dm; J = 52.8, 1 H); 3.87 (m, 1 H); 3.18 (s, 3H); 2.52 (m, 1 H); 2.38-2.10 (m, 2H); 1.74 (m, 1 H); 1.39 (s, 9H). Example C43: fert-Butyl [(1 R*,2R*,4R*)-4-azido-2-fluorocyclopentyl]carbamate

Starting from (1 S*,3R*,4R*)-3-[(fert-butoxycarbonyl)amino]-4-fluorocyclopent yl methanesulfonate (example C42; 4.4 g; 14.8 mmol) and following the procedure as described in example C5, 3.5 g of the title compound is obtained as colourless solid.

1 H-NMR (300 MHz, DMSO-d ₆): 7.07 (br.d, J = 5.8, 1 H, -NH); 4.85 (dm; J = 52.8, 1 H); 4.20 (m, 1 H); 3.98 (m, 1 H); 2.36 (m, 1 H); 1 .97 (m, 1 H); 1.92-1.73 (m, 2H); 1.39 (s, 9H).

Example C44: fert-Butyl [(1 R*,2R*,4R*)-4-amino-2-fluorocyclopentyl]carbamate

Starting from fert-butyl [(1 R*,2R*,4R*)^4-azido-2-fluorocyclopentyl]carbamate (example C43; 1.7 g; 7.0 mmol) and following the procedure as described in example C1 1 , 1.5 g of the title compound is obtained as colourless solid.

¹ H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 4.76 (dm; J = 52.8, 1 H); 4.04 (m, 1 H); 3.31 (m, 1 H); 2.23

(m, 1 H); 1.67 (m, 2H); 1.48 (m, 1 H); 1 .39 (s, 9H).

HR-MS (ESI): m/z = 219.1495 ([MH] ⁺, C ₁₀H ₂₀FN ₂O ₂ ⁺, calc. 219.1503). Example C45: (1 R*,2R*,4R*)-4-Azido-2-fluorocyclopentanamine hydrochloride

Starting from fert-butyl [(1 R*,2R*,4R*)^4-azido-2-fluorocyclopentyl]carbamate (example C43; 1.8 g; 7.5 mmol) and following the procedure as described in example C12, 1.3 g of the title compound is obtained as colourless solid. ¹H-NMR (300 MHz, DMSO-d ₆): 8.54 (br.s, 3H, -NH ₃ ⁺); 5.19 (dm; J = 52.4, 1 H); 4.34 (m, 1 H); 3.75

(m, 1 H); 2.49 (m, 1 H); 2.17 (m, 1 H); 2.06-1.88 (m, 2H).

HR-MS (ESI): m/z = 145.0888 ([MH] ⁺, C ₅H ₁₀FN ₄ ⁺, calc. 145.0884). Example C46: (1 S*,2R*,4R*)^-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocycloh exanol

Starting from ((2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocycloh exanone (example C14;

18.7 g; 50.4 mmol) and following the procedure as described in example C15 17.9 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohex- ane/AcOEt - 100:0 to 85:15).

1H-NMR (300 MHz, CDCI ₃): 7.67 (m, 4H); 7.38 (m, 6H); 4.31 (dddd, J = 47.1 , 10.7, 4.8, 2.9, 1 H); 3.94 (m, 1 H); 3.61 (m, 1 H); 2.14-1.67 (m, 4H & 1 H, -OH); 2.92 (m, 1 H); 1.20 (m, 1 H); 1.05 (s, 9H).

Example C47: (1 R*,2R*,4R*H-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xyl 3- nitrobenzoate

Starting from (1 S*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexanol (example C46;

17.8 g; 47.9 mmol) and following the procedure as described in example C25 15.8 g of the title compound is obtained as pale yellow oil after column chromatography on silica gel (cyclohex- ane/AcOEt - 100:0 to 85:15).

¹H-NMR (300 MHz, DMSO-d ₆): 8.60 (m, 1 H); 8.49 (m, 1 H); 8.34 (m, 1 H); 7.83 (t, J = 8.2, 1 H); 7.64 (m, 4H); 7.46 (m, 6H); 5.09 (m, 1 H); 4.65 (dm, J = 50.6, 1 H); 3.87 (m, 1 H); 2.24 (m, 1 H); 1.97 (m, 1 H); 1.87-1.50 (m, 3H); 1.35 (m, 1 H); 1.02 (s, 9H).

Example C48: (1 R*,2R*,4R*H-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xanol Starting from (1 R*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl 3-nitrobenzoate (example C47; 15.8 g; 30.3 mmol) and following the procedure as described in example C26 10.9 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohexane/AcOEt - 100:0 to 85:15).

¹H-NMR (300 MHz, DMSO-d ₆): 7.61 (m, 4H); 7.45 (m, 6H); 4.97 (d, J = 4.7, 1 H, -OH); 4.01 (dm, J = 50.4, 1 H); 3.71 (m, 1 H); 3.40 (m, 1 H); 2.09 (m, 1 H); 1.67 (m, 2H); 1.53 (m, 1 H); 1.37 (m, 1 H); 1.00 (s, 9H & m, 1 H).

Example C49: (1 R*,2R*,4R*H-{[fert-Butyl(diphenyl)silyl]oxy}-2-fluorocyclohe xyl methanesulfonate

Starting from (1 R*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexanol (example C48; 13.1 g; 35.2 mmol) and following the procedure as described in example C4 14.8 g of the title compound is obtained as pale yellow oil after column chromatography on silica gel (cyclohexane/AcOEt - 100:0 to 80:20). ¹ H-NMR (400 MHz, DMSO-d ₆): 7.62 (m, 4H); 7.45 (m, 6H); 4.63 (m, 1 H); 4.45 (dm, J = 50.3, 1 H); 3.83 (m, 1 H); 3.13 (s, 3H); 2.19 (m, 1 H); 1.97 (m, 1 H); 1.72 (m, 2H); 1.51 (m, 1 H); 1.35 (m, 1 H); 1.00 (s, 9H). Example C50: {[(1 R*,3R*,4S*)-4-Azido-3-fluorocyclohexyl]oxy}(fert-butyl)diphe nylsilane

Starting from (1 R*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl methanes ulfonate (example C49; 14.7 g; 32.7 mmol) and following the procedure as described in example C5 10.2 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohexane/AcOEt - 100:0 to 95:05).

1 H-NMR (300 MHz, CDCI ₃): 7.66 (m, 4H); 7.39 (m, 6H); 4.41 (dm, J = 46.4, 1 H); 3.79 (m, 1 H); 3.60 (m, 1 H); 2.13-1.81 (m, 3H); 1 .71 -1 .46 (m, 2H); 1 .22 (m, 1 H); 1.05 (s, 9H).

Example C51 : fert-Butyl [(1 S*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2- fluorocyclohexyl]carbamate

Starting from {[(1 R*,3R*,4S*)-4-azido-3-fluorocyclohexyl]oxy}(fert-butyl)diphe nylsilane (example

C50; 10.1 g; 25.6 mmol) and following the procedure as described in example C7 10.5 g of the title compound is obtained as colourless solid after column chromatography on silica gel (cyclohex- ane/AcOEt - 100:0 to 95:05).

¹ H-NMR (300 MHz, CDCI ₃): 7.66 (m, 4H); 7.39 (m, 6H); 4.92 (br.s, 1 H, -NH); 4.64 (dm, J = 46.7, 1 H); 3.89 (m, 1 H); 3.66 (m, 1 H); 2.08 (m, 2H); 1.87-1 .37 (m, 4H); 1.45 (s, 9H); 1.06 (s, 9H).

Example C52: fert-Butyl [(1 R*,2S*,4S*)-2-fluoro^-hydroxycyclohexyl]carbamate

Starting from fert-butyl [(1 S*,2R*,4R*)-4-{[fert-butyl(diphenyl)silyl]oxy}-2-fluorocyclo hexyl]carbamate (example C51 ; 10.4 g; 22.0 mmol) and following the procedure as described in example C19 4.5 g of the title compound is obtained as colourless oil after column chromatography on silica gel (cyclohexane/AcOEt - 50:50).

¹ H-NMR (300 MHz, CDCI ₃): 4.89 (dm, J = 48.9, 1 H); 4.87 (br.s, 1 H, -NH); 3.97 (m, 1 H); 3.66 (m, 1 H); 2.31 (m, 1 H); 2.19 (m, 1 H); 2.01 -1.80 (m, 2H); 1.78-1.54 (m, 2H & 1 H, -OH); 1.45 (s, 9H). Example C53: (1 S*,3S*,4R*)^4-[(fert-Butoxycarbonyl)amino]-3-fluorocyclohexy l methanesulfonate

Starting from fert-butyl [(1 R*,2S*,4S*)-2-fluoro-4-hydroxycyclohexyl]carbamate (example C52; 4.4 g; 18.7 mmol) and following the procedure as described in example C4 5.1 g of the title compound is obtained as pale yellow solid after column chromatography on silica gel (cyclohexane/AcOEt - 50:50).

¹ H-NMR (300 MHz, CDCI ₃): 4.97 (m, 1 H); 4.88 (br.s, 1 H, -NH); 4.80 (dm, J = 48.9, 1 H); 3.68 (m, 1 H); 3.03 (s, 3H); 2.56 (m, 1 H); 2.19 (m, 1 H); 2.01 -1.63 (m, 4H); 1 .45 (s, 9H). Example C54: fert-Butyl [(1 R*,2S*,4R*)-4-azido-2-fluorocyclohexyl]carbamate

Starting from (1 S*,3S*,4R*)-4-[(fert-butoxycarbonyl)amino]-3-fluorocyclohexy l methanesulfonate (example C53; 5.0 g; 16.1 mmol) and following the procedure as described in example C5 3.0 g of the title compound is obtained as colourless solid after column chromatography on silica gel (cyclohexane/fert-BuOMe - 80:20).

¹H-NMR (300 MHz, CDCI ₃): 4.86 (dm, J = 49.5, 1 H); 4.77 (br.s, 1 H, -NH); 3.75-3.51 (m, 2H); 2.38 (m, 1 H); 2.08 (m, 1 H); 1.90 (m, 1 H); 1.70-1.37 (m, 3H); 1.44 (m, 9H).

Example C55: fert-Butyl [(1 R*,2S*,4R*H-amino-2-fluorocyclohexyl]carbamate

Starting from fert-butyl [(1 R*,2S*,4R*)-4-azido-2-fluorocyclohexyl]carbamate (example C54; 0.72 g; 2.8 mmol) and following the procedure as described in example C11 0.65 g of the title compound is obtained as off-white solid.

HR-MS (ESI): m/z = 233.1665 ([MH] ⁺, C ₁₁H ₂₂FN ₂O ₂ ⁺, calc. 233.1660). Example C56: (1 R*,2S*,4R*)-4-Azido-2-fluorocyclohexanamine hydrochloride

Starting from fert-butyl [(1 R*,2S*,4R*)-4-azido-2-fluorocyclohexyl]carbamate (example C54; 1.29 g; 5.0 mmol) and following the procedure as described in example C12 0.92 g of the title compound is obtained as off-white solid.

HR-MS (ESI): m/z = 159.1036 ([MH] ⁺, C ₆H ₁₂FN ₄ ⁺, calc. 159.1041 ).

Example D.a1: Ethyl 4-(5-cyclopropylmethoxy-benzo[1 ,3]dioxol^4-yl)-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylate

Ethyl-4-chloro-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carb oxylate from example A4 (11.98 g; 50.0 mmol), dioxane (200 ml_) and Cs ₂CO ₃ (2M aqueous solution; 75.0 ml_; 150.0 mmol) is heated to 80 ⁰C under nitrogen before addition of Pd(OAc) ₂ (247 mg; 1.1 mmol) and tricyclohexylphosphine (617 mg; 2.2 mmol). After 30 min a solution of 5-cyclopropylmethoxy-4-(4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolan-2-yl)-benzo[1 ,3]dioxole from example B.c1 (17.50 g; 55.0 mmol) in dioxane (50.0 mL) is added and the reaction mixture is heated to 100 ⁰C until the starting material is consumed according to LC-MS.

The cooled reaction mixture is diluted with water (250 mL) and acidified to pH = 6 by carefule addition of 2M aqueous citric acid. The precipitated crude is filtered, dissolved in dioxane and filtered through a short column of neutral alumina containing 5 wt% of water. The column is rinsed with several portions of dioxane. The filtrate is concentrated under reduced pressure and the product is collected with tert-butyl methyl ether to yield the title compound as off-white solid.

MS (ESI): m/z = 396 (MH ⁺, 100%); 382.

¹H-NMR (300 MHz, DMSO-d ₆): 12.09 (br.s, 1 H, -NH); 8.92 (s, 1 H); 7.00 (d, J = 8.6, 1 H); 6.55 (d, J = 8.6, 1 H); 5.99 (s, 2H); 4.31 (qu, J = 7.1 , 2H); 3.75 (d, J = 6.7, 2H); 2.72 (s, 3H); 1.33 (t, J = 7.1 , 3H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.1 1 (m, 2H). The following compounds were prepared analogously to the procedure described in above example D.a1. Example D.a2: Ethyl 4-(2-cyclopropylmethoxy-4-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2- (2-cyclopropylmethoxy-4-fluoro-phenyl)^4,4,5,5-tetramethyl-[ 1 ,3,2]dioxaborolane (example B.c3)the title compound is obtained as off-white solid

MS (ESI): m/z = 392 (MNa ⁺); 370 (MH ⁺); 356 (100 %); 314; 302.

¹H-NMR (400 MHz, DMSO-d ₆): 11.89 (br.s, 1 H ₁ -NH); 9.19 (s, 1 H); 7.64 (dd, J = 8.4, 7.4, 1 H); 7.08 (dd, J = 11.6, 2.1 , 1 H); 6.95 (ddd; J = 8.4, 8.4, 2.1 , 1 H); 4.31 (qu, J = 6.9, 2H); 3.90 (d, J = 6.9, 2H); 2.74 (s, 3H); 1.34 (t, J = 6.9, 3H); 0.94 (m, 1 H); 0.38 (m, 2H); 0.24 (m, 2H). Example D.a3: Ethyl 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-

(2-cyclopropylmethoxy-5-fluoro-phenyl)^4,4,5,5-tetramethy l-[1 ,3,2]dioxaborolane (example B.c4)the title compound is obtained as off-white solid

MS (ESI): m/z = 424 (MH ⁺, 100%); 356.

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.92 (br.s, 1 H, -NH); 8.96 (s, 1 H); 7.41 (dd, J = 9.0, 3.2, 1 H); 7.37

(ddd, J = 9.1 , 8.3, 3.2, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 4.32 (qu, J = 7.1 , 2H); 3.87 (d, J = 6.9, 2H);

2.74 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H). Example D.a4: Ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7- carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and commercially available 2-ethoxy-5-fluoro-phenyl-boronιc acid the title compound is obtained as pale yellow solid

MS (ESI): m/z = 344 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .95 (s, 1 H, -NH); 8.95 (s, 1 H); 7.41 (ddd, J = 8.9, 8.9, 3.3, 1 H);

7.37 (dd, J = 8.2, 3.3, 1 H); 7.22 (dd, J = 8.9, 4.4, 1 H); 4.31 (qu, J = 7.1 , 2H); 4.08 (qu, J = 6.9, 2H);

2.74 (s, 3H); 1.34 (t, J = 7.1 , 3H); 1 .10 (t, J = 6.9, 3H). Example D.a5: Ethyl 4-(2-cyclopropylmethoxy^4-methoxy-phenyl)-6-methyl-5/-/-pyrr olo[3,2- cf]pyπmidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2- (2-cyclopropylmethoxy-4-methoxy-phenyl)-4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane (example B.c6) the title compound is obtained as off-white solid MS (ESI): m/z = 404 (MNa ⁺); 382 (MH ⁺, 100%); 368; 314.

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (br.s, 1 H, -NH); 8.90 (s, 1 H); 7.56 (d, J = 8.4, 1 H); 6.71 (dd, J = 8.4, 2.2, 2H); 6.68 (d, J = 2.2, 1 H); 4.30 (qu, J = 7.0, 2H); 3.90 (d, J = 6.9, 2H); 3.85 (s, 3H); 2.73 (s, 3H); 1.33 (t, J = 7.1 , 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.25 (m, 2H).

Example D.a6: Ethyl 4-(2-cyclopropylmethoxy-5-methoxy-phenyl)-6-methyl-5/-/-pyrr olo[3,2- cf]pyπmidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5H-pyrrolo[3,2-cflpyrimidine-7-carboxylate (example A4) and 2- (2-cyclopropylmethoxy-5-methoxy-phenyl)-4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane (example B.c7) the title compound is obtained as yellow solid

MS (ESI): m/z = 404 (MNa ⁺); 382 (MH ⁺, 100%); 368; 298.

¹H-NMR (300 MHz, DMSO-d ₆): 11.84 (br.s, 1 H, -NH); 8.94 (s, 1 H); 7.15 (t, J = 1.8, 1 H); 7.09 (d, J = 1.8, 2H); 4.31 (qu, J = 7.1 , 2H); 3.81 (d, J = 6.9, 2H); 3.76 (s, 3H); 2.73 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.91 (m, 1 H); 0.34 (m, 2H); 0.18 (m, 2H).

Example D.a7: Ethyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrr olo[3,2- c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-(2-cyclopropylmethoxy-5-methyl-phenyl)-4,4,5,5-tetramethyl -[1 ,3,2]dioxaborolane (example B.c8) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 366 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.82 (s, 1 H, -NH); 8.93 (s, 1 H); 7.41 (d, J = 2.1 , 1 H); 7.32 (dd, J = 8.4, 2.1 , 1 H); 7.05 (d, J = 8.4, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.85 (d, J = 6.8, 2H); 2.72 (s, 3H); 2.33 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m, 2H).

Example D.a8: Ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-(2-Cyclopropylmethoxy-5-trifluoromethyl-phenyl)-4,4,5,5-te tramethyl-[1 ,3,2]dioxaborolane (example B.c9) the title compound is obtained as off-white solid.

MS (ESI): m/z = 420 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.98 (s, 1 H, -NH); 8.98 (s, 1 H); 7.93-7.85 (m, 2H); 7.37 (m, 1 H); 4.32 (qu, J = 7.1 , 2H); 3.99 (d, J = 6.9, 2H); 2.74 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.89 (m, 1 H); 0.39 (m, 2H); 0.26 (m, 2H).

Example D.a9: Ethyl 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3 ,2- d]pyrimidine-7-carboxylate Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-(2-Ethoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane (example B.c10) the title compound is obtained as off-white solid.

MS (ESI): m/z = 394 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.01 (s, 1 H, -NH); 8.97 (s, 1 H); 7.91 (dd, J = 8.9, 2.1 , 1 H); 7.89 (d, J = 2.1 , 1 H); 7.41 (d, J = 8.9, 1 H); 4.32 (qu, J = 7.1 , 2H); 4.20 (qu, J = 6.9, 2H); 2.74 (s, 3H); 1.34 (t, J = 7.1 , 3H); 1.15 (t, J = 6.9, 3H).

Example D.a10: Ethyl 4-(2-cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-6-methyl- 5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and

2-(2-Cyclopropylmethoxy^4-fluoro-5-methoxy-phenyl)-4,4,5, 5-tetramethyl-[1 ,3,2]dioxaborolane

(example B.c2) the title compound is obtained as off-white solid.

MS (ESI): m/z = 422 (MNa ⁺, 100%); 400 (MH ⁺); 368; 316.

1H-NMR (300 MHz, DMSO-d ₆): 11.84 (br.s, 1 H, -NH); 8.95 (s, 1 H); 7.37 (d, J = 9.8, 1 H); 7.17 (d, J

= 13.5, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.84 (s, 3H); 3.83 (d, J = 6.9, 2H); 2.74 (s, 3H); 1.34 (t, J = 7.1 ,

3H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.19 (m, 2H).

Example D.a11 : Ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and

2-(2-cyclopropylmethoxy^4-fluoro-5-methyl-phenyl)-4,4,5,5 -tetramethyl-[1 ,3,2]dioxaborolane

(example B.c11 ) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 384 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.92 (s, 1 H); 7.52 (d, J = 9.7, 1 H); 7.03 (d, J =

12.2, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.87 (d, J = 6.9, 2H); 2.73 (s, 3H); 2.24 (d, J = 1.3, 3H); 1.34 (t, J

= 7.1 , 3H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.22 (m, 2H).

Example D.a12: Ethyl 4-(2-cyclopropylmethoxy-5-fluoro-4-methoxy-phenyl)-6-methyl- 5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and

2-(2-cyclopropylmethoxy-5-fluoro-4-methoxy-phenyl)-4,4,5, 5-tetramethyl-[1 ,3,2]dioxaborolane

(example B.c12) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 422 (MNa ⁺); 400 (MH ⁺, 100%); 386; 331.

1H-NMR (300 MHz, DMSO-d ₆): 11.81 (br.s, 1 H, -NH); 8.91 (s, 1 H); 7.45 (d, J = 11.8, 1 H); 6.92 (d, J

= 7.3, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.96 (s, 3H); 3.93 (d, J = 7.0, 2H); 2.74 (s, 3H); 1.33 (t, J = 7.1 ,

3H); 0.94 (m, 1 H); 0.38 (m, 2H); 0.23 (m, 2H). Example D.a13: Ethyl 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-4,4,5,5-tetramethyl-1 ,3,2- dioxaborolane (example B.c13) the title compound is obtained as off-white solid.

MS (ESI): m/z = 438 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.95 (s, 1 H); 7.63 (d, J = 2.4, 1 H); 7.54 (dd, J = 8.6, 2.4, 1 H); 7.14 (d, J = 8.6, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.99 (m, 2H); 3.90 (d, J = 6.9. 2H); 3.71 (m, 2H); 2.73 (s, 3H); 1.58 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.a14: Ethyl 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5/-/-pyrro lo[3,2- c(]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-(2-cyclopropylmethoxy-5-ethyl-phenyl)^4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolane (example B.c14) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 380 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.94 (s, 1 H); 7.43 (d, J = 2.4, 1 H); 7.35 (dd, J = 8.4, 2.4, 1 H); 7.07 (d, J = 8.4, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.86 (d, J = 6.9, 2H); 2.73 (s, 3H); 2.63 (qu, J = 7.5, 2H); 1.34 (t, J = 7.1 , 3H); 1.18 (t, J = 7.5, 3H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m, 2H).

Example D.a15: Ethyl 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H - pyrrolo[3,2-cf]pyπmidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-4,4,5,5-tet ramethyl-1 ,3,2-dioxaborolane (example

B.c15) the title compound is obtained as off white solid.

MS (ESI): m/z = 394 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.84 (s, 1 H, -NH); 8.94 (s, 1 H); 7.45 (d, J = 2.4, 1 H); 7.39 (dd, J =

8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 4.31 (qu, J = 7.1 , 2H); 3.86 (d, J = 6.9, 2H); 2.94 (sept, J = 6.9, 1 H); 2.73 (s, 3H); 1.34 (t, J = 7.1 , 3H); 1.22 (d, J = 6.9, 6H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m,

2H).

Example D.a16: Methyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dιmethyl-5-{[ 2- (trιmethylsιlyl)ethoxy]methyl}-5H-pyrrolo[3,2-Q ^f]pyrιmιdιne-7-carboxylate

Starting from methyl 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 /-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylate (example A.11 ) and 2-(2-cyclopropylmethoxy-5-methyl-phenyl)^4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolane (example B.c8) the title compound is obtained as off white solid. MS (ESI): m/z = 496 (MH ⁺ , 100%) ¹H-NMR (300 MHz, DMSO-d ₆): 7.31 (dd, J = 8.4, 2.0, 1 H); 7.23 (d, J = 2-0, 1 H); 7.03 (d, J =

8.4,1 H); 5.38 (d, J = 11.0, 1 H); 4.98 (d, J = 11.0, 1 H); 3.85 (s, 3H); 3.79 (dd, J = 10.4, 6.6, 1 H);

3.75 (dd, J = 10.4, 6.9, 1 H); 2.87 (m, 2H); 2.78 (s, 3H); 2.67 (s, 3H); 2.31 (s, 3H); 0.87 (m, 1 H);

0.52 (m, 2H); 0.30 (m, 2H); 0.03 (m, 2H); -0.17 (s, 9H).

Example D.a17: Methyl 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6- dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxylate

Starting from methyl 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 /-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylate (example A.1 1 ) and 2-(2-cyclopropylmethoxy-5-fluoro-4-methoxy- phenyl)-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane (example B.c15) the title compound is obtained as off white solid.

MS (ESI) : 530 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 7.29 (d, J = 11.5, 1 H); 6.92 (d, J = 7.3, 1 H), 5.43 (d, J = 11.0, 1 H);

5.03 (d, J = 11.0, 1 H); 3.95 (s, 3H); 3.85 (s, 3H); 3.83 (m, 2H); 2.95 (m, 2H); 2.80 (s, 3H); 2.67 (s, 3H); 0.88 (m, 1 H); 0.55 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.17 (s, 9H).

Example D.a18: Methyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6- dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxylate

Starting from methyl 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 /-/-pyrrolo[3,2- cdpyrimidine-7-carboxylate (example A.1 1 ) and 2-(2-cyclopropylmethoxy-4-fluoro-5-methoxy- phenyl)-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane e (example B.c2) the title compound is obtained as off white solid.

MS (ESI): m/z = 530 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 7.23 (d, J = 9.9, 1 H); 7.16 (d, J = 13.1 , 1 H); 5.36 (d, J = 10.9, 1 H); 4.97 (d, J = 10.9, 1 H); 3.85 (s, 3H); 3.81 (s, 3H); 3.79 (dd, J = 10.2, 6.4, 1 H); 3.72 (dd, J = 10.2,

6.9, 1 H); 3.04-2.87 (m, 2H); 2.79 (s, 3H); 2.68 (s, 3H); 0.86 (m, 1 H); 0.57 (m, 2H); 0.30 (m, 2H);

0.01 (m, 2H); -0.15 (s, 9H).

Example D.a19: Ethyl 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxylate

Starting from ethyl 4-chloro-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxyla te (example A4) and 2-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]^4,4,5,5- tetramethyl-1 ,3,2-dioxaborolane (example B.c16) the title compound is obtained as off-white solid.

1H-NMR (300 MHz, DMSO-d ₆): 11.93 (s, 1 H, -NH); 8.97 (s, 1 H); 7.81 (d, J = 2.1 , 1 H); 7.74 (dd, J = 8.8, 2.1 , 1 H); 7.30 (d, J = 8.8, 1 H); 7.08 (t, J = 55.9, 1 H); 4.32 (qu, J = 7.1 , 2H); 3.96 (d, J = 6.9, 2H); 2.74 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example D.b1 : Ethyl 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate

Sodium hydride (1.77 g; -60% dispersion in oil) is washed with hexane (2x25) and suspended in dry DMF(150 mL) and dry DMSO (50 mL). Ethyl 4-(5-cyclopropylmethoxy-benzo[1 ,3]dioxol-4-yl)-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxylate from example D.a1 (14.55 g; 36.8 mmol) is added st the well stirred suspension in several small portions. After complete addition the reaction mixture is stirred for one hour at 60 ⁰C and cooled to 10 ⁰C before slow addition of (2-chloromethoxy- ethyl)-trimethyl-silane (7.98 g; 47.8 mmol). After stirring over night at ambient temperature the mixture is poured on ice-cold water and repeatedly extracted with dichloromethane. The combined organic layer is dried over MgSO4, The solvent is evaporated. The crued product is purified by column chromatography on silica gel (ethylacetate/cyclohexane - 1 :1 ) to yield the title compound as pale yellow viscous oil.

MS (ESI): m/z = 526 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.02 (d, J = 0.6, 1 H); 5.92 (d, J = 0.6, 1 H); 5.39 (d, J = 10.9, 1 H); 5.13 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.76 (dd, J = 10.2, 6.6, 1 H); 3.67 (dd, J = 10.2, 6.8, 1 H); 3.01 (m, 2H); 2.82 (s, 3H); 1.35 (t, J = 7.1 , 3H); 0.86 (m, 1 H); 0.62 (m, 2H); 0.29 (m, 2H); 0.00 (m, 2H); -0.13 (s, 9H).

The following compounds were prepared analogously to the procedure described in above example D.b1.

Example D.b2: Ethyl 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylate

Starting from 4-(2-Cyclopropylmethoxy-4-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2-c(]pyrimidine-7- carboxylic acid ethyl ester (example D.a2) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is prepared as pale yellow viscous oil.

MS (ESI): m/z = 500 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 8.97 (s, 1 H); 7.49 (dd, J = 8.4, 6.9, 1 H); 7.09 (dd, J = 11.3, 2.4, 1 H);

6.97 (ddd, J = 8.4, 8.4, 2.4, 1 H); 6.41 (d, J = 10.9, 1 H); 4.99 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.89 (dd, J = 10.3, 6.5, 1 H); 3.80 (dd, J = 10.3, 7.0, 1 H); 2.93 (m, 2H); 2.82 (s, 3H); 1.35 (t, J =

7.1 , 3H); 0.91 (m, 1 H); 0.56 (dd, J = 9.5, 6.9, 2H); 0.33 (m, 2H): 0.06 (m, 2H); -0.16 (s, 9H).

Example D.b3: Ethyl 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxylate

Starting from ethyl 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2-c(]pyrimidine- 7-carboxylate (example D.a3) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is prepared as pale yellow viscous oil.

MS (ESI): m/z = 500 (MH ⁺). ¹H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 7.38 (ddd, J = 9.1 , 8.4, 3.2, 1 H); 7.30 (dd, J = 8.6, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 5.42 (d, J = 10.9, 1 H); 5.00 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.83 (dd, J = 10.4, 6.6, 1 H); 3.76 (dd, J = 10.4, 6.9, 1 H); 2.94 (m, 2H); 2.82 (s, 3H); 1.35 (t, J = 7.1 , 3H); 0.88 (m, 1 H); 0.56 (m, 2H); 0.31 (m, 2H); 0.03 (m, 2H); -0.15 (s, 9H).

Example D.b4: Ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate

Starting from ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2-d]pyri midine-7-carboxylate (example D.a4) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title com- pound is obtained as yellow viscous oil.

MS (ESI): m/z = 474 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.98 (s, 1 H); 7.39 (ddd, J = 9.1 , 8.8, 3.3, 1 H); 7.29 (dd, J = 8.6, 3.3, 1 H); 7.20 (dd, J = 9.1 , 4.4, 1 H); 5.40 (d, J = 1 1.0, 1 H); 4.98 (d, J = 11.0, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.99 (qu, J = 6.9, 2H); 2.99-2.88 (m, 2H); 2.82 (s, 3H); 1.35 (t, J = 7.1 , 3H); 1.01 (t, J = 6.9, 3H); 0.57 (m, 2H); -0.15 (s, 9H).

Example D.b5: Ethyl 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylate

Starting from ethyl 4-(2-cyclopropylmethoxy-4-methoxy-phenyl)-6-methyl-5/-/-pyrr olo[3,2- cdpyrimidine-7-carboxylate (example D.a5) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 512 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.94 (s, 1 H); 7.40 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69

(d, J = 2.2, 1 H); 5.46 (d, J = 10.9, 1 H); 5.06 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.0, 2H); 3.88 (dd, J = 10.2, 5.5, 1 H); 3.85 (s, 3H); 3.77 (dd, J = 10.2, 6.9, 1 H); 2.91 (t, J = 8.0, 2H); 2.82 (s, 3H); 1.35 (t, J

= 7.0, 3H); 0.88 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.06 (m, 2H); -0.18 (s, 9H).

Example D.b6: Ethyl 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimid ine-7-carboxylate

Starting from ethyl 4-(2-cyclopropylmethoxy-5-methoxy-phenyl)-6-methyl-5/-/-pyrr olo[3,2- cf]pyπmidine-7-carboxylate (example D.a6) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 512 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.98 (s, 1 H); 7.10 (d, J = 1.5, 2H); 7.01 (t, J = 1.5, 1 H); 5.42 (d, J = 11.0, 1 H); 5.04 (d, J = 1 1.0, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.76 (s, 3H & dd, J = 10.2, 6.5, 1 H); 3.70

(dd, J = 10.2, 6.9, 1 H); 2.92 (m, 2H); 2.82 (s, 3H); 1.35 (t, J = 7.1 , 3H); 0.85 (m, 1 H); 0.54 (m, 2H);

0.29 (m, 2H); 0.00 (m, 2H); -0.18 (s, 9H). Example D.b7: Ethyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/-pyrr olo[3,2- c(]pyrimidine-7-carboxylate (example D.a7) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 8.97 (s, 1 H); 7.33 (dd, J = 8.5, 2.0, 1 H); 7.26 (d, J = 2.0, 1 H); 7.05 (d, J = 8.5, 1 H); 5.43 (d, J = 11.0, 1 H); 5.03 (d, J = 11.0, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.81 (dd, J = 10.2, 6.5, 1 H); 3.74 (dd, J = 10.2, 6.9, 1 H); 2.89 (m, 2H); 2.81 (s, 3H); 2.32 (s, 3H); 1.35 (t, J = 7.1 , 3H); 0.88 (m, 1 H); 0.55 (m, 2H); 0.31 (m, 2H); 0.03 (m, 2H); -0.17 (s, 9H).

Example D.b8: Ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylate

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5H-pyrrolo[3,2- cyjpyrimidine-7-carboxylate (example D.a8) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 550 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 9.01 (s, 1 H); 7.90 (dd, J = 8.8, 2.1 , 1 H); 7.77 (d, J = 2.1 , 1 H); 7.38

(d, J = 8.8, 1 H); 5.40 (d, J = 10.9, 1 H); 4.96 (d, J = 10.9, 1 H); 4.36 (qu, J = 7.1 , 2H); 3.98 (dd, J = 10.4, 6.6, 1 H); 3.91 (dd, J = 10.4, 7.1 , 1 H); 2.92 (t, J = 8.2, 2H); 2.83 (s, 3H); 1.36 (t, J = 7.1 , 3H);

0.94 (m, 1 H); 0.51 (m, 2H); 0.35 (m, 2H); 0.10 (m, 2H); -0.18 (s, 9H).

Example D.b9: Ethyl 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c(]pyrimidi ne-7-carboxylate

Starting from ethyl 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo [3,2-c(]pyrimidine-7- carboxylate (example D.a9) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.00 (s, 1 H); 7.91 (dd, J = 8.8, 2.2, 1 H); 7.76 (d, J = 2.2, 1 H); 7.40 (d, J = 8.8, 1 H); 5.38 (d, J = 10.9, 1 H); 4.94 (d, J = 10.9, 1 H); 4.30 (qu, J = 7.1 , 2H); 4.17^.08 (m,

2H); 2.93 (t, J = 8.3, 2H); 2.83 (s, 3H); 1.35 (t, J = 7.1 , 3H); 1.07 (t, J = 7.0, 3H); 0.59-0.45 (m, 2H);

-0.18 (s, 9H).

Example D.b10: Ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxylate

Starting from 4-(2-cyclopropylmethoxy^4-fluoro-5-methoxy-phenyl)-6-methyl- 5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid ethyl ester (example D.a10) and commercially available (2- chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil. MS (ESI): m/z = 552 (MNa ⁺); 530 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 8.98 (s, 1 H); 7.27 (d, J = 9.7, 1 H); 7.18 (d, J = 13.3, 1 H); 5.41 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.82 (s, 3H); 3.80 (dd, J = 10.4, 6.7, 1 H); 3.74 (dd, J = 10.4, 7.0, 1 H); 2.97 (m, 2H); 2.82 (s, 3H); 1.35 (t, J = 7.1 , 3H); 0.87 (m, 1 H); 0.56 (m, 2H); 0.31 (m, 2H); 0.02 (m, 2H); -0.15 (s, 9H).

Example D.b11: Ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylate

Starting from ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylate (example D.a11 ) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow solid.

MS (ESI): m/z = 514 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.96 (s, 1 H); 7.37 (d, J = 8.9, 1 H); 7.05 (d, J = 12.1 , 1 H); 5.43 (d, J

= 11.0, 1 H); 5.02 (d, J = 1 1.0, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.85 (dd, J = 10.4, 6.6, 1 H); 3.77 (dd, J = 10.4, 7.1 , 1 H); 2.94 (m, 2H); 2.82 (s, 3H); 2.23 (d, J = 1.3, 3H); 1.35 (t, J = 7.1 , 3H); 0.89 (m, 1 H);

0.54 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.16 (s, 9H).

Example D.b12: Ethyl 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -5-

{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]py rimidine-7-carboxylate

Starting from ethyl 4-(2-cyclopropylmethoxy-5-fluoro-4-methoxy-phenyl)-6-methyl- 5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylate (example D.a12) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 552 (MNa ⁺, 100 %); 530 (MH ⁺); 458 (MH ⁺-C ₃H ₈Si).

¹H-NMR (300 MHz, DMSO-d ₆): 8.95 (s, 1 H); 7.30 (d, J = 1 1.5, 1 H); 6.92 (d, J = 7.3, 1 H); 5.46 (d, J = 11.1 , 1 H); 5.06 (d, J = 1 1.1 , 1 H); 4.34 (qu, J = 7.1 , 2H); 3.94 (s, 3H); 3.87 (dd, J = 10.2, 6.6, 1 H);

3.80 (dd, J = 10.2, 7.0, 1 H); 2.95 (m, 2H); 2.81 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.87 (m, 1 H); 0.54 (m,

2H); 0.31 (m, 2H); 0.03 (m, 2H); -0.18 (s, 9H).

Example D.b13: Ethyl 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxylate

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxylate (example D.a13) and commercially available (2- chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 568 (MH ⁺, 100%).

Example D.b14: Ethyl 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo [3,2-cy]pyrimidine- 7-carboxylate (example D.a14) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 510 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 8.97 (s, 1 H); 7.41 (dd, J = 8.6, 2.2, 1 H); 7.29 (d, J = 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 5.42 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.84 (dd, J = 10.2, 6.4, 1 H); 3.74 (dd, J = 10.2, 6.8, 1 H); 2.89 (m, 2H); 2.81 (s, 3H); 2.62 (qu, J = 7.5, 2H); 1.34 (t, J = 7.1 , 3H); 1.20 (t, J = 7.5, 3H); 0.93 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.18 (s, 9H).

Example D.b15: Ethyl 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5/ -/-pyrrolo[3,2- cf]pyπmidine-7-carboxylate (example D.a15) and commercially available (2-chloromethoxy-ethyl)- trimethyl-silane the title compound is obtained as yellow viscous oil.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.97 (s, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.32 (d, J = 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 5.41 (d, J = 10.9, 1 H); 5.04 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.74 (dd, J = 10.2, 6.8, 1 H); 2.98-2.84 (m, 3H); 2.82 (s, 3H); 1.36 (t, J = 7.1 , 3H); 1.23 (dd, J = 6.9, 2.2, 6H); 0.89 (m, 1 H); 0.51 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.19 (s, 9H).

Example D.c1: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid

Ethyl 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]m ethyl}- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxylate from example D.b1 (15.28 g; 29.0 mmol) is dissolved in 1 ,4-dioxane (150 ml_) and aqueous LiOH (prepared from 1.04 g; 43.5 mmol; and 75 ml_ of water). The stirred reaction mixture is heated to 80 ⁰C until the starting material is consumd according to LC-MS. The mixture is concentrated under reduced pressure, and diluted with water. The product is precipitated by addition of 2M citric acid to adjust pH to 5, isolated by sucction filtration, washed with several small portions of water and dried in high vacuo at 40 ⁰C to yield 13.55 g of the title compound as pale yellow solid.

MS (ESI): m/z = 498 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.93 (s, 1 H); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.02 (d, J = 0.6, 1 H); 5.91 (d, J = 0.6, 1 H); 5.37 (d, J = 11.0, 1 H); 5.11 (d, J = 11.0, 1 H); 3.76 (dd, J = 10.2, 6.6, 2H); 3.68 (dd, J = 10.2, 6.8, 1 H); 3.01 (m, 2H); 2.84 (s, 3H); 0.87 (m, 1 H); 0.61 (m, 2H); 0.29 (m, 2H); 0.00 (m, 2H); -0.13 (s, 9H). The following compounds were prepared analogously to the procedure described in above example D.c1.

Example D.c2: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxylate (example D.b2) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 472 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 8.70 (s, 1 H); 7.46 (dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 11.5, 2.4, 1 H); 6.95 (ddd, J = 8.4, 8.4, 2.4, 1 H); 5.32 (d, J = 10.9, 1 H); 4.93 (d, J = 10.9, 1 H); 3.89 (dd, J = 10.3, 6.6, 1 H); 3.79 (dd, J = 10.3, 6.9, 1 H); 2.90 (m, 2H); 2.89 (s, 3H); 0.91 (m, 1 H); 0.54 (dd, J = 8.2, 7.8, 2H); 0.32 (m, 2H): 0.06 (m, 2H); -0.16 (s, 9H). Example D.c3: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c^pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b3) the title compound is obtained as yellow foam.

MS (ESI): m/z = 472 (MH ⁺).

¹H-NMR (300 MHz, DMSO-d ₆): 8.77 (s, 1 H); 7.36 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.27 (dd, J = 8.6, 3.3, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 5.35 (d, J = 10.9, 1 H); 4.94 (d, J = 10.9, 1 H); 3.83 (dd, J = 10.2, 6.6, 1 H); 3.76 (dd, J = 10.2, 6.9, 1 H); 2.92 (m, 2H); 2.88 (s, 3H); 0.88 (m, 1 H); 0.56 (m, 2H); 0.30 (m, 2H); 0.03 (m, 2H); -0.16 (s, 9H).

Example D.c4: 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)e thoxy]methyl}- 5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid

Starting from ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)e thoxy]methyl}-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylate (example D.b4) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 446 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 8.78 (s, 1 H); 7.37 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.27 (dd, J = 8.8, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 5.33 (d, J = 11.0, 1 H); 4.94 (d, J = 11.0, 1 H); 3.99 (qu, J = 6.9, 2H); 3.01-2.86 (m, 2H); 2.87 (s, 3H); 1.02 (t, J = 6.9, 3H); 0.57 (m, 2H); -0.15 (s, 9H).

Example D.c5: 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyOethoxylmethylJ-SH-pyrroloIS^-dlpyrimidine^-ca rboxylic acid Starting from ethyl 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxylate (example D.b5) the title compound is obtained as yellow foam.

MS (ESI): m/z = 484 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.35 (br.s, 1 H, CO ₂H); 8.92 (s, 1 H); 7.40 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 5.46 (d, J = 10.9, 1 H); 5.06 (d, J = 10.9, 1 H); 3.87 (dd, J = 10.2, 6.4, 1 H); 3.85 (s, 3H); 3.78 (dd, J = 10.2, 6.9, 1 H); 2.91 (t, J = 8.0, 2H); 2.82 (s, 3H); 0.89 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.06 (m, 2H); -0.18 (s, 9H). Example D.c6: 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b6) the title compound is obtained as yellow foam.

MS (ESI): m/z = 484 (MH ⁺, 100%).

Example D.c7: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b7) the title compound is obtained as yellow solid.

¹H-NMR (400 MHz, DMSO-d ₆): 12.35 (br.s, 1 H, CO ₂H); 8.96 (s, 1 H); 7.33 (dd, J = 8.6, 2.0, 1 H); 7.27 (d, J = 2.0, 1 H); 7.06 (d, J = 8.6, 1 H); 5.43 (d, J = 11.0, 1 H); 5.03 (d, J = 11.0, 1 H); 3.82 (dd, J = 10.3, 6.5, 1 H); 3.75 (dd, J = 10.2, 6.9, 1 H); 2.89 (m, 2H); 2.83 (s, 3H); 2.32 (s, 3H); 0.89 (m, 1 H); 0.52 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.17 (s, 9H).

Example D.c8: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxylate (example D.b8) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 8.91 (s, 1 H); 7.90 (dd, J = 8.8, 2.1 , 1 H); 7.76 (d, J = 2.1 , 1 H); 7.38 (d, J = 8.8, 1 H); 5.37 (d, J = 11.0, 1 H); 4.94 (d, J = 1 1.0, 1 H); 3.98 (dd, J = 10.5, 6.6, 1 H); 3.91 (dd, J = 10.5, 7.0, 1 H); 2.91 (t, J = 8.2, 2H); 2.86 (s, 3H); 0.95 (m, 1 H); 0.51 (m, 2H); 0.35 (m, 2H); 0.10 (m, 2H); -0.18 (s, 9H). Example D.c9: 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxylic acid

Starting from ethyl 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b9) the title compound is obtaines as pale yellow solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 8.75 (s, 1 H); 7.90 (dd, J = 8.8, 2.2, 1 H); 7.74 (d, J = 2.2, 1 H); 7.39 (d, J = 8.8, 1 H); 5.30 (d, J = 11.0, 1 H); 4.89 (d, J = 11.0, 1 H); 4.18-4.06 (m, 2H); 2.90 (t, J = 8.6, 2H); 2.89 (s, 3H); 1.08 (t, J = 7.0, 3H); 0.52 (m, 2H); -0.18 (s, 9H).

Example D.dO: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate (example D.b10) the title compound is obtained as yellow foam.

MS (ESI): m/z = 524 (MNa ⁺); 502 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.38 (br.s, 1 H, -CO ₂H); 8.98 (s, 1 H); 7.28 (d, J = 9.7, 1 H); 7.19 (d, J = 13.1 , 1 H); 5.42 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 3.82 (s, 3H); 3.81 (dd, J = 10.3, 6.6, 1 H); 3.73 (dd, J = 10.3, 7.0, 1 H); 3.05 - 2.89 (m, 2H); 2.83 (s, 3H); 0.87 (m, 1 H); 0.56 (m, 2H); 0.31 (m, 2H); 0.02 (m, 2H); -0.15 (s, 9H).

Example D.c11 : 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b11 ) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 514 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.96 (s, 1 H); 7.37 (d, J = 8.9, 1 H); 7.05 (d, J = 12.1 , 1 H); 5.43 (d, J = 11.0, 1 H); 5.02 (d, J = 1 1.0, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.85 (dd, J = 10.4, 6.6, 1 H); 3.77 (dd, J = 10.4, 7.1 , 1 H); 2.94 (m, 2H); 2.82 (s, 3H); 2.23 (d, J = 1.3, 3H); 1.35 (t, J = 7.1 , 3H); 0.89 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.16 (s, 9H).

Example D.c12: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylate (example D.b12) the title compound is obtained as yellow foam.

MS (ESI): m/z = 552 (MNa ⁺, 100 %); 530 (MH ⁺); 458 (MH ⁺-C ₃H ₈Si). ¹H-NMR (300 MHz, DMSO-d ₆): 8.95 (s, 1 H); 7.30 (d, J = 1 1.5, 1 H); 6.92 (d, J = 7.3, 1 H); 5.46 (d, J = 11.1 , 1 H); 5.06 (d, J = 1 1.1 , 1 H); 4.34 (qu, J = 7.1 , 2H); 3.94 (s, 3H); 3.87 (dd, J = 10.2, 6.6, 1 H); 3.80 (dd, J = 10.2, 7.0, 1 H); 2.95 (m, 2H); 2.81 (s, 3H); 1.34 (t, J = 7.1 , 3H); 0.87 (m, 1 H); 0.54 (m, 2H); 0.31 (m, 2H); 0.03 (m, 2H); -0.18 (s, 9H).

Example D.c13: 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimi dine-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylate (example D.b13) the title compound is obtained as yellow foam.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.93 (s, 1 H); 7.56 (dd, J = 8.8, 2.4, 1 H); 7.49 (d, J = 2.4, 1 H); 7.14 (d, J = 8.8, 1 H); 5.38 (d, J = 11.1 , 1 H); 5.03 (d, J = 11.1 , 1 H); 4.00 (m, 2H); 3.86 (dd, J = 10.2, 6.4, 1 H); 3.78 (dd, J = 10.2, 6.9, 1 H); 3.73 (m, 2H); 2.89 (m, 2H); 2.84 (s, 3H); 1.59 (s, 3H); 0.91 (m, 1 H); 0.50 (m, 2H); 0.32 (m, 2H); 0.06 (m, 2H); -0.20 (s, 9H).

Example D.c14: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylate (example D.b14) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.97 (s, 1 H); 7.41 (dd, J = 8.6, 2.2, 1 H); 7.29 (d, J = 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 5.42 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.35 (qu, J = 7.1 , 2H); 3.84 (dd, J = 10.2, 6.4, 1 H); 3.74 (dd, J = 10.2, 6.8, 1 H); 2.89 (m, 2H); 2.81 (s, 3H); 2.62 (qu, J = 7.5, 2H); 1.34 (t, J = 7.1 , 3H); 1.20 (t, J = 7.5, 3H); 0.93 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.18 (s, 9H).

Example D.c15: 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c^pyrimidine-7 -carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxylate (example D.b15) the title compound is obtained as yellow foam.

MS (ESI): m/z = 496 (MH ⁺, 100%).

Example D.c16: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5-{[2 - (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid Starting from methyl 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5-{[2 - (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7 -carboxylate (example D.a16) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 482 (MH ⁺ , 100%)

1 H-NMR (300 MHz, DMSO-d ₆): 12.32 (br.s, 1 H, -CO ₂H); 7.33 (dd, J = 8.4, 1.8, 1 H); 7.24 (d, J = 1.8, 1 H); 7.05 (d, J = 8.4, 1 H); 5.42 (d, J = 1 1 .0, 1 H); 5.01 (d, J = 1 1.0, 1 H); 3.80 (dd, J = 10.2, 6.6, 1 H); 3.76 ( dd, J = 10.2, 6.9, 1 H); 2.89 (m, 2H); 2.81 (s, 3H); 2.70 (s, 3H); 2.32 (s, 3H); 0.89 (m, 1 H); 0.52 (m, 2H); 0.31 (m, 2H); 0.05 (m, 2H); -0.17 (s, 9H). Example D.c17: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6-dime thyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid

Starting from methyl 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6-dime thyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7 -carboxylate (example D.a17) the title compound is obtained as pale yellow foam

MS (ESI) : 516 (MH ⁺, 100%)

¹ H-NMR (300 MHz, DMSO-d ₆): 12.32 (br.s, 1 H ₁ -CO ₂H); 7.30 (d, J = 1 1.3, 1 H); 6.93 (d, J = 7.3, 1 H), 5.46 (d, J = 1 1.1 , 1 H); 5.05 (d, J = 1 1.1 , 1 H); 3.95 (s, 3H); 3.85 (m, 2H); 2.96 (m, 2H); 2.82 (s, 3H); 2.70 (s, 3H); 0.89 (m, 1 H); 0.55 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.17 (s, 9H). Example D.c18: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6-dime thyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c^pyrimidin e-7-carboxylic acid

Starting from methyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6-dιm ethyl-5-{[2- (trιmethylsιlyl)ethoxy]methyl}-5H-pyrrolo[3,2-c/]pyrιmιd ιne-7-carboxylate (example D.a18) the title compound is obtained as pale yellow foam

MS (ESI): m/z = 516 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 7.25 (d, J = 9.7, 1 H); 7.17 (d, J = 13.1 , 1 H); 5.38 (d, J = 10.8, 1 H); 5.01 (d, J = 10.8, 1 H); 3.82 (s, 3H); 3.80 (dd, J = 10.4, 6.6, 1 H); 3.73 (dd, J = 10.4, 7.0, 1 H); 3.06- 2.90 (m, 2H); 2.82 (s, 3H); 2.72 (s, 3H); 0.88 (m, 1 H); 0.57 (m, 2H); 0.33 (m, 2H); 0.04 (m, 2H); - 0.15 (s, 9H).

Example D.d1 : tert-Butyl 4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrim idin-7-yl)carbonyl]amino}piperidine-1- carboxylate

4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]m ethyl}-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid from example D.c1 (3.98 g; 8.0 mmol), triethylamine (2.43 g; 24.0 mmol) and HOBt (1.08 g; 8.0 mmol) is stirred in dry dichloromethane (40 mL) for 30 min, before addition of EDC (1.84 g; 9.6 mmol). The reaction mixture is stirred for one hour at ambient temperature. After addition of tert-butyl 4-amino-piperidine-1 -carboxylate hydrochloride (2.27 g; 9.6 mmol) the reaction mixture is stirred at ambient temperature until the starting material is consumed according to LC-MS and chromatographed on silica gel (ethylacetate/cyclohexane - 1 :1 ) to yield the title compound as colorless foam.

MS (ESI): m/z = 680 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.02 (d, J = 7.2, 1 H, -NH); 9.01 (s, 1 H); 7.01 (d, J = 8.4, 1 H); 6.57 (d, J = 8.4, 1 H); 6.07 (s, 1 H); 5.92 (s, 1 H); 5.39 (d, J = 11.0, 1 H); 5.12 (d, J = 11.0, 1 H); 4.06 (m, 1 H); 3.85 (m, 2H); 3.76 (dd, J = 10.2, 6.5, 1 H); 3.68 (dd, J = 10.2, 6.9, 1 H); 3.13-2.94 (m, 4H); 2.91 (s, 3H); 1.93 (m, 2H); 1.46 (m, 2H); 1.42 (s, 9H); 0.86 (m, 1 H); 0.61 (m, 2H); 0.29 (m, 2H); 0.01 (m, 2H); -0.13 (s, 9H).

The following compounds were prepared analogously to the procedure described in above example D.d1.

Example D.d2: tert-Butyl (trans-4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[5-(yyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c1 ) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is ob- tained as pale yellow viscous oil. The compound is further processed without characterisation.

Example D.d3: tert-Butyl (cis-4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[5-(yyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c1 ) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil. The compound is further processed without characterisation. Example D.d4: tert-Butyl (3R)-3-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}pyrrolidine-1 -carboxylate

Starting from 4-[5-(yyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c1 ) and commercially available tert-butyl (R)-3-amino-pyrrolidine-1 -carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 666 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 9.13 (d, J = 6.8, 1H, -NH); 8.99 (s, 1H); 7.01 (d, J = 8.6, 1H); 6.57 (d, J = 8.6, 1H); 6.02 (d, J = 0.6, 1H); 5.92 (d, J = 0.6, 1H); 5.40 (d, J = 10.9, 1H); 5.12 (d, J = 10.9, 1H); 4.50 (m, 1H); 3.76 (dd, J = 10.2, 6.6, 1H); 3.67 (dd, J = 10.2, 6.9, 1H); 3.61 (m, 1H); 3.43 (m, 2H); 3.25 (m, 1H); 3.00 (m, 2H); 2.91 (s, 3H); 2.22 (m, 1H); 1.96 (m, 1H); 1.41 (s, 9H); 0.86 (m, 1H); 0.61(m, 2H); 0.29 (m, 2H); 0.01 (m, 2H); -0.14 (s, 9H).

Example D.d5: tert-Butyl (3R*,4R*)-3-{[(4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-y l]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-4- hydroxypyrrolidine-1-carboxylate

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylicacid (example D.c1) and commercially available tert-butyl (3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 682 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.06 (br.s, 1H, -NH); 8.97 (s, 1H); 7.02 (d, J = 8.6, 1H); 6.57 (d, J =

8.6, 1H); 6.02 (s, 1H); 5.92 (s, 1H); 5.48 (d, J = 3.8, 1H, -OH); 5.40 (d, J = 11.0, 1H); 5.12 (d, J =

11.0, 1H); 4.24 (m, 2H); 3.76 (dd, J = 10.2,6.6, 1H); 3.67 (dd, J = 10.2,6.9, 1H&m, 1H); 3.56 (m, 1H); 3.23 (m, 2H); 3.09-2.92 (m, 2H); 2.91 (s, 3H); 1.43 (s, 9H); 0.86 (m, 1H); 0.61 (m, 2H); 0.29 (m, 2H); 0.01 (m, 2H); -0.13 (s, 9H).

Example D.d6: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[ 2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylicacid (example D.c2) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 654 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 9.07 (d, J = 7.7, 1H, -NH); 8.99 (s, 1H); 7.49 (dd, J = 8.4, 6.8, 1H); 7.10 (dd, J = 11.3,2.4, 1H); 6.97 (ddd, J = 8.4, 8.4,2.4, 1H); 5.41 (d, J = 11.1, 1H); 4.98 (d, J =

11.1, 1H); 4.08 (m, 1H); 3.90 (dd, J = 10.2,6.6, 1H); 3.81 (dd, J = 10.2, 7.1, 1H); 3.92-3.78 (m, 2H); 3.06 (m, 2H); 2.92 (m, 2H); 2.91 (s, 3H); 1.93 (m, 2H); 1.45 (m, 2H); 1.42 (s, 9H); 0.91 (m, 1H); 0.54 (dd, J = 9.1, 7.3, 2H); 0.34 (m, 2H): 0.08 (m, 2H); -0.16 (s, 9H). Example D.d7: Tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-meth yl-5-

{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-cf]pyri midin-7- yl)carbonyl]amino}cyclohexyl)carbamate Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c2) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 668 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 8.90 (d, J = 7.7, 1 H, -NH); 7.49 (dd, 8.4, 6.9, 1 H); 7.10 (dd, 11.3, 2.2, 1 H); 6.97 (ddd, 8.4, 8.4, 2.2, 1 H); 6.72 (d, J = 7.9, 1 H, -NH); 5.40 (d, J = 11.1 , 1 H); 4.98 (d, J = 11.1 , 1 H); 3.90 (dd, J = 10.2, 6.6, 1 H); 3.80 (dd, J = 10.2, 7.1 , 1 H); 3.79 (m, 1 H); 3.29 (m, 1 H); 2.92 (m, 2H); 2.90 (s, 3H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.91 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.16 (s 9H).

Example D.d8: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl -5-

{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]py rimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c2) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 668 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 9.29 (d, J = 7.7, 1 H, -NH); 9.04 (s, 1 H); 7.50 (dd, 8.4, 6.7, 1 H); 7.12

(dd, 11.5, 2.4, 1 H); 6.97 (ddd, 8.4, 8.4, 2.4, 1 H & br.s, 1 H, -NH); 5.42 (d, J = 10.9, 1 H); 4.98 (d, J =

10.9, 1 H); 4.07 (m, 1 H); 3.85 (dd, J = 10.4, 6.6, 1 H); 3.80 (dd, J = 10.4, 7.1 , 1 H); 3.42 (m, 1 H); 2.91

(m, 2H & s, 3H); 1.88-1.48 (m, 8H); 1.40 (s, 9H); 0.92 (m, 1 H); 0.54 (dd, J = 9.1 , 7.1 , 2H); 0.35 (m,

2H); 0.09 (m, 2H); -0.16 (s 9H).

Example D.d9: Tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl -5-

{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]py rimidin-7-yl)carbonyl]amino}pyrrolidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c2) and commercially available tert-butyl (R)-3-amino-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 640 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 9.17 (d, J = 6.7, 1 H, -NH); 8.98 (s, 1 H); 7.50 (dd, J = 8.4, 6.9, 1 H); 7.10 (dd, J = 1 1.3, 2.4, 1 H); 6.97 (ddd, J = 8.4, 8.4, 2.4, 1 H); 5.42 (d, J = 11.0, 1 H); 4.99 (d, J =

11.0, 1 H); 4.50 (m, 1 H); 3.90 (dd, J = 10.2, 6.4, 1 H); 3.80 (dd, J = 10.2, 7.1 , 1 H); 3.62 (m, 1 H); 3.43

(m, 2H); 3.27 (m, 1 H); 2.92 (m, 2H); 2.91 (s. 3H); 2.22 (m, 1 H); 1.96 (m, 1 H); 1.41 (s, 9H); 0.91 (m,

1 H); 0.54 (dd, J = 9.1 , 7.3, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.16 (s, 9H). Example D.d10: tert-Butyl (3r,4r)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-met hyl- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyr imidin-7-yl)carbonyl]amino}-4- hydroxypyrrolidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c2) and commercially available tert-butyl (3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 656 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 9.11 (br.s, 1 H, -NH); 8.95 (s, 1 H); 7.50 (dd, J = 8.4, 6.9, 1 H); 7.10 (dd, J = 1 1.5, 2.4, 1 H); 6.97 (ddd, J = 8.4, 8.4, 2.4, 1 H); 5.48 (d, J = 5.5, 1 H ₁-OH); 5.42 (d, J = 11.1 , 1 H); 4.99 (d, J = 11.1 , 1 H); 4.26 (m, 1 H); 4.20 (m, 1 H); 3.90 (dd, J = 10.2, 6.6, 1 H); 3.80 (dd, J = 10.2, 6.9, 1 H); 3.68 (m, 1 H); 3.56 (m, 1 H); 3.25 (m, 2H); 2.94 (m, 2H); 2.91 (s, 3H); 1.43 (s, 9H); 0.90 (m, 1 H); 0.54 (m, 2H); 0.34 (m, 2H); 0.08 (m, 2H), -0.16 (s, 9H).

Example D.d11 : tert-Butyl (3S*,4S*)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c2) and tert- butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1 -carboxylate (example C2) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 670 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 9.1 1 (d, J = 7.5, 1 H, -NH); 8.99 (s, 1 H); 7.50 (dd, J = 8.4, 7.1 , 1 H); 7.1 1 (dd, J = 1 1 .3, 2.4, 1 H); 6.98 (ddd, J = 8.4, 8.4, 2.4, 1 H); 5.42 (d, J = 1 1.0, 1 H); 5.26 (t, J = 5.1 ,

1 H, -OH); 4.99 (d, J = 1 1 .0, 1 H); 3.99-3.75 (m, 5H); 3.45 (m, 1 H); 3.27 (m, 1 H); 3.06-2.88 (m, 3H);

2.92 (s. 3H); 2.79 (m, 1 H); 2.07 (m, 1 H); 1 .43 (s, 9H & m, 1 H); 0.92 (m, 1 H); 0.55 (m, 2H); 0.35 (m,

2H); 0.10 (m, 2H); -0.15 (s, 9H). Example D.d12: tert-Butyl (4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{ [2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c3) and commercially available tert-butyl 4-amino-piperidine-1 -carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 654 (MH ⁺).

¹ H-NMR (300 MHz, DMSO-d ₆): 9.05 (d, J = 7.7, 1 H, -NH); 9.01 (s, 1 H); 7.39 (ddd, J = 9.1 , 8.8, 3.1 , 1 H); 7.30 (dd, J = 8.6, 3.1 , 1 H); 7.20 (dd, J = 9.1 , 4.4, 1 H); 5.42 (d, J = 1 1.0, 1 H); 4.99 (d, J = 1 1.0, 1 H); 4.08 (m, 1 H); 3.84 (dd, J = 10.4, 6.6, 1 H); 3.83 (m, 2H); 3.77 (dd, J = 10.4, 7.1 , 1 H); 3.06 (m, 2H); 2.94 (m, 2H); 2.92 (s, 3H); 1.93 (m, 2H); 1.45 (m, 2H); 1.42 (s, 9H); 0.88 (m, 1 H); 0.55 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.15 (s, 9H). Example D.d13: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-

5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(] pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c3) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 668 (IVlH ⁺).

¹H-NMR (300 MHz, DMSO-d ₆): 9.01 (s, 1 H); 8.89 (d, J = 7.9, 1 H, -NH); 7.38 (ddd, J = 9.1 , 8.4, 3.3,

1 H); 7.30 (dd, J = 8.6, 3.3, 1 H); 7.20 (dd, J = 9.1 , 4.4, 1 H); 6.73 (d, J = 7.1 , 1 H, -NH); 5.42 (d, J = 11.0, 1 H); 4.99 (d, J = 1 1.0, 1 H); 3.84 (dd, J = 10.2, 6.6, 1 H); 3.76 (dd, J = 10.2, 6.9, 1 H & m, 1 H);

3.28 (m, 1 H); 2.93 (m, 2H); 2.91 (s, 3H); 2.01 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H);

0.88 (m, 1 H); 0.55 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.16 (s, 9H).

Example D.d14: tert-Butyl (4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{ [2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c3) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 668 (MH ⁺).

¹H-NMR (300 MHz, DMSO-d ₆): 9.26 (d, J = 7.9, 1 H, -NH); 9.05 (s, 1 H); 7.39 (ddd, J = 9.1 , 8.7, 3.1 , 1 H); 7.30 (dd, J = 8.7, 3.1 , 1 H); 7.20 (dd, J = 9.1 , 4.4, 1 H); 6.92 (m, 1 H, -NH); 5.42 (d, J = 11.1 , 1 H); 4.99 (d, J = 11.1 , 1 H); 4.07 (m, 1 H); 3.85 (dd, J = 10.4, 6.6, 1 H); 3.77 (dd, J = 10.4, 7.0, 1 H); 3.43 (m, 1 H); 2.94 (m, 2H); 2.92 (s, 3H); 1.85-1.52 (m, 8H); 1.40 (s, 9H); 0.87 (m, 1 H); 0.56 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.15 (s, 9H).

Example D.d15: tert-butyl (3R,4R)-4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-δ-lp-^rimethylsily^ethoxylmethylJ-SH-pyrrolop^-dlpyr imidin^-y^carbonyllaminoJ-S- hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c3) and commercially available tert-butyl (R)-3-amino-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow viscous oil. MS (ESI): m/z = 640 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.16 (d, J = 6.8, 1 H, -NH); 8.99 (s, 1 H); 7.39 (ddd, J = 9.1 , 8.4, 3.3, 1 H); 7.30 (ddd, J = 8.6, 3.3, 1.1 , 1 H); 7.20 (dd, J = 9.1 , 4.4, 1 H); 5.43 (d, J = 10.9, 1 H); 4.99 (d, J = 10.9, 1 H); 4.50 (m, 1 H); 3.84 (dd, J = 10.2, 6.6, 1 H); 3.76 (d, J = 10.2, 7.0, 1 H); 3.62 (m, 1 H); 3.43 (m, 2H); 3.27 (m, 1 H); 2.94 (m, 2H); 2.92 (s, 3H); 2.21 (m, 1 H); 1.96 (m, 1 H); 1.42 (s, 9H); 0.88 (m, 1 H); 0.56 (dd, J = 9.1 , 7.2, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.16 (s, 9H).

Example D.d16: tert-Butyl (3R*,4R*)^-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c3) and tert- butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate (example C2) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 670 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.10 (d, J = 7.5, 1 H, -NH); 9.01 (s, 1 H); 7.39 (ddd, J = 8.9, 8.9, 3.3, 1 H); 7.30 (ddd, J = 8.4, 3.1 , 0.7, 1 H); 7.20 (dd, J = 8.9, 4.4, 1 H); 5.43 (d, J = 11.1 , 1 H); 5.24 (dd, J = 5.1 , 5.1 , 1 H, -OH); 4.99 (d, J = 11.1 , 1 H); 4.02-3.71 (m, 5H); 3.45 (m, 1 H); 3.00-2.88 (m, 3H); 2.92 (s, 3H); 2.78 (m, 1 H); 2.07 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.89 (m, 1 H); 0.56 (m, 2H); 0.32 (m, 2H); 0.06 (m, 2H), -0.15 (s, 9H).

Example D.d17: tert-Bbutyl 4-({[4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl]carbonyl}amino)piperidine-1- carboxylate

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)e thoxy]methyl}-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxylic acid (example D.c4) and commercially available tert-butyl 4- amino-piperidine-1 -carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 628 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.05 (d, J = 7.5, 1 H, -NH); 9.00 (s, 1 H); 7.40 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.30 (dd, J = 8.6, 3.3, 1 H); 7.21 (dd, J = 9.1 , 4.4, 1 H); 5.41 (d, J = 11.0, 1 H); 4.98

(d, J = 11.0, 1 H); 4.08 (m, 1 H); 3.99 (qu, J = 7.1 , 2H); 3.85 (m, 2H); 3.06 (m, 2H); 2.94 (m, 2H);

2.91 (s, 3H); 1.93 (m, 2H); 1.42 (s, 9H &m, 2H); 1.02 (t, J = 7.1 , 3H); 0.56 (m, 2H); -0.15 (s, 9H).

Example D.d18: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrim idin-7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c5) and commercially available tert-butyl 4-amino-piperidine-i-carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 666 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.09 (d, J = 7.5, 1 H, -NH); 8.96 (s, 1 H); 7.41 (d, J = 8.4, 1 H); 6.73 (dd, J = 8.4, 2.2, 2H); 6.70 (d, J = 2.2, 1 H); 5.46 (d, J = 10.9, 1 H); 5.05 (d, J = 10.9, 1 H); 4.06 (m, 1 H); 3.87 (dd, J = 10.2, 6.6, 1 H); 3.85 (s, 3H); 3.83 (m, 2H); 3.78 (dd, J = 10.2, 7.1 , 1 H); 3.08 (m, 2H); 2.91 (s, 3H & m, 2H); 1.93 (m, 2H); 1.45 (m, 2H); 1.42 (s, 9H); 0.89 (m, 1 H); 0.51 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.18 (s, 9H). Example D.d19: tert-Butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c5) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 680 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.96 (s, 1 H); 8.93 (d, J = 7.9, 1 H, -NH); 7.41 (d, J = 8.4, 1 H); 6.73

(dd, J = 8.4, 2.2, 2H); 6.70 (d, J = 2.2, 1 H & br.s, 1 H, -NH); 5.46 (d, J = 11.1 , 1 H); 5.05 (d, J = 11.1 , 1 H); 3.87 (dd, J = 10.2, 6.4, 1 H); 3.85 (s, 3H); 3.77 (dd, J = 10.2, 7.0, 1 H & m, 1 H); 3.28 (m, 1 H);

2.90 (s, 3H & m, 2H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.89 (m, 1 H); 0.51 (m,

2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.18 (s, 9H).

Example D.d20: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyr imidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c5) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam .

MS (ESI): m/z = 680 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.29 (d, J = 7.7, 1 H, -NH); 9.01 (s, 1 H); 7.41 (d, J = 8.4, 1 H); 6.92 (br.s, 1 H, -NH); 6.73 (dd, J = 8.4, 2.2, 2H); 6.70 (d, J = 2.2, 1 H); 5.46 (d, J = 10.9, 1 H); 5.06 (d, J = 10.9, 1 H); 4.07 (m, 1 H); 3.88 (dd, J = 10.2, 6.6, 1 H); 3.85 (s, 3H); 3.78 (dd, J = 10.2, 7.1 , 1 H); 3.43 (m, 1 H); 2.91 (s, 3H & m, 2H); 1.86-1.53 (m, 8H); 1.40 (s, 9H); 0.90 (m, 1 H); 0.51 (m, 2H); 0.34 (m, 2H); 0.08 (m, 2H); -0.18 (s, 9H). Example D.d21: tert-Butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methy l- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyr imidin-7-yl)carbonyl]amino}pyrrolidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c5) and commercially available tert-butyl (R)-3-amino-pyrrolidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 652 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.20 (d, J = 6.8, 1 H, -NH); 8.95 (s, 1 H); 7.41 (d, J = 8.4, 1 H); 6.73 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 5.47 (d, J = 11.1 , 1 H); 5.06 (d, J = 1 1.1 , 1 H); 4.50 (m, 1 H); 3.87 (dd, J = 10.2, 6.6, 1 H); 3.85 (s, 3H); 3.78 (dd, J = 10.2, 7.1 , 1 H); 3.62 (m, 1 H); 3.43 (m, 2H); 3.25 (m, 1 H); 2.91 (s, 3H & m, 2H); 2.22 (m, 1 H); 1.96 (m, 1 H); 1.41 (s, 9H); 0.88 (m, 1 H); 0.51 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.17 (s, 9H). Example D.d22: tert-Butyl (3R,4R)-3-[[(4-[2-(cyclopropylmethoxy)^-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-4- hydroxypyrrolidine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c5) and commercially available tert-butyl (3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 668 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.13 (br.s, 1 H, -NH); 8.92 (s, 1 H); 7.41 (d, J = 8.4, 1 H); 6.73 (dd, J

= 8.4, 2.2, 2H); 6.70 (d, J = 2.2, 1 H); 5.48 (d, J = 6.2, 1 H); 5.47 (d, J = 1 1.0, 1 H); 5.06 (d, J = 11.0, 1 H); 4.26 (m, 1 H); 4.20 (m, 1 H); 3.87 (dd, J = 10.4, 6.6, 1 H); 3.85 (s, 3H); 3.77 (dd, J = 10.4, 7.3,

1 H); 3.68 (m, 1 H); 3.55 (m, 1 H); 3.24 (m, 2H); 2.91 (s, 3H & m, 2H); 1.43 (s, 9H); 0.89 (m, 1 H);

0.51 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.18 (s, 9H).

Example D.d23: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrim idin-7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c6) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 666 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.07 (d, J = 7.7, 1 H, -NH); 9.00 (s, 1 H); 7.1 1 (d, J = 1.6, 2H); 7.02

(t, J = 1.6, 1 H); 5.42 (d, J = 10.9, 1 H); 5.04 (d, J = 10.9, 1 H); 4.08 (m, 1 H); 3.85 (m, 2H); 3.77 (dd, J = 10.2, 6.6, 1 H); 3.76 (s, 3H); 3.70 (dd, J = 10.2, 6.9, 1 H); 3.06 (m, 2H); 2.91 (s, 3H & m, 2H); 1.93 (m, 2H); 1.46 (m, 2H); 1.42 (s, 9H); 0.86 (m, 1 H); 0.53 (m, 2H); 0.30 (m, 2H); 0.01 (m, 2H); -0.17 (s, 9H). Example D.d24: tert-Butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d ]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c6) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless solid.

MS (ESI): m/z = 680 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.00 (s, 1 H); 8.91 (d, J = 7.7, 1 H, -NH); 7.1 1 (d, J = 1.6, 2H); 7.02

(t, J = 1.6, 1 H); 6.72 (d, J = 7.5, 1 H, -NH); 5.41 (d, J = 11.0, 1 H); 5.03 (d, J = 11.0, 1 H); 3.77 (dd, J = 10.2, 6.6, 1 H); 3.76 (s, 3H & m, 1 H); 3.70 (dd, J = 10.2, 6.9, 1 H); 3.29 (m, 1 H); 2.90 (s, 3H & m,

2H); 2.01 (m, 2H); 1.86 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 0.85 (m, 1 H); 0.53 (m, 2H); 0.24 (m,

2H); 0.01 (m, 2H); -0.17 (s, 9H).

Example D.d25: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyr imidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c6) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 680 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.27 (d, J = 7.7, 1 H, -NH); 9.04 (s, 1 H); 7.1 1 (d, J = 1.6, 2H); 7.02 (t, J = 1.6, 1 H); 6.92 (~br.d, 1 H, -NH); 5.41 (d, J = 11.0, 1 H); 5.03 (d, J = 1 1.0, 1 H); 4.07 (m, 2H); 3.78 (dd, J = 10.2, 6.6, 1 H); 3.76 (s, 3H); 3.71 (dd, J = 10.2, 6.9, 1 H); 3.43 (m, 1 H); 2.91 (s, 3H & m, 2H); 1.85-1.52 (m, 8H); 1.40 (s, 9H); 0.86 (m, 1 H); 0.54 (m, 2H); 0.31 (m, 2H); 0.02 (m, 2H); - 0.17 (s, 9H).

Example D.d26: tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimi din-7-yl)carbonyl]amino}pyrrolidine-1 - carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c6) and commercially available tert-butyl (R)-3-amino-pyrrolidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 652 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.18 (d, J = 6.8, 1 H, -NH); 8.98 (s, 1 H); 7.1 1 (d, J = 1.8, 2H); 7.02 (t, J = 1.8, 1 H); 5.43 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.50 (m, 1 H); 3.76 (dd, J = 10.4, 6.6, 1 H & s, 3H); 3.70 (dd, J = 10.4, 6.9, 1 H); 3.62 (m, 1 H); 3.43 (m, 2H); 3.26 (m, 1 H); 2.91 (s, 3H & m, 2H); 2.21 (m, 1 H); 1.96 (m, 1 H); 1.41 (s, 9H); 0.85 (m, 1 H); 0.53 (m, 2H); 0.29 (m, 2H); 0.01 (m, 2H); -0.17 (s, 9H). Example D.d27: tert-Butyl (3R,4R)-4-[[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c6) and: tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate (Example C2) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 682 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.11 (d, J = 7.3, 1 H, -NH); 8.99 (s, 1 H); 7.1 1 (d, J = 1.6, 2H); 7.02 (t, J = 1.6, 1 H); 5.43 (d, J = 10.9, 1 H); 5.24 (t, J = 4.9, 1 H, -OH); 5.04 (d, J = 10.9, 1 H); 3.99-3.66 (m, 5H); 3.76 (s, 3H); 3.45 (m, 1 H); 2.91 (s, 3H & m, 1 H); 2.79 (m, 1 H); 2.07 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.86 (m, 1 H); 0.53 (m, 2H); 0.30 (m, 2H); 0.02 (m, 2H); -0.17 (s, 9H).

Example D.d28: Tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[ 2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c7) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 650 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.08 (d, J = 7.7, 1 H, -NH); 8.98 (s, 1 H); 7.34 (dd, J = 8.4, 2.0, 1 H); 7.26 (d, J = 2.0, 1 H); 7.07 (d, J = 8.4, 1 H); 5.43 (d, J = 11.0, 1 H); 5.02 (d, J = 1 1.0, 1 H); 4.08 (m, 1 H); 3.87 (m, 2H); 3.82 (dd, J = 10.4, 6.6, 1 H); 3.75 (dd, J = 10.4, 7.0, 1 H); 3.06 (m, 2H); 2.93-2.86 (m, 2H); 2.90 (s, 3H); 2.32 (s, 3H); 1.93 (m, 2H); 1.46 (m, 2H); 1.43 (s, 9H); 0.88 (m, 1 H); 0.52 (m, 2H); 0.31 (m, 2H); 0.05 (m, 2H); -0.17 (s, 9H). Example D.d29: tert-Butyl (trans^-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methy l- 5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyr imidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c7) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless solid.

MS (ESI): m/z = 664 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): ¹ H-NMR (400 MHz, DMSO-d ₆): 8.98 (s, 1 H); 8.92 (d, J = 7.7, 1 H, - NH); 7.34 (dd, J = 8.4, 2.0, 1 H); 7.27 (d, J = 2.0, 1 H); 7.07 (d, J = 8.4, 1 H); 6.72 (d, J = 6.6, 1 H, - NH); 5.42 (d, J = 11.0, 1 H); 5.02 (d, J = 1 1.0, 1 H); 3.81 (dd, J = 10.3, 6.5, 1 H); 3.78 (m, 1 H); 3.74 (dd, J = 10.2, 7.0, 1 H); 3.28 (m, 1 H); 2.90 (s, 3H); 2.88 (m, 2H); 2.32 (s, 3H); 2.00 (m, 2H); 1.86 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.88 (m, 1 H); 0.51 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.18 (s, 9H).

Example D.d30: Tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl -5-

{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-cf]pyri midin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c7) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 664 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 9.31 (d, J = 7.7, 1 H, -NH); 9.03 (s, 1 H); 7.34 (dd, J = 8.4, 2.0, 1 H); 7.27 (d, J = 2.0, 1 H); 7.07 (d, J = 8.4, 1 H); 6.89 (br.s, 1 H, -NH); 5.42 (d, J = 1 1 .0, 1 H); 5.04 (d, J =

1 1.0, 1 H); 4.09 (m, 1 H); 3.83 (dd, J = 10.2, 6.6, 1 H); 3.75 (dd, J = 10.2, 6.9, 1 H); 3.44 (m, 1 H); 2.91

(s, 3H); 2.90 (m, 2H); 2.33 (s, 3H); 1.86-1.55 (m, 8H); 1.41 (s, 9H); 0.90 (m, 1 H); 0.53 (m, 2H); 0.33

(m, 2H); 0.06 (m, 2H); -0.17 (s, 9H). Example D.d31 : tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}piperidine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylic acid (example D.c8) and commercially available tert-butyl 4-amino-piperidine-1 -carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 704 (MH ⁺, 100%). ¹H-NMR (400 MHz, DMSO-d ₆): 9.05 (d, J = 7.6, 1 H, -NH); 9.03 (s, 1 H); 7.91 (dd, J = 8.8, 2.1 , 1 H); 7.77 (d, J = 2.1 , 1 H); 7.39 (d, J = 8.8, 1 H); 5.40 (d, J = 11.0, 1 H); 4.95 (d, J = 1 1.0, 1 H); 4.08 (m, 1 H); 3.98 (dd, J = 10.4, 6.6, 1 H); 3.91 (dd, J = 10.4, 7.1 , 1 H); 3.85 (m, 2H); 3.06 (m, 2H); 2.92 (s, 3H & t, J = 8.2, 2H); 1.94 (m, 2H); 1.47 (m, 2H); 1.42 (s, 9H); 0.95 (m, 1 H); 0.50 (m, 2H); 0.35 (m, 2H); 0.11 (m, 2H); -0.19 (s, 9H).

Example D.d32: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phe nyl]- 6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylic acid (example D.c8) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 718 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 9.03 (s, 1 H); 8.89 (d, J = 7.7, 1 H, -NH); 7.90 (dd, J = 8.8, 2.1 , 1 H);

7.77 (d, J = 2.1 , 1 H); 7.39 (d, J = 8.8, 1 H); 6.72 (d, J = 7.9, 1 H, -NH); 5.40 (d, J = 11.0, 1 H); 4.94 (d, J = 11.0, 1 H); 3.98 (dd, J = 10.5, 6.6, 1 H); 3.91 (dd, J = 10.5, 7.1 , 1 H); 3.78 (m, 1 H); 3.29 (m, 1 H); 2.91 (s, 3H & t, J = 8.0, 2H); 2.01 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.35 (m, 4H); 0.94 (m, 1 H); 0.50 (m, 2H); 0.35 (m, 2H); 0.1 1 (m, 2H); -0.19 (s, 9H).

Example D.d33: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)pheny l]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylic acid (example D.c8) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 718 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 9.26 (d, J = 7.7, 1 H, -NH); 9.07 (s, 1 H); 7.91 (dd, J = 8.8, 2.1 , 1 H);

7.78 (d, J = 2.1 , 1 H); 7.40 (d, J = 8.8, 1 H); 6.93 (br.s, 1 H, -NH); 5.40 (d, J = 10.9, 1 H); 4.94 (d, J = 10.9, 1 H); 4.08 (m, 1 H); 3.99 (dd, J = 10.2, 6.7, 1 H); 3.92 (dd, J = 10.2, 7.1 , 1 H); 3.43 (m, 1 H); 2.92 (s, 3H & t, J = 8.1 , 2H); 1.86-1.51 (m, 8H); 1.40 (s, 9H); 0.95 (m, 1 H); 0.50 (m, 2H); 0.36 (m, 2H); 0.12 (m, 2H); -0.19 (s, 9H).

Example D.d34: tert-Butyl 4-{[(4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2- (trimethylsilyOethoxylmethylJ-SH-pyrrolop^-dlpyrimidin^-yOca rbonyllaminoJpiperidine-i- carboxylate Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2-(trime thylsilyl)ethoxy]methyl}-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxylic acid (example D.c9) and commercially available tert-butyl 4- amino-piperidine-1 -carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 678 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.08 (d, J = 7.7, 1 H, -NH); 9.05 (s, 1 H); 7.96 (dd, J = 8.8, 2.2, 1 H); 7.80 (d, J = 2.2, 1 H); 7.74 (d, J = 8.8, 1 H); 5.41 (d, J = 1 1.0, 1 H); 4.97 (d, J = 11.0, 1 H); 4.22-4.04 (m, 2H & m, 1 H); 3.88 (m, 2H); 3.09 (m, 2H); 2.95 (s, 3H & m, 2H); 1.97 (m, 2H); 1.50 (m, 2H); 1.46 (s, 9H); 1.11 (t, J = 7.0, 3H); 0.55 (m, 2H); -0.15 (s, 9H). Example D.d35: tert-Butyl 4-{[(4-[2- cyclopropylmethoxy-4-fluoro-5-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7- yl)carbonyl]amino}piperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.d O) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 684 (MH ⁺, 100 %); 628 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 9.06 (d, J = 7.5, 1 H, -NH); 9.00 (s, 1 H); 7.27 (d, J = 9.7, 1 H); 7.19

(d, J = 13.1 , 1 H); 5.42 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.08 (m, 1 H); 3.87 (m, 2H); 3.82 (s, 3H); 3.80 (dd, J = 10.3, 6.7, 1 H); 3.75 (dd, J = 10.3, 7.1 , 1 H); 3.06 (m, 2H); 3.03 - 2.88 (m, 2H);

2.91 (s, 3H); 1.93 (m, 2H); 1.46 (m, 2H); 1.42 (s, 9H); 0.87 (m, 1 H); 0.55 (m, 2H); 0.31 (m, 2H);

0.04 (m, 2H); -0.16 (s, 9H).

Example D.d36: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl} -5/-/-pyrrolo[3,2-c(]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.d O) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 698 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 9.00 (s, 1 H); 8.90 (d, J = 7.7, 1 H); 7.27 (d, J = 9.7, 1 H); 7.19 (d, J = 13.3, 1 H); 6.72 (d, J = 7.5, 1 H, -NH); 5.41 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 3.82 (s, 3H & m, 1 H); 3.80 (dd, J = 10.4, 6.7, 1 H); 3.72 (dd, J = 10.4, 7.0, 1 H); 3.29 (m, 1 H); 3.03 - 2.88 (m, 2H); 2.91 (s, 3H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.86 (m, 1 H); 0.55 (m, 2H); 0.31 (m, 2H); 0.03 (m, 2H); -0.16 (s, 9H). Example D.d37: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl ]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.d O) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 698 (MH ⁺, 100 %); 642 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 9.26 (d, J = 7.8, 1 H, -NH); 9.04 (s, 1 H); 7.27 (d, J = 9.5, 1 H); 7.19 (d, J = 13.3, 1 H); 6.91 (br.s, 1 H, -NH); 5.42 (d, J = 10.9, 1 H); 5.02 (d, J = 10.9, 1 H); 4.07 (m, 1 H); 3.82 (s, 3H); 3.81 (dd, J = 10.2, 6.7, 1 H); 3.73 (dd, J = 10.2, 7.0, 1 H); 3.43 (m, 1 H); 3.04 - 2.89 (m, 2H); 2.92 (s, 3H); 1.87 - 1.51 (m, 8H); 1.40 (s, 9H); 0.88 (m, 1 H); 0.55 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.16 (s, 9H). Example D.d38: tert-Butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl} -5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl)carbonyl]amino}-3-hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.d O) and tert-butyl (3R*,4R*)^4-amino-3-hydroxy-piperidine-1-carboxylate (example C2) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 700 (MH ⁺, 100 %); 644 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 9.12 (d, J = 7.3, 1 H, -NH); 9.01 (s, 1 H); 7.28 (dd, J = 9.7, 1.4, 1 H);

7.20 (d, J = 12.6, 1 H); 5.44 (d, J = 10.9, 1 H); 5.27 (dd, J = 4.9, 4.2, 1 H, -OH); 5.02 (d, J = 10.9, 1 H); 3.99-3.68 (m, 5H); 3.82 (s, 3H); 3.44 (m, 1 H); 3.03-2.86 (m, 3H); 2.92 (s, 3H); 2.79 (m, 1 H);

2.07 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.87 (m, 1 H); 0.55 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.16 (s,

9H).

Example D.d39: tert-Butyl (3S*,4S*)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl} -5/-/-pyrrolo[3,2-cy]pyrimidin-7- yl)carbonyl]amino}-4-hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.d O) and tert-butyl (3S*,4S*)-3-amino-4-hydroxy-piperidine-1-carboxylate (Example C3) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 700 (MH ⁺, 100 %); 644 (MH ⁺-C ₄H ₈). Example D.d40: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}piperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c11 ) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 668 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.07 (d, J = 7.7, 1 H, -NH); 8.98 (s, 1 H); 7.38 (d, J = 9.3, 1 H); 7.06 (d, J = 12.1 , 1 H); 5.43 (d, J = 11.0, 1 H); 5.01 (d, J = 11.0, 1 H); 4.08 (m, 1 H); 3.86 (m, 2H & dd, J = 10.8, 6.6, 1 H); 3.77 (dd, J = 10.8, 7.1 , 1 H); 3.06 (m, 2H); 2.94 (m, 2H); 2.91 (s, 3H); 2.24 (d, J = 1.3, 3H); 1.93 (m, 2H); 1.45 (m, 2H); 1.42 (s, 9H); 0.90 (m, 1 H); 0.53 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.17 (s, 9H). Example D.d41: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylpheny l]-

6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrol o[3,2-cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c11 ) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 682 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.98 (s, 1 H); 8.91 (d, J = 7.9, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 7.05

(d, J = 11.9, 1 H); 6.72 (br.d, J = 7.9, 1 H, -NH); 5.42 (d, J = 10.9, 1 H); 5.00 (d, J = 10.9, 1 H); 3.86 (dd, J = 10.2, 6.6, 1 H); 3.76 (m, 1 H & dd, J = 10.2, 7.1 , 1 H); 3.29 (m, 1 H); 2.94 (m, 2H); 2.92 (m,

2H); 2.90 (s, 3H); 2.23 (d, J = 1.1 , 3H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 0.89

(m, 1 H); 0.53 (m, 2H); 0.32 (m, 2H); 0.06 (m, 2H); -0.17 (s, 9H).

Example D.d42: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl] -6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c11 ) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 682 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.28 (d, J = 7.7, 1 H, -NH); 9.03 (s, 1 H); 7.39 (d, J = 8.9, 1 H); 7.06

(d, J = 11.9, 1 H); 6.91 (br.s, 1 H, -NH); 5.43 (d, J = 1 1.1 , 1 H); 5.01 (d, J = 11.1 , 1 H); 4.07 (m, 1 H); 3.87 (dd, J = 10.4, 6.6, 1 H); 3.77 (dd, J = 10.4, 7.1 , 1 H); 3.43 (m, 1 H); 2.94 (m, 2H); 2.91 (s, 3H); 2.24 (d, J = 1.3, 3H); 1.86-1.51 (m, 8H); 1.40 (s, 9H); 0.90 (m, 1 H); 0.53 (m, 2H); 0.34 (m, 2H); 0.07 (m, 2H); -0.16 (s, 9H). Example D.d43: tert-Butyl (3R,4R)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}- 5/-/-pyrrolo[3,2-c(]pyrimidin-7- yOcarbonyljaminoJ-S-hydroxypiperidine-i-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- 5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c11 ) and tert-butyl (3R*,4R*)^4-amino-3-hydroxy-piperidine-1-carboxylate (example C2) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 684 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.11 (d, J = 7.3, 1 H, -NH); 8.98 (s, 1 H); 7.39 (d, J = 8.9, 1 H); 7.06

(d, J = 11.9, 1 H); 5.44 (d, J = 11.0, 1 H); 5.24 (dd, J = 4.9, 3.7, 1 H, -OH); 5.02 (d, J = 1 1.0 1 H); 4.00-3.37 (m, 3H); 3.86 (ddd, J = 10.4, 7.9, 1.1 , 1 H); 3.77 (ddd, J = 10.4, 7.1 , 2.7, 1 H); 3.45 (m,

1 H); 2.98 (m, 1 H); 2.93 (m, 2H); 2.92 (s, 3H); 2.79 (m, 1 H); 2.24 (s, 3H); 2.07 (m, 1 H); 1.42 (s, 9H);

1.38 (m, 1 H); 0.90 (m, 1 H); 0.54 (m, 2H); 0.34 (m, 2H); 0.07 (m, 2H); -0.16 (s, 9H).

Example D.d44: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7- yl)carbonyl]amino}piperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c12) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 684 (MH ⁺, 100%); 628 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 9.07 (d, J = 7.7, 1 H, -NH); 8.98 (s, 1 H); 7.32 (d, J = 11.3, 1 H); 6.94 (d, J = 7.3, 1 H); 5.47 (d, J = 11.1 , 1 H); 5.07 (d, J = 11.1 , 1 H); 4.07 (m, 1 H); 3.96 (s, 3H); 3.92 - 3.79 (m, 4H); 3.06 (m, 2H); 2.95 (m, 2H); 2.92 (s, 3H); 1.93 (m, 2H); 1.45 (m, 2H); 1.41 (s, 9H); 0.88 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.17 (s, 9H).

Example D.d45: tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphen yl]- 6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-c(]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c12) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow foam. MS (ESI): m/z = 698 (MH ⁺, 100%); 642 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 8.98 (s, 1 H); 8.91 (d, J = 7.7, 1 H, -NH); 7.32 (d, J = 11.3, 1 H); 6.94 (d, J = 7.3, 1 H); 6.72 (d, J = 7.5, 1 H, -NH); 5.47 (d, J = 10.9 1 H); 5.06 (d, J = 10.9, 1 H); 3.96 (s, 3H); 3.89 (dd, J = 10.2, 6.6, 1 H); 3.81 (dd, J = 10.2, 7.1 , 1 H); 3.77 (m, 2H); 2.94 (m, 2H); 2.91 (s, 3H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.88 (m, 1 H); 0.54 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.18 (s, 9H).

Example D.d46: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl ]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c12) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as colorless foam.

MS (ESI): m/z = 698 (MH ⁺, 100%); 642 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 9.27 (s, 1 H, -NH); 9.02 (s, 1 H); 7.32 (d, J = 11.3, 1 H); 6.91 (d, J = 7.3, 1 H); 6.91 (br.s, 1 H, -NH); 5.47 (d, J = 11.1 1 H); 5.07 (d, J = 1 1.1 , 1 H); 4.07 (m, 1 H); 3.96 (s, 3H); 3.90 (dd, J = 10.3, 6.6, 1 H); 3.82 (dd, J = 10.3, 6.9, 1 H); 3.43 (m, 1 H); 3.05 (m, 2H); 2.92 (s, 3H); 1.77 (m, 2H); 1.64 (m, 6H); 1.40 (s, 9H); 0.89 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.17 (s, 9H).

Example D.d47: tert-Butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro^- methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl} -5H-pyrrolo[3,2-c^pyrimidin-7- yl)carbonyl]amino}-3-hydroxypiperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c12) and tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate (Example C2) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 700 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.12 (d, J = 7.7, 1 H, -NH); [8.98 (s), 8.96 (s), 1 H)]; 7.34 (d, J = 11.5,

1 H); 6.94 (d, J = 7.3, 1 H); [5.50 (d, J = 11.0), 5.49 (d, J = 1 1.0), 1 H)]; 5.27 (t, J = 4.9, 1 H, -OH);

5.07 (d, J = 11.0, 1 H); 3.96 (s, 3H); 3.95-3.75 (m, 5H); 3.44 (m, 1 H); 2.93 (s, 3H & m, 3H); 2.79 (m,

1 H); 2.07 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.88 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -

0.17 (s, 9H).

Example D.d48: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2 - (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2-(tri methylsilyl)ethoxy]methyl}- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid (example D.c14) and commercially available tert-butyl 4-amino-piperidine-i -carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 664 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 9.08 (d, J = 7.5, 1 H, -NH); 8.99 (s, 1 H); 7.37 (dd, J = 8.6, 2.2, 1 H); 7.29 (d, J = 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 5.42 (d, J = 11.1 , 1 H); 5.03 (d, J = 1 1.1 , 1 H); 4.08 (m, 1 H); 3.87 (m, 2H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.75 (dd, J = 10.2, 6.9. 1 H); 3.06 (m, 2H); 2.94-2.82 (m, 2H); 2.91 (s, 3H); 2.63 (qu, J = 7.6, 2H); 1.94 (m, 2H); 1.46 (m, 2H); 1.40 (s, 9H); 1.20 (t, J = 7.6, 3H); 0.89 (m, 1 H); 0.51 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.19 (s, 9H).

Example D.d49: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methy l-5-

{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]py rimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2-(tri methylsilyl)ethoxy]methyl}- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid (example D.c14) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 678 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 8.92 (d, J = 7.3, 1 H, -NH); 7.37 (dd, J = 8.6, 2.2, 1 H);

7.29 (d, J = 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 6.72 (d, J = 8.1 , 1 H, -NH); 5.42 (d, J = 10.9, 1 H); 5.02 (d, J = 10.9, 1 H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.74 (dd, J = 10.2, 6.9. 1 H & m, 1 H); 3.27 (m, 1 H);

2.90 (s, 3H); 2.88 (t, J = 8.2, 2H); 2.63 (qu, J = 7.5, 2H); 2.00 (m, 2H); 1.85 (m, 2H); 1.40 (s, 9H);

1.37 (m, 4H); 1.20 (t, J = 7.6, 3H); 0.88 (m, 1 H); 0.50 (m, 2H); 0.31 (m, 2H); 0.04 (m, 2H); -0.19 (s,

9H). Example D.d50: tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5-

{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrim idin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2-(tri methylsilyl)ethoxy]methyl}-

5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid (example D.c14) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 678 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): ¹ H9.28 (d, J = 7.9, 1 H, -NH); 9.03 (s, 1 H); 7.35 (dd, J = 8.6, 2.2,

1 H); 7.30 (d, J = 2.2, 1 H); 7.09 (d, J = 8.6, 1 H); 6.92 (br.d, J ~ 7.2, 1 H, -NH); 5.42 (d, J = 1 1 .1 , 1 H);

5.03 (d, J = 1 1.1 , 1 H); 4.07 (m, 1 H); 3.83 (dd, J = 10.2, 6.4, 1 H); 3.75 (dd, J = 10.2, 6.9. 1 H & m, 1 H); 3.43 (m, 1 H); 2.91 (s, 3H); 2.89 (m, 2H); 2.64 (qu, J = 7.5, 2H); 1 .86-1.51 (m, 8H); 1.40 (s,

9H); 1.20 (t, J = 7.5, 3H); 0.90 (m, 1 H); 0.51 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.18 (s, 9H). Example D.d51: tert-Butyl (3R*,4R*)-3-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-4- hydroxypyrrolidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-rnethyl-5-{[2-(tr irnethylsilyl)ethoxy]rnethyl}- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxylic acid (example D.c14) and commercially available tert-butyl (3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 666 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.13 (br.s, 1 H, -NH); 8.95 (s, 1 H); 7.37 (dd, J = 8.6, 2.4, 1 H); 7.29 (d, J = 2.4, 1 H); 7.09 (d, J = 8.6, 1 H); 5.48 (d, J = 3.8, 1 H, -OH); 5.43 (d, J = 10.9, 1 H); 5.03 (d, J = 10.9, 1 H); 4.27 (m, 1 H); 4.21 (m, 1 H); 3.83 (d, J = 10.2, 6.6, 1 H); 3.74 (ddd, J = 10.2, 7.1 , 0.9, 1 H); 3.69 (m, 1 H); 3.56 (m, 1 H); 3.24 (m, 2H); 2.91 (s, 3H); 2.88 (m, 2H); 2.63 (qu, J = 7.5, 2H); 1.40 (s, 9H); 1.20 (t, J = 7.5, 3H); 0.87 (m, 1 H); 0.50 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.18 (s, 9H). Example D.d52: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl-

5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy] pyrimidin-7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c15) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 678 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.08 (d, J = 7.7, 1 H, -NH); 8.99 (s, 1 H); 7.40 (dd, J = 8.6, 2.2, 1 H);

7.32 (d, J = 2.2, 1 H); 7.09 (d; J = 8.6, 1 H); 5.42 (d, J = 10.9, 1 H); 5.04 (d, J = 10.9, 1 H); 4.08 (m, 1 H); 3.90-3.79 (m, 3H); 3.75 (dd, J = 10.2, 6.9, 1 H); 3.06 (m, 2H); 2.98-2.82 (m, 3H); 2.91 (s, 3H);

1.93 (m, 2H); 1.47 (m, 2H); 1.40 (s, 9H); 1.22 (dd, J = 6.9, 2.2, 6H); 0.89 (m, 1 H); 0.50 (m, 2H);

0.32 (m, 2H); 0.05 (m, 2H); -0.19 (s, 9H).

Example D.d53: tert-Butyl (trans^4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl] -6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c15) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 692 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 8.92 (d, J = 7.7, 1 H, -NH); 7.40 (dd, J = 8.6, 2.4, 1 H);

7.32 (d, J = 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 6.72 (br.d, J -8.6, 1 H, -NH); 5.41 (d, J = 11.0, 1 H); 5.03 (d, J = 11.0, 1 H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.74 (dd, J = 10.2, 6.9, 1 H &m, 2H); 3.27 (m, 1 H); 2.99-2.80 (sept, J = 6.9, 1 H & m, 2H); 2.90 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1.39 (s, 9H); 1.37 (m, 4H); 1.22 (dd, J = 6.9, 2.4, 6H); 0.89 (m, 1 H); 0.49 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.19 (s, 9H).

Example D.d54: tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6 - methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5- {[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c15) and commercially available tert-butyl cis-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 692 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 9.28 (d, J = 7.9, 1 H, -NH); 9.03 (s, 1 H); 7.41 (dd, J = 8.6, 2.4, 1 H); 7.33 (d, J = 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 6.92 (br.d, J -6.9, 1 H, -NH); 5.41 (d, J = 1 1 .0, 1 H); 5.04

(d, J = 1 1 .0, 1 H); 4.07 (m, 1 H); 3.83 (dd, J = 10.4, 6.6, 1 H); 3.75 (dd, J = 10.4, 6.9, 1 H); 3.43 (m,

1 H); 2.91 (s, 3H & m, 2H & sept, J = 6.9, 1 H); 1.85-1.53 (m, 8H); 1.40 (s, 9H); 1.24 (dd, J = 6.9,

2.4, 6H); 0.90 (m, 1 H); 0.51 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.19 (s, 9H). Example D.d55: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2- yl)phenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H- pyrrolo[3,2-c^pyrimidin-7- yl)carbonyl]amino}piperidine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxylic acid (example D.c13) and commercially available tert-butyl 4-amino-piperidine-1 -carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 722 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 9.08 (d, J = 7.6, 1 H, -NH); 9.00 (s, 1 H); 7.57 (dd, J = 8.7, 2.3, 1 H);

7.50 (d, J = 2.3, 1 H); 7.15 (d, J = 8.7, 1 H); 5.40 (d, J = 1 1.0, 1 H); 5.04 (d, J = 1 1.0, 1 H); 4.09 (m, 1 H); 4.00 (m, 2H); 3.90-3.70 (m, 6H); 3.06 (m, 2H); 2.97-2.83 (s, 3H & m, 2H); 1 .99 (s, 3H); 1 .94

(m, 2H); 1.46 (m, 2H); 1.43 (s, 9H); 0.90 (m, 1 H); 0.49 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.20 (s,

9H).

Example D.d56: tert-Butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan- 2-yl)phenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5 H-pyrrolo[3,2-c^pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxylic acid (example D.c13) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 736 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 9.00 (s, 1 H); 8.93 (d, J = 7.6, 1 H, -NH); 7.56 (dd, J = 8.7, 2.3, 1 H); 7.50 (d, J = 2.3, 1 H); 7.15 (d, J = 8.7, 1 H); 6.72 (br.d, J ~ 7.5, 1 H, -NH); 5.40 (d, J = 11.1 , 1 H); 5.03 (d, J = 11.1 , 1 H); 4.00 (m, 2H); 3.86 (dd, J = 10.2, 6.6, 1 H); 3.78 (dd. J = 10.2, 6.9, 1 H); 3.73 (m, 2H & m, 1 H); 3.27 (m, 1 H); 2.97-2.82 (m, 2H); 2.91 (s, 3H); 2.01 (m, 2H); 1.99 (s, 3H); 1.86 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 0.90 (m, 1 H); 0.49 (m, 2H); 0.33 (m, 2H); 0.06 (m, 2H); -0.20 (s, 9H).

Example D.d57: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- 5-

{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]py rimidin-7-yl)carbonyl]amino}piperidine-1- carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-5-{[2 - (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c16) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 664 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 9.31 (d, J = 7.5, 1 H, -NH); 7.32 (dd, J = 8.4, 2.0, 1 H); 7.22 (d, J = 2.0, 1 H); 7.04 (d, J = 8.4, 1 H); 5.39 (d, J = 1 1.0, 1 H); 4.98 (d, J = 11.0, 1 H); 4.15-4.01 (m, 1 H);

3.87-3.69 (m, 4H); 3.12 (m, 2H); 2.87 (m, 5H); 2.71 (s, 3H); 2.32 (s, 3H); 1.99-1.87 (m, 2H); 1.46

(m, 2H); 1.43 (s, 9H); 0.89 (m, 1 H); 0.51 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.17 (s, 9H).

Example D.d58: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6 - dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-c(]pyrimidin-7- yl)carbonyl]amino}piperidine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6-dime thyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxylic acid (example D.c17) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI) : 698 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 9.30 (d, J = 7.5, 1 H, -NH); 7.28 (d, J = 11.3, 1 H); 6.93 (d, J = 7.3, 1 H), 5.43 (d, J = 11.0, 1 H); 5.02 (d, J = 11.0, 1 H); 4.13-4.00 (m, 1 H); 3.95 (s, 3H); 3.93-3.74 (m, 4H); 3.12 (m, 2H); 2.94 (m, 2H); 2.89 (s, 3H); 2.71 (s, 3H); 1.98-1.86 (m, 2H); 1.47 (m, 2H); 1.42 (s, 9H); 0.88 (m, 1 H); 0.54 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.17 (s, 9H). Example D.d59: tert-Butyl 4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6 - dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-cy]pyrimidin-7- yl)carbonyl]amino}piperidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c18) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as colorless foam.

MS (ESI): m/z = 698 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.29 (d, J = 7.5, 1 H, -NH); 7.22 (d, J = 9.9, 1 H); 7.17 (d, J = 13.3, 1 H); 5.36 (d, J = 10.9, 1 H); 4.97 (d, J = 10.9, 1 H); 4.07 (m, 1 H); 3.81 (s, 3H & dd, J = 10.4, 6.6, 1 H & m, 2H); 3.72 (dd, J = 10.4, 7.1 , 1 H); 3.12 (m, 2H); 3.04-2.90 (m, 2H); 2.88 (s, 3H); 2.72 (s, 3H); 1.93 (m, 2H); 1.47 (m, 2H); 1.40 (s, 9H); 0.87 (m, 1 H); 0.56 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); - 0.15 (s, 9H). Example D.d60: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2- hydroxycyclopentyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]me thyl}-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxylic acid (example D.c18) and commercially available (1 S,2S)-2-amino-cyclopentanol the title compound is obtained as colorless foam.

MS (ESI): m/z = 551 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.04 (d, J = 7.1 , 1 H, -NH); 8.98 (s, 1 H); 7.34 (dd, J = 8.6, 2.0, 1 H);

7.27 (d, J = 2.0, 1 H); 7.06 (d, J = 8.6, 1 H); 5.43 (d, J = 11.0, 1 H); 5.02 (d, J = 11.0, 1 H); 4.91 (dd, J = 4.2, 1.3, 1 H; -OH); 4.09 (m, 1 H); 4.00 (m, 1 H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.74 (dd, J = 10.2,

6.9, 1 H); 2.91 (s, 3H); 2.88 (t, J = 7.8, 2H); 2.32 (s, 3H); 2.12 (m, 1 H); 1.91 (m, 1 H); 1.74 (m, 2H); 1.54 (m, 2H); 0.88 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.17 (s, 9H).

Example D.d61: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2R)-2- hydroxycyclopentyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]me thyl}-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxylic acid (example D.c18) and commercially available (1 R,2S)-2-amino-cyclopentanol the title compound is obtained as colorless foam.

MS (ESI): m/z = 551 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.26 (d, J = 7.9, 1 H, -NH); 8.96 (s, 1 H); 7.34 (dd, J = 8.4, 1.8, 1 H);

7.28 (d, J = 1.8, 1 H); 7.06 (d, J = 8.4, 1 H); 5.43 (d, J = 11.1 , 1 H); 5.02 (d, J = 11.1 , 1 H); 4.92 (dd, J = 4.0, 3.8, 1 H; -OH); 4.17 (m, 1 H); 4.04 (m, 1 H); 3.82 (ddd, J = 10.4, 6.6, 1.5, 1 H); 3.74 (ddd, J = 10.4, 6.9, 2.2, 1 H); 2.92 (s, 3H); 2.88 (t, J = 7.9, 2H); 2.32 (s, 3H); 2.03-1.73 (m, 3H); 1.71-1.47 (m, 3H); 0.88 (m, 1 H); 0.52 (m, 2H); 0.31 (m, 2H); 0.05 (m, 2H); -0.17 (s, 9H). Example D.d62: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2- hydroxycyclopentyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]me thyl}-5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxylic acid (example D.c18) and commercially available (1 R,2R)-2-amino-cyclopentanol the title compound is obtained as colorless foam.

MS (ESI): m/z = 551 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.04 (d, J = 7.1 , 1 H, -NH); 8.98 (s, 1 H); 7.34 (dd, J = 8.6, 2.0, 1 H);

6.9, 1 H); 2.91 (s, 3H); 2.88 (t, J = 7.8, 2H); 2.32 (s, 3H); 2.12 (m, 1 H); 1.91 (m, 1 H); 1.74 (m, 2H);

1.54 (m, 2H); 0.88 (m, 1 H); 0.52 (m, 2H); 0.32 (m, 2H); 0.04 (m, 2H); -0.17 (s, 9H).

Example D.e1: tert-Butyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine -1 -carboxylate

A solution of tert-butyl 4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}piperidine-1- carboxylate from example D.d1 (3.74 g; 5.5 mmol), tetrabutylammonium fluoride trihydrate (5.21 g;

16.5 mmol) and ethane-1 ,2-diamine(0.50 g; 8.25 mmol) in tetrahydrofurane (40 ml_) is heated to gentle reflux until the starting material is completly consumed according to LC-MS. The crude is purified by column chromatography on silica gel (ethyl acetate / cyclohexane - 1 :1 to 2:1 ) to yield the title compound as colorless solid.

MS (ESI): m/z = 550 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.99 (s, 1 H, -NH); 8.93 (s, 1 H); 8.74 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.04 (m, 1 H); 3.85 (m, 2H); 3.76 (d, J = 6.8, 2H);

3.05 (m, 2H); 2.76 (s, 3H); 1.92 (m, 2H); 1.44 (m, 2H); 1.42 (s, 9H); 0.87 (m, 1 H); 0.30 (m, 2H);

0.12 (m, 2H).

The following compounds were prepared analogously to the procedure described in above example D.e1.

Example D.e2: tert-Butyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate Starting from tert-butyl (trans-4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d2) the title compound is obtained as colorless solid.

MS (ESI): m/z = 564 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.96 (s, 1 H, -NH); 8.93 (s, 1 H); 8.58 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.71 (br.d, J ~ 7.7, 1 H, -NH); 6.55 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.76 (d, J = 6.8, 2H & m, 1 H); 3.27 (m, 1 H); 2.76 (s, 3H); 1.99 (m, 2H); 1.84 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H). Example D.e3: tert-Butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d3) the title compound is obtained as colorless solid.

MS (ESI): m/z = 694 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 9.23 (d, J = 7.8, 1 H, -NH); 9.05 (s, 1 H); 7.02 (d, J = 8.6, 1 H); 6.91 (br.d, J ~ 6.4, 1 H, -NH); 6.57 (d, J = 8.6, 1 H); 6.03 (d, J = 0.6, 1 H); 5.92 (d, J = 0.6, 1 H); 5.39 (d, J = 10.8, 1 H); 5.12 (d, J = 10.8, 1 H); 4.07 (m, 1 H); 3.76 (dd, J = 10.2, 6.6, 2H); 3.68 (dd, J = 10.2, 6.9, 1 H); 3.34 (m, 1 H); 3.01 (m, 2H); 2.92 (s, 3H); 1.86-1.51 (m, 8H); 1.40 (s, 9H); 0.87 (m, 1 H); 0.61 (m, 2H); 0.30 (m, 2H); 0.02 (m, 2H); -0.13 (s, 9H).

Example D.e4: tert-Butyl (3R)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]pyr rolidine-1 -carboxylate

Starting from tert-butyl (3R)-3-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}pyrrolidine-1- carboxylate (example D.d4) the title compound is obtained as colorless solid.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); 8.92 (s, 1 H); 8.85 (d, J = 6.8, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.49 (m, 1 H); 3.76 (d, 6.8, 2H); 3.61 (m, 1 H); 3.42 (m, 2H); 3.22 (m, 1 H); 2.77 (s, 3H); 2.20 (m, 1 H); 1.95 (m, 1 H); 1.42 (s, 9H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example D.e5: tert-Butyl (3R*,4R*)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4- hydroxypyrrolidine-1-carboxylate Starting from tert-butyl (3R*,4R*)-3-{[(4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrim idin-7-yl)carbonyl]amino}-4- hydroxypyrrolidine-1-carboxylate (example D.d5) the title compound is obtained as pale yellow viscous oil. MS (ESI): m/z = 552 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.05 (br.s, 1 H, -NH); 8.89 (s, 1 H); 8.79 (br.s, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 5.47 (d, J = 3.8, 1 H, -OH); 4.21 (m, 2H); 3.76 (d, J = 6.8, 2H); 3.68 (m, 1 H); 3.55 (m, 1 H); 3.26 (m, 2H); 2.77 (s, 3H); 1.43 (s, 9H); 0.86 (m, 1 H); 0.31 (m, 2H); 0.12 (m, 2H).

Example D.e6: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5/-/ - pyrrolop^-cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[ 2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrirnidi n-7-yl)carbonyl]arnino}piperidine-1- carboxylate (example D.d6) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 524 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.79 (s, 1 H, -NH); 8.94 (s. 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.66

(dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 1 1.5, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.05 (m, 1 H); 3.91 (d, J = 6.9, 2H); 3.85 (m, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 1.92 (m, 2H); 1.42 (m, 2H & s, 9H);

0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m, 2H).

Example D.e7: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-meth yl-

5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohe xyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-4-fluorophenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}cyclohexyl)carbamate

(example D.d7) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 538 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.95 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.09 (dd, 11.3, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 6.77 (d, J = 7.7, 1 H, -NH);

3.90 (d, J = 6.9, 2H); 3.76 (m, 1 H); 3.31 (m, 1 H); 2.77 (s, 3H); 1.98 (m, 2H); 1.85 (m, 2H); 1.39 (s,

9H); 1.33 (m, 4H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e8: Tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate

Starting from tert-butyl (cis^4-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi din-7-yl)carbonyl]amino}cyclohexyl)carbamate

(example D.d8) the title compound is obtained as colorless viscous oil .

MS (ESI): m/z = 538 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.98 (s, 1 H); 8.97 (d, J = 6.6, 1 H, -NH); 7.66

(dd, 8.5, 7.1 , 1 H); 7.09 (dd, 11.6, 2.3, 1 H); 6.96 (ddd, 8.5, 8.5, 2.3, 1 H); 6.92 (br.s, 1 H, -NH); 4.04

(m, 1 H); 3.91 (d, J = 7.0, 2H); 3.43 (m, 1 H); 2.78 (s, 3H); 1.85-1.54 (m, 8H); 1.40 (s, 9H); 0.96 (m,

1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example D.e9: tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)^-fluorophenyl]-6-methyl- 5H- pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate

Starting from tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]rnethyl}-5/-/-pyrrolo[3,2-c(]pyrirnid in-7-yl)carbonyl]arnino}pyrrolidine-1 - carboxylate (example D.d9) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .83 (s, 1 H, -NH); 8.93 (s, 1 H); 8.91 (d, J = 6.7, 1 H, -NH); 7.66 (dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 1 1.5, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.49 (m, 1 H); 3.91 (d, J = 6.9, 2H); 3.62 (m, 1 H); 3.43 (m, 2H); 3.23 (m, 1 H); 2.79 (s. 3H); 2.21 (m, 1 H); 1.94 (m, 1 H); 1.42 (s, 9H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example D.e10: tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-4- hydroxypyrrolidine-1 -carboxylate Starting from tert-butyl (3R*,4S*)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}-4-hydroxypyrrolidine-

1 -carboxylate (example D.d10) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 526 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .85 (s, 1 H, -NH); 8.91 (s, 1 H); 8.84 (br.s, 1 H, -NH); 7.66 (dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); 5.47 (d, J = 3.8, 1 H, -

OH); 4.26 (m, 1 H); 4.19 (m, 1 H); 3.91 (d, 7.1 , 2H); 3.68 (m, 1 H); 3.55 (m, 1 H); 3.25 (m, 2H); 2.79

(s. 3H); 1.43 (s, 9H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example D.e11 : Tert-butyl (3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-3- hydroxypiperidine-1 -carboxylate

Starting from tert-butyl (3S*,4S*)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin-7- yl)carbonyl]amino}-3-hydroxypiperidine- 1 -carboxylate (example D.d1 1 ) the title compound is obtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100 %).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1 .79 8s, 1 H, -NH); 8.94 (s, 1 H); 8.84 (d, J = 7.3, 1 H, -NH); 7.65 (dd, J = 8.6, 6.9, 1 H); 7.08 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.6, 8.6, 2.4, 1 H); 5.24 (d, J = 4.9, 1 H, -OH); 3.98-3.74 (m, 3H); 3.91 (d, J = 6.9, 2H, -NH; 3.43 (m, 1 H); 2.98 (m, 1 H); 2.78 (s. 3H); 2.06 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example D.e12: tert-Butyl 4-({1 -[4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl]-methanoyl}-amino)-pipeπdine- 1 -carboxylate Starting from tert-butyl (4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{ [2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d12) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 524 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.97 (s, 1 H); 8.79 (d, J = 7.6, 1 H, -NH); 7.43 (dd, J = 9.0, 3.2, 1 H); 7.37 (ddd, J = 9.1 , 8.3, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.07 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.84 (m, 2H); 3.05 (m, 2H); 2.79 (s, 3H); 1.92 (m, 2H); 1.42 (s, 9H & m, 2H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example D.e13: tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-

5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohe xyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-5-fluorophenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d13) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 538 (MH ⁺).

¹H-NMR (300 MHz, DMSO-d ₆): 11.81 (br.s, 1 H, -NH); 8.97 (s, 1 H); 8.62 (d, J = 7.8, 1 H, -NH); 7.42 (dd, J = 8.9, 3.1 , 1 H); 7.36 (ddd, J = 9.0, 8.6, 3.1 , 1 H); 7.18 (dd, J = 9.0, 4.4, 1 H); 6.72 (d, J = 7.5, 1 H, -NH); 3.87 (d, J = 6.9, 2H); 3.82-3.70 (m, 2H); 2.78 (s, 3H); 1.98 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.35 (m, 4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.e14: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl -5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate

Starting from tert-butyl (4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5-{ [2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d14) the title compound is obtained as colorless solid.

MS (ESI): m/z = 538 (MH ⁺).

¹H-NMR (300 MHz, DMSO-d ₆): 11.81 (br.s, 1 H, -NH); 9.00 (s, 1 H); 8.96 (d, J = 7.7, 1 H, -NH); 7.43 (dd, J = 8.9, 3.3, 1 H); 7.38 (ddd, J = 8.9, 8.2, 3.3, 1 H); 7.19 (dd, J = 8.9, 4.4, 1 H); 6.92 (br.s, 1 H, - NH); 4.04 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.42 (m, 1 H); 2.79 (s, 3H); 1.85-1.53 (m, 8H); 1.40 (s, 9H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.e15: tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl - 5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]pyrrolidin e-1 -carboxylate

Starting from tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}pyrrolidine-1- carboxylate (example D.d15) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 510 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.95 (s, 1 H); 8.89 (d, J = 6.8, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H); 7.38 (ddd, J = 9.1 , 8.4, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.49 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.62 (m, 1 H); 3.42 (m, 2H); 3.22 (m, 1 H); 2.79 (s, 3H); 2.20 (m, 1 H); 1.94 (m, 1 H); 1.42 (s, 9H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.e16: tert-Butyl (3R*,4R*H-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-3-hyd roxypiperidine-1-carboxylate Starting from tert-butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-m ethyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}-3-hydroxypiperidine- 1 -carboxylate (example D.d16) the title compound is obtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.97 (s, 1 H); 8.83 (d, J = 7.5, 1 H, -NH); 7.42 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.36 (dd, J = 8.2, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 5.24 (d, J = 4.9, 1 H, -OH); 3.99-3.74 (m, 3H); 3.87 (d, J = 6.8, 2H); 3.43 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H & m, 1 H); 2.06 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.e17: tert-Butyl 4-({[4-(2-ethoxy-5-fluorophenyl)-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl]carbonyl}amino)piperidine-1 -carboxylate

Starting from tert-butyl 4-({[4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsi lyl)ethoxy]methyl}- 5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl]carbonyl}amino)piperidine -1-carboxylate (example D.d17) the title compound is obtained as colorless solid.

MS (ESI): m/z = 498 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 11.87 (br.s, 1 H, -NH); 8.96 (s, 1 H); 8.78 (d, J = 7.7, 1 H, -

NH); 7.43 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.38 (dd, J = 8.2, 3.3, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.08 (qu, J = 6.9, 2H & m, 1 H); 3.85 (m, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 1.92 (m, 2H); 1.42 (s, 9H &m,

2H); 1.11 (t, J = 6.9, 3H).

Example D.e18: tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5/- /- pyrrolo[3,2-cf]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5-{ [2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d18) the title compound is obtained as pale yellow foam.

MS (ESI): m/z =

1H-NMR (300 MHz, DMSO-d ₆):

Example D.e19: tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-4-methoxyphenyl]-6-meth yl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d19) the title compound is obtained as colorless solid.

MS (ESI): m/z = 550 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.64 (s, 1 H, -NH); 8.91 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.58 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.68 (d, J = 2.2, 1 H & br.s, 1 H, -NH); 3.90 (d , J = 6.9, 2H);

3.85 (s, 3H); 3.76 (m, 1 H); 3.28 (m, 1 H); 2.77 (s, 3H); 1.99 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.37-1.21 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H). Example D.e20: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l-

5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohe xyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d20) the title compound is obtained as colorless solid.

MS (ESI): m/z = 550 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.64 (s, 1 H, -NH); 8.99 (d, J = 7.9, 1 H, -NH); 8.94 (s, 1 H); 7.59 (d, J = 8.4, 1 H); 6.92 (br.s, 1 H, -NH); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H); 4.03 (m, 1 H); 3.91 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.43 (m, 1 H); 2.77 (s, 3H); 1.84-1.54 (m, 8H); 1.40 (s, 9H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.27 (m, 2H).

Example D.e21 : tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methy l- 5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate

Starting from tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}pyrrolidine-1- carboxylate (example D.d21 ) the title compound is obtained as pale yellow solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.93 (d, J = 6.8, 1 H, -NH); 8.89 (s, 1 H); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H); 4.48 (m, 1 H); 3.91 (d, J = 6.9, 2H);

3.86 (s, 3H); 3.61 (m, 1 H); 3.43 (m, 2H); 3.22 (m, 1 H); 2.78 (s, 3H); 2.21 (m, 1 H); 1.93 (m, 1 H); 1.42 (s, 9H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e22: tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxyH-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4- hydroxypyrrolidine-1 -carboxylate Starting from tert-butyl (3R*,4R*)-3-{[(4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6- methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}-4-hydroxypyrrolidine- 1 -carboxylate (example D.d22) the title compound is obtained as colorless solid.

MS (ESI): m/z = 538 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H, -NH); 8.87 (s, 1 H & br.s, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H); 5.46 (d, J = 3.8, 1 H, -OH); 4.25 (m, 1 H); 3.90 (d, J = 6.9, 2H); 3.86 (s, 3H); 3.68 (m, 1 H); 3.54 (m, 1 H); 3.23 (m, 2H); 2.78 (s, 3H); 1.43 (s, 9H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e23: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/- /- pyrrolop^-cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5-{ [2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimidin- 7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d23) the title compound is obtained as colorless viscous oil.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 4.07 (m, 1 H); 3.87 (m, 2H); 3.82 (d, J = 6.8, 2H); 3.77 (s, 3H); 3.05 (m, 2H); 2.78 (s, 3H); 1.92 (m, 2H); 1.42 (s, 9H & m, 2H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example D.e24: tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-5-methoxyphenyl]-6-meth yl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d24) the title compound is obtained as colorless foam.

MS (ESI): m/z = 450 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.07 (s, 1 H, -NH); 9.01 (s, 1 H); 8.59 (d, J = 7.9, 1 H, -NH); 8.03 (br.d, J - 4.8, 3H, -NH ₃ ⁺); 7.20 (t, J = 1.8, 1 H); 7.14 (d, J = 1.8, 2H); 3.84 (d, J = 6.9, 2H & m, 1 H); 3.78 (s, 3H); 3.09 (m, 1 H); 2.80 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example D.e25: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-

5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl }carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}cyclohexyl)carbamate

(example D.d25) the title compound is obtained as colorless foam.

MS (ESI): m/z = 549 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.99 (s, 1 H); 8.97 (d, J = 7.9, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 6.92 (br.d, J ~ 7.1 , 1 H, -NH); 4.03 (m, 1 H); 3.83 (d, J = 6.9, 2H);

3.77 (s, 3H); 3.43 (m, 1 H); 2.78 (s, 3H); 1.85-1.52 (m, 8H); 1.40 (s, 9H); 0.92 (m, 1 H); 0.35 (m, 2H);

0.20 (m, 2H). Example D.e26: tert-Butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l- 5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1 -carboxylate

Starting from tert-butyl (3R)-3-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]rnethyl}-5/-/-pyrrolo[3,2-c(]pyrirnid in-7-yl)carbonyl]arnino}pyrrolidine-1- carboxylate (example D.d26) the title compound is obtained as colorless viscous oil.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s, 1 H); 8.91 (d, J = 6.8, 1 H, -NH); 7.18 (t, J = 1.6, 2H); 7.11 (d, J = 1.6, 1 H); 4.49 (m, 1 H); 3.82 (d, J = 6.9, 2H); 3.77 (s, 2H); 3.62 (m, 1 H); 3.42 (m, 2H); 3.22 (m, 1 H); 2.78 (s, 3H); 2.21 (m, 1 H); 1.94 (m, 1 H); 1.42 (s, 9H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example D.e27: tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-3-h ydroxypiperidine-1 -carboxylate Starting from tert-butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}-3-hydroxypiperidine- 1 -carboxylate (example D.d27) the title compound is obtained as colorless viscous oil.

MS (ESI): m/z = 552 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H); 8.95 (s, 1 H); 8.85 (d, J = 7.3, 1 H, -NH); 7.18 (t, J = 1.6, 1 H); 7.1 1 (d, J = 1.6, 2H); 5.24 (d, J = 4.9, 1 H, -OH); 3.98-3.79 (m, 3H); 3.82 (d, J = 6.8, 2H); 3.77 (s, 3H); 3.43 (m, 1 H); 2.98 (m, 1 H); 2.78 (s, 3H & m, 1 H); 2.06 (m, 1 H); 1.42 (s, 9H); 1.38 (m, 1 H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example D.e28: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/ - pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5-{[ 2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi din-7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d28) the title compound is obtained as pale yellow foam .

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.94 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 2.2, 1 H); 7.33 (dd, J = 8.6, 2.0, 1 H); 7.06 (d, J = 8.6, 1 H); 4.06 (m, 1 H); 3.86 (d, J = 6.9, 2H & m, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 2.33 (s, 3H); 1.92 (m, 2H); 1.43 (s, 9H & m, 2H); 0.94 (m, 1 H);

0.35 (m, 2H); 0.22 (m, 2H).

Example D.e29: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-meth yl- 5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}ca rbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-5-methylphenyl]-6-methy l-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d29) the title compound is obtained as colorless solid. MS (ESI): m/z = 534 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.71 (s, 1 H, -NH); 8.94 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 2.2, 1 H); 7.32 (dd, J = 8.6, 2.0, 1 H); 7.05 (d, J = 8.6, 1 H); 6.72 (d, J = 7.1 , 1 H, -NH); 3.85 (d, J = 6.9, 2H); 3.76 (m, 1 H); 3.30 (m, 1 H); 2.77 (s, 3H); 2.33 (s, 3H); 1.99 (m, 2H); 1 .85 (m, 2H); 1.39 (s, 9H); 1.33 (m, 4H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example D.e30: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl -

5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl }carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrirnidi n-7-yl)carbonyl]arnino}cyclohexyl)carbarnate

(example D.d30) the title compound is obtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .73 (s, 1 H, -NH); 9.00 (d, J = 9.3, 1 H, -NH); 8.98 (s, 1 H); 7.43 (d,

J = 2.1 , 1 H); 7.33 (dd, J = 8.4, 2.1 , 1 H); 7.06 (d, J = 8.4, 1 H); 6.97 (d, J = 7.7, 1 H, -NH); 4.03 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.42 (m, 1 H); 2.78 (s, 3H); 2.32 (s, 3H); 1.81 -1.51 (m, 8H); 1.40 (s, 9H);

0.94 (m, 1 H);0.37 (m, 2H); 0.23 (m, 2H).

Example D.e31 : tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]pip eridine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimi din-7-yl)carbonyl]amino}piperidine-1 - carboxylate (example D.d31 ) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 574 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.91 (d,

J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.05 (m, 1 H); 4.00 (d, J = 6.9, 2H);

3.85 (m, 2H); 3.05 (m, 2H); 2.79 (s, 3H); 1.93 (m, 2H); 1.45 (m, 2H); 1.43 (s, 9H); 0.98 (m, 1 H);

0.39 (m, 2H); 0.27 (m, 2H). Example D.e32: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phe nyl]-

6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]c yclohexyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phe nyl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrim idin-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d32) the title compound is obtained as pale yellow solid.

Alternatively, following the procedure as described for example D.d1 the title compound is prepared from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5H-pyrrolo[3,2-c^pyrimidine-7- carboxylic acid (example D.g2) and commercially available fert-butyl trans-(4-amino-cyclohexyl)- carbamate.

MS (ESI): m/z = 588 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.62 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.6, 2.0, 1 H); 7.38 (d, J = 8.6, 1 H); 6.72 (d, J = 7.2, 1 H, -NH); 4.00 (d, J = 7.0, 2H); 3.76 (m, 1 H); 3.29 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1 .85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.e33: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)pheny l]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyc lohexyl}carbamate

Starting from tert-Butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)pheny l]-6-methyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi din-7-yl)carbonyl]amino}cyclohexyl)carbamate

(example D.d33) the title compound is obtained as colorless solid.

MS (ESI): m/z = 588 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.87 (s, 1 H, -NH); 9.03 (s, 1 H); 8.96 (d, J = 7.7, 1 H, -NH); 7.91 (d,

J = 2.1 , 1 H); 7.89 (dd, J = 8.5, 2.1 , 1 H); 7.38 (d, J = 8.5, 1 H); 6.92 (br.s, 1 H, -NH); 4.06 (m, 1 H);

4.00 (d, J = 6.9, 2H); 3.43 (m, 1 H); 2.79 (s, 3H); 1.84-1.54 (m, 8H); 1.40 (s, 9H); 0.99 (m, 1 H); 0.40

(m, 2H); 0.28 (m, 2H). Example D.e34: tert-Butyl 4-[({4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}piperidine-1 - carboxylate (example D.d34) the title compound is obtained as colorless solid.

MS (ESI): m/z = 548 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.92 (s, 1 H, -NH); 8.98 (s, 1 H); 8.78 (d, J = 7.7, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.90 (dd, J = 9.5, 2.2, 1 H); 7.42 (d, J = 9.5, 1 H); 4.21 (qu, J = 7.0, 2H); 4.06 (m, 1 H); 3.85 (m, 2H); 3.05 (m, 2H); 2.79 (s, 3H); 1.97 (m, 2H); 1.92 (m, 2H); 1.42 (s, 9H & m, 2H); 1.15 (t, J = 7.0, 3H).

Example D.e35: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piper idine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2- cyclopropylmethoxy^-fluoro-S-methoxyphenyll-θ-methyl-S-^- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d35) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 554 (MH ⁺, 100 %); 498 (MH ⁺-C ₄H ₈); 454 (MH ⁺-C ₅H ₈O ₂).

¹H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.96 (s, 1 H); 8.79 (d, J = 7.8, 1 H, -NH); 7.39 (d, J = 9.8, 1 H); 7.18 (d, J = 13.5, 1 H); 4.04 (m, 1 H); 3.87 (m, 2H); 3.84 (s, 3H & d, J = 6.9, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 1.93 (m, 2H); 1.42 (s, 9H & m, 1 H); 1.29 (m, 1 H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example D.e36: tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimidin-7-yl}car bonyl)amino]cyclohexyl}carbamate Starting from tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphen yl]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-cf]pyrimid in-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d36) the title compound is obtained as colorless solid.

MS (ESI): m/z = 568 (MH ⁺, 100 %); 512 (MH ⁺-C ₄H ₈).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.64 (d, J = 7.9, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 6.72 (d, J = 7.7, 1 H, -NH); 3.84 (s, 3H & d, J = 6.8, 2H); 3.76 (m, 1 H); 3.27 (m, 1 H); 2.78 (s, 3H); 1.99 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.35 (m, 4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example D.e37: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl ]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl ]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrim idin-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d37) the title compound is obtained as colorless solid.

MS (ESI): m/z = 568 (MH ⁺, 100 %); 512 (MH ⁺-C ₄H ₈); 468 (MH ⁺-C ₅H ₈O ₂).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.99 (s, 1 H); 8.96 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.19 (d, J = 13.3, 1 H); 6.91 (br.s, 1 H, -NH); 4.03 (m, 1 H); 3.85 (s, 3H); 3.84 (d, J = 6.8, 2H); 3.43 (m, 1 H); 2.78 (s, 3H); 1.77 (m, 2H); 1.64 (m, 6H); 1.40 (s, 9H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example D.e38: tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)^-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]-3-hydroxypiperidine-1- carboxylate

Starting from tert-butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyp henyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1-carboxylate (example D.d38) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 570 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.96 (s, 1 H); 8.84 (d, J = 7.3, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 5.24 (d, J = 4.9, 1 H, -OH); 3.99-3.73 (m, 3H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.43 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H & m, 1 H); 2.06 (m, 1 H); 1.42 (s, 9H); 1.37 (m, 1 H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example D.e39: tert-Butyl (3S*,4S*)-3-[({4-[2-(cyclopropylmethoxyH-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}c arbonyl)amino]-4-hydroxypiperidine-1- carboxylate

Starting from tert-butyl (3S*,4S*)-3-{[(4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyp henyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidin-7-yl)carbonyl]amino}-4- hydroxypiperidine-1 -carboxylate (example D.d39) the title compound is obtained as colorless solid. MS (ESI): m/z = 570 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.92 (s, 1 H); 8.86 (d, J = 7.5, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 5.09 (d, J = 4.6, 1 H, -OH); 3.84 (s, 3H & d, J = 6.8, 2H & m, 3H); 3.69 (m, 1 H); 3.53 (m, 1 H); 3.31 (m, 1 H); 2.79 (s, 3H); 1.90 (m, 1 H); 1.47 (m, 1 H); 1.31 (br.s, 9H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example D.e40: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6- methyl-5H-pyrrolo[3,2-cf]pyrimidin-7-yl}carbonyl)amino]piper idine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-6-me thyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d40) the title compound is obtained as colorless solid.

MS (ESI): m/z = 538 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.93 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.03 (d, J = 12.2, 1 H); 4.06 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.84 (m, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 1.92 (m, 2H); 1.42 (s, 9H & m, 2H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.e41 : tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylpheny l]-

6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]c yclohexyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylpheny l]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-cf]pyrimid in-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d41 ) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 552 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.63 (d, J = 7.7, 1 H, -NH); 7.54 (dd, J = 9.1 , 0.6, 1 H); 7.03 (d, J = 11.9, 1 H); 6.72 (d, J = 6.9, 1 H, -NH); 3.87 (d, J = 6.9, 2H); 3.76

(m, 1 H); 3.29 (m, 1 H); 2.77 (s, 3H); 2.25 (d, J = 1.1 , 3H); 1.99 (m, 2H); 1.86 (m, 2H); 1.39 (s, 9H);

1.35 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.23 (m, 2H). Example D.e42: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)^4-fluoro-5-methylphenyl] -6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl] -6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c(]pyrirnidin- 7-yl)carbonyl]arnino}cyclohexyl)carbarnate (example D.d42) the title compound is obtained as colorless viscous oil.

MS (ESI): m/z = 552 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .72 (s, 1 H, -NH); 8.97 (s, 1 H & d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.7, 1 H); 7.03 (d, J = 12.2, 1 H); 6.92 (br.s, 1 H, -NH); 4.04 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.43 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 1.81 -1 .52 (m, 8H); 1.40 (s, 9H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.e43: tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)^-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}car bonyl)amino]-3-hydroxypiperidine-1 - carboxylate

Starting from tert-butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylph enyl]-6-methyl-

5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy] pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1 -carboxylate (example D.d43) the title compound is obtained as colorless foam.

MS (ESI): m/z = 554 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.74 (s, 1 H, -NH); 8.93 (s, 1 H); 8.84 (d, J = 7.3, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.03 (d, J = 12.0, 1 H); 5.23 (d, J = 5.1 , 1 H, -OH); 3.99-3.74 (m, 3H); 3.87 (d, J = 6.9,

2H); 3.43 (m, 1 H); 2.98 (m, 1 H); 2.81 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.06 (m, 1 H); 1 .42

(s, 9H); 1.37 (m, 1 H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.e44: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]pip eridine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-m ethyl-5-{[2-

(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrimi din-7-yl)carbonyl]amino}piperidine-1 - carboxylate (example D.d44) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 554 (MH ⁺, 100%); 498 (MH ⁺-C ₄H ₈); 454 (MH+-C ₅H ₈O).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.92 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.47 (d,

J = 1 1.9, 1 H); 6.92 (d, J = 7.3, 1 H); 4.05 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.84 (m, 2H);

3.05 (m, 2H); 2.98 (s, 3H); 1.92 (m, 2H); 1.42 (s, 9H & m, 2H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m,

2H). Example D.e45: tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carb onyl)amino]cyclohexyl}carbamate Starting from (example D.d45) the title compound is obtained as colorless foam. The compound is further processed without characterisation. Example D.e46: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl ]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl ]-6-methyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrim idin-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d46) the title compound is obtained as colorless foam.

MS (ESI): m/z = 568 (MH ⁺, 100%); 512 (MH ⁺-C ₄H ₈); 468 (MH ⁺-C ₅H ₈O ₂).

¹H-NMR (300 MHz, DMSO-d ₆): 11.69 (s, 1 H, -NH); 8.98 (d, J = 7.8, 1 H, -NH); 8.96 (s, 1 H); 7.47 (d, J = 11.9, 1 H); 6.93 (d, J = 7.1 , 1 H); 6.92 (br.s, 1 H, -NH); 4.04 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.43 (m, 1 H); 2.79 (s, 3H); 1.76 (m, 2H); 1.64 (m, 6H); 1.40 (s, 9H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example D.e47: tert-Butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}c arbonyl)amino]-3-hydroxypiperidine-1- carboxylate

Starting from tert-butyl (3R*,4R*)-4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyp henyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7-yl)carbonyl]amino}-3- hydroxypiperidine-1-carboxylate (example D.d47) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 570 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.92 (s, 1 H); 8.85 (d, J = 7.3, 1 H, -NH); 7.42 (d, J = 11.9, 1 H); 6.92 (d, J = 7.3, 1 H); 5.23 (d, J = 4.9, 1 H, -OH); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H & m, 2H); 3.82 (m, 1 H); 3.43 (m, 1 H); 2.99 (m, 1 H); 2.79 (s, 3H & m, 1 H); 2.06 (m, 1 H); 1.42 (s, 9H & m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example D.e48: tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H- pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5-{[2 - (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-d]pyrimidin- 7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d48) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 534 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.45 (d,

J = 2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.4, 1 H); 4.06 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.84 (m, 2H); 3.05 (m, 2H); 2.78 (s, 3H); 2.64 (qu, J = 7.6, 2H); 1.93 (m, 2H); 1.45 (m, 2H); 1.43 (s,

9H); 1.18 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example D.e49: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methy l- 5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}ca rbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cydopropylmethoxy)-5-ethylphenyl]-6-methyl -5-{[2- (trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-c(]pyrirnidin- 7-yl)carbonyl]arnino}cyclohexyl)carbarnate (example D.d49) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 548 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.95 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.35 (dd, J = 8.4, 2.4, 1 H); 7.07 (d, J = 8.4, 1 H); 6.72 (d, J = 7.3, 1 H, -NH); 3.86 (d, J = 6.8, 2H); 3.75 (m, 1 H); 3.27 (m, 1 H); 2.77 (s, 3H); 2.63 (qu, J = 7.5, 2H); 2.00 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 1.17 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example D.e50: tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5H- pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carba mate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate

(example D.d50) the title compound is obtained as colorless solid.

MS (ESI): m/z = 548 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.98 (s, 1 H & d, J = 7.1 , 1 H, -NH); 7.45 (d, J =

2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 6.93 (br.s, 1 H, -NH); 4.04 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.43 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 1.85-1.54 (m, 8H); 1.40 (s, 9H);

1.19 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.e51 : tert-Butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4- hydroxypyrrolidine-1-carboxylate Starting from tert-butyl (3R*,4R*)-3-{[(4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-me thyl-5-{[2-

(trimethylsily^ethoxylmethylJ-δH-pyrroloIS^-dlpyrimidin^ -y^carbonyllaminoJ^-hydroxypyrrolidine-

1 -carboxylate (example D.d51 ) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.91 (s, 1 H); 8.85 (br.s, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.4, 1 H); 5.47 (d, J = 3.8, 1 H, -OH); 4.25 (m, 1 H); 4.19 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.68 (m, 1 H); 3.55 (m, 1 H); 3.22 (m, 2H); 2.78 (s, 3H); 2.63 (qu, J = 7.6, 2H); 1.43 (s, 9H); 1.18 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.e52: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl- 5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d52) the title compound is obtained as pale yellow viscous oil. MS (ESI): m/z = 548 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.75 (s, 1 H, -NH); 8.95 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 4.06 (m, 1 H); 3.87 (d, J = 6.8, 2H & m, 2H); 3.05 (m, 2H); 2.94 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 1 .92 (m, 2H); 1.45 (m, 2H); 1.43 (s, 9H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.e53: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl] -6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl] -6-methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrirnidi n-7-yl)carbonyl]arnino}cyclohexyl)carbarnate (example D.d53) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 692 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 8.99 (s, 1 H); 8.92 (d, J = 7.7, 1 H, -NH); 7.40 (dd, J = 8.6, 2.4, 1 H); 7.32 (d, J = 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 6.72 (br.d, J -8.6, 1 H, -NH); 5.41 (d, J = 1 1 .0, 1 H); 5.03 (d, J = 1 1.0, 1 H); 3.82 (dd, J = 10.2, 6.6, 1 H); 3.74 (dd, J = 10.2, 6.9, 1 H &m, 2H); 3.27 (m, 1 H); 2.99-2.80 (sept, J = 6.9, 1 H & m, 2H); 2.90 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1 .39 (s, 9H); 1 .37 (m, 4H); 1.22 (dd, J = 6.9, 2.4, 6H); 0.89 (m, 1 H); 0.49 (m, 2H); 0.32 (m, 2H); 0.05 (m, 2H); -0.19 (s, 9H). Example D.e54: tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6 - methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from tert-butyl (cis-4-{[(4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6 -methyl-5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}cyclohexyl)carbamate (example D.d54) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 562 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .72 (s, 1 H, -NH); 8.99 (s, 1 H); 8.98 (d, J = 7.1 , 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.40 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 6.82 (br.d, J -6.0, 1 H, -NH); 4.04 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.43 (m, 1 H); 2.95 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 1.85-1.52 (m, 8H); 1.40 (s, 9H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.e55: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2- yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbo nyl)amino]piperidine-1-carboxylate Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrimidin-7- yl)carbonyl]amino}piperidine-1 -carboxylate (example D.d55) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 722 (MH ⁺, 100%). ¹ H-NMR (400 MHz, DMSO-d ₆): 9.08 (d, J = 7.6, 1 H, -NH); 9.00 (s, 1 H); 7.57 (dd, J = 8.7, 2.3, 1 H); 7.50 (d, J = 2.3, 1 H); 7.15 (d, J = 8.7, 1 H); 5.40 (d, J = 1 1.0, 1 H); 5.04 (d, J = 1 1.0, 1 H); 4.09 (m, 1 H); 4.00 (m, 2H); 3.90-3.70 (m, 6H); 3.06 (m, 2H); 2.97-2.83 (s, 3H & m, 2H); 1 .99 (s, 3H); 1 .94 (m, 2H); 1.46 (m, 2H); 1.43 (s, 9H); 0.90 (m, 1 H); 0.49 (m, 2H); 0.33 (m, 2H); 0.07 (m, 2H); -0.20 (s, 9H).

Example D.e56: tert-Butyl {trans^4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan- 2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbon yl)amino]cyclohexyl}carbamate Starting from tert-butyl (trans-4-{[(4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]- 6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3 ,2-c(]pyrimidin-7- yl)carbonyl]amino}cyclohexyl)carbamate (example D.d56) the title compound is obtained as pale yellow viscous oil.

MS (ESI): m/z = 606 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.75 (s, 1 H, -NH); 8.97 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.66 (d, J = 2.4, 1 H); 7.55 (dd, J = 8.7, 2.4, 1 H); 7.14 (d, J = 8.7, 1 H); 6.72 (br.d, J ~ 7.3, 1 H, -NH); 3.99 (m, 2H); 3.90 (d, J = 6.9, 2H); 3.76 (m, 1 H); 3.71 (m, 2H); 3.27 (m, 1 H); 2.77 (s, 3H); 2.01 (m, 2H); 1.99 (s, 3H); 1.86 (m, 2H); 1.39 (s, 9H); 1.34 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.e57: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- 5/-/- pyrroloβ^-cdpyrimidin^-yljcarbony^aminojpiperidine-i -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- 5-{[2- (trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrimidin -7-yl)carbonyl]amino}piperidine-1 - carboxylate (example D.d57) the title compound is obtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺ , 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1 .58 (s, 1 H, -NH); 9.04 (d, J = 7.7, 1 H, -NH); 7.38 (d, J = 2.2, 1 H); 7.31 (dd, J = 8.4, 2.2, 1 H); 7.04 (d, J = 8.4, 1 H); 4.13-3.99 (m, 1 H); 3.89-3.74 (m, 4H); 3.12 (m, 2H); 2.74 (s, 3H); 2.72 (s, 3H); 2.32 (s, 3H); 1.97-1.86 (m, 2H); 1.48 (m, 2H); 1.43 (s, 9H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H). Example D.e58: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6 - dimethyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]pipe ridine-1 -carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2,6 -dimethyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-c(]pyrim idin-7-yl)carbonyl]amino}piperidine-1 - carboxylate (example D.d58) the title compound is obtained as colorless foam.

MS (ESI) : 568 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .56 (s, 1 H, -NH); 9.04 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 1 1.7, 1 H); 6.91 (d, J = 7.3, 1 H); 4.06 (m, 1 H); 3.96 (s, 3H); 3.93 (d, J = 6.9, 2H); 3.87-3.73 (m, 2H); 3.12 (m, 2H); 2.75 (s, 3H); 2.71 (s, 3); 1.98-1.85 (m, 2H); 1.46 (m, 2H); 1.42 (s, 9H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.24 (m, 2H).

Example D.e59: tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6 - dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]p iperidine-1-carboxylate

Starting from tert-butyl 4-{[(4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6 -dimethyl-5- {[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2-cy]pyrim idin-7-yl)carbonyl]amino}piperidine-1- carboxylate (example D.d59) the title compound is obtained as colorless foam.

MS (ESI): m/z = 568 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.60 (s, 1 H, -NH); 9.02 (d, J = 7.7, 1 H, -NH); 7.33 (d, J = 9.9, 1 H); 7.16 (d, J = 13.3, 1 H); 4.05 (m, 1 H); 3.84 (s, 3H); 3.82 (d, J = 6.8, 2H); 3.78 (m, 2H); 3.12 (m, 2H); 2.74 (s, 3H); 2.73 (s, 3H); 1.99-1.86 (m, 2H); 1.47 (m, 2H); 1.42 (s, 9H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H). The following compounds were prepared analogously to the procedure described in above example D.d 1

Example D.e60: tert.-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-cf]pyrimidin-7-yl}carbonyl)amino]piper idine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylic acid (example D.g1 ) and commercially available tert-butyl 4-amino- piperidine-1 -carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 556 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.85 (s, 1 H, -NH); 8.98 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.83 (d, J = 2.0, 1 H); 7.74 (dd, J = 8.8, 2.0, 1 H); 7.31 (d, J = 8.8, 1 H); 7.08 (t, J = 56.0, 1 H); 4.07 (m, 1 H);

3.96 (d, J = 6.9, 2H); 3.91 -3.79 (m, 2H); 3.05 (m, 2H); 2.79 (s, 3H); 1.93 (m, 2H); 1.43 (s, 9H & m,

2H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e61 : tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phen yl]- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]c yclohexyl}carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1 ) and commercially available tert-butyl trans-(4-amino- cyclohexyl)-carbamate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 570 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.82 (s, 1 H, -NH); 8.98 (s, 1 H); 8.64 (d, J = 7.9, 1 H, -NH); 7.82 (d, J = 2.0, 1 H); 7.74 (dd, J = 8.6, 2.0, 1 H); 7.31 (d, J = 8.6, 1 H); 7.08 (t, J = 56.0, 1 H); 6.72 (br.d, J = 8.2, 1 H, -NH); 3.96 (d, J = 6.9, 2H); 3.76 (m, 1 H); 3.29 (m, 1 H); 2.78 (s, 3H); 1.98 (m, 2H); 1.85 (m, 2H); 1.39 (s, 9H); 1.36 (m, 4H); 0.97 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H). Example D.e62: fert-Butyl {(1 S*,2S*,4S*)^-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl) phenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl) amino]-2-fluorocyclohexyl}carbamate Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c^pyrimidine^-carboxylic acid (example D.g1 ) and fert-butyl [(1 S*,2S*,4S*)-4-amino-2- fluorocyclohexyl]carbamate (example C22) the title compound is obtained as pale yellow foam. MS (ESI): m/z = 588 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.85 (s, 1 H, -NH); 8.99 (s, 1 H); 8.73 (d, J = 7.7, 1 H, -NH); 7.83 (d, J = 2.0, 1 H); 7.74 (dd, J = 8.6, 2.0, 1 H); 7.31 (d, J = 8.6, 1 H); 7.08 (t, J = 56.0, 1 H); 6.93 (br.s, 1 H, - NH); 4.41 (m, 1 H); 3.96 (d, J = 6.9, 2H); 3.90 (m, 1 H); 3.51 (m, 1 H); 2.78 (s, 3H); 2.41 (m, 1 H); 1.99-1 .77 (m, 2H); 1 .65 (m, 1 H); 1 .40 (s, 9H & m, 2H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e63: fert-Butyl {(1 S*,3S*,4S*)^-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl) phenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl) amino]-3-methylcyclohexyl}carbamate Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1 ) and fert-butyl [(1 R*,3R*,4R*)-4-amino-3- methylcyclohexyl]carbamate (example C1 1 ) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 584 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.58 (d, J = 8.6, 1 H, -NH); 7.83 (s, 1 H); 7.75 (d, J = 8.8, 1 H); 7.31 (d, J = 8.8, 1 H); 7.09 (t, J = 56.2, 1 H); 6.78 (d, J = 7.7, 1 H, -NH);

3.96 (d, J = 6.8, 2H); 3.49 (m, 1 H); 3.35 (m, 1 H); 2.79 (s, 3H); 2.03-1.75 (m, 4H); 1.58 (m, 1 H);

1.391 (s, 9H); 1 .38-1.21 (m, 1 H); 1.06 (m, 1 H); 0.99 (m, 1 H); 0.94 (d, J = 6.4, 3H); 0.39 (m, 2H);

0.28 (m, 2H). Example D.e64: fert-Butyl {(1 S,3S)-3-[({4-[2-(cyclopropylmethoxy)-5-

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyri midin-7- yl}carbonyl)amino]cyclopentyl}carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1 ) and fert-butyl [(1 S,3S)-3- aminocyclopentyl]carbamate hydrochloride (example C6) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 556 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .82 (s, 1 H, -NH); 8.98 (s, 1 H); 8.75 (d, J = 7.3, 1 H, -NH); 7.83 (t,

J = 1.1 , 1 H); 7.74 (td, J = 8.7, 1.1 , 1 H); 7.31 (d, J = 8.7, 1 H); 7.08 (t, J = 56.0, 1 H); 6.95 (br.d, J ~ 5.5, 1 H, -NH); 4.42 (m, 1 H); 3.98 (m, 1 H); 3.96 (d, J = 7.1 , 2H); 2.78 (s, 3H); 2.20-1.98 (m, 2H);

1.84 (m, 2H); 1.49 (m, 2H); 1.40 (s, 9H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example D.e65: N-[(1 S*,3S*,4S*)-4-Azido-3-methylcyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c^pyrimidine^-carboxylic acid (example D.g1) and (1R*,3R*,4R*)-4-azido-3- methylcyclohexanamine hydrochloride (example C12) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.98 (s, 1H); 8.65 (d, J = 8.4, 1H, -NH); 7.83 (s, 1H); 7.75 (d, J = 8.6, 1H); 7.31 (d, J = 8.6, 1H); 7.09 (t, J = 55.8, 1H); 3.96 (d, J = 7.1, 2H); 3.88 (m, 1H); 3.12 (m, 1H); 2.78 (s, 3H); 2.13-1.99 (m, 3H); 1.62-1.37 (m, 3H); 1.21 (m, 1H); 1.02 (d, J = 6.5, 3H); 0.97 (m, 1H); 0.38 (m, 2H); 0.27 (m, 2H).

Example D.e66: fert-Butyl (2S,4S)-4-[({4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid in-7-yl}carbonyl)amino]-2- methylpyrrolidine-1-carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1)and commercially available fert-butyl (2S,4S)-4- amino-2-methylpyrrolidine-1-carboxylate the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 557 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.94 (s, 1H); 8.87 (d, J = 6.2, 1H, -NH); 7.83 (s, 1H); 7.74 (d, J = 8.7, 1H); 7.31 (d, J = 8.7, 1H); 7.08 (t, J = 56.0, 1H); 4.55 (m, 1H); 3.96 (d, J = 7.0, 2H& m, 1H); 3.61 (m, 1H); 3.29 (m, 1H); 2.79 (s, 3H); 2.14 (m, 1H); 1.92 (m, 1H); 1.41 (s, 9H); 1.23 (d, J = 5.6, 3H); 0.97 (m, 1H); 0.38 (m, 2H); 0.26 (m, 2H). Example D.e67: N-[(1R*,2R*,4R*H-Azido-2-fluorocyclohexyl]-4-[2-(cyclopropyl methoxy)-

5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]py rimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1) and (1S*,2S*,4S*)^4-azido-2-fluorocyclohexanamine hydrochloride (example C23) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 514 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.89 (s, 1H, -NH); 8.99 (s, 1H); 8.80 (d, J = 8.2, 1 H, -NH); 7.83 (t, J = 1.0, 1H); 7.75 (td, J = 8.6, 1.0, 1H); 7.31 (d, J = 8.6, 1H); 7.09 (t, J = 56.0, 1H); 4.69 (tdd, J = 49.9, 10.0, 4.5, 1H); 4.11 (m, 1H); 3.96 (d, J = 6.9, 2H); 3.69 (m, 1H); 2.79 (s, 3H); 2.43 (m, 1H); 2.06 (m, 1H); 1.95 (m, 1H); 1.68 (m, 1H); 1.50 (m, 2H); 0.98 (m, 1H); 0.39 (m, 2H); 0.26 (m, 2H).

Example D.e68: fert-Butyl {(1S*,2S*,4R*)^-[({4-[2-(cyclopropylmethoxy)-5-(difluorometh yl) phenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl) amino]-2-methylcyclopentyl}carbamate Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cflpyπmicline-7-carboxylic acid (example D.g1 ) and fert-butyl [(1 S*,2S*,4R*)-4-amino-2- methylcyclopentyl]carbamate (example C33) the title compound is obtained as pale yellow foam. MS (ESI): m/z = 570 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.83 (s, 1 H, -NH); 8.99 (s, 1 H); 8.78 (d, J = 7.5, 1 H, -NH); 7.83 (d, J = 1.1 , 1 H); 7.74 (dd, J = 8.7, 1 .1 , 1 H); 7.31 (d, J = 8.7, 1 H); 7.09 (t, J = 56.0, 1 H); 6.87 (d, J = 8.2, 1 H, -NH); 4.37 (m, 1 H); 3.97 (d, J = 6.9, 2H); 3.55 (m, 1 H); 2.78 (s, 3H); 2.30 (m, 1 H); 1.95-1 .72 (m, 3H); 1.40 (s, 9H); 1.20 (m, 1 H); 1.04 (d, J = 6.6, 3H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example D.e69: N-[(1 R*,2R*,4S*H-Azido-2-methylcyclopentyl]-4-[2-

(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5 /-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1 ) and (1 S*,2S*,4R*)-4-azido-2- methylcyclopentanamine hydrochloride (example C34) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.86 (s, 1 H, -NH); 8.98 (s, 1 H); 8.74 (d, J = 7.9, 1 H, -NH); 7.83 (dd, J = 0.9, 0.9, 1 H); 7.74 (ddd, J = 8.7, 0.9, 0.9, 1 H); 7.31 (d, J = 8.7, 1 H); 7.08 (t, J = 56.0, 1 H); 4.20 (m, 1 H); 4.04 (m, 1 H); 3.96 (d, J = 7.1 , 2H); 2.79 (s, 3H); 2.39 (m, 1 H); 2.13 (m, 1 H); 2.03-1.83 (m, 2H); 1.31 (m, 1 H); 1 .09 (d, J = 7.1 , 3H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.e70: fert-Butyl {(1 S*,2S*,4S*H-[({4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7-yl}carbonyl)amino]-2- fluorocyclopentyljcarbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxylic acid (example D.g1 ) and fert-butyl [(1 R*,2R*,4R*)-4-amino-2- fluorocyclopentyl]carbamate (example C44) the title compound is obtained as pale yellow foam. MS (ESI): m/z = 574 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.84 (s, 1 H, -NH); 8.97 (s, 1 H); 8.90 (d, J = 7.5, 1 H, -NH); 7.83

(~s, 1 H); 7.74 (~d, J = 8.6, 1 H); 7.31 (d, J = 8.6, 1 H); 7.14 (br.d, J ~ 5.1 , 1 H, -NH); 7.08 (t, J = 55.9, 1 H); 4.93 (dm, J = 52.2, 1 H); 4.60 (m, 1 H); 4.09 (m, 1 H); 3.96 (d, J = 6.9, 2H); 2.79 (s, 3H); 2.44 (m, 1 H); 2.03 (m, 2H); 1 .83 (m, 1 H); 1.41 (s, 9H); 0.98 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example D.e71 : N-[(1 R*,2R*,4R*)^4-azido-2-fluorocyclopentyl]^4-[2-(cyclopropylme thoxy)-

5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylic acid (example D.g1 ) and (1 R*,2R*,4R*)-4-azido-2- fluorocyclopentanamine hydrochloride (example C45) the title compound is obtained as pale yellow foam.

MS (ESI): m/z = 500 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.85 (d, J = 7.5, 1 H, -NH); 7.83 (~s, 1 H); 7.74 (~d, J = 8.7, 1 H); 7.31 (d, J = 8.7, 1 H); 7.08 (t, J = 56.0, 1 H); 5.16 (dm, J = 53.7, 1 H); 4.59 (m, 1 H); 4.37 (m, 1 H); 3.96 (d, J = 7.1 , 2H); 2.79 (s, 3H); 2.67-2.47 (m, 1 H); 2.26-1.86 (m, 3H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.e72: fert-Butyl {(1 S ^*,2R ^*,4S ^*)-4-[({4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid in-7-yl}carbonyl)amino]-2- fluorocyclohexyl}carbamate

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylic acid (example D.g1 ) and fert-butyl [(1 R ^*,2S ^*,4R ^*)-4-amino-2- fluorocyclohexyl]carbamate (example C55) the title compound is obtained as pale yellow foam. HR-MS (ESI): m/z = 588.2797 ([MH] ⁺, C ₃₀H ₃₇F ₃N ₅O ₄ ⁺, calc. 588.2792).

¹H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.99 (s, 1 H); 8.63 (d, J = 7.9, 1 H, -NH); 7.83 (s, 1 H); 7.75 (d, J = 8.7, 1 H); 7.31 (d, J = 8.7, 1 H); 7.09 (t, J = 55.8, 1 H); 6.97 (d, J = 7.7, 1 H); 4.86 (~d, J = 50.3, 1 H); 4.12 (m, 1 H); 3.96 (d, J = 7.1 , 2H); 3.55 (m, 1 H); 2.79 (s, 3H); 2.30 (m, 1 H); 1.99 (m, 1 H); 1.85-1.60 (m, 3H); 1.55 (m, 1 H); 1.41 (s, 9H); 0.95 (m,1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.e73: N-[(1 S*,2R*,4S*)-4-Azido-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxylic acid (example D.g1 ) and (1 R ^*,2S ^*,4R ^*)-4-azido-2-fluorocyclohexanamine hydrochloride (example C56) the title compound is obtained as pale yellow foam.

HR-MS (ESI): m/z = 514.2176 ([MH] ⁺, C ₂₅H ₂₇F ₃N ₇O ₂ ⁺, calc. 514.2173).

¹H-NMR (400 MHz, DMSO-d ₆): 11.92 (s, 1 H, -NH); 8.99 (s, 1 H); 8.98 (d, J = 6.9, 1 H, -NH); 7.84 (~s, 1 H); 7.75 (~d, J = 8.7, 1 H); 7.32 (d, J = 8.7, 1 H); 7.09 (t, J = 56.0, 1 H); 4.99 (~d, J = 50.1 , 1 H); 4.20 (dm, J = 31.9, 1 H); 3.97 (d, J = 7.0, 2H); 3.77 (m, 1 H); 2.80 (s, 3H); 2.33 (m, 1 H); 2.05 (m, 1 H); 1.96-1.67 (m, 3H); 1.59 (m, 1 H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example D.fl: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-piperidin-4-yl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

tert-Butyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-αf]pyrimidin- 7-yl}carbonyl)amino]piperidine-1-carboxylate from example D.e1 (2.72 g; 4.95 mmol) is dissolved in dry 2-propanol (50 mL). After addition of 4M HCI in dioxane (5.0 mL) the stirred reaction mixture is haeted to 80 ⁰C for two hours. At ambient temperature tert.-butyl methyl ether (100 mL) is added. The precipitated product is isolated by sucction filtration, washed with several portions of tert.-butyl methyl ether and dried in high vacuo at 40 ⁰C to yield the title compound as yellow solid.

MS (ESI): m/z = 450 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.38 (s, 1 H, -NH); 9.03 (s, 1 H); 9.00 (br.s, 2H, -NH ₂ ⁺); 8.66 (d, J = 7.5, 1 H, -NH); 7.04 (d, J = 8.6, 1 H); 6.58 (d, J = 8.6, 1 H); 6.03 (s, 2H); 4.15 (m, 1 H); 3.78 (d, J = 6.8, 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.80 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.90 (m, 1 H); 0.32 (m, 2H); 0.15 (m, 2H).

The following compounds were prepared analogously to the procedure described in above example D.f1.

Example D.f2: N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4- yl]-6-methyl-5H-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e2) the title compound is obtained as yellow solid.

MS (ESI): m/z = 464 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.27 (s, 1 H, -NH); 8.98 (s, 1 H); 8.54 (d, J = 7.9, 1 H, -NH); 8.04 (br.d, J - 4.8, 3H, -NH ₃ ⁺); 7.04 (d, J = 8.6, 1 H); 6.57 (d, J = 8.6, 1 H); 6.02 (s, 2H); 3.80 (m, 1 H); 3.77 (d, J = 6.8, 2H); 3.09 (m, 1 H); 2.79 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.14 (m, 2H).

Example D.f3: N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-

6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/- pyrrolo[3,2-cdpyrimidin-7-yl}carbonyl)amino]cyclohexyl}carba mate (example D.e3) the title compound is obtained as yellow solid.

MS (ESI): m/z = 464 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.40 (s, 1 H, -NH); 9.10 (s, 1 H); 8.91 (d, J = 7.5, 1 H, -NH); 8.15 (br.s, 3H, -NH ₃ ⁺); 7.05 (d, J = 8.6, 1 H); 6.58 (d, J = 8.6, 1 H); 6.04 (s, 2H); 4.12 (m, 1 H); 3.79 (d, J =

6.8, 2H); 3.17 (m, 1 H); 2.81 (s, 3H); 1.96-1.64 (m, 8H); 0.91 (m, 1 H); 0.33 (m, 2H); 0.16 (m, 2H).

Example D.f4: 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamid e hydrochloride

Starting from tert-butyl (3R)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpyrrolidine-i -carboxylate (example D.e4) the title compound is obtained as yellow solid.

MS (ESI): m/z = 436 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 12.39 (s, 1 H, -NH); 9.32 (br.s, 2H, -NH ₂ ⁺); 9.02 (s, 1 H); 8.80 (d, J = 6.8, 1 H, -NH); 7.04 (d, J = 8.6, 1 H); 6.58 (d, J = 8.6, 1 H); 6.03 (s, 2H); 4.63 (m, 1 H); 3.78 (d, 6.8, 2H); 3.52 (m, 1 H); 3.39 (m, 1 H); 3.26 (m, 1 H); 3.17 (m, 1 H); 2.79 (s, 3H); 2.34 (m, 1 H); 2.01 (m, 1 H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.14 (m, 2H).

Example D.f5: 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4- hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine -7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-3-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrro lidine-1-carboxylate (example D.e5) the title compound is obtained as yellow solid.

MS (ESI): m/z = 452 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.04 (s, 1 H); 7.05 (d, J = 8.6, 1 H); 6.60 (d, J = 8.6, 1 H); 6.04 (s, 2H); 4.43 (m, 2H); 3.79 (d, J = 6.9, 2H); 3.67 (m, 1 H); 3.47 (m, 1 H); 3.33 (m, 1 H); 3.20 (m, 1 H); 2.81 (s, 3H); 0.91 (m, 1 H); 0.33 (m, 2H); 0.16 (m, 2H).

Example D.f6: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-5/-/ -pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate (example D.e6) the title compound is obtained as yellow solid.

MS (ESI): m/z = 424 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.03 (s. 1 H); 8.99 (br.s, 2H, -NH ₂ ⁺); 8.71 (d, J = 7.7, 1 H, -NH); 7.68 (dd, J = 8.4, 6.9, 1 H); 7.12 (dd, J = 1 1.7, 2.4, 1 H); 6.99 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.15 (m, 1 H); 3.93 (d, J = 7.1 , 2H); 3.31 (m, 2H); 3.07 (m, 2H); 2.80 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.26 (m, 2H).

Example D.f7: N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-meth yl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e7) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.18 (s, 1 H, -NH); 9.00 (s, 1 H); 8.56 (d, J = 7.8, 1 H, -NH); 8.10

(br.s, 3H, -NH ₃ ⁺); 7.68 (dd, 8.4, 6.9, 1 H); 7.12 (dd, 1 1.7, 2.4, 1 H); 7.00 (ddd, 8.4, 8.4, 2.4, 1 H); 3.93 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.08 (m, 1 H); 2.81 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.96 (m, 1 H);

0.38 (m, 2H); 0.26 (m, 2H). Example D.f8: N-(cis-4-aminocyclohexyl)^4-[2-(cydopropylmethoxy)^4-fluorop henyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl -5H-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate (example D.e8) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.09 (s, 1 H); 8.97 (d, J = 7.5, 1 H, -NH); 8.14 (br.s, 3H, -NH ₃ ⁺); 7.69 (dd, 8.6, 6.9, 1 H); 7.12 (dd, 1 1.7, 2.4, 1 H); 7.00 (ddd, 8.6, 8.6, 2.4, 1 H); 4.13 (m, 1 H); 3.93 (d, J = 7.1 , 2H); 3.18 (m, 1 H); 2.81 (s, 3H); 1.87 (m, 4H); 1.74 (m, 4H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.f9: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-

5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl -5H-pyrrolo[3,2- d]pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1-carboxylate (example D.e9) the title compound is obtained as yellow solid.

MS (ESI): m/z = 410 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.31 (br.s, 2H, -NH ₂ ⁺); 9.01 (s, 1 H); 8.85 (d, J =

6.6, 1 H, -NH); 7.68 (dd, J = 8.4, 6.9, 1 H); 7.11 (dd, J = 1 1.7, 2.4, 1 H); 6.99 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.63 (m, 1 H); 3.93 (d, J = 7.1 , 2H); 3.51 (m, 1 H); 3.39 (m, 1 H); 3.27 (m, 1 H); 3.16 (m, 1 H);

2.80 (s. 3H); 2.35 (m, 1 H); 2.01 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example D.f10: 4-[2-(CyclopropylmethoxyH-fluorophenyl]-N-[(3R*,4R*)-4- hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrro lidine-1-carboxylate (example D.e10) the title compound is obtained as yellow solid.

MS (ESI): m/z = 426 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.07 (s, 1 H, -NH); 9.42 (br.s, 2H, -NH ₂ ⁺); 8.99 (s, 1 H); 8.85 (d, J = 6.0, 1 H, -NH); 7.68 (dd, J = 8.4, 6.9, 1 H); 7.11 (dd, J = 1 1.7, 2.4, 1 H); 6.98 (ddd, J = 8.4, 8.4, 2.4,

1 H); 4.53-4.34 (m, 2H); 3.92 (d, 7.1 , 2H); 3.63 (m, 1 H); 3.43 (m, 1 H); 3.27 (m, 1 H); 3.16 (m, 1 H);

2.80 (s. 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H).

Example D.f11: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride

Starting from tert-butyl (3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-m ethyl-5/-/- pyrrolop^-cyjpyrimidin^-ylJcarbonyOaminol-S-hydroxypiperidin e-i -carboxylate (example D.e11 ) the title compound is obtained as yellow solid. MS (ESI): m/z = 440 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 12.20 (s, 1 H, -NH); [9.37 (br.s), 9.04 (br.s), 2H, -NH ₂ ⁺); 9.04 (s, 1 H); 8.78 (d, J = 7.3, 1 H, -NH); 7.69 (dd, J = 8.6, 6.9, 1 H); 7.12 (dd, J = 1 1.7, 2.4, 1 H); 7.00 (ddd, J = 8.6, 8.6, 2.4, 1 H); 4.02 (m, 1 H); 3.93 (d, 7.1 , 2H); 3.63 (m, 1 H); 3.88 (m, 1 H); 3.26 (m, 2H); 3.05 (m, 1 H); 2.86 (m, 1 H); 2.82 (s. 3H); 2.24 (m, 1 H); 1.76 (m, 1 H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.27 (m, 2H).

Example D.f12: 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- cf]pyπmidine-7-carboxylic acid piperidin-4-ylamide hydrochloride

Starting from tert-butyl 4-({1 -[4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrro lo[3,2- c(]pyrimidin-7-yl]-methanoyl}-amino)-piperidine-1 -carboxylate (example D.e12) the title compound is obtained as yellow solid.

MS (ESI): m/z = 424 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 12.03 (br.s, 1 H, -NH); 9.02 (s, 1 H); 8.78 (br.s, 2H, -NH ₂ ⁺); 8.75 (d, J = 6.5, 1 H, -NH); 7.44 (dd, J = 9.0, 3.2, 1 H); 7.40 (ddd, J = 9.1 , 8.2, 3.2, 1 H); 7.20 (dd, J = 9.1 , 4.4,

1 H); 4.15 (m, 1 H); 3.88 (d, J = 7.0, 2H); 3.32 (m, 2H); 3.08 (m, 2H); 2.80 (s, 3H); 2.13 (m, 2H); 1.78

(m, 2H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.f13: N-(trans-4-aminocyclohexyl)-4-[2-(cydopropylmethoxy)-5-fluor ophenyl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e13) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 12.04 (s, 1 H, -NH); 8.99 (s, 1 H); 8.60 (d, J = 7.9, 1 H, -NH); 8.07

(br.s, 3H, -NH ₃ ⁺); 7.44 (dd, J = 8.4, 3.2, 1 H); 7.39 (ddd, J = 8.9, 8.3, 3.2, 1 H); 7.20 (dd, J = 8.9, 4.3,

1 H); 3.88 (d, J = 7.1 , 2H); 3.81 (m, 1 H); 3.09 (m, 1 H); 2.80 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.94

(m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example D.f14: N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro phenyl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl -5/-/-pyrrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate (example D.e14) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 12.10 (br.s, 1 H, -NH); 9.08 (s, 1 H); 8.98 (d, J = 7.5, 1 H, -NH); 8.15 (br.s, 3H, -NH ₃ ⁺); 7.46 (dd, J = 8.9, 3.3, 1 H); 7.41 (ddd, J = 8.9, 8.6, 3.3, 1 H); 7.21 (dd, J = 9.1 , 4.4, 1 H); 4.12 (m, 1 H); 3.89 (d, J = 6.9, 2H); 3.18 (m, 1 H); 2.81 (s, 3H); 1.95-1.67 (m, 8H); 0.95 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.f15: 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3- yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl -5/-/-pyrrolo[3,2- c^pyrimidin-7-yl}carbonyl)amino]pyrrolidine-1-carboxylate (example D.e15) the title compound is obtained as yellow solid.

MS (ESI): m/z = 410 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.34 (br.s, 2H, -NH ₂ ⁺); 9.02 (s, 1 H); 8.86 (d, J = 6.6, 1 H, -NH); 7.46 (dd, J = 8.9, 3.2, 1 H); 7.41 (ddd, J = 9.1 , 8.4, 3.2, 1 H); 7.21 (dd, J = 9.1 , 4.4, 1 H); 4.64 (m, 1 H); 3.89 (d, J = 6.9, 2H); 3.50 (m, 1 H); 3.39 (m, 1 H); 3.27 (m, 1 H); 3.16 (m, 1 H); 2.81 (s, 3H); 2.35 (m, 1 H); 2.01 (m, 1 H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.23 (m, 2H). Example D.f16: 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine- 7-carboxamide hydrochloride

Starting from tert-butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-m ethyl-5/-/- pyrroloβ^-cdpyrimidin^-ylJcarbony^aminoJ-S-hydroxypiperidin e-i -carboxylate (example D.e16) the title compound is obtained as yellow solid.

MS (ESI): m/z = 440 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.05 (s, 1 H); 7.46 (ddd, J = 9.1 , 8.8, 3.1 , 1 H); 7.40 (dd, J = 8.2, 3.1 , 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.03 (m, 1 H); 3.90 (d, J = 6.9, 2H & m, 1 H); 3.30 (m, 1 H); 3.25 (m, 1 H); 3.09 (m, 1 H); 2.90 (m, 1 H); 2.82 (s, 3H); 2.27 (m, 1 H); 1.76 (m, 1 H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f17: 4-(2-Ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5/-/ -pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-({[4-(2-ethoxy-5-fluorophenyl)-6-methyl-5H-pyrrolo[3,2-c^p yrimidin-7- yl]carbonyl}amino)piperidine-1-carboxylate (example D.e17) the title compound is obtained as yel- low solid.

MS (ESI): m/z = 398 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.11 (br.s, 1 H, -NH); 9.02 (s, 1 H); 8.96 (br.s, 2H, -NH ₂ ⁺); 8.72 (d, J = 7.5, 1 H, -NH); 7.45 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.41 (dd, J = 8.2, 3.3, 1 H); 7.24 (dd, J = 9.1 , 4.4, 1 H); 4.14 (m, 1 H); 4.08 (qu, J = 6.9, 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.80 (s, 3H); 2.12 (m, 2H); 1.78 (m, 2H); 1.11 (t, J = 6.9, 3H).

Example D.f18: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-piperi din^4-yl- 5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2- dlpyrimidin-y-yljcarbonyljaminolpiperidine-i-carboxylate (example D.e18) the title compound is obtained as yellow solid.

MS (ESI): m/z = 436 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.28 (br.s, 1 H, -NH); 9.04 (s, 1 H); 8.98 (br.s, 2H, -NH ₂ ⁺); 8.66 (d, J = 7.5, 1 H, -NH); 7.62 (d, J = 8.4, 1 H); 6.77 (dd, J = 8.4, 2.2, 2H); 6.73 (d, J = 2.2, 1 H); 4.03 (m, 1 H);

3.93 (d, J = 6.9, 2H); 3.88 (s, 3H); 3.31 (m, 2H); 3.08 (m, 2H); 2.82 (s, 3H); 2.12 (m, 2H); 1.79 (m, 2H); 0.97 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example D.f19: N-(trans-4-aminocyclohexyl)-4-[2-(cydopropylmethoxy)-4-metho xyphenyl]-

6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-met hyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e19) the title compound is obtained as yellow solid.

MS (ESI): m/z = 450 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.39 (s, 1 H, -NH); 9.03 (s, 1 H); 8.48 (d, J = 7.7, 1 H, -NH); 8.1 1 (br.d, J ~ 4.2, 3H, -NH ₃ ⁺); 7.62 (d, J = 8.4, 1 H); 6.78 (dd, J = 8.4, 2.2, 1 H); 6.74 (d, J = 2.2, 1 H );

3.94 (d , J = 6.9, 2H); 3.88 (s, 3H); 3.81 (m, 1 H); 3.08 (m, 1 H); 2.83 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.97 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.f20: N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-methox yphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e20) the title compound is obtained as yellow solid.

MS (ESI): m/z = 450 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.35 (br.s, 1 H, -NH); 9.14 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 8.19 (br.s, 3H, -NH ₃ ⁺); 7.63 (d, J = 8.4, 1 H); 6.78 (dd, J = 8.4, 2.2, 2H); 6.75 (d, J = 2.2, 1 H ); 4.14 (m, 1 H); 3.94 (d , J = 6.9, 2H); 3.88 (s, 3H); 3.18 (m, 1 H); 2.83 (s, 3H); 1.96-1.66 (m, 8H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example D.f21: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin- 3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methy l-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpyrrolidine-i -carboxylate (example D.e21 ) the title compound is obtained as yellow solid.

MS (ESI): m/z = 422 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 12.28 (br.s, 1 H, -NH); 9.31 (br.s, 2H, -NH ₂ ⁺); 9.02 (s, 1 H); 8.81 (d, J = 6.8, 1 H, -NH); 7.63 (d, J = 8.4, 1 H); 6.77 (dd, J = 8.4, 2.2, 2H); 6.73 (d, J = 2.2, 1 H ); 4.63 (m, 1 H); 3.93 (d , J = 7.1 , 2H); 3.88 (s, 3H); 3.51 (m, 1 H); 3.39 (m, 1 H); 3.27 (m, 1 H); 3.16 (m, 1 H); 2.82 (s, 3H); 2.35 (m, 1 H); 2.01 (m, 1 H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.27 (m, 2H).

Example D.f22: 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*H- hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6- methyl-5/-/- pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrro lidine-1-carboxylate (example D.e22) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.36 (br.s, 1 H, -NH); [9.64 (br.s, 1 H), 9.48 (br.s, 1 H), -NH ₂ ⁺]; 9.01 (s, 1 H); 8.78 (d, J = 6.2, 1 H, -NH); 7.63 (d, J = 8.4, 1 H); 6.77 (dd, J = 8.4, 2.2, 2H); 6.74 (d, J = 2.2, 1 H ); 4.39 (m, 2H); 3.94 (d , J = 6.9, 2H); 3.88 (s, 3H); 3.63 (m, 1 H); 3.43 (m, 1 H); 3.26 (m, 1 H); 3.15 (m, 1 H); 2.82 (s, 3H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.27 (m, 2H).

Example D.f23: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din^4-yl-

5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5/- /-pyrrolo[3,2- cdpyrimidin^-yljcarbony^aminojpiperidine-i-carboxylate (example D.e23) the title compound is obtained as yellow solid.

MS (ESI): m/z = 436 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.12 (s, 1 H, -NH); 9.04 (s, 1 H); 8.94 (br.s, 2H, -NH ₂ ⁺); 8.72 (d, J =

7.5, 1 H, -NH); 7.20 (t, J = 1.6, 1 H); 7.15 (d, J = 1.6, 1 H); 4.16(m, 1 H); 3.84 (d, J = 6.8, 2H); 3.78 (s, 3H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.93 (m, 1 H); 0.35 (m,

2H); 0.20 (m, 2H).

Example D.f24: N-(trans-4-aminocyclohexyl)-4-[2-(cydopropylmethoxy)-5-metho xyphenyl]-

6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-met hyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e24) the title compound is obtained as yellow solid.

MS (ESI): m/z = 450 (MH ⁺, 100%).

3.78 (s, 3H); 3.09 (m, 1 H); 2.80 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.92 (m, 1 H); 0.34 (m, 2H);

0.19 (m, 2H). Example D.f25: N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methox yphenyl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e25) the title compound is obtained as yellow solid.

MS (ESI): m/z = 450 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (br.s, 1 H, -NH); 9.11 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 8.13 (br.s, 3H, -NH ₃ ⁺); 7.22 (t, J = 1.6, 1 H); 7.15 (d, J = 1.6, 2H); 4.13 (m, 1 H); 3.85 (d, J = 6.9, 2H); 3.78 (s, 3H); 3.18 (m, 1 H); 2.82 (s, 3H); 1.95-1.67 (m, 8H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m, 2H).

Example D.f26: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin- 3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl (3R)-3-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methy l-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpyrrolidine-i -carboxylate (example D.e26) the title compound is obtained as yellow solid.

MS (ESI): m/z = 422 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.07 (s, 1 H); 7.24 (dd, J = 2.2, 0.9, 2H); 7.17 (d, J = 2.2, 1 H); 7.16 (d, J = 0.9, 1 H); 4.64 (m, 1 H); 3.85 (d, J = 6.9, 2H); 3.78 (s, 2H); 3.53 (m, 1 H); 3.44 (m, 1 H); 3.29 (m, 1 H); 3.22 (m, 1 H); 2.83 (s, 3H); 2.37 (m, 1 H); 2.04 (m, 1 H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m, 2H).

Example D.f27: 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine- 7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6- methyl-5H- pyrroloβ^-cdpyrimidin^-ylJcarbony^aminoJ-S-hydroxypiperidin e-i -carboxylate (example D.e27) the title compound is obtained as yellow solid.

MS (ESI): m/z = 452 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.09 (s, 1 H); 7.24 (s, 1 H); 7.18 (s, 2H); 4.04 (m, 1 H); 3.93 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.80 (m, 3H); 3.32 (m, 1 H); 3.25 (m, 1 H); 3.09 (m, 1 H); 2.90 (m, 1 H); 2.84 (s, 3H); 2.27 (m, 1 H); 1.77 (m, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.f28: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5/-/ -pyrrolo[3,2- cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carboxylate (example D.e28) the title compound is obtained as yellow solid.

MS (ESI): m/z = 420 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 12.25 (br.s, 1 H, -NH); 9.11 (br.s, 2H, -NH ₂ ⁺); 9.06 (s, 1 H); 7.47 (d, J = 2.1 , 1 H); 7.39 (dd, J = 8.4, 2.1 , 1 H); 7.10 (d, J = 8.6, 1 H); 4.12 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.34 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.25 (m, 2H).

Example D.f29: N-(Trans-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]- 6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-meth yl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e29) the title compound is obtained as yellow solid.

MS (ESI): m/z = 434 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.25 (br.s, 1 H, -NH); 9.03 (s, 1 H); 8.55 (d, J = 7.9, 1 H, -NH); 8.09 (br.d, J = 4.2, 3H, -NH ₃ ⁺); 7.46 (d, J = 2.1 , 1 H); 7.39 (dd, J = 8.4, 2.1 , 1 H); 7.1 1 (d, J = 8.6, 1 H); 3.88 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.09 (m, 1 H); 2.81 (s, 3H); 2.34 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.24 (m, 2H).

Example D.f30: N-(Cis^4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-methyl phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl -5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e30) the title compound is obtained as yellow solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 9.00 (d, J = 9.3, 1 H, -NH); 8.98 (s, 1 H); 7.43 (d,

0.94 (m, 1 H);0.37 (m, 2H); 0.23 (m, 2H).

Example D.f31: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-

(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamid e hydrochloride

Starting tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2- c^pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylatefrom (example D.e31 ) the title compound is obtained as yellow solid.

MS (ESI): m/z = 474 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.11 (s, 1 H, -NH); 9.04 (s, 1 H); 8.98 (br.s, 2H, -NH ₂ ⁺); 8.75 (d, J = 7.5, 1 H, -NH); 7.93 (d, J = 2.0, 1 H); 7.91 (dd, J = 8.8, 2.0, 1 H); 7.39 (d, J = 8.8, 1 H); 4.16 (m, 1 H);

4.01 (d, J = 6.9, 2H); 3.32 (m, 2H); 3.08 (m, 2H); 2.80 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.98 (m,

1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example D.f32: N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide hydrochloride Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phe nyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e32) the title compound is obtained as yellow solid.

MS (ESI): m/z = 488 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.08 (s, 1 H, -NH); 9.01 (s, 1 H); 8.61 (d, J = 8.6, 1 H, -NH); 8.07 (br.s, 3H, -NH ₃ ⁺); 7.92 (d, J = 2.0, 1 H); 7.91 (dd, J = 8.8, 2.0, 1 H); 7.39 (d, J = 8.8, 1 H); 4.01 (d, J = 7.0, 2H); 3.81 (m, 2H); 3.09 (m, 2H); 2.80 (s, 3H); 2.04 (m, 4H); 1.48 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.f33: N-(cis-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- (trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxamide hydrochloride Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)pheny l]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e33) the title compound is obtained as yellow solid.

MS (ESI): m/z = 488 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 12.04 (s, 1 H, -NH); 9.08 (s, 1 H); 8.98 (d, J = 7.3, 1 H, -NH); 7.99 (br.s, 3H, -NH ₃ ⁺); 7.94 (d, J = 2.1 , 1 H); 7.92 (dd, J = 8.7, 2.1 , 1 H); 7.40 (d, J = 8.7, 1 H); 4.13 (m, 1 H); 4.02 (d, J = 6.9, 2H); 3.20 (m, 1 H); 2.82 (s, 3H); 1.89 (m, 4H); 1.75 (m, 4H); 0.99 (m, 1 H); 0.41 (m, 2H); 0.29 (m, 2H).

Example D.f34: 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5/-/-py rrolo[3,2- c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1-carboxylate (example D.e34) the title compound is obtained as yellow solid.

MS (ESI): m/z = 448 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (br.s, 1 H, -NH); 9.04 (s, 1 H); 8.99 (br.s, 2H, -NH ₂ ⁺); 8.73 (d, J = 7.1 , 1 H, -NH); 7.93 (d, J = 2.2, 1 H); 7.92 (dd, J = 9.5, 2.2, 1 H); 7.43 (d, J = 9.5, 1 H); 4.22 (qu, J =

6.9, 2H); 4.17 (m, 1 H); 3.31 (m, 2H); 3.08 (m, 2H); 2.80 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 1.16 (t,

J = 6.9, 3H).

Example D.f35: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N- piperidin-4-yl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-m ethyl-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate (example D.e35) the title compound is obtained as yellow solid. MS (ESI): m/z = 454 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.11 (s, 1 H, -NH); 9.04 (s, 1 H); 8.96 (br.s, 3H, NH ₂ ⁺); 8.72 (d, J = 6.9, 1 H, -NH); 7.43 (d, J = 9.9, 1 H); 7.22 (d, J = 13.3, 1 H); 4.15 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.85 (s, 3H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.f36: N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carbox amide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphen yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl }carbamate (example D.e36) the title compound is obtained as yellow solid.

MS (ESI): m/z = 468 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.02 (s, 1 H); 8.56 (d, J = 7.7, 1 H, -NH); 8.09 (br.s, 3H, NH ₃ ⁺); 7.43 (d, J = 9.7, 1 H); 7.22 (d, J = 13.5, 1 H); 3.86 (d, J = 6.9, 2H); 3.85 (s, 3H); 3.79 (m, 1 H); 3.08 (m, 1 H); 2.81 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example D.f37: N-(cis-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluoro -5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl ]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e37) the title compound is obtained as yellow solid.

MS (ESI): m/z = 468 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 12.19 (s, 1 H, -NH); 9.12 (s, 1 H); 8.95 (d, J = 7.5, 1 H, -NH); 8.18 (br.s, 3H, NH ₃ ⁺); 7.45 (d, J = 9.7, 1 H); 7.23 (d, J = 13.5, 1 H); 4.14 (m, 1 H); 3.87 (d, J = 6.9, 2H);

3.86 (s, 3H); 3.17 (m, 1 H); 2.82 (s, 3H); 1.81 (m, 8H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.23 (m, 2H).

Example D.f38: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyp henyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3- hydroxypiperidine-1 -carboxylate

(example D.e38) the title compound is obtained as yellow solid.

MS (ESI): m/z = 470 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.08 (s, 1 H); 7.47 (d, J = 9.9, 1 H); 7.24 (d, J = 13.3, 1 H); 4.05 (m, 1 H); 3.87 (s, 3H & d, J = 6.9, 2H & m, 1 H); 3.29 (m, 2H); 3.11 (m, 1 H); 2.92 (m, 1 H); 2.84

(s, 3H); 2.28 (m, 1 H); 1.76 (m, 1 H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example D.f39: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride Starting from tert-butyl (3S*,4S*)-3-[({4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyp henyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4- hydroxypiperidine-1 -carboxylate (example D.e39) the title compound is obtained as yellow solid.

MS (ESI): m/z = 470 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.05 (s, 1 H); 7.45 (d, J = 9.7, 1 H); 7.23 (d, J = 13.3, 1 H); 4.08 (m, 1 H); 3.86 (s, 3H & d, J = 6.8, 2H & m, 1 H); 3.50 (m, 1 H); 3.30 (m, 1 H); 3.00 (m, 1 H); 2.83 (s, 3H); 2.10 (m, 1 H); 1.73 (m, 1 H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f40: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin- 4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-me thyl-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate (example D.e40) the title compound is obtained as yellow solid.

MS (ESI): m/z = 438/ (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.32 (s, 1 H, -NH); 9.10 (br.s, 2H, -NH ₂ ⁺); 9.06 (s, 1 H); 8.66 (d, J = 7.5, 1 H, -NH); 7.58 (d, J = 8.9, 1 H); 7.09 (d, J = 12.1 , 1 H); 4.14 (m, 1 H); 3.90 (d, J = 7.1 , 2H); 3.31 (m, 2H); 3.07 (m, 2H); 2.82 (s, 3H); 2.26 (d, J = 0.9, 3H); 2.13 (m, 1 H); 1.80 (m, 2H); 0.96 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f41: N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carbo xamide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylpheny l]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e41 ) the title compound is obtained as yellow solid.

MS (ESI): m/z = 452 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.96 (s, 1 H); 8.66 (d, J = 7.9, 1 H, -NH); 7.98 (br.d, J - 4.6, 3H, -NH ₃ ⁺); 7.55 (dd, J = 9.1 , 0.6, 1 H); 7.06 (d, J = 12.0, 1 H); 3.88 (d, J = 7.1 , 2H); 3.82 (m, 1 H); 3.09 (m, 1 H); 2.79 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.04 (m, 4H); 1.47 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f42: N-(cis-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluoro -5- methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxa mide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl] -6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e42) the title compound is obtained as yellow solid.

MS (ESI): m/z = 452 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 12.20 (br.s, 1 H, -NH); 9.10 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 8.16 (br.s, 3H, -NH ₃ ⁺); 7.58 (dd, J = 8.9, 0.6, 1 H); 7.08 (d, J = 12.1 , 1 H); 4.13 (m, 1 H); 3.90 (d, J = 6.9, 2H); 3.17 (m, 1 H); 2.82 (s, 3H); 2.26 (d, J = 1.1 , 3H); 1.93-1.56 (m, 8H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example D.f43: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride

Starting from tert-butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylph enyl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3-hydroxy piperidine-1-carboxylate (example D.e43) the title compound is obtained as yellow solid.

MS (ESI): m/z = 454 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.51 (s, 1 H, -NH); [9.62 (br.m, 1 H), 9.18 (br.m, 1 H), -NH ₂ ⁺]; 9.06 (s, 1 H); 8.70 (d, J = 7.1 , 1 H, -NH); 7.60 (d, J = 8.9, 1 H); 7.10 (d, J = 12.0, 1 H); 4.01 (m, 1 H); 3.91 (d, J = 7.1 , 2H & m, 1 H); 3.26 (m, 2H); 3.04 (m, 2H); 2.84 (s, 3H & m, 1 H); 2.26 (s, 3H); 2.23 (m, 1 H); 1.78 (m, 1 H); 0.97 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.f44: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -N- piperidin-4-yl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-m ethyl-5/-/- pyrroloβ^-cdpyrimidin^-yljcarbony^aminojpiperidine-i-carbox ylate (example D.e44) the title compound is obtained as yellow solid.

MS (ESI): m/z = 454 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.27 (br.s, 1 H, -NH); 9.10 (br.s, 2H, -NH ₂ ⁺); 9.04 (s, 1 H); 8.67 (d, J

= 7.5, 1 H, -NH); 7.53 (d, J = 11.9, 1 H); 6.96 (d, J = 7.3, 1 H); 4.15 (m, 1 H); 3.99 (s, 3H); 3.97 (d, J = 6.9, 2H); 3.31 (m, 2H); 3.07 (m, 2H); 2.82 (s, 3H); 2.13 (m, 2H); 1.80 (m, 2H); 0.97 (m, 1 H); 0.39

(m, 2H); 0.26 (m, 2H).

Example D.f45: N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carbox amide hydrochloride

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphen yl]-6-methyl-

5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl }carbamate (example D.e45) the title compound is obtained as yellow solid.

MS (ESI): m/z = 468 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.32 (br.s, 1 H, -NH); 9.01 (s, 1 H); 8.51 (d, J = 7.7, 1 H, -NH); 8.18 (br.d, J = 4.6, 3H, -NH ₃ ⁺); 7.54 (d, J = 11.7, 1 H); 6.96 (d, J = 7.3, 1 H); 3.99 (s, 3H); 3.97 (d, J = 7.4,

2H); 3.81 (m, 1 H); 3.07 (m, 1 H); 2.83 (s, 3H); 2.05 (m, 4H); 1.48 (m, 4H); 0.97 (m, 1 H); 0.39 (m,

2H); 0.27 (m, 2H). Example D.f46: N-(cis-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluoro ^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-car boxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl ]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e46) the title compound is obtained as yellow solid.

MS (ESI): m/z = 468 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.36 (br.s, 1 H, -NH); 9.14 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 8.25 (br.s, 3H, -NH ₃ ⁺); 7.55 (d, J = 11.7, 1 H); 6.97 (d, J = 7.3, 1 H); 4.14 (m, 1 H); 3.99 (s, 3H); 3.97 (d, J = 7.1 , 2H); 3.16 (m, 1 H); 2.84 (s, 3H); 1.86 (m, 4H); 1.74 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example D.f47: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride Starting from tert-butyl (3R*,4R*)-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyp henyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-3- hydroxypiperidine-1 -carboxylate (example D.e47) the title compound is obtained as yellow solid.

MS (ESI): m/z = 470 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 9.04 (s, 1 H); 7.54 (d, J = 11.9, 1 H); 6.96 (d, J = 7.3, 1 H); 4.02 (m, 1 H); 3.99 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.88 (m, 1 H); 3.29 (m, 2H); 3.10 (m, 1 H); 2.93 (m, 1 H); 2.84 (s, 3H); 2.29 (m, 1 H); 1.78 (m, 1 H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.27 (m, 2H).

Example D.f48: 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5/-/- pyrrolo[3,2- cdpyrimidin^-yljcarbony^aminojpiperidine-i-carboxylate (example D.e48) the title compound is obtained as yellow solid.

MS (ESI): m/z = 434 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.22 (s, 1 H, -NH); 9.06 (s, 1 H); 9.00 (br.s, 2H, -NH ₂ ⁺); 8.69 (d, J =

7.5, 1 H, -NH); 7.48 (d, J = 2.2, 1 H); 7.42 (dd, J = 8.6, 2.2, 1 H); 7.12 (d, J = 8.6, 1 H); 4.16 (m, 1 H); 3.89 (d, J = 6.9, 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.65 (qu, J = 7.5, 2H); 2.13 (m, 2H);

1.79 (m, 2H); 1.20 (t, J = 7.5, 3H); 0.95 (m, 1 H); 0.36 (m, 2H); 0.24 (m, 2H).

Example D.f49: N-(trans-4-aminocyclohexyl)-4-[2-(cydopropylmethoxy)-5-ethyl phenyl]-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methy l-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e49) the title compound is obtained as yellow solid.

MS (ESI): m/z = 448 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 12.21 (s, 1 H, -NH); 9.02 (s, 1 H); 8.55 (d, J = 7.7, 1 H, -NH); 8.09 (br.s, 3H, -NH ₃ ⁺); 7.48 (d, J = 2.2, 1 H); 7.42 (dd, J = 8.6, 2.2, 1 H); 7.12 (d, J = 8.6, 1 H); 3.89 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.08 (m, 1 H); 3.08 (m, 2H); 2.81 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.05 (m, 4H); 1.48 (m, 4H); 1.20 (t, J = 7.5, 3H); 0.95 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example D.f50: N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-ethylp henyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl- 5/-/-pyrrolo[3,2- c^pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate (example D.e50) the title compound is obtained as yellow solid.

MS (ESI): m/z = 448 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 12.18 (br.s, 1 H, -NH); 9.1 1 (s, 1 H); 8.96 (d, J = 7.7, 1 H, -NH); 8.15 (br.s, 3H, -NH ₃ ⁺); 7.48 (d, J = 2.2, 1 H); 7.42 (dd, J = 8.6, 2.2, 1 H); 7.13 (d, J = 8.6, 1 H); 4.13 (m, 1 H); 3.89 (d, J = 6.8, 2H); 3.18 (m, 1 H); 3.08 (m, 1 H); 2.82 (s, 3H); 2.65 (qu, J = 7.5, 2H); 1 .96-1 .66 (m, 8H); 1.20 (t, J = 7.5, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f51 : 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4- hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride

Starting from tert-butyl (3R*,4R*)-3-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-me thyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-4-hydroxypyrro lidine-1 -carboxylate (example D.e51 ) the title compound is obtained as yellow solid.

MS (ESI): m/z = 436 (MH ⁺, 100%).

Example D.f52: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-N- (piperidin-4- yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-meth yl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1 -carboxylate (example D.e52) the title compound is obtained as yellow solid.

MS (ESI): m/z = 548 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.75 (s, 1 H, -NH); 8.95 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 4.06 (m, 1 H); 3.87 (d, J = 6.8, 2H & m, 2H); 3.05 (m, 2H); 2.94 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 1.92 (m, 2H); 1.45 (m, 2H); 1.43 (s, 9H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example D.f53: N-(trans-4-Aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(pro pan-2- yl)phenyl]-6-methyl-5H-pyrrolo[3,2-cdpyrimidine-7-carboxamid e hydrochloride Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl] -6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e53) the title compound is obtained as yellow solid.

MS (ESI): m/z = 462 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.15 (br.s, 1 H, -NH); 9.02 (s, 1 H); 8.56 (d, J = 7.9, 1 H, -NH); 8.06 (br.d, J - 4.0, 3H, -NH ₃ ⁺); 7.49 (d, J = 2.4, 1 H); 7.45 (dd, J = 8.6, 2.4, 1 H); 7.12 (d; J = 8.6, 1 H); 3.89 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.10 (m, 1 H); 2.95 (sept, J = 6.9, 1 H); 2.80 (s, 3H); 2.04 (m, 4H); 1.47 (m, 4H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example D.f54: N-(cis-4-Aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(propa n-2- yl)phenyl]-6-methyl-5H-pyrrolo[3,2-cdpyrimidine-7-carboxamid e hydrochloride

Starting from tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6 -methyl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e54) the title compound is obtained as yellow solid.

MS (ESI): m/z = 462 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.28 (br.s, 1 H, -NH); 9.15 (s, 1 H); 8.95 (d, J = 7.7, 1 H, -NH); 8.19 (br.s, 3H, -NH ₃ ⁺); 7.51 (d, J = 2.4, 1 H); 7.47 (dd, J = 8.6, 2.4, 1 H); 7.14 (d; J = 8.6, 1 H); 4.14 (m, 1 H); 3.90 (d, J = 6.9, 2H); 3.18 (m, 1 H); 2.96 (sept, J = 6.9, 1 H); 2.82 (s, 3H); 1.96-1.66 (m, 8H); 1.23 (d, J = 6.9, 6H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example D.f55: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride

tert-Butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]-6-methyl-5H- pyrroloβ^-cdpyrimidin^-yljcarbony^aminojpiperidine-i-carbox ylate from example D.e55 (1.77 g; 2.99 mmol) is dissolved in dry acetone (30 ml_). After addition of 4M HCI in dioxane (3 ml_) the strred mixture is gently refluxed until the starting material is consumed accrding to LC-MS. At ambient temperature the product is precipitated by addition of tert. -butyl methyl ether, isolated by sucction filtration, washed with several portions of tert.-butyl methyl ether and dried in high vacuo at 40 ⁰C to yield 1.40 g of the title compound as pale yellow solid.

MS (ESI): m/z = 448 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 12.18 (s, 1 H, -NH); 9.06 (s, 1 H); 8.99 (br.s, 2H, -NH ₂ ⁺); 8.73 (d, J = 7.5, 1 H, -NH); 8.23 (d, J = 2.3, 1 H); 8.17 (dd, J = 8.8, 2.3, 1 H); 7.32 (d, J = 8.8, 1 H); 4.10 (m, 1 H); 4.02 (d, J = 7.1 , 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.59 (s, 3H); 2.13 (m, 2H); 1.80 (m, 2H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.29 (m, 2H).

Example D.f56: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans-4-aminocy clohexyl)-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride Starting from tert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1 ,3-dioxolan-2-yl)phenyl]- 6-methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycl ohexyl}carbamate (example D.e56) and following the procedure as described for above example D.f55 the title compound is obtained as yellow solid.

MS (ESI): m/z = 462 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 12.15 (s, 1 H, -NH); 9.03 (s, 1 H); 8.60 (d, J = 7.7, 1 H, -NH); 8.23 (d, J = 2.2, 1 H); 8.17 (dd, J = 8.8, 2.2, 1 H); 8.08 (br.s, 3H, -NH ₃ ⁺); 7.31 (d, J = 8.8, 1 H); 4.02 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.09 (m, 1 H); 2.81 (s, 3H); 2.59 (s, 3H); 2.05 (m, 4H); 1.48 (m, 4H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example D.f57: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4- yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl- 5/-/-pyrrolo[3,2- cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carboxylate (example D.e57) the title compound is obtained as colorless solid.

MS (ESI): m/z = 434 (MH ⁺ , 100%)

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 7.49 (d, J = 2.0, 1 H); 7.45 (dd, J = 8.6, 2.0, 1 H); 7.15 (d, J = 8.6, 1 H); 4.22-4.08 (m, 1 H); 3.90 (d, J = 6.9, 2H); 3.35-3.22 (m, 2H); 3.16-3.00 (m, 2H); 2.87 (s, 3H); 2.83 (s, 3H); 2.35 (s, 3H); 2.20-2.07 (m, 2H); 1.83 (m, 2H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example D.f58: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6-dime thyl-N- (piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6 -dimethyl-5/-/- pyrroloβ^-cdpyrimidin^-yljcarbony^aminojpiperidine-i-carbox ylate (example D.e58) the title compound is obtained as colorless solid.

MS (ESI) : 468 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆,MeOH-d ₄): 7.60 (d, J = 11.7, 1 H); 6.98 (d, J = 7.1 , 1 H); 4.21 -4.07 (m, 1 H); 4.03-3.94 (m, 5H); 3.34-3.22 (m, 2H); 3.18-3.00 (m, 1 H); 2.86 (s, 3H); 2.83 (s, 3H); 2.19-2.08 (m, 2H); 1.91-1.74 (m, 2H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H).

Example D.f59: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N- (piperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamid e hydrochloride

Starting from tert-butyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6 -dimethyl-5/-/- pyrroloβ^-c^pyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate (example D.e59) the title compound is obtained as colorless solid.

MS (ESI): m/z = 468 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆, MeOH-Cl ₄): 7.49 (d, J = 9.5, 1 H); 7.27 (d, J = 13.3, 1 H); 4.16 (m, 1 H); 3.88 (s, 3H & d, J = 6.9, 2H); 3.35 (m, 1 H); 3.30 (m, 1 H); 3.14 (m, 2H); 2.86 (s, 3H); 2.83 (s, 3H); 2.15 (m, 2H); 1.81 (m, 2H); 0.95 (m, 1 H); 0.39 (m, 2H); 0.23 (m, 2H). Example D.f60: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-

(piperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxa mide hydrochloride

Starting from fert.-butyl 4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-m ethyl-5/-/- pyrrolop^-cyjpyrimidin^-ylJcarbonyOaminolpiperidine-i-carbox ylate (example D.e60) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 456.2210 ([MH] ⁺, C ₂₄H ₂₈F ₂N ₅O ₂ ⁺, calc. 456.2206).

Example D.f61: N-(trans-4-Aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride Starting from fert-butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phen yl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate (example D.e61 ) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 470.2347 ([MH] ⁺, C ₂₅H ₃₀F ₂N ₅O ₂ ⁺, calc. 470.2362).

Example D.f62: N-[(1 S*,3S*,4S*H-Amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmetho xy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide hydrochloride

Starting from fert-butyl {(1 S*, 2S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)ph enyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]-2-flu orocyclohexyl}carbamate (example

D.e62) the title compound is obtained as colorless solid.

MS (ESI): m/z = 488 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.11 (s, 1 H, -NH); 9.01 (s, 1 H); 8.71 (d, J = 7.9, 1 H, -NH); 8.45

(br.d, J ~ 3.1 , 3H, -NH ₃ ⁺); 7.84 (d, J = 2.0, 1 H); 7.76 (dd, J = 8.8, 2.0, 1 H); 7.33 (d, J = 8.8, 1 H);

7.09 (t, J = 55.9, 1 H); 4.76 (m, 1 H); 4.01 (m, 1 H); 3.97 (d, J = 7.1 , 2H); 3.33 (m, 1 H); 2.81 (s, 3H);

2.46 (m, 1 H); 2.10 (m, 1 H); 2.00 (m, 1 H); 1.77 (m, 1 H); 1.54 (m, 2H); 0.98 (m, 1 H); 0.38 (m, 2H);

0.27 (m, 2H).

Example D.f63: N-[(1 S*,2S*,4S*)-4-Amino-2-methylcyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide hydrochloride Starting from fert-butyl {(1 S*,3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl )phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]-3- methylcyclohexyl}carbamate (example D.e63) the title compound is obtained as colorless solid.

¹H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 9.00 (s, 1 H); 8.59 (d, J = 8.6, 1 H, -NH); 7.98 (br.s, 3H, -NH ₃ ⁺); 7.82 (s, 1 H); 7.76 (d, J = 8.7, 1 H); 7.32 (d, J = 8.7, 1 H); 7.10 (t, J = 55.8, 1 H); 3.97 (d, J = 6.9, 2H); 3.56 (m, 1 H); 3.16 (m, 1 H); 2.80 (s, 3H); 2.01 (m, 3H); 1.69 (m, 1 H); 1.45 (m, 2H); 1.24 (m, 1 H); 0.98 (m, 1 H & d, J = 6.4, 3H); 0.39 (m, 2H); 0.28 (m, 2H).

Example D.f64: N-[(1 S,3S)-3-Aminocyclopentyl]-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride

Starting from fert-butyl {(1 S,3S)-3-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)pheny l]-6-methyl- 5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cyclopentyl}c arbamate (example D.e64) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 456.2218 ([MH] ⁺, C ₂₄H ₂₈F ₂N ₅O ₂ ⁺, calc. 456.2206).

Example D.f66: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(3S,5S)- 5-methylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide hydrochloride

Starting from fert-butyl (2S,4S)^4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phe nyl]-6-methyl- 5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-2-methylp yrrolidine-1 -carboxylate (example D.e66) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 456.2210 ([MH] ⁺, C ₂₄H ₂₈F ₂N ₅O ₂ ⁺, calc. 456.2206).

Example D.f68: N-[(1 R*,3S*,4S*)-3-amino-4-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide hydrochloride Starting from fert-butyl {(1 S*,2S*,4R*)^-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl) phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]-2-met hylcyclopentyl}carbamate (example D.e68) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 470.2363 ([MH] ⁺, C ₂₅H ₃₀F ₂N ₅O ₂ ⁺, calc. 470.2362). Example D.f70: N-[(1 S*,3S*,4S*)-3-Amino-4-fluorocyclopentylH-[2-(cyclopropylmeth oxy)-

5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]py rimidine-7-carboxamide hydrochloride Starting from fert-butyl {(1 S*, 2S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)ph enyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]-2-flu orocyclopentyl}carbamate (example D.e70) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 474.21 17 ([MH] ⁺, C ₂₄H ₂₇F ₃N ₅O ₂ ⁺, calc. 474.21 1 1 ).

Example D.f72: N-[(1 S*,3R*,4S*)-4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide hydrochloride Starting from fert-butyl {(1 S*,2R*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl )phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]-2- fluorocyclohexyl}carbamate (example D.e72) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 488.2271 ([MH] ⁺, C ₂₅H ₂₉F ₃N ₅O ₂ ⁺, calc. 488.2268). Example D.f65: N-[(1 S*,3S*,4S*)-4-Amino-3-methylcyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide hydrochloride N-[(1 S*,3S*,4S*)^4-azido-3-methylcyclohexyl]-4-[2-(cyclopropylmet hoxy)-5-(difluoromethyl)phenyl]- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide (example D.e65; 1.3 g; 2.6 mmol) is dissolved in MeOH (25 mL) and pressure hydrogenated over Pd(OH) ₂ (20% on charcoal; 70.0 mg) at 20 bar and ambient temperature over night. After filtration through a pad of celite the solvent is removed under reduced pressure. The residual amine is dissolved in dioxane (5 mL). At ice bath temperature HCI (4M in dioxane; 0.7 mL) is added followed by fert-BuOMe (10 mL). The precipitate is collected by suction filtration, washed with several small portions of fert-BuOMe and dried under re- duced pressure to yield 1.3 g of the title compound as pale yellow solid.

HR-MS (ESI): m/z = 484.2525 ([MH] ⁺, C ₂₆H ₃₂F ₂N ₅O ₂ ⁺, calc. 484.2519).

The following compounds were prepared analogously to the procedure described in the above example D.f65. The compounds were obtained after pressure hydrogenation and removal of the catalyst and solvent.

Example D.f67: N-[(1 R*,2R*,4R*)-4-Amino-2-fluorocyclohexylH-[2-(cyclopropylmetho xy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from N-[(1 R*,2R*,4R*)-4-azido-2-fluorocyclohexylH-[2-(cyclopropylmetho xy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide (example D.e67) the title compound (free base) is obtained as colorless solid.

HR-MS (ESI): m/z = 488.2265 ([MH] ⁺, C ₂₅H ₂₉F ₃N ₅O ₂ ⁺, calc. 488.2268).

Example D.f69: N-[(1 R*,2R*,4S*)-4-amino-2-methylcyclopentyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/ -pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from N-[(1 R*,2R*,4S*)-4-azido-2-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5-

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyri midine-7-carboxamide (example D.e69) the title compound (free base) is obtained as colorless solid.

HR-MS (ESI): m/z = 470.2369 ([MH] ⁺, C ₂₅H ₃₀F ₂N ₅O ₂ ⁺, calc. 470.2363).

Example D.f71: N-[(1 R*,2R*,4R*)-4-Amino-2-fluorocyclopentylH-[2-(cyclopropylmeth oxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from N-[(1 R*,2R*,4R*)-4-azido-2-fluorocyclopentylH-[2-(cyclopropylmeth oxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.e71 ) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 474.2115 ([MH] ⁺, C ₂₄H ₂₇F ₃N ₅O ₂ ⁺, calc. 474.2111 ). Example D.f73: N-[(1 S*,2R*,4S*)-4-Amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)- 5-(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from N-[(1 S*,2R*,4S*)-4-azido-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide (example D.e73) the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 488.2265 ([MH] ⁺, C ₂₅H ₂₉F ₃N ₅O ₂ ⁺, calc. 488.2268).

Example D.g1 : 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid

Ethyl 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -5/-/-pyrrolo[3,2-c(]pyrimidine-7- carboxylate (example D.a19; 52.73 g; 131.4 mmol) is dissolved in fert. BuOH (500.0 ml_) and water (5.0 ml_). After addition of commercially available KOtBu (73.70 g; 656.8 mmol) the reaction mixture is stirred at 100 ⁰C over night and cooled to ambient temperature. Water (1500 ml_) is added and pH is adjusted to 6.0 by careful addition of 2M aqueous citric acid. The precipitated product is filtered washed with several portions of water and dried under reduced pressure to yield 45.3 g of the title compound as off-white solid.

¹H-NMR (300 MHz, DMSO-d ₆): 12.22-1 1.77 (br.s, 2H, -NH, -CO ₂H); 8.96 (s, 1 H); 7.82 (d, J = 2.0, 1 H); 7.74 (dd, J = 8.6, 2.0, 1 H); 7.31 (d, J = 8.6, 1 H); 7.08 (t, J = 56.0, 1 H); 3.96 (d, J = 6.9, 2H); 2.74 (s, 3H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.26 (m, 2H).

Example D.g2: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxylic acid

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxylate (example D.a8) and following the procedure as described in example D.g1 the title compound is obtained as off-white solid.

¹ H-NMR (300 MHz, DMSO-d ₆/MeOH-d ₄): 8.95 (s, 1 H); 7.89 (d, J = 2.1 , 1 H); 7.88 (dd, J = 8.4, 2.1 , 1 H); 7.37 (d, J = 8.4, 1 H); 4.00 (d, J = 7.1 , 2H); 2.74 (s, 3H); 1.00 (m, 1 H); 0.40 (m, 2H); 0.27 (m, 2H). Example E1 : N-(1 -Acetylpiperidin^4-yl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/-pyrrolo[ 3,2- c(]pyrimidine-7-carboxamide hydrochloride from example D.f1 (486 mg; 1 .0 mmol) and DBU (2.5 mmol) is dissolved in dry dichloromethane (5 ml_). Acetyl chloride (1.1 mmol) is syringed into the reaction mixture at ice bath temperature. After addition the mixture is stirred at ambient temperature over night. Methanol (1 mL) is added and stirring is continued for two hours. The volatiles are evaporated. The residue is purified by reversed phase preparative HPLC. The collected product fraction is freeze-dried to yield the title compound as colorless solid. MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 8.93 (s, 1 H); 8.76 (d, J = 7.8, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.23-4.04 (m, 2H); 3.80 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.77 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.38 (m, 1 H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

The following compounds are prepared analogously to the procedure described in above example E1. Example E2: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.fi ) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 8.93 (s, 1 H); 8.75 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.25-4.03 (m, 2H); 3.79 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.25 (m, 1 H); 2.95 (m, 1 H); 2.77 (s, 3H); 2.36 (qu, J = 7.5, 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.39 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E3: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.fi ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 8.93 (s, 1 H); 8.75 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.55 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.22^.03 (m, 2H); 4.12 (d, J = 1.8, 2H); 3.76 (d, J = 6.8, 2H); 3.73 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.77 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E4: Ethyl 4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-5/-/- pyrroloβ^-cdpyrimidin^-yljcarbony^aminojpiperidine-i-carbox ylate

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.fi ) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.99 (s, 1 H, -NH); 8.93 (s, 1 H); 8.75 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.06 (m, 1 H & qu, J = 7.1 , 2H); 3.88 (m, 2H); 3.76 (d, J = 6.8, 2H); 3.11 (m, 2H); 2.77 (s, 3H); 1.94 (m, 2H); 1.46 (m, 2H); 1.20 (t, J = 7.1 , 3H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E5: N-(trans-4-acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.93 (s, 1 H); 8.59 (d, J = 7.7, 1 H, -NH); 7.72 (d, J = 7.9, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.55 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.80 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.58 (m, 1 H); 2.76 (s, 3H); 2.00 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E6: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[trans-4-

(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.93 (s, 1 H); 8.60 (d, J = 7.7, 1 H, -NH); 7.62 (d,

J = 7.9, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.79 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.59 (m, 1 H); 2.76 (s, 3H); 2.05 (qu, J = 7.6, 2H); 2.01 (m, 2H); 1.86 (m, 2H); 1.35 (m,

4H); 0.99 (t, J = 7.6, 3H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example E7: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{trans^4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.93 (s, 1 H); 8.59 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.2, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.78 (m, 1 H & s, 2H);

3.76 (d, J = 6.8, 2H); 3.68 (m, 1 H); 3.31 (s, 3H); 2.76 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m,

4H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H). Example E8: Ethyl {trans^4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl- 5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}ca rbamate

Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.93 (s, 1 H); 8.59 (d, J = 7.7, 1 H, -NH); 7.00 (d, J = 6.8, 1 H & d, J = 8.6, 1 H, -NH); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.98 (qu, J = 6.9, 2H); 3.94 (m, 1 H); 3.76 (m, 1 H & d, J = 6.8, 2H); 3.33 (m, 1 H); 2.76 (s, 3H); 2.00 (m, 2H); 1.87 (m, 2H); 1.35 (m, 4H); 1.16 (t, J = 6.9, 3H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example E9: N-(cis-4-acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f3) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.98 (s, 1 H, -NH); 8.96 (s, 1 H); 8.87 (d, J = 7.5, 1 H, -NH); 7.84 (d,

J = 7.3, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.01 (m, 1 H); 3.77 (m, 1 H & d, J = 6.8, 2H); 2.77 (s, 3H); 1.83 (s, 3H); 1.82-1.51 (m,8H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13

(m, 2H).

Example E10: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[cis-4-

(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-

5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f3) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.98 (s, 1 H, -NH); 8.96 (s, 1 H); 8.87 (d, J = 7.5, 1 H, -NH); 7.75 (d, J = 7.5, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.01 (m, 1 H); 3.76 (m,

1 H & d, J = 6.8, 2H); 2.77 (s, 3H); 2.11 (qu, J = 7.5, 2H); 1.87-1.50 (m,8H); 1.00 (t, J = 7.6, 3H);

0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E11: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f3) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.98 (s, 1 H, -NH); 8.97 (s, 1 H); 8.91 (d, J = 7.3, 1 H, -NH); 7.67 (d, J = 7.9, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.04 (m, 1 H); 3.81 (s, 2H); 3.76 (m, 1 H & d, J = 6.8, 2H); 3.31 (s, 3H); 2.77 (s, 3H); 1.87-1.57 (m,8H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E12: Ethyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidin-7-yl}carbonyl)amino]cyclohexyl}carb amate

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f3) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.96 (s, 1 H); 8.91 (d, J = 7.9, 1 H, -NH); 7.20

(br.d, J ~ 6.2, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 3.99 (m, 1 H & qu, J = 7.1 , 2H); 3.76 (d, J = 6.8, 2H); 3.48 (m, 1 H); 2.77 (s, 3H); 1.85-1.54 (m,8H); 1.17 (t, J = 7.1 ,

3H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example E13: N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-

4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamid e

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f4) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); 8.93 (s, 1 H); [8.88 (d, J = 7.0), 8.85 (d, 6.7), 1 H, -NH]; 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); [4.59 (m), 4.49 (m), 1 H]; [3.84 (m),

3.68-3.58 (m), 2H]; 3.76 (d, J = 6.7, 2H); 3.56-3.27 (m, 2H); [2.78 (s), 2.77 (s), 3H]; 2.34-2.16

(m,1 H); 2.08-1.87 (m, 1 H); [1.98 (s), 1.96 (s), 3H]; 0.88 (m, 1 H); 0.31 (m, 2H); 0.12 (m, 2H).

Example E14: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-1- propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7-ca rboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f4) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); 8.92 (s, 1 H); [8.88 (d, J = 7.0), 8.85 (d, 6.7), 1 H, -NH]; 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); [4.59 (m), 4.49 (m), 1 H]; [3.82 (m), 3.69-3.57 (m), 2H]; 3.76 (d, J = 6.7, 2H); 3.55-3.26 (m, 2H); [2.78 (s), 2.77 (s), 3H]; 2.34-2.16 (m,1 H); [2.29 (qu, J = 7.5), 2.25 (qu, J = 7.5), 2H]; [2.03 (m), 1.92 (m), 1 H]; [1.01 (t, J = 7.5), 0.99 (t, J = 7.5), 3H]; 0.88 (m, 1 H); 0.31 (m, 2H); 0.12 (m, 2H).

Example E15: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R)-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f4) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); [8.93 (s), 8.92 (s), 1 H]; [8.87 (d, J = 7.2), 8.85 (d, 6.9), 1 H, -NH]; 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); [4.59 (m), 4.49 (m), 1 H];

[4.06 (d, J = 6.6), 4.01 (d, J = 2.2), 2H]; [3.80 (m), 3.68(m), 1 H]; 3.76 (d, J = 6.7, 2H); 3.63-3.42 (m, 2H); 3.39-3.26 (m, 1 H); [3.32 (s), 3.30 (s), 3H]; 2.77 (s, 3H); 2.34-2.15 (m,1 H); [2.03 (m), 1.91 (m), 1 H]; 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example E16: N-[(3R*,4R*)-1 -acetyl-4-hydroxypyrrolidin-3-yl]-4-[5-(cyclopropylmethoxy)- 1 ,3-benzodioxol-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine -7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxypyrrolidin-3- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f5) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 494.2040 ([MH] ⁺, C ₂₅H ₂₈N ₅O ₆ ⁺, calc. 494.2034).

Example E17: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxy-1 - propionylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxypyrrolidin-3- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f5) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 508.2191 ([MH] ⁺, C ₂₆H30N ₅O ₆ ⁺, calc. 508.2191 ). Example E18: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxy-1 -

(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxypyrrolidin-3- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f5) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 524.2140 ([MH] ⁺, C ₂₆H ₃₀N ₅O ₇ ⁺, calc. 524.2140).

Example E19: N-(1 -acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)^4-fluorophe nyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/-pyrrolo[3,2- cflpyπmidine-7-carboxamide hydrochloride (example D.f6) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 466 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s. 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.66 (dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.23^.04 (m, 2H); 3.91 (d, J = 6.9, 2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.38 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m, 2H). Example E20: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-(1-prop ionylpiperidin-

4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f6) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s. 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.66 (dd, J = 8.6, 7.1 , 1 H); 7.08 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.6, 8.6, 2.4, 1 H); 4.26^.04 (m, 2H); 3.91 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.25 (m, 1 H); 2.96 (m, 1 H); 2.78 (s, 3H); 2.36 (qu, J = 7.5, 3H); 1.95 (m, 2H); 1.51 (m, 1 H); 1.38 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m, 2H).

Example E21: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[1 -(methoxyacetyl)piperidin-4- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/-pyrrolo[3,2- cdpyrimidine-7-carboxamide hydrochloride (example D.f6) and commercially available methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s. 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.66

(dd, J = 8.6, 7.1 , 1 H); 7.09 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.6, 8.6, 2.4, 1 H); 4.24^.04 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.91 (d, J = 7.1 , 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.24 (m, 1 H); 2.98 (m,

1 H); 2.78 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m,

2H).

Example E22: N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4- fluorophenyl]- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f7) and commercially available acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 480 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.94 (s, 1 H); 8.65 (d, J = 7.9, 1 H, -NH); 7.72(d, J = 7.7, 1 H, -NH); 7.66 (dd, 8.4, 7.1 , 1 H); 7.08 (dd, 11.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 3.91 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1.86(m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E23: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[trans^ 4-

(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidin e-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f7) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.94 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.65

(dd, 8.4, 7.1 , 1 H); 7.62 (d, J = 7.6, 1 H, -NH); 7.08 (dd, 1 1.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 3.91 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.06 (qu, J = 7.5, 2H); 2.01 (m, 2H);

1.86(m, 2H); 1.35 (m, 4H); 0.99 (t, J = 7.5, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E24: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{trans-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f7) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.94 (s, 1 H); 8.64 (d, J = 7.9, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.57 (d, J = 8.4, 1 H, -NH); 7.08 (dd, 1 1.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H);

3.91 (d, J = 6.9, 2H); 3.78 (s, 2H & m, 1 H); 3.68 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.01 (m, 2H);

1.82(m, 2H); 1.43 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E25: N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fl uorophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro phenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f8) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.97 (s, 1 H); 8.93 (d, J = 7.5, 1 H, -NH); 7.84 (d,

J = 7.7, 1 H, -NH); 7.66 (dd, 8.4, 7.1 , 1 H); 7.09 (dd, 11.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H);

4.02 (m, 1 H); 3.91 (d, J = 7.1 , 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.84 (s, 3H); 1.84-1.51 (m, 8H); 0.96

(m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example E26: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-4-fluorop henyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f8) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.97 (s, 1 H); 8.93 (d, J = 7.7, 1 H, -NH); 7.75 (d, J = 7.7, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.09 (dd, 11.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 4.02 (m, 1 H); 3.92 (d, J = 7.1 , 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 2.11 (qu, J = 7.5, 2H); 1.84-1.51 (m, 8H); 1.00 (t, J = 7.5, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E27: 4-[2-(Cyclopropylmethoxy)^4-fluorophenyl]-N-{cis-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro phenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f8) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.98 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 7.67 (d, J = 7.6, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.09 (dd, 11.5, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H);

4.05 (m, 1 H); 3.91 (d, J = 7.1 , 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s, 3H); 2.79 (s, 3H); 1.86-1.58

(m, 8H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E28: N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-4 -fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f9) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 452 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.94 (s, 1 H); [8.93 (d, J = 6.8), 8.90 (d, J = 6.9),

1 H, -NH]; 7.66 (ddd, J = 8.4, 7.1 , 1.1 , 1 H); 7.09 (dd, J = 1 1.5, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4,

1 H); [4.59 (m), 4.49 (m), 1 H]; 3.91 (d, J = 7.1 , 2H); [3.84 (m), 3.69-3.58 (m), 2H]; 3.56-3.27 (m, 2H);

[2.79 (s), 2.78 (s), 3H]; 2.35-2.16(m, 1 H); 2.08-1.86 (m, 1 H); [1.98 (s), 1.96 (s), 3H]; 0.95 (m, 1 H);

0.38 (m, 2H); 0.25 (m, 2H).

Example E29: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-1 - propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-c arboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5H- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f9) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 466 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); [8.93 (d, J = 7.1 ), 8.90 (d, J = 6.8), 1 H ₁ -NH];

[8.93 (s), 8.92 (s), 1 H]; 7.66 (ddd, J = 8.4, 7.1 , 0.7, 1 H); 7.08 (dd, J = 11.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); [4.59 (m), 4.49 (m), 1 H]; 3.91 (d, J = 7.1 , 2H); [3.82 (m), 3.70-3.58 (m), 2H]; 3.55- 3.27 (m, 2H); [2.79 (s), 2.78 (s), 3H]; 2.34-2.15(m, 1 H); [2.29 (qu, J = 7.5), 2.25 (qu, J = 7.5), 2H]; 2.08-1.86 (m, 1 H); [1.01 (t, J = 7.5), 0.99 (t, J = 7.5), 3H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E30: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f9) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 482 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .83 (s, 1 H, -NH); [8.94 (s), 8.93 (s), 1 H]; [8.92 (d, J = 7.1 ), 8.90 (d, J = 6.8), 1 H, -NH]; 7.66 (ddd, J = 8.4, 6.9, 0.7, 1 H); 7.09 (dd, J = 1 1.5, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); [4.59 (m), 4.49 (m), 1 H]; [4.06 (d, J = 4.0), 4.01 (d, J = 1 .1 ), 2H]; 3.91 (d, J = 6.9, 2H); [3.79 (m), 3.68 (m), 1 H]; 3.62-3.42 (m, 2H); 3.38-3.27 (m, 1 H); [3.32 (s), 3.29 (s), 3H]; 2.79 (s, 3H); 2.33-2.15(m, 1 H); [2.03 (m), 1 .91 (m), 1 H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E31 : N-[(3R*,4R*)-1 -acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 4- fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f10) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 468 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1 .84 (s, 1 H, -NH); 8.93 (s, 1 H); [8.88 (d, J = 7.2), 8.83 (d, J = 6.6), 1 H, -NH]; 7.65 (dd, J = 8.4, 7.1 , 1 H); 7.09 (dd, J = 1 1.7, 2.0, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.0, 1 H);

[5.56 (d, J = 3.2), 5.48 (d, J = 3.9), 1 H, -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); 3.91 (d, 7.2,

2H); [3.76 (m), 3.69(m), 3.58 (m), 3.45 (m), 2H]; 3.41 -3.27 (m, 2H); 2.79 (s. 3H); [1.99 (s), 1.98 (s),

3H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example E32: 4-[2-(CyclopropylmethoxyH-fluorophenyl]-N-[(3R*,4R*)-4-hydro xy-1 - propanoylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f10) and

commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 482 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.84 (s, 1 H, -NH); 8.91 (s, 1 H); [8.88 (d, J = 7.1 ), 8.82 (d, J = 6.8), 1 H, -NH]; 7.65 (dd, J = 8.4, 7.1 , 1 H); 7.09 (dd, J = 11.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H);

[5.55 (d, J = 3.8), 5.47 (d, J = 4.0), 1 H, -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); 3.91 (d, 6.9, 2H); [3.86 (m), 3.59(m), 1 H]; 3.72 (m, 1 H); 3.49-3.27 (m, 2H); 2.78 (s. 3H); [2.28 (qu, J = 7.5), 2.27 (qu, J = 7.5), 2H]; [1.03 (t, J = 7.5), 1.01 (t, J = 7.5), 3H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E33: 4-[2-(CyclopropylmethoxyH-fluorophenyl]-N-[(3R*,4R*)-4-hydro xy-1 - (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.fl O) and

commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 498 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.85 (s, 1 H, -NH); [8.91 (s), 8.90(s), 1 H]; [8.87 (d, J = 7.1 ), 8.83 (d, J = 6.6), 1 H, -NH]; 7.65 (dd, J = 8.4, 7.3, 1 H); 7.09 (dd, J = 1 1.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); [5.56 (d, J = 3.8), 5.50 (d, J = 4.0), 1 H ₁ -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); [4.09 (dd, J = 14.6,3.5) 4.02 (d, J = 14.6) 2H]; 3.91 (d, 6.9, 2H); [3.85 (m), 3.62(m), 1 H]; 3.73 (m, 1 H); 3.49-3.27 (m, 2H); [3.34 (s), 3.32 (s), 3H]; 2.78 (s. 3H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E34: N-[(3S*,4S*)-1 -acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)-4 - fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3-hydroxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f1 1 ) and

commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 482.2196 ([MH] ⁺, C ₂₅H ₂₉FN ₅O ₄ ⁺, calc. 482.2198). Example E35: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hyd roxy-1 - propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3-hydroxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f1 1 ) and

commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 496.2345 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₄ ⁺, calc. 496.2355).

Example E36: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hyd roxy-1 - (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3-hydroxypiperidin^4-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f11 ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 512.2288 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₅ ⁺, calc. 512.2304).

Example E37: 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- cf]pyπmidine-7 -carboxylic acid (1-acetyl-piperidin-4-yl)-amide

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo [3,2-d]pyrimidine-7- carboxylic acid piperidin-4-ylamide hydrochloride (example D.f12) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 466 (MH ⁺, 100%), 356, 302.

¹H-NMR (300 MHz, DMSO-d ₆): 11.84 (br.s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.43 (dd, J = 9.0, 3.3, 1 H); 7.37 (ddd, J = 9.1 , 8.3, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.22-4.06 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.78 (m, 1 H); 3.27 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.39 (m, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E38: 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-(1-prop ionylpiperidin-

4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2-d]pyrimidine-7- carboxylic acid piperidin^4-ylamide hydrochloride (example D.f12) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.84 (s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.42

(dd, J = 9.0, 3.2, 1 H); 7.36 (ddd, J = 9.1 , 8.3, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.25-4.04 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.27 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu, J = 7.5,

2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.39 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22

(m, 2H).

Example E39: 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- cf]pyπmidine-7 -carboxylic acid [1-(2-methoxy-acetyl)-piperidin^4-yl]-amide

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo [3,2-d]pyrimidine-7- carboxylic acid piperidin^4-ylamide hydrochloride (example D.f12) and commercially methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%), 356, 302.

1H-NMR (300 MHz, DMSO-d ₆): 11.84 (br.s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.43 (dd, J = 9.0, 3.3, 1 H); 7.37 (ddd, J = 9.1 , 8.3, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.23-4.07 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.87 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E40: Ethyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperidine-1-ca rboxylate

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2-d]pyrimidine-7- carboxylic acid piperidin-4-ylamide hydrochloride (example D.f12) and commercially ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.84 (s, 1 H, -NH); 8.97 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.42

(dd, J = 9.1 , 3.3, 1 H); 7.37 (ddd, J = 9.1 , 8.2, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.06 (qu, J = 7.2, 2H & m, 1 H); 3.87 (d, J = 6.9, 2H & m, 2H); 3.1 1 (m, 2H); 2.79 (s, 3H); 1.94 (m, 2H); 1.46 (m, 2H); 1.20 (t, J = 7.2, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E41: N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- fluorophenyl]-

6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f13) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.81 (s, 1 H, -NH); 8.97 (s, 1 H); 8.67 (d, J = 7.7, 1 H, -NH); 7.72 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 8.9, 3.2, 1 H); 7.36 (ddd, J = 9.1 , 8.4, 3.2, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E42: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[trans^ 4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f13) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.81 (s, 1 H, -NH); 8.97 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.62 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H); 7.36 (ddd, J = 9.1 , 8.2, 3.3, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.60 (m, 1 H); 2.78 (s, 3H); 2.06 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E43: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide ( Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f13) and commercially methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.81 (s, 1 H, -NH); 8.97 (s, 1 H); 8.63 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.2, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H); 7.36 (ddd, J = 8.9, 8.2, 3.3, 1 H); 7.18 (dd, J = 8.9, 4.4, 1 H); 3.87 (d, J = 6.9, 2H); 3.78 (s, 2H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E44: Ethyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-meth yl-5/-/- pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carb amate

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f13) and commercially ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.81 (s, 1 H, -NH); 8.96 (s, 1 H); 8.63 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H); 7.36 (ddd, J = 9.1 , 8.3, 3.3, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 7.01 (d, J = 7.3, 1 H, -NH); 3.98 (qu, J = 7.1 , 2H); 3.87 (d, J = 6.9, 2H); 3.77 (m, 1 H); 3.34 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1.87 (m, 2H); 1.36 (m, 4H); 1.16 (d, J = 6.7, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E45: N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fl uorophenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro phenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f14) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 9.00 (s, 1 H); 8.92 (d, J = 7.5, 1 H, -NH); 7.85 (d, J = 7.7, 1 H, -NH); 7.43 (dd, J = 8.9, 3.3, 1 H); 7.38 (ddd, J = 8.9, 8.2, 3.3, 1 H); 7.19 (dd, J = 8.9, 4.4, 1 H); 4.03 (m, 1 H); 3.88 (d, J = 6.8, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.84 (s, 3H); 1.82-1.52 (m, 8H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.23 (m, 2H).

Example E46: N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5 -fluorophenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f15) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 452 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.88 (s, 1 H ₁ -NH); 8.97 (s, 1 H); [8.93 (d, J = 6.9), 8.89 (d, J = 6.9), 1 H, -NH]; 7.43 (dd, J = 8.9, 3.2, 1 H); 7.38 (ddd, J = 9.0, 8.6, 3.2, 1 H); 7.19 (dd, J = 9.0, 4.4, 1 H);

[4.59 (m), 4.49 (m), 1 H]; 3.88 (d, J = 6.9, 2H); [3.84 (m), 3.65 (m), 1 H]; 3.62 (m, 1 H); 3.55-3.26 (m, 2H); [2.80 (s); 2.79 (s), 3H]; 2.35-2.16 (m, 1 H); 2.09-1.87 (m, 1 H); [1.98 (s), 1.96 (s), 3H]; 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E47: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-1 - propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7-c arboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f15) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 466 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.96 (s, 1 H); [8.92 (d, J = 7.1 ), 8.89 (d, J = 6.8), 1 H, -NH]; 7.42 (dd, J = 8.9, 3.3, 1 H); 7.38 (ddd, J = 9.1 , 8.4, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H);

[4.59 (m), 4.49 (m), 1 H]; 3.87 (d, J = 6.9, 2H); [3.82 (m), 3.66 (m), 1 H]; 3.61 (m, 1 H); 3.55-3.26 (m, 2H); [2.80 (s); 2.79 (s), 3H]; 2.34-2.15 (m, 1 H); [2.29 (qu, J = 7.5), 2.25 (qu, J = 7.5), 2H]; [2.03 (m), 1.92 (m), 1 H]; [1.01 (t, J = 7.5), 1.00 (t, J = 7.5), 3H]; 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E48: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R)-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f15) and commercially methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 482 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.96 (s, 1 H); [8.91 (d, J = 7.1 ), 8.89 (d, J = 6.8), 1 H, -NH]; 7.42 (ddd, J = 8.9, 3.3, 0.6, 1 H); 7.38 (ddd, J = 9.1 , 8.4, 3.3, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); [4.59 (m), 4.50 (m), 1 H]; [4.06 (d, J = 4.0), 4.01 (d, J = 1.1 ), 2H]; 3.87 (d, J = 6.9, 2H); [3.80 (m), 3.68 (m), 1 H]; 3.63-3.42 (m, 2H); 3.36 (m, 1 H); [3.32 (s), 3.30 (s), 3H]; 2.79 (s, 3H); 2.34-2.13 (m, 1 H); [2.03 (m), 1.92 (m), 1 H]; 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E49: N-[(3R*,4R*)-1 -acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)-5 - fluorophenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f16) and commercially acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 482.2199 ([MH] ⁺, C ₂₅H ₂₉FN ₅O ₄ ⁺, calc. 482.2198). Example E50: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxy-1- propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f16) and commercially propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 496.2359 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₄ ⁺, calc. 496.2355).

Example E51: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxy-1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f16) and commercially methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2294 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₅ ⁺, calc. 512.2304). Example E52: N-(1 -acetylpiperidin-4-yl)-4-(2-ethoxy-5-fluorophenyl)-6-methyl- 5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide (example D.f17) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 440 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.95 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.42 (ddd, J = 9.1 , 8.9, 3.2, 1 H); 7.38 (dd, J = 8.2, 3.2, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.22-4.06 (m, 2H); 4.08 (qu, J = 7.0, 2H); 3.78 (m, 1 H); 3.27 (m, 1 H); 2.95 (m, 2H); 2.79 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.38 (m, 1 H); 1.10 (t, J = 7.0, 3H).

Example E53: 4-(2-Ethoxy-5-fluorophenyl)-6-methyl-N-(1-propanoylpiperidin -4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide (example D.f17) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 454 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆, MeOH-d ₄): 11.87 (s, 1 H, -NH); 8.95 (s, 1 H); 8.79 (d, J = 7.7, 1 H, - NH); 7.42 (ddd, J = 9.1 , 8.9, 3.2, 1 H); 7.38 (dd, J = 8.2, 3.2, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.25- 4.03 (m, 2H); 4.08 (qu, J = 6.9, 2H); 3.81 (m, 1 H); 3.25 (m, 1 H); 2.96 (m, 2H); 2.78 (s, 3H); 2.36 (qu, J = 7.3, 2H); 1.95 (m, 2H); 1.52 (m, 1 H); 1.38 (m, 1 H); 1.1 1 (t, J = 6.9, 3H); 1.01 (t, J = 7.3, 3H). Example E54: 4-(2-Ethoxy-5-fluorophenyl)-N-[1 -(methoxyacetyl)piperidin-4-yl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7 -carboxamide

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5H-p yrrolo[3,2-cy]pyrimidine-7- carboxamide (example D.f17) and commercially methoxy-acetyl chloride the title compound is ob- tained as colorless solid.

MS (ESI): m/z = 470 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.87 (s, 1 H, -NH); 8.95 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.42 (ddd, J = 9.1 , 8.9, 3.2, 1 H); 7.38 (dd, J = 8.3, 3.2, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.21 -4.06 (m, 2H); 4.12 (d, J = 3.0, 2H); 4.08 (qu, J = 7.0, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.78 (s, 3H); 1.97 (m, 2H); 1 .53 (m, 1 H); 1.41 (m, 1 H); 1.1 1 (t, J = 6.9, 3H).

Example E55: N-(1 -acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-4-methoxyph enyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f18) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.68 (s, 1 H, -NH); 8.90 (s, 1 H); 8.84 (d, J = 7.7, 1 H, -NH); 7.59 (d,

J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 4.21 -4.04 (m, 2H); 3.91 (d, J = 6.9, 2H); 3.86 (s, 3H); 3.78 (m, 1 H); 3.27 (m, 1 H); 2.95 (m, 1 H); 2.78 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H);

1.54 (m, 1 H); 1.38 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example E56: 4-[2-(Cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-(1 - propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide hydrochloride (example D.f18) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.68 (s, 1 H, -NH); 8.90 (s, 1 H); 8.84 (d, J = 7.8, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 4.25-4.03 (m, 2H); 3.90 (d, J = 6.9,

2H); 3.86 (s, 3H); 3.81 (m, 1 H); 3.25 (m, 1 H); 2.96 (m, 1 H); 2.78 (s, 3H); 2.36 (qu, J = 7.3, 2H);

1.95 (m, 2H); 1.51 (m, 1 H); 1 .38 (m, 1 H); 1.01 (t, J = 7.3, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m,

2H). Example E57: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[1 -

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7 -carboxamide Starting from 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f18) and commercially methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.68 (s, 1 H, -NH); 8.90 (s, 1 H); 8.84 (d, J = 7.7, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 4.21-4.06 (m, 2H); 4.12 (d, J = 1.5, 2H); 3.90 (d, J = 6.8, 2H); 3.86 (s, 3H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.99 (m, 1 H); 2.78 (s, 3H); 1.96 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example E58: N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carb oxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f19) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.66 (s, 1 H, -NH); 8.91 (s, 1 H); 8.67 (d, J = 7.9, 1 H, -NH); 7.72 (d, J = 7.9, 1 H, -NH); 7.58 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.68 (d, J = 2.2, 1 H ); 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.77 (s, 3H); 2.00 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example E59: N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)^4- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carbox amide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-methox yphenyl]-6-methyl-5/-/- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f20) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.66 (s, 1 H, -NH); 8.95 (d, J = 6.9, 1 H, -NH); 8.94 (s, 1 H); 7.84 (d, J = 7.5, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H ); 4.02 (m, 1 H); 3.91 (d , J = 6.8, 2H); 3.86 (s, 3H); 3.75 (m, 1 H); 2.78 (s, 3H); 1.84 (s, 3H); 1.81-1.51 (m, 8H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.27 (m, 2H).

Example E60: N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)^4 - methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f21 ) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 464 (MH ⁺, 100%). ¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (br.s, 1 H, -NH); [8.96 (d, J = 6.8), 8.93 (d, J = 6.8), 1 H, -NH]; 8.91 (s, 1 H); 7.59 (dd, J = 8.4, 0.9, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); [4.58 (m), 4.49 (m), 1 H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); [3.83 (m), 3.65 (m), 1 H]; 3.62 (m, 1 H); 3.55-3.27 (m, 2H); [2.78 (s), 2.77 (s), 3H]; 2.34-2.15 (m 1 H); 2.08-1.86 (m, 1 H); [1.98 (s), 1.96 (s), 3H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example E61 : 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- 1 - propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f21 ) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.71 (br.s, 1 H, -NH); [8.96 (d, J = 6.8), 8.93 (d, J = 6.8), 1 H, -NH];

[8.90 (s), 8.89 (s), 1 H]; 7.59 (dd, J = 8.4, 0.7, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H );

[4.58 (m), 4.48 (m), 1 H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); [3.81 (m), 3.67 (m), 1 H]; 3.60 (m, 1 H);

3.55-3.26 (m, 2H); [2.79 (s), 2.78 (s), 3H]; 2.34-2.15 (m 1 H); [2.28 (qu, J = 7.5), 2.25 (qu, J = 7.5),

2H]; [2.03 (m), 1.91 (m), 1 H]; [1.01 (t, J = 7.5), 0.99 (t, J = 7.5), 3H]; 0.95 (m, 1 H); 0.37 (m, 2H);

0.26 (m, 2H). Example E62: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R)-1 -

(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5H- pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f21 ) and commercially methoxy- acetyl choride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.71 (br.s, 1 H, -NH); [8.95 (d, J = 6.8), 8.93 (d, J = 6.8), 1 H, -NH];

[8.90 (s), 8.89 (s), 1 H]; 7.59 (dd, J = 8.4, 0.7, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H );

[4.58 (m), 4.49 (m), 1 H]; [4.06 (d, J = 3.8), 4.01 (d, J = 1.1 ), 2H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H);

[3.79 (m), 3.68 (m), 1 H]; 3.62-3.42 (m, 2H); 3.38-3.27 (m, 1 H); [3.32 (s), 3.29 (s), 3H]; 2.78 (s, 3H); 2.33-2.14 (m 1 H); [2.03 (m), 1.90 (m), 1 H]; 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H).

Example E63: N-[(3R*,4R*)-1 -acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f22) and commercially acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (br.s, 1 H ₁ -NH); [8.91 (d, J = 7.1 ), 8.85 (d, J = 6.8), 1 H ₁ -NH]; 8.89 (s, 1 H); 7.59 (dd, J = 8.4, 0.7, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); 5.50 (br.s, 1 H, -OH); [4.35 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.79-3.65 (m, 1 H); 3.62-3.53 (m, 1 H); 3.48-3.32 (m, 2H); 2.78 (s, 3H); [1.99 (s); 1.98 (s), 3H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example E64: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- propionylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f22) and commercially propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H, -NH); [8.90 (d, J = 7.1 ), 8.85 (d, J = 6.6), 1 H, -NH]; 8.87 (s, 1 H); 7.58 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); [5.54 (br.s), 5.46 (br.s), 1 H ₁ -OH]; [4.35 (m), 4.18 (m), 1 H]; 4.27 (m, 1 H); 3.91 (d , J = 7.1 , 2H); 3.86 (s, 3H);

3.79-3.66 (m, 1 H); 3.63-3.55 (m, 1 H); 3.48-3.32 (m, 2H); 2.78 (s, 3H); [2.28 (qu, J = 7.5), 2.27 (qu, J = 7.5), 2H]; [1.03 (d, J = 7.5); 1.01 (d, J = 7.5), 3H]; 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H).

Example E65: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f22) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 510 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.74 (br.s, 1 H, -NH); [8.90 (d, J = 7.1 ), 8.85 (d, J = 6.6), 1 H ₁ -NH];

[8.87 (s), 8.86 (s), 1 H]; 7.58 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); 5.68- 5.36 (br.s, 1 H, -OH); [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); [4.09 (dd, J = 14.6, 3.5), 4.01 [d, J = 14.6), 2H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.78-3.68 (m, 1 H); 3.66-3.58 (m, 1 H); 3.48-3.32 (m, 2H); [3.33 (s), 3.31 (s), 3H]; 2.78 (s, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H).

Example E66: N-(1 -acetylpiperidin^4-yl)^4-[2-(cyclopropylmethoxy)-5-methoxyph enyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f23) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 4.22-3.93 (m, 2H); 3.82 (d, J = 6.8, 2H); 3.77 (s, 3H & m, 1 H); 3.27 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.39 (m, 1 H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example E67: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f23) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 1 H); 4.25^.05 (m, 2H); 3.82 (d, J = 6.9, 2H); 3.79 (m, 1 H); 3.77 (s, 3H); 3.25 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu, J = 7.5, 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.38 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.20 (m, 2H). Example E68: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[1-

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f23) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 4.21-4.06 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.82 (d, J = 6.8, 2H); 3.77 (s, 3H); 3.73 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.20 (m, 2H).

Example E69: N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f24) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.72 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.10 (d, J = 1.8, 2H); 3.82 (d, J = 6.8, 2H); 3.77 (s, 3H & m, 1 H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example E70: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[trans ^4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth oxyphenyl]-6-methyl- 5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f24) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.62 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.10 (d, J = 1.8, 2H); 3.82 (d, J = 6.8, 2H); 3.79 (m, 1 H); 3.77 (s, 3H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.06 (qu, J = 7.5, 2H); 2.01 (m, 2H); 1.86 (m, 2H); 1.35 (m, 4H); 0.99 (t, J = 7.5, 3H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H). Example E71: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{trans-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f24) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.2, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.10 (d, J = 1.8, 2H); 3.82 (d, J = 6.8, 2H); 3.78 (s, 2H); 3.77 (s, 3H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example E72: N-(cis-4-acetamidocyclohexyl)^4-[2-(cyclopropylmethoxy)-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carbox amide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methox yphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f25) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.99 (s, 1 H); 8.93 (d, J = 7.5, 1 H, -NH); 7.85 (d,

J = 7.3, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.1 1 (d, J = 1.8, 2H); 4.02 (m, 1 H); 3.83 (d, J = 6.8, 2H);

3.77 (s, 3H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.84 (s, 3H); 1.81-1.52 (m, 8H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example E73: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[cis^4 - (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methox yphenyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f25) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.99 (s, 1 H); 8.92 (d, J = 7.7, 1 H, -NH); 7.75 (d, J = 7.7, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.1 1 (d, J = 1.8, 2H); 4.02 (m, 1 H); 3.83 (d, J = 6.9, 2H); 3.77 (s, 3H); 3.75 (m, 1 H); 2.79 (s, 3H); 2.11 (qu, J = 7.5, 2H); 1.86-1.50 (m, 8H); 1.00 (t, J = 7.5, 3H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example E74: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-methoxy phenyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f25) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.99 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 7.67 (d, J = 7.7, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.1 1 (d, J = 1.8, 2H); 4.05 (m, 1 H); 3.83 (d, J = 6.7, 2H); 3.80 (s, 2H & m, 1 H); 3.77 (s, 3H); 3.31 (s, 3H); 2.79 (s, 3H); 1.87-1.58 (m, 8H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example E75: N-[(3R)-1-acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5 - methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f26) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 464.2290 ([MH] ⁺, C ₂₅H ₃₀N ₅O ₄ ⁺, calc. 464.2292).

Example E76: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- 1- propionylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-d]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f26) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 478.2450 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₄+, calc. 478.2449).

Example E77: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R)-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f26) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 494.2393 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₅ ⁺, calc. 494.2398). Example E78: N-[(3R*,4R*)-1 -acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)-5 - methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxypiperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f27) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 494.2405 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₅ ⁺, calc. 494.2398).

Example E79: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxy-1- propanoylpiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide (

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxypiperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f27) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 508.2551 ([MH] ⁺, C ₂₇H ₃₄N ₅O ₅ ⁺, calc. 508.2554). Example E80: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxy-1-

(methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxypiperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f27) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 524.2501 ([MH] ⁺, C ₂₇H ₃₄N ₅O ₆ ⁺, calc. 524.2504).

Example E81: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methylphe nyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f28) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 420 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.25 (br.s, 1 H, -NH); 9.11 (br.s, 2H, -NH ₂ ⁺); 9.06 (s, 1 H); 7.47 (d, J

= 2.1 , 1 H); 7.39 (dd, J = 8.4, 2.1 , 1 H); 7.10 (d, J = 8.6, 1 H); 4.12 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.31 (m, 2H); 3.08 (m, 2H); 2.81 (s, 3H); 2.34 (s, 3H); 2.13 (m, 2H); 1.79 (m, 2H); 0.93 (m, 1 H); 0.36 (m,

2H); 0.25 (m, 2H).

Example E82: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f28) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 476 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.68 (br.s, 1 H, -NH); 8.93 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 1.8, 1 H); 7.32 (dd, J = 8.4, 1.8, 1 H); 7.05 (d, J = 8.4, 1 H); 4.26^.05 (m, 2H); 3.86 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.25 (m, 1 H); 2.96 (m, 1 H); 2.78 (s, 3H); 2.36 (qu, J = 7.3, 2H); 2.33 (s, 3H); 1.96 (m, 2H); 1.51 (m, 1 H); 1.39 (m, 1 H); 1.01 (t, J = 7.3, 3H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E83: 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-N-[1-(methoxyacety l)piperidin-4- yl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f28) and commercially available methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.67 (br.s, 1 H, -NH); 8.92 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.42

(d, J = 1.8, 1 H); 7.32 (dd, J = 8.4, 1.8, 1 H); 7.06 (d, J = 8.4, 1 H); 4.23^.04 (m, 2H); 4.12 (d, J = 1.8, 2H); 3.86 (d, J = 6.8, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.99 (m, 1 H); 2.77 (s, 3H); 2.33

(s, 3H); 1.97 (m, 2H); 1.53 (m, 1 H); 1.40 (m, 1 H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E84: N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carbo xamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f29) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 434 (MH ⁺, 100%).

3.88 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.09 (m, 1 H); 2.81 (s, 3H); 2.34 (s, 3H); 2.04 (m, 4H); 1.47 (m,

4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.24 (m, 2H).

Example E85: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[trans^ 4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f29) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.94 (s, 1 H); 8.67 (d, J = 7.7, 1 H, -NH); 7.62 (d,

J = 7.9, 1 H, -NH); 7.43 (d, J = 2.0, 1 H); 7.32 (dd, J = 8.4, 2.0, 1 H); 7.06 (d, J = 8.4, 1 H); 3.86 (d, J =

6.9, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.77 (s, 3H); 2.33 (s, 3H); 2.05 (qu, J = 7.5, 2H); 2.01 (m, 2H);

1.86 (m, 2H); 1.35 (m, 4H); 0.99 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H). Example E86: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f29) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.71 (s, 1 H, -NH); 8.94 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.4, 1 H, -NH); 7.43 (d, J = 2.1 , 1 H); 7.32 (dd, J = 8.4, 2.1 , 1 H); 7.06 (d, J = 8.4, 1 H); 5.40 (t, J = 5.9, 1 H, -OH); 3.86 (d, J = 6.9, 2H); 3.78 (s, 2H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.77 (s, 3H); 2.33 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.34 (m, 4H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E87: N-[cis-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)- 5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carbo xamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methyl phenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f30) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 476 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.97 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 7.85 (d, J = 7.7, 1 H, -NH); 7.44 (d, J = 1.8, 1 H); 7.33 (dd, J = 8.4, 1.8, 1 H); 7.06 (d, J = 8.4, 1 H); 4.02 (m,

1 H); 3.86 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.33 (s, 3H); 1.84 (s, 3H); 1.81 -1.51 (m, 8H);

0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E88: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[cis^4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methyl phenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f30) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.97 (s, 1 H); 8.94 (d, J = 7.5, 1 H, -NH); 7.75 (d,

J = 7.7, 1 H, -NH); 7.44 (d, J = 1.8, 1 H); 7.33 (dd, J = 8.4, 1.8, 1 H); 7.06 (d, J = 8.4, 1 H); 4.02 (m,

1 H); 3.86 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.33 (s, 3H); 2.1 1 (qu, J = 7.7, 2H); 1 .83-1 .53

(m, 8H); 1.00 (t, J = 7.7, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E89: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-methylp henyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f30) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.97 (s, 1 H & d, J = 7.5, 1 H, -NH); 7.67 (d, J = 7.7, 1 H, -NH); 7.44 (d, J = 2.1 , 1 H); 7.33 (dd, J = 8.4, 2.1 , 1 H); 7.06 (d, J = 8.4, 1 H); 4.05 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.33 (s, 3H); 1.84-1.61 (m, 8H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E90: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-

(trifluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f31 ) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 516 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.80 (d, J = 7.9, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.23-4.05 (m, 2H); 4.00 (d, J = 7.0, 2H); 3.79 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.80 (s, 3H); 2.04 (s, 3H); 1.96 (m, 2H); 1.55 (m, 1 H); 1.39 (m, 1 H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E91: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c^pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifiuoromethyl)phenyl]-6-methy l-N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f31 ) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 530 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.26-4.06 (m, 2H); 4.00 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.28 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu, J = 7.4, 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.39 (m, 1 H); 1.01 (t, J = 7.4, 3H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E92: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f31 ) and commercially available methoxy-methyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 546 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.24-4.06 (m, 2H); 4.12 (s, 2H); 4.00 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.23 (m, 1 H); 2.99 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E93: N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- (trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(tri fluoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f32) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 530 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.72 (d, J = 7.7, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 4.00 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.59 (m, 1 H); 2.79 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.36 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E94: 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-[trans-4-

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(tri fluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f32) and commercially available propionyl chloride the title compound is obtained as colorless solid.

Alternative the above obtained solid is re-crystal ised from ethylene glycol/water mixture (5/1 ).

MS (ESI): m/z = 544 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.90 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.63 (d, J = 7.8, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 3.99 (d, J =

6.9, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.79 (s, 3H); 2.06 (qu, J = 7.5, 2H); 2.01 (m, 2H); 1.86 (m,

2H); 1.36 (m, 4H); 0.98 (t, J = 7.5, 3H & m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E95: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{tran s^4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(tri fluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f32) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 560 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.63 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.57 (d, J = 8.2, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 4.00 (d, J = 7.0, 2H); 3.78 (s, 2H & m, 1 H); 3.70 (m, 1 H); 3.31 (s, 3H); 2.79 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.44 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example E96: N-[cis-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)- 5- (trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin e-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(trifl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f33) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 530 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.88 (br.s, 1 H, -NH); 9.02 (s, 1 H); 8.92 (d, J = 7.5, 1 H, -NH); 7.91 (s, 1 H); 7.88 (d, J = 8.2, 1 H); 7.85 (d, J = 7.6, 1 H, -NH); 7.38 (d, J = 8.2, 1 H); 4.04 (m, 1 H); 4.00 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.80 (s, 3H); 1 .84 (s, 3H); 1.81 -1.52 (m, 8H); 0.99 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H).

Example E97: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-[cis-4-

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(trifl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f33) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 544 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.88 (br.s, 1 H, -NH); 9.01 (s, 1 H); 8.92 (d, J = 7.3, 1 H, -NH); 7.91 (s, 1 H); 7.89 (d, J = 8.7, 1 H); 7.79 (d, J = 7.6, 1 H, -NH); 7.38 (d, J = 8.7, 1 H); 4.03 (m, 1 H); 4.00 (d,

J = 7.0, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 2.12 (qu, J = 7.6, 2H); 1.83-1.52 (m, 8H); 1.00 (t, J = 7.6,

3H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H).

Example E98: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis- 4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(trifl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f33) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 560 (MH ⁺, 100%).

1 H-NMR (400 MHz, DMSO-d ₆): 1 1.91 (s, 1 H, -NH); 9.03 (s, 1 H); 8.96 (d, J = 7.3, 1 H, -NH); 7.91 (s, 1 H); 7.90 (d, J = 8.8, 1 H); 7.72 (d, J = 7.8, 1 H, -NH); 7.39 (d, J = 8.8, 1 H); 4.06 (m, 1 H); 4.00 (d, J = 7.0, 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s, 3H); 2.80 (s, 3H); 1.85-1.60 (m, 8H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H). Example E99: N-(1 -acetylpiperidin^4-yl)^4-[2-ethoxy-5-(trifluoromethyl)phenyl ]-6-methyl-

5H-pyrrolo[3,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/-pyrrolo[3,2- cflpyπmidine-7-carboxamide hydrochloride (example D.f34) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 11.92 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.91 (dd, J = 9.4, 2.2, 1 H); 7.43 (d, J = 9.4, 1 H); 4.21 (qu, J = 7.0, 2H); 4.18^.07 (m, 2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.39 (m, 1 H); 1.16 (t, J = 7.0, 3H). Example E100: 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(1-propano ylpiperidin-4- yl)-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f34) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.93 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.91 (dd, J = 9.4, 2.2, 1 H); 7.42 (d, J = 9.4, 1 H); 4.21 (qu, J = 7.0, 2H); 4.17^.07 (m, 2H); 3.82 (m, 1 H); 3.26 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu, J = 7.1 , 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.38 (m, 1 H); 1.16 (t, J = 7.0, 3H); 1.01 (t, J = 7.1 , 3H).

Example E101: 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-[1 -(methoxyacetyl)piperidin-4-yl]- 6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f34) and commercially available methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.93 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.91 (dd, J = 9.5, 2.2, 1 H); 7.42 (d, J = 9.5, 1 H); 4.21 (qu, J = 7.0, 2H); 4.17-4.06 (m, 2H); 4.12 (d, J = 2.8, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.23 (m, 1 H); 2.99 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 1.16 (t, J = 7.0, 3H).

Example E102: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f35) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100 %). ¹H-NMR (300 MHz, 11.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.23 - 4.05 (m, 2H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.38 (m, 1 H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E103: 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl -N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f35) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.25 - 4.05 (m, 2H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.79 (m, 1 H); 3.26 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu J = 7.4, 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.38 (m, 1 H); 1.01 (t, J = 7.4, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E104: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f35) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.96 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.22 - 4.05 (m, 2H); 4.11 (s, 2H); 3.84 (s, 3H & d, J = 6.9, 2H); 3.75 (m, 1 H); 3.24 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E105: Ethyl 4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-m ethyl-

5/-/-pyrrolo[3,2-cy]pyrimidin-7-yl}carbonyl)amino]piperid ine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f35) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.06 (qu, J = 7.1 , 2H & m, 1 H); 3.88 (m, 2H); 3.84 (s, 3H & d, J

= 6.8, 2H); 3.11 (m, 2H); 2.78 (s, 3H); 1.94 (m, 2H); 1.46 (m, 1 H); 1.20 (t, J = 7.1 , 3H); 0.93 (m,

1 H); 0.36 (m, 2H); 0.21 (m, 2H). Example E106: N-(trans-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4- fluoro-5- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-car boxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (s, J = 7.7, 1 H, -NH); 7.72 (d, J = 7.7, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E107: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl -N-[trans-4-

(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidin e-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.62 (d,

J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.06 (qu, J = 7.6, 2H); 2.01 (m, 2H); 1.86 (m, 2H); 1.35 (m, 4H);

0.99 (t, J = 7.6, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E108: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{trans ^4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.64 (s, J = 7.7, 1 H, -NH); 7.56 (d, J = 8.2, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 3.84 (s, 3H); 3.83 (d, J = 6.8, 2H);

3.78 (s, 2H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m,

4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E109: Ethyl {trans^4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphen yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available ethyl chloroformate the title compound is obtained as colorless solid. MS (ESI): m/z = 540 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 7.01 (d, J = 7.1 , 1 H, -NH); 3.98 (qu, J = 7.0, 2H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.76 (m, 1 H); 3.33 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1.87 (m, 2H); 1.36 (m, 4H); 1.16 (t, J = 7.0, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E110: N-(cis-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fl uoro-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carbox amide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-4-fluoro- 5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f37) and commercially available acetyl chloride chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.99 (s, 1 H); 8.91 (d, J = 7.5, 1 H, -NH); 7.84 (d,

J = 7.3, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.02 (m, 1 H); 3.85 (s, 3H & d, J = 6.7, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.84 (s, 3H); 1.82 - 1.51 (m, 8H); 0.93 (m, 1 H); 0.36 (m, 2H);

0.21 (m, 2H).

Example E111: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-6-methyl -N-[cis-4-

(propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f37) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.99 (s, 1 H); 8.91 (d, J = 7.5, 1 H, -NH); 7.75 (d, J = 7.3, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.19 (d, J = 13.3, 1 H); 4.02 (m, 1 H); 3.85 (s, 3H & d, J =

6.9, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 2.1 1 (qu, J = 7.7, 2H); 1.85 - 1.51 (m, 8H); 1.00 (t, J = 7.7, 3H);

0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E112: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{cis^4 - [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f37) and commercially available mehoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 540 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.99 (s, 1 H); 8.95 (d, J = 7.3, 1 H, -NH); 7.66 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 9.7, 1 H); 7.19 (d, J = 13.5, 1 H); 4.05 (m, 1 H); 3.85 (s, 3H & d, J = 6.9, 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.29 (s, 3H); 2.79 (s, 3H); 1.86 - 1.58 (m, 8H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H). Example E113: N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)- 4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f38) and commercially available acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 512.2310 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₄ ⁺, calc. 512.2304).

Example E114: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxy-1 -propionylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f38) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 526.2462 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₄ ⁺, calc. 526.2460).

Example E115: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxy-1 -(methoxyacetyl)piperidin^4-yl]-6-methyl-5H-pyrrolo[3,2-d]py rimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f38) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 542.2399 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409). Example E116: N-[(3S*,4S*)-1 -Acetyl-4-hydroxypiperidin-3-yl]-4-[2-(cyclopropylmethoxy)-

4-fluoro-5-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]py rimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride (example D.f39) and commercially available acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 512.2302 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₄ ⁺, calc. 512.2304).

Example E117: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxy-1 -propionylpiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride (example D.f39) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 526.2462 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₄ ⁺, calc. 526.2460). Example E118: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxy-i^methoxyacetyljpiperidin-S-yll-e-methyl-SH-pyrroloI S^-dlpyrimidine-y-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f39) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 542.2401 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409). Example E119: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f40) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 554 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.93 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.0, 1 H); 4.22-4.05 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.38 (m, 1 H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E120: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-6-methyl- N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c^pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f40) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.93 (s, 1 H); 8.81 (d, J = 7.9, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.0, 1 H); 4.25-4.05 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.26 (m, 1 H); 2.96 (m, 1 H); 2.78 (s, 3H); 2.36 (qu, J = 7.5, 2H); 2.24 (d, J = 1.1 , 3H); 1.95 (m, 2H); 1.51 (m, 1 H); 1.38 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E121: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f40) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.93 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.0, 1 H); 4.22-4.06 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.78 (s, 3H); 2.24 (d, J = 1.1 , 3H); 1.96 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Exam pie E122: N-[trans-4-(Acety lam i no)cyclohexyl]^4-[2-(cyclop ropyl methoxy)^4-f I uoro-5- methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxa mide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5-methylphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f41 ) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.72 (d,

J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.03 (d, J = 12.0, 1 H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H);

3.58 (m, 1 H); 2.77 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.00 (m, 2H); 1.86 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E123: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-[trans-4-

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f41 ) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.62 (d,

J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.03 (d, J = 12.0, 1 H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.77 (s, 3H); 2.25 (d, J = 0.9, 3H); 2.05 (qu, J = 7.7, 2H); 2.01 (m, 2H); 1.85 (m, 2H);

1.35 (m, 4H); 0.99 (t, J = 7.7, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E124: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^ 4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f41 ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.03 (d, J = 12.0, 1 H); 3.87 (d, J = 6.9, 2H); 3.78 (m, 1 H & s, 2H); 3.68 (m, 1 H); 3.31 (s, 3H); 2.77 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.01 (m, 2H); 1.82 (m, 2H);

1.43 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H). Example E125: N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)^ 4-fluoro-5- methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxa mide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-4-fluoro- 5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f42) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.93 (d, J = 7.7, 1 H, -NH); 7.84 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.0, 1 H); 4.03 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 1.84 (s, 3H); 1.84-1.51 (m, 8H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E126: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-[cis-4-

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f42) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.93 (d, J = 7.5, 1 H, -NH); 7.75 (d,

J = 7.5, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.2, 1 H); 4.03 (m, 1 H); 3.88 (d, J = 7.1 , 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.11 (qu, J = 7.5, 2H); 1.84-1.51 (m, 8H); 1.00 (t, J

= 7.5, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E127: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{cis^4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f42) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.97 (s, 1 H); 8.96 (d, J = 7.8, 1 H, -NH); 7.66 (d, J = 7.8, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.04 (d, J = 12.2, 1 H); 4.05 (m, 1 H); 3.88 (d, J = 6.9, 2H);

3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s 3H); 2.78 (s, 3H); 2.25 (d, J = 1.1 , 3H); 1.86-1.59 (m, 8H); 0.95

(m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example E128: N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)- 4-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-cf]pyrimidi ne-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxypiperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f43) and commercially available acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 496.2373 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₄ ⁺, calc. 496.2355).

Example E129: 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3- hydroxy-1 -propanoylpiperidin^4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxypiperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f43) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 510.2534 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₄ ⁺, calc. 510.2511 ). Example E130: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3- hydroxy-1-(methoxyacetyl)piperidin^4-yl]-6-methyl-5H-pyrrolo [3,2-d]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxypiperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f43) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 526.2474 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₅ ⁺, calc. 526.2460).

Example E131: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f44) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H, -NH); 8.92 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47

(d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 4.22 - 4.04 (m, 2H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.78 (m, 1 H); 3.27 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.04 (s, 3H); 1.95 (m, 2H); 1.54 (m, 1 H); 1.38 (m,

1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E132: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-(1- propionylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f44) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (br.s, 1 H, -NH); 8.91 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.92 (d, J = 7.3, 1 H); 4.19 (m, 1 H); 4.12 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9,

2H); 3.81 (m, 1 H); 3.25 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.36 (qu, J = 7.3, 2H); 1.95 (m,2H);

1.51 (m, 1 H); 1.38 (m, 1 H); 1.01 (t, J = 7.3, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example E133: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[1- (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f44) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H, -NH); 8.92 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.92 (d, J = 7.3, 1 H); 4.22 - 4.06 (s, 2H & m, 2H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (m, 1 H); 3.22 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H); 1.96 (m, 2H); 1.53 (m, 1 H); 1.40 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E134: Ethyl 4-[({4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-m ethyl-

5/-/-pyrrolo[3,2-c(]pyrimidin-7-yl}carbonyl)amino]piperid ine-1 -carboxylate

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f44) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (br.s, 1 H, -NH); 8.92 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47

(d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 4.06 (qu, J = 7.1 , 2H & m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 7.1 , 2H); 3.88 (m, 2H); 3.1 1 (m, 2H); 2.79 (s, 3H); 1.94 (m, 2H); 1.45 (m, 1 H); 1.20 (t, J = 7.1 , 3H); 0.96

(m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example E135: N-(trans-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5- fluoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f45) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 468 (MH ⁺, 100%).

2H); 3.81 (m, 1 H); 3.07 (m, 1 H); 2.83 (s, 3H); 2.05 (m, 4H); 1.48 (m, 4H); 0.97 (m, 1 H); 0.39 (m,

2H); 0.27 (m, 2H).

Example E136: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-[trans-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f45) and commercially available propionyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.92 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.62 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.8, 1 H); 6.92 (d, J = 7.5, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.80 (m,1 H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.05 (qu, J = 7.7, 2H); 2.00 (m, 2H); 1.86 (m, 2H); 1.35 (m, 4H); 0.99 (t, J = 7.7, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E137: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{trans ^4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f45) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.92 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.56 (d, J = 8.2, 1 H, -NH); 7.47 (d, J = 11.7, 1 H); 6.92 (d, J = 7.3, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.78 (s, 2H & m,1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example E138: N-(cis-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fl uoro-4- methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-car boxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro -4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.95 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 7.84 (d, J = 7.5, 1 H, -NH); 7.48 (d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 4.02 (m, 1 H); 3.97 (s, 3H); 3.95 (d, J

= 6.9, 2H); 3.75 (m,1 H); 2.79 (s, 3H); 1.84 (s, 3H); 1.80 - 1.52 (m, 8H); 0.96 (m, 1 H); 0.39 (m, 2H);

0.25 (m, 2H).

Example E139: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-[cis-4- (propionylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro -4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.95 (s, 1 H); 8.93 (d, J = 7.7, 1 H, -NH); 7.75 (d, J = 7.5, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 4.02 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.75 (m,1 H); 2.79 (s, 3H); 2.1 1 (qu, J = 7.6, 2H); 1.83 - 1.52 (m, 8H); 1.00 (t, J = 7.6, 1 H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H). Example E140: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-{cis^4 - [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-fluoro- 4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.97 (d, J = 7.7, 1 H, -NH); 8.96 (s, 1 H); 7.67 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 4.05 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 7.1 , 2H); 3.82 (s, 2H); 3.79 (m,1 H); 3.31 (s, 3H); 2.79 (s, 3H); 1.85 - 1.59 (m, 8H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example E141: Ethyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl ]-6- methyl-5H-pyrrolo[3,2-c^pyrimidin-7-yl}carbonyl)amino]cycloh exyl}carbamate

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro -4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available ethyl chloroformate the title compound is obtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.69 (s, 1 H, -NH); 8.98 (d, J = 7.7, 1 H, -NH); 8.95 (s, 1 H); 7.47 (d, J = 11.9, 1 H); 7.21 (br.d, J = 6.0, 1 H, -NH); 6.93 (d, J = 7.3, 1 H); 4.03 (m, 1 H); 3.99 (qu, J = 7.1 ,

2H); 3.97 (s, 3H); 3.94 (d, J = 7.1 , 2H); 3.48 (m, 1 H); 2.78 (s, 3H); 1.85 - 1.54 (m, 8H); 1.17 (t, J =

7.1 , 3H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example E142: N-[(3R*,4R*)-1 -Acetyl-3-hydroxypiperidin-4-yl]-4-[2-(cyclopropylmethoxy)- 5-fluoro^4-methoxyphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f47) and commercially available acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 512.2301 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₅ ⁺, calc. 512.2304).

Example E143: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-3- hydroxy-1 -propanoylpiperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f47) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = HR-MS (ESI): m/z = 526.2454 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₅ ⁺, calc. 526.2460). Example E144: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-3- hydroxy-1 -(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f47) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 542.2398 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409).

Example E145: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-ethylphen yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f48) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 476 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.45 (d,

J = 2.2, 1 H); 7.36 (dd, J = 8.6, 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 4.22-4.04 (m, 2H); 3.87 (d, J = 6.9,

2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.04 (s, 3H);

1.96 (m, 2H); 1.54 (m, 1 H); 1.39 (m, 1 H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.25 (m,

2H).

Example E146: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c^pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f48) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.94 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 4.25-4.04 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.25 (m, 1 H); 2.97 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.36 (qu, J = 7.5, 2H); 1.96 (m, 2H); 1.52 (m, 1 H); 1.38 (m, 1 H); 1.18 (t, J = 7.5, 3H); 1.01 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E147: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[1 -(methoxyacetyl)piperidin-4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5H-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f48) and commercially available methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%). ¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 4.22-4.04 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.99 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 1 .96 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E148: N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carbo xamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-ethy lphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f49) and commercially available acetylchloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.95 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.72 (d,

J = 7.7, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.35 (dd, J = 8.6, 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 3.86 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.77 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.00 (m, 2H); 1.87 (m,

2H); 1.79 (s, 3H); 1.35 (m, 4H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E149: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[trans^4 -

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-ethy lphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f49) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.95 (s, 1 H); 8.67 (d, J = 7.7, 1 H, -NH); 7.62 (d, J = 7.7, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.36 (dd, J = 8.6, 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 3.86 (d, J =

6.9, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.77 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.06 (qu, J = 7.7, 2H);

2.01 (m, 2H); 1.86 (m, 2H); 1.35 (m, 4H); 1.18 (t, J = 7.5, 3H); 0.99 (t, J = 7.5, 3H); 0.94 (m, 1 H);

0.36 (m, 2H); 0.22 (m, 2H). Example E150: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-ethy lphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f49) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.86 (br.s, 1 H, -NH); 8.93 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.2, 1 H, -NH); 7.44 (d, J = 2.4, 1 H); 7.35 (dd, J = 8.6, 2.4, 1 H); 7.07 (d, J = 8.6, 1 H); 3.86 (d, J = 6.9, 2H); 3.78 (s, 2H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.77 (s, 3H); 2.63 (qu, J = 7.5, 2H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E151: N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)- 5- ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carbo xamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-ethylph enyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f50) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.98 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 7.85 (d, J = 7.5, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 4.03 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 1.84 (s, 3H); 1.82-1.51 (m, 8H); 1.19 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example E152: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[cis^4-

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine -7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-ethylp henyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f50) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.98 (s, 1 H); 8.94 (d, J = 7.5, 1 H, -NH); 7.75 (d, J = 7.5, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.36 (dd, J = 8.6, 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 4.02 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.11 (qu, J = 7.5, 2H); 1.89-1.52 (m, 8H); 1.19 (t, J = 7.5, 3H); 1.00 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E153: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-ethylp henyl]-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f50) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.98 (s, 1 H); 8.97 (d, J = 7.5, 1 H, -NH); 7.67 (d, J = 7.5, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.36 (dd, J = 8.6, 2.2, 1 H); 7.08 (d, J = 8.6, 1 H); 4.06 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.64 (qu, J = 7.6, 2H); 1.89-1.55 (m, 8H); 1.19 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example E154: N-[(3R*,4R*)-1 -Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 5-ethylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-car boxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f51 ) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.93 (s, 1 H); [8.90 (d, J = 7.1 ), 8.84 (d, J = 6.6), 1 H, -NH]; 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.4, 1 H); [5.56 (d, J = 3.8), 5.48 (J = 4.0), 1 H ₁ -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.80-3.65 (m, 1 H); [3.58 (m), 3.45 (m), 1 H]; 3.41-3.27 (m, 2H); [2.78 (s), 2.77 (s), 3H]; 2.63 (qu, J = 7.6, 2H);

[1.99 (s)-1.98 (s), 3H]; 1.18 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E155: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxy-1- propanoylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f51 ) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.79 (s, 1 H, -NH); 8.91 (s, 1 H); [8.88 (d, J = 7.1 ), 8.84 (d, J = 6.6), 1 H, -NH]; 7.44 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); [5.55 (d, J = 3.7), 5.47 (d, J = 3.9), 1 H, -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.73 (m, 1 H); [3.59 (m), 3.45 (m), 1 H]; 3.42-3.27 (m, 2H); 2.78 (s, 3H); 2.63 (qu, J = 7.6, 2H); [2.29 (qu, J =7.5), 2.28 (qu, J = 7.5), 2H]; 1.18 (t, J = 7.6, 3H); [1.03 (t, J = 7.5), 1.01 (t, J = 7.5), 3H]; 0.93 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E156: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxy-1- (methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f51 ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 508 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); [8.91 (s), 8.90 (s), 1 H]; [8.88 (d, J = 7.1 ), 8.84 (d, J = 6.6), 1 H, -NH]; 7.44 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.4, 1 H); [5.57 (d, J = 3.7), 5.50 (d, J = 3.9), 1 H, -OH]; [4.36 (m), 4.19 (m), 1 H]; 4.27 (m, 1 H); [4.07 (d, J = 3.5), 4.04 (s), 2H]; 3.86 (d, J = 6.9, 2H); 3.73 (m, 1 H); [3.62 (m), 3.46 (m), 1 H]; 3.44-3.27 (m, 2H); [3.34 (s), 3.32 (s), 3H]; 2.78 (s, 3H); 2.63 (qu, J = 7.6, 2H); 1.18 (t, J = 7.6, 3H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H). Example E157: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-(propan-2 - yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxa mide

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-N- (piperidin-4-yl)-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f52) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1 .76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 4.23-4.05 (m, 2H); 3.87 (d, J = 6.9, 2H); 3.78 (m, 1 H); 3.28 (m, 1 H); 2.94 (m, 1 H & sept, J = 6.9, 1 H); 2.78 (s, 3H); 2.04 (s, 3H); 1 .96 (m, 2H); 1.54 (m, 1 H); 1.39 (m, 1 H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E158: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-[1 - (methoxyacetyl)piperidin^4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-N- (piperidin-4-yl)-5H- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f52) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.9, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 4.21 -4.05 (m, 2H); 4.12 (d, J = 1.6, 2H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.22 (m, 1 H); 2.94 (m, 1 H & sept, J = 6.9,

1 H); 2.78 (s, 3H); 1.96 (m, 2H); 1 .54 (m, 1 H); 1.41 (m, 1 H); 1 .22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E159: N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5-(propan- 2-yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carbo xamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(pro pan-2-yl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f53) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.72 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.58 (m, 1 H); 2.94 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 2.01 (m, 2H); 1 .87 (m, 2H); 1.79 (s, 3H); 1.35 (m, 4H); 1 .22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E160: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{trans^4-

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2 -c^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(pro pan-2-yl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f53) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 534 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.95 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.57 (d, J = 8.2, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 3.87 (d, J = 6.9, 2H); 3.78 (s, 2H & m, 1 H); 3.69 (m, 1 H); 3.31 (s, 3H); 2.94 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E161: N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)- 5-(propan-2- yl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxa mide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(propa n-2-yl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f54) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.98 (s, 1 H); 8.93 (d, J = 7.5, 1 H, -NH); 7.85 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.40 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 4.02 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.94 (sept, J = 6.8, 1 H); 2.78 (s, 3H); 1.84 (s, 3H); 1.81 - 1.51 (m, 8H); 1.22 (d, J = 6.8, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example E162: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{cis-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(propa n-2-yl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f54) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 534 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.99 (s, 1 H); 8.97 (d, J = 7.3, 1 H, -NH); 7.67 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.40 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 4.06 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.82 (s, 2H); 3.79 (m, 1 H); 3.31 (s, 3H); 2.95 (sept, J = 6.9, 1 H); 2.78 (s, 3H); 1.86-1.61 (m, 8H); 1.22 (d, J = 6.9, 6H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.24 (m, 2H).

Example E163: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(1-acetylpiperid in-4-yl)-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f55) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺, 100%). ¹H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.99 (s, 1 H); 8.92 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.15 (dd, J = 8.8, 2.3, 1 H); 7.30 (d, J = 8.8, 1 H); 4.22-4.07 (m, 2H); 4.01 (d, J = 7.1 , 2H); 3.79 (m, 1 H); 3.28 (m, 1 H); 2.95 (m, 1 H); 2.79 (s, 3H); 2.58 (s, 3H); 2.04 (s, 3H); 1.96 (m, 2H); 1.55 (m, 1 H); 1.40 (m, 1 H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example E164: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f55) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.99 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.2, 1 H); 8.15 (dd, J = 8.8, 2.2, 1 H); 7.30 (d, J = 8.8, 1 H); 4.20 (m, 1 H); 4.13 (m, 1 H); 4.01 (d, J = 7.0, 2H); 3.82 (m, 1 H); 3.27 (m, 1 H); 2.96 (m, 1 H); 2.79 (s, 3H); 2.58 (s, 3H); 2.36 (dqu, J = 7.5, 1.3, 2H); 1.96 (m, 2H); 1.53 (m, 1 H); 1.39 (m, 1 H); 1.01 (t, J = 7.5, 3H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example E165: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-[1 -(methoxyacetyl)piperidin-

4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamid e

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f55) and commercially available methoxy- acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.99 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.15 (dd, J = 8.8, 2.3, 1 H); 7.30 (d, J = 8.8, 1 H); 4.22-4.07 (m, 2H); 4.12 (d, J = 3.0,

2H); 4.01 (d, J = 7.0, 2H); 3.75 (m, 1 H); 3.31 (s, 3H); 3.23 (m, 1 H); 2.98 (m, 1 H); 2.79 (s, 3H); 2.58

(s, 3H); 1.97 (m, 2H); 1.55 (m, 1 H); 1.42 (m, 1 H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example E166: N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-acetyl-2- (cyclopropylmethoxy)phenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimi dine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-aminocy clohexyl)-6-methyl-5f-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f56) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 504 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 11.23 (br.s, 1 H, -NH); 8.97 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 8.20

(d, J = 2.2, 1 H); 8.14 (dd, J = 8.8, 2.2, 1 H); 7.73 (d, J = 7.7, 1 H, -NH); 7.29 (d, J = 8.8, 1 H); 4.01 (d,

J = 7.0, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.77 (s, 3H); 2.58 (s, 3H); 2.01 (m, 2H); 1.86 (m, 2H); 1.79

(s, 3H); 1.35 (m, 4H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example E167: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-[trans^ 4- (propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-d]pyrimidine-7- carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-aminocy clohexyl)-6-methyl-5f-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f56) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 518 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.78 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 8.20 (d, J = 2.3, 1 H); 8.14 (dd, J = 8.9, 2.3, 1 H); 7.62 (d, J = 7.7, 1 H, -NH); 7.29 (d, J = 8.9, 1 H); 4.01 (d, J = 7.0, 2H); 3.80 (m, 1 H); 3.59 (m, 1 H); 2.78 (s, 3H); 2.58 (s, 3H); 2.05 (qu, J = 7.7, 2H); 2.01 (m, 2H); 1.86 (m, 2H); 1.36 (m, 4H); 0.99 (t, J = 7.7, 3H & m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example E168: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-aminocy clohexyl)-6-methyl-5f-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f56) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

1 H-NMR (400 MHz, DMSO-d ₆): 1 1.84 (br.s, 1 H, -NH); 8.99 (s, 1 H); 8.64 (d, J = 7.8, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.14 (dd, J = 8.8, 2.3, 1 H); 7.57 (d, J = 8.2, 1 H, -NH); 7.30 (d, J = 8.8, 1 H); 4.01 (d, J = 7.0, 2H); 3.81 (m, 1 H); 3.78 (s, 2H); 3.70 (m, 1 H); 3.31 (s, 3H); 2.78 (s, 3H); 2.58 (s, 3H); 2.02 (m, 2H); 1.82 (m, 2H); 1.44 (m, 4H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example E169: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-methylphe nyl]-2,6- dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f57) and commercially available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 476 (MH ⁺ , 100%)

1 H-NMR (300 MHz, DMSO-d ₆): 1 1 .59 (s, 1 H, -NH); 9.05 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 1 .8, 1 H);

7.31 (dd, J = 8.4, 1.8, 1 H); 7.04 (d, J = 8.4, 1 H); 4.18-4.03 (m, 2H); 3.85 (d, J = 6.9, 2H); 3.77 (m,

1 H); 3.40-3.23 (m, 1 H); 3.06 (m, 1 H); 2.75 (s, 3H); 2.72 (s, 3H); 2.33 (s, 3H); 2.04 (s, 3H); 1.95 (m,

2H); 1.63-1.33 (m, 2H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example E170: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(1 - propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-c^pyrimidine-7-carbo xamide Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4-yl)-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f57) and commercially available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 490 (MH ⁺ , 100%)

1H-NMR (300 MHz, DMSO-d ₆): 11.58 (s, 1 H ₁ -NH); 9.05 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 2.0, 1 H); 7.31 (dd, J = 8.4, 2.0, 1 H); 7.04 (d, J = 8.4, 1 H); 4.18-4.03 (m, 2H); 3.85 (d, J = 6.9, 2H); 3.77 (m, 1 H); 3.37-3.22 (m, 1 H); 3.07 (m, 1 H); 2.75 (s, 3H); 2.72 (s, 3H); 2.36 (qu, J = 7.3, 2H); 2.33 (s, 3H); 1.95 (m, 2H); 1.60-1.34 (m, 2H); 1.01 (t, J = 7.3, 3H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H). Example E171: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1 -(methoxyacetyl)piperidin-

4-yl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f57) and commercially available available methoxy-acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺ , 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 11.58 (s, 1 H, -NH); 9.05 (d, J = 7.7, 1 H, -NH); 7.39 (d, J = 1.8, 1 H); 7.31 (dd, J = 8.6, 1.8, 1 H); 7.04 (d, J = 8.6, 1 H); 4.20-4.02 (m, 2H); 4.12 (d, J = 0.9, 2H); 3.85 (d, J = 6.9, 2H); 3.72 (m, 1 H); 3.31 (s, 3H); 3.27 (m, 1 H); 3.09 (m, 1 H); 2.75 (s, 3H); 2.72 (s, 3H); 2.33 (s, 3H); 1.97 (m, 2H); 1.63-1.35 (m, 2H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.21 (m, 2H).

Example E172: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4- methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f58) and commercially available available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI) : m/z = 510 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 11.56 (s, 1 H, -NH); 9.04 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 11.9, 1 H); 6.91 (d, J = 7.3, 1 H); 4.18-4.03 (m, 2H); 3.96 (s, 3H); 3.93 (d, J = 6.9, 2H); 3.81-3.70 (m, 1 H); 3.38-3.25 (m, 1 H); 3.06 (m, 1 H); 2.76 (s, 3H); 2.71 (s, 3H); 2.04 (s, 3H); 1.94 (m, 2H); 1.62-1.33 (m, 2H); 0.95 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example E173: N-(1 -Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-2,6-dimethyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f59) and commercially available available acetyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.59 (br.s, 1 H, -NH); 9.02 (d, J = 7.7, 1 H, -NH); 7.33 (d, J = 9.9, 1 H); 7.16 (d, J = 13.5, 1 H); 4.19-4.03 (m, 2H); 3.84 (s, 3H); 3.82 (d, J = 6.8, 2H); 3.76 (m, 2H); 3.34 (m, 1 H); 3.05 (m, 1 H); 2.75 (s, 3H); 2.73 (s, 3H); 2.04 (s, 3H); 1.95(m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.19 (m, 2H).

Example E174: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(1- propanoylpiperidin-4-yl)-5/-/-pyrrolo[3,2-cy]pyrimidine-7-ca rboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f59) and commercially available available propionyl chloride the title compound is obtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.60 (br.s, 1 H, -NH); 9.02 (d, J = 7.7, 1 H, -NH); 7.33 (d, J = 9.9, 1 H); 7.16 (d, J = 13.3, 1 H); 4.19-4.03 (m, 2H); 3.84 (s, 3H); 3.83 (d, J = 6.8, 2H); 3.77 (m, 2H); 3.28 (m, 1 H); 3.07 (m, 1 H); 2.75 (s, 3H); 2.73 (s, 3H); 2.36 (qu, J = 7.3, 2H); 1.95(m, 2H); 1.52 (m, 1 H); 1.41 (m, 1 H); 1.01 (t, J = 7.3, 3H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.19 (m, 2H).

Example E175: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-[1 - (methoxyacety^piperidin^-yl^θ-dimethyl-SH-pyrroloβ^-dlpyri midine^-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f59) and commercially available available methoxy-acetyl chloride the title compound is obtained as colorless solid. MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.60 (br.s, 1 H, -NH); 9.02 (d, J = 7.7, 1 H, -NH); 7.33 (d, J = 9.9, 1 H); 7.16 (d, J = 13.5, 1 H); 4.20-4.01 (m, 2H); 4.12 (s, 2H); 3.84 (s, 3H); 3.83 (d, J = 6.8, 2H); 3.72 (m, 1 H); 3.31 (s, 3H); 3.24 (m, 1 H); 3.08 (m, 1 H); 2.75 (s, 3H); 2.73 (s, 3H); 1.96 (m, 2H); 1.63-1.33 (m, 2H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example E176: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2- hydroxycyclopentyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine-7-c arboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2S)-2-hydroxycyclopentyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide (example

D.d60) the title compound is obtained as colorless solid.

MS (ESI): m/z = 421 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.94 (s, 1 H); 8.78 (d, J = 7.1 , 1 H, -NH); 7.44 (d, J = 2.2, 1 H); 7.33 (dd, J = 8.6, 2.2, 1 H); 7.06 (d, J = 8.6, 1 H); 4.92 (d, J = 4.0, 1 H; -OH); 4.07 (m,

1 H); 3.99 (m, 1 H); 3.86 (d, J = 6.9, 2H); 2.78 (s, 3H); 2.33 (s, 3H); 2.12 (m, 1 H); 1.91 (m, 1 H); 1.74

(m, 2H); 1.53 (m, 2H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example E177: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S, 2R)-2- hydroxycyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine- 7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S,2R)-2-hydroxycyclopentyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -c(]pyrirnidine-7-carboxarnide (example D.d61 ) the title compound is obtained as colorless solid.

MS (ESI): m/z = 421 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.66 (s, 1 H, -NH); 8.99 (d, J = 7.1 , 1 H, -NH); 8.92 (s, 1 H); 7.43 (d, J = 2.0, 1 H); 7.32 (dd, J = 8.6, 2.0, 1 H); 7.06 (d, J = 8.6, 1 H); 4.882 (d, J = 4.2, 1 H; -OH); 4.16 (m, 1 H); 4.02 (m, 1 H); 3.86 (d, J = 6.9, 2H); 2.79 (s, 3H); 2.33 (s, 3H); 2.01-1.73 (m, 3H); 1.70-1.46 (m, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example E178: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2- hydroxycyclopentyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine- 7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R,2R)-2-hydroxycyclopentyl]-6- methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide (example D.d62) the title compound is obtained as colorless solid.

MS (ESI): m/z = 421 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.77 (d, J = 7.1 , 1 H, -NH); 7.44 (d, J = 2.2, 1 H); 7.32 (dd, J = 8.6, 2.2, 1 H); 7.05 (d, J = 8.6, 1 H); 4.92 (d, J = 4.0, 1 H; -OH); 4.07 (m, 1 H); 3.98 (m, 1 H); 3.85 (d, J = 6.9, 2H); 2.78 (s, 3H); 2.33 (s, 3H); 2.11 (m, 1 H); 1.91 (m, 1 H); 1.74 (m, 2H); 1.53 (m, 2H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example E179: N-[(3R)-1-Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)^4 -fluoro-5- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carbox amide

MS (ESI): m/z = 482 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.69 (s, 1 H, -NH); 8.93 (s, 1 H); [8.92 (d, J = 6.9), 8.89 (d, J = 6.7), 1 H, -NH]; 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.5, 1 H); [4.58 (m),4.49 (m), 1 H]; 3.84 (d, J = 6.8, 2H & s, 3H); 3.68-3.57 (m, 1 H); 3.55-3.35 (m, 2H); 3.32-3.21 (m, 1 H); 2.77 (s, 3H); 2.34-2.16 (m, 1 H); [2.04 (m), 1.91 (m), 1 H]; [1.98 (s), 1.96 (s), 3H]; 0.93 (m, 1 H); 0.35 (m, 2H); 0.20 (m, 2H).

Example E180: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-[(3R)-1- propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carb oxamide

MS (ESI): m/z = 496 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.70 (s, 1 H, -NH); 8.93 (s, 1 H); [8.92 (d, J = 6.9), 8.89 (d, J = 6.9), 1 H, -NH]; 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.5, 1 H); [4.58 (m),4.49 (m), 1 H]; 3.84 (d, J = 6.9, 2H & s, 3H); 3.69-3.57 (m, 1 H); 3.55-3.42 (m, 1 H); 3.40-3.22 (m, 2H); 2.78 (s, 3H); 2.34-2.15 (m, 1 H); [2.29 (qu, J = 7.4), 2.25 (qu, J = 7.4), 2H]; [2.04 (m), 1.91 (m), 1 H]; [1.01 (t, J = 7.4), 0.99 (t, J = 7.4), 3H]; 0.93 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H). Example E181: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-[(3R)- 1 - (methoxyacetyOpyrrolidin-S-yll-e-methyl-SH-pyrroloIS^-dlpyri midine-y-carboxamide

MS (ESI): m/z = 512 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.78 (s, 1 H, -NH); 8.94 (s, 1 H); [8.92 (d, J = 7.4), 8.90 (d, J = 7.9, 1 H, -NH); 7.39 (d, J = 9.7, 1 H); 7.18 (d, J = 13.4, 1 H); [4.58 (m),4.49 (m), 1 H]; [4.06 (d, J = 4.2), 4.01 (d, J = 1.3), 2H]; 3.84 (d, J = 6.9, 2H & s, 3H); [3.80 (m), 3.68 (m), 1 H]; 3.62-3.43 (m, 2H); 3.36 (m, 1 H); 3.32 (s, 3H); 2.78 (s, 3H); 2.33-2.15 (m, 1 H); [2.04 (m), 1.90 (m), 1 H]; 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example E182: Ethyl (3R)-3-[({4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl ]-6- methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]pyrrol idine-1 -carboxylate

MS (ESI): m/z = 512 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.80 (s, 1 H, -NH); 8.95 (s, 1 H); 8.91 (d, J = 6.7, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.19 (d, J = 13.5, 1 H); 4.51 (m, 1 H); 4.05 (qu, J = 6.9, 2H); 3.84 (d, J = 6.9, 2H & s, 3H); 3.66 (m, 1 H); 3.47 (m, 2H); 3.27 (m, 1 H); 2.78 (s, 3H); 2.23 (m, 1 H); 1.91 (m, 1 H); 1.19 (t, J = 6.9, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E183: N-[(3R*,4R*)-1 -Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

MS (ESI): m/z = 498 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.75 (br.s, 1 H, -NH); 8.93 (s, 1 H); [8.88 (d, J = 7.1 ), 8.82 (d, J = 6.6), 1 H, -NH]; 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.5, 1 H); [5.56 (d, J = 3.8), 5.49 (d, J = 4.0), 1 H, - OH]; 4.39^.16 (m, 2H); 3.91 (m, 1 H); 3.83 (d, J = 6.9, 2H & s, 3H); 3.73 (m, 1 H); 3.47-3.22 (m, 2H); 2.78 (s, 3H); [1.99 (s), 1.98 (s), 3H]; 0.92 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example E184: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-4- hydroxy-1 -propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimid ine-7-carboxamide

MS (ESI): m/z = 512 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.69 (br.s, 1 H, -NH); 8.90 (s, 1 H); [8.87 (d, J = 7.1 ), 8.82 (d, J = 6.6), 1 H, -NH]; 7.38 (d, J = 9.9, 1 H); 7.18 (d, J = 13.5, 1 H); [5.56 (d, J = 3.5), 5.47 (d, J = 3.8), 1 H, - OH]; 4.39^.14 (m, 2H); 3.88 (m, 1 H); 3.84 (d, J = 6.9, 2H & s, 3H); 3.72 (m, 1 H); 3.63-3.20 (m, 2H); 2.78 (s, 3H); 2.28 (m, 2H); [1.03 (t, J = 7.7), 1.01 (t, J = 7.5), 3H]; 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example E185: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-4- hydroxy-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]p yrimidine-7-carboxamide MS (ESI): m/z = 528 (MH+, 100 %). 1 H-NMR (300 MHz, DMSO-d6): 11.68 (br.s, 1 H ₁ -NH); [8.90 (s), 8.89 (s), 1 H]; [8.86 (d, J = 7.1 ), 8.82 (d, J = 6.8), 1 H, -NH]; 7.38 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); [5.57 (d, J = 2.4), 5.50 (d, J = 3.7), 1 H, -OH]; 4.40^.15 (m, 2H); [4.06 (d, J = 3.3), 4.04 (s), 2H]; 3.86 (m, 1 H); 3.84 (d, J = 6.8, 2H & s, 3H); 3.73 (m, 1 H); 3.65-3.22 (m, 2H); [3.33 (s), 3.31 (s), 3H]; 2.77 (s, 3H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example E186: N-[(3R)-1-Acetylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5 -fluoro-4- methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carbox amide

MS (ESI): m/z = 482 (MH+, 100%).

Example E187: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-6-methyl -N-[(3R)-1- propionylpyrrolidin-3-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carb oxamide

MS (ESI): m/z = 496 (MH+, 100%). Example E188: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)- 1 -

(methoxyacetyOpyrrolidin-S-yll-e-methyl-SH-pyrroloβ^-dlp yrimidine^-carboxamide

MS (ESI): m/z = 512 (MH+, 100%).

Example E189: N-[(3R*,4R*)-1 -Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 5-fluoro^4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

MS (ESI): m/z = 498 (MH+, 100%).

Example E190: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-4- hydroxy-1 -propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimid ine-7-carboxamide

MS (ESI): m/z = 512 (MH+, 100%).

Example E191: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-4- hydroxy-1 -(methoxyacetyl)pyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]p yrimidine-7-carboxamide MS (ESI): m/z = 528 (MH+, 100%).

Example E192: N-[(3R*,4R*)-1 -Acetyl-4-hydroxypyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)- 5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carb oxamide

MS (ESI): m/z = 480 (MH+, 100%). Example E193: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1 - propionylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

MS (ESI): m/z = 494 (MH+, 100%). Example E194: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxy-1- (methoxyacetyOpyrrolidin-S-yll-e-methyl-SH-pyrroloIS^-dlpyri midine-y-carboxamide

MS (ESI): m/z = 510 (MH+, 100%). Example E195: N-[(1 R ^*,3S ^*,4S ^*)-3-(Acetylamino)-4-methylcyclopentyl]-4-[2-

(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5 /-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from N-[(1 R*,3S*,4S*)-3-amino^4-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f68) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2463 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468).

Example E196: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N- [(1 R*,3S*,4S*)-3-methyl^4-(propanoylamino)cyclopentyl]-5/-/-pyr rolo[3,2-cy]pyrimidine-7- carboxamide

Starting from N-[(1 R*,3S*,4S*)-3-amino^4-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride (example D.f68) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 526.2624 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₃ ⁺, calc. 526.2624).

Example E197: 4-[2-(Cyclopropylmethoxy )-5-(difluoromethyl)phenyl]-N-{(1 R*,3S*,4S*)-3- [(methoxyacetyl)amino]-4-methylcyclopentyl}-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide Starting from N-[(1 R*,3S*,4S*)-3-amino^4-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride (example D.f68) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 542.2570 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₄ ⁺, calc. 542.2573).

Example E198: N-[(1 R*,2R*,4S*)-4-(acetylamino)-2-methylcyclopentyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-p yrrolo[3,2-d]pyrimidine-7- carboxamide

Starting from N-[(1 R*,2R*,4S*)-4-amino-2-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimidine -7 -carboxamide (example D.f69) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2475 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468). Example E199: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N- [(1 R*,2R*,4S*)-2-methyl^4-(propanoylamino)cyclopentyl]-5H-pyrro lo[3,2-d]pyrimidine-7- carboxamide

Starting from N-[(1 R*,2R*,4S*)-4-amino-2-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7 -carboxamide (example D.f69) and commercially available propionyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 526.2622 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₃ ⁺, calc. 526.2624).

Example E200: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4S*)-4- [(methoxyacetyl)amino]-2-methylcyclopentyl}-6-methyl-5/-/-py rrolo[3,2-c(]pyrimidine-7 -carboxamide Starting from N-[(1 R*,2R*,4S*)-4-amino-2-methylcyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7 -carboxamide (example D.f69) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 542.2575 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₄ ⁺, calc. 542.2573).

Example E201: N-[(1 S*,3S*,4S*)-3-(Acetylamino)-4-fluorocyclopentyl]-4-[2-

(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5 /-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from N-[(1 S*,3S*,4S*)-3-amino^4-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride

(example D.f70) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 516.2215 ([MH] ⁺, C ₂₆H ₂₉F ₃N ₅O ₃ ⁺, calc. 516.2217).

Example E202: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,3S*,4S*)-3- fluoro^4-(propanoylamino)cyclopentyl]-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidine-7-carboxamide

Starting from N-[(1 S*,3S*,4S*)-3-amino^4-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5-

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyri midine-7-carboxamide hydrochloride

(example D.f70) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2382 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₃ ⁺, calc. 530.2374).

Example E203: 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3S*,4S*)-3- fluoro^4-[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5H-pyrr olo[3,2-d]pyrimidine-7-carboxamide Starting from N-[(1 S*,3S*,4S*)-3-amino^4-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride

(example D.f70) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 546.2323 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₄ ⁺, calc. .546.2323). Example F1: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(1-glycoloylpiperidin-4-yl)-

6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/-pyrrolo[ 3,2- cdpyrimidine-7-carboxamide hydrochloride from example D.f1 (486 mg; 1.0 mmol) is dissolved in dry dichloromethane (5 ml_) and DBU (2.5 mmol). Commercially available 2-chloro-2-oxoethyl acetate (1.1 mmol) is syringed into the reaction mixture at ice bath temperature. After addition stirring is continued at ambient temperature overnight. Methanol (1 mL) is added and stirring is continued for two hours. The volatiles are evaporated.

The residue is dissolved in methanol (5 mL), treated with 5M KOH (1.5 mmol) and stirred overnight at ambient temperature. The pH of the reaction mixture is adjusted to 6-7 by addition of 2M citric acid. The volatiles are evaporated. The residue is purified by reversed phase preparative HPLC.

The collected product fraction is freeze-dried to yield the title compound as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 8.93 (s, 1 H); 8.76 (d, J = 7.7, 1 H, -NH); 7.00 (d,

J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.50 (t, J = 5.3, 1 H, -OH); 4.25-4.03 (m, 2H); 4.12

(m, 2H); 3.76 (d, J = 6.8, 2H); 3.67 (m, 1 H); 3.19 (m, 1 H); 3.02 (m, 1 H); 2.77 (s, 3H); 1.97 (m, 2H);

1.54 (m, 1 H); 1.42(m, 1 H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H). The following compounds are prepared analogously to the procedure described in above example F1.

Example F2: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-N-piperidin-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.fi ) and commercially available

(2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 12.00 (s, 1 H, -NH); 8.93 (s, 1 H); 8.76 (d, J = 7.5, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 4.86 (d, J = 6.8, 1 H, -OH); 4.46 (m, 1 H); 4.28-4.07

(m, 2H); 3.95 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.26 (m, 1 H); 2.99 (m, 1 H); 2.77 (s, 3H); 1.98 (m, 2H);

1.54 (m, 1 H); 1.42(m, 1 H); 1.21 (br.s, 3H); 0.88 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example F3: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[trans-4- (glycoloylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c^pyrimi dine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid. MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.94 (s, 1 H); 8.60 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 8.2, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 5.40 (t, J = 5.8, 1 H, - OH); 3.79 (m, 1 H & d, J = 5.8, 2H); 3.76 (d, J = 6.8, 2H); 3.68 (m, 1 H); 2.76 (s, 3H); 2.00 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example F4: 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(trans^4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d ]pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f2) and commercially available (2S)-1 -chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid. MS (ESI): m/z = 536 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.94 (s, 1 H); 8.59 (d, J = 7.7, 1 H, -NH); 7.42 (d, J = 8.2, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 5.40 (d, J = 5.1 , 1 H, - OH); 3.94 (m, 1 H); 3.80 (m, 1 H); 3.76 (d, J = 6.8, 2H); 3.63 (m, 1 H); 2.76 (s, 3H); 2.00 (m, 2H); 1.83 (m, 2H); 1.42 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.88 (m, 1 H); 0.30 (m, 2H); 0.12 (m, 2H).

Example F5: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[cis-4-

(glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl-

5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f3) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.97 (s, 1 H, -NH); 8.97 (s, 1 H); 8.90 (d, J = 7.5, 1 H, -NH); 7.53 (d, J = 7.9, 1 H, -NH); 7.01 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 5.32 (t, J = 5.8, 1 H, -

OH); 4.05 (m, 1 H); 3.82 (d, J = 5.8, 2H); 3.76 (m, 1 H & d, J = 6.8, 2H); 2.77 (s, 3H); 1.85-1.57

(m,8H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H).

Example F6: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f3) and commercially available (2S)-1 -chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid. MS (ESI): m/z = 536 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.98 (s, 1 H, -NH); 8.97 (s, 1 H); 8.89 (d, J = 7.3, 1 H, -NH); 7.48 (d, J = 7.9, 1 H, -NH); 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); 5.36 (d, J = 5.5, 1 H, - OH); 4.05 (m, 1 H); 3.98 (m, 1 H); 3.76 (m, 1 H & d, J = 6.8, 2H); 2.77 (s, 3H); 1.83-1.57 (m,8H); 1.22 (d, J = 6.8, 3H); 0.89 (m, 1 H); 0.31 (m, 2H); 0.13 (m, 2H). Example F7: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol^4-yl]-N-[(3R)-1 - glycoloylpyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrim idine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f4) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); 8.93 (s, 1 H); [8.87 (d, J = 7.0), 8.84 (d, 6.7), 1 H, -NH]; 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); [4.60 (m), 4.49 (m), 1 H]; 4.55 (t, J = 5.6, 1 H, -OH); [4.05 (d, J = 5.6), 4.01 (d, J = 5.6), 2H]; 3.79-3.69 (m, 1 H), 3.76 (d, J = 6.7, 2H); 3.61 -3.45 (m, 2H); 3.40-3.27 (m, 1 H); 2.77 (s, 3H); 2.33-2.16 (m, 1 H); [2.04 (m), 1.92 (m), 1 H]; 0.88 (m, 1 H); 0.31 (m, 2H); 0.12 (m, 2H).

Example F8: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3R)-1 -[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-6-methyl-N-[(3R)-pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f4) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

1 H-NMR (400 MHz, DMSO-d ₆): 12.03 (s, 1 H, -NH); [8.92 (s), 8.89 (s), 1 H]; [8.88 (d, J = 6.9), 8.87 (d, 6.6), 1 H, -NH]; 7.00 (d, J = 8.6, 1 H); 6.56 (d, J = 8.6, 1 H); 6.00 (s, 2H); [4.91 (d, J = 6.8), 4.84 (d, J = 6.8), 1 H, -OH]; [4.58 (m), 4.51 (m), 1 H]; [4.33 (m), 4.25(m), 1 H]; [3.84 (m), 3.78 (m), 1 H], 3.76 (d, J = 6.6, 2H); 3.71 -3.53 (m, 2H); 3.46 (m), 3.36 (m), 1 H]; 2.77 (s, 3H); [2.27 (m), 2.20 (m), 1 H]; [2.04 (m), 1.92 (m), 1 H]; [1.23 (d, J = 6.5), 1 .20 (d, J = 6.5), 3H]; 0.88 (m, 1 H); 0.31 (m, 2H); 0.12 (m, 2H).

Example F9: 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-1 -glycoloyl-4- hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxypyrrolidin-3- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f5) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 510.1963 ([MH] ⁺, C ₂₆H ₃₀NSO ₇ ⁺, calc. 510.1983). Example F10: Diastereomeric mixture of 4-[5-(Cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-

N-{(3R,4R)^-hydroxy-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyr rolo[3,2- cf]pyπmidine-7-carboxamide and 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-{(3S,4S)^4- hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl -5H-pyrrolo[3,2-c^pyrimidine-7- carboxamide

Starting from 4-[5-(cyclopropylmethoxy)-1 ,3-benzodioxol-4-yl]-N-[(3R*,4R*)-4-hydroxypyrrolidin-3- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide hydrochloride (example D.f5) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 524.2123 ([MH] ⁺, C ₂₆H ₃₀N ₅O ₇ ⁺, calc. 524.2140).

Example F11: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(1-glycoloylpipe ridin-4-yl)-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide hydrochloride (example D.f6) and commercially available 2-chloro-2- oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 482 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s. 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.66 (dd, J = 8.4, 6.9, 1 H); 7.08 (dd, J = 11.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); 4.51 (t, J = 5.3, 1 H, -OH); 4.25^.04 (m, 2H); 4.13(dd, J = 5.3, 4.9, 2H); 3.91 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m, 2H).

Example F12: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrolo[3,2-c^p yrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluorophenyl]-6-methyl-N-piperid in-4-yl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide hydrochloride (example D.f6) and commercially available (2S)-1- chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.94 (s. 1 H); 8.81 (d, J = 5.9, 1 H, -NH); 7.65 (dd, J = 8.4, 7.1 , 1 H); 7.08 (dd, J = 11.5, 2.3, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.3, 1 H); 4.88 (d, J = 6.7, 1 H, -OH); 4.47 (m, 1 H); 4.28^.09 (m, 2H); 3.96 (m, 1 H); 3.91 (d, J = 6.9, 2H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 1.21 (br.s, 3H); 0.96 (m, 1 H); 0.38 (m, 2H): 0.25 (m, 2H).

Example F13: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[trans-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7 -carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide hydrochloride (example D.f7) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100 %). ¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.95 (s, 1 H); 8.65 (d, J = 7.9, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.48 (d, J = 8.2, 1 H, -NH); 7.08 (dd, 1 1.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 5.40 (t, J = 5.7, 1 H, -OH); 3.91 (d, J = 7.1 , 2H); 3.79 (d, J = 5.7, 2H & m, 1 H); 3.68 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.83(m, 2H); 1.44 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F14: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(trans-4-{[(2S)- 2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo rophenyl]-6-methyl-5H- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f7) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.95 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.66 (dd, 8.4, 7.1 , 1 H); 7.42 (d, J = 8.2, 1 H, -NH); 7.08 (dd, 1 1.7, 2.4, 1 H); 6.95 (ddd, 8.4, 8.4, 2.4, 1 H); 5.40 (d, J = 5.1 , 1 H, -OH); 3.94 (m, 1 H); 3.91 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.63 (m, 1 H); 2.78 (s, 3H); 1.99 (m, 2H); 1.82(m, 2H); 1.42 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F15: 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[cis-4-

(glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro phenyl]-6-methyl-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f8) and commercially available

2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.98 (s, 1 H); 8.96 (d, J = 7.6, 1 H, -NH); 7.66 (dd, 8.4, 6.9, 1 H); 7.53 (d, J = 7.7, 1 H, -NH); 7.09 (dd, 11.7, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H);

5.33 (t, J = 5.8, 1 H, -OH); 4.06 (m, 1 H); 3.91 (d, J = 6.9, 2H); 3.82 (d, J = 5.8, 2H); 3.80 (m, 1 H);

2.79 (s, 3H); 1.82-1.58 (m, 8H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example F16: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro phenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f8) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100 %).

1H-NMR (300 MHz, DMSO-d ₆): 11.78 (s, 1 H, -NH); 8.98 (s, 1 H); 8.95 (d, J = 7.3, 1 H, -NH); 7.66 (dd, 8.4, 7.1 , 1 H); 7.48 (d, J = 7.9, 1 H, -NH); 7.09 (dd, 1 1.5, 2.4, 1 H); 6.96 (ddd, 8.4, 8.4, 2.4, 1 H); 5.37 (d, J = 5.5, 1 H, -OH); 4.06 (m, 1 H); 3.99 (m, 1 H); 3.92 (d, J = 6.9, 2H); 3.74 (m, 1 H); 2.79 (s, 3H); 1.83-1.56 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H). Example F17: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R)-1- (hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f9) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 468 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.83 (s, 1 H, -NH); 8.94 (s, 1 H); [8.93 (d, J = 7.1 ), 8.90 (d, J = 7.0), 1 H, -NH]; 7.66 (dd, J = 8.4, 7.1 , 1 H); 7.09 (dd, J = 11.7, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H);

[4.60 (m), 4.50 (m), 1 H]; 4.56 (t, J = 5.7, 1 H, -OH); [4.06 (d, J = 5.7), 4.01 (d, J = 5.7), 2H]; 3.91 (d, J = 6.9, 2H); 3.80-3.68 (m, 1 H); 3.62-3.43 (m, 2H); 3.40-3.27 (m, 1 H); 2.79 (s, 3H); 2.34-2.16(m, 1 H); [2.05 (m), 1.92 (m), 1 H]; 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F18: 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-{(3R)-1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f9) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 498.2129 ([MH] ⁺, C ₂₅H ₂₉FN ₅O ₄ ⁺, calc. 498.2147).

Example F19: 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*H-hydro xy-1- (hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f10) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 484 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (br.s, 1 H, -NH); [8.93 (s), 8.92(s), 1 H]; [8.87 (d, J = 7.1 ), 8.82 (d, J = 6.8), 1 H, -NH]; 7.65 (dd, J = 8.4, 7.0, 1 H); 7.09 (dd, J = 1 1.5, 2.4, 1 H); 6.96 (ddd, J = 8.4, 8.4, 2.4, 1 H); [5.57 (br.s), 5.51 (br.s), 1 H, -OH]; 4.60 (m, 1 H, -OH); [4.37 (m), 4.20 (m), 1 H]; 4.28 (m, 1 H); 4.05 (br.d, J ~ 2.0, 2H); 3.91 (d, 6.9, 2H); 3.87-3.59 (m, 2H); 3.48-3.27 (m, 2H); 2.78 (s. 3H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F20: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3S,4S)-4-hydro xy- 1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-py rrolo[3,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[(3R*,4R*)-4-hyd roxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f10) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 482.2178 ([MH] ⁺, C ₂₅H ₂₉FN ₅O ₄ ⁺, calc. 482.2198).

Example F21 : 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-[(3S*,4S*)-3-hyd roxy-1 - (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3-hydroxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f1 1 ) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 498.2134 ([MH] ⁺, C ₂₅H ₂₈FN ₅O ₅ ⁺, calc. 498.2147). Example F22: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-

{(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- cf]pyπmidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{(3R,4R)-3-hydro xy- 1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2-c(]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-N-[ (3R*,4S*)-3-hydroxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f1 1 ) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 512.2293 ([MH] ⁺, C ₂₆H ₃iFN ₅O ₅ ⁺, calc. 512.2304). Example F23: 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- c(]pyrimidine-7-carboxylic acid [1 -(2-hydroxy-acetyl)-piperidin-4-yl]-amide

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2-d]pyrimidine-7- carboxylic acid piperidin^4-ylamide hydrochloride (example D.f12) and commercially available 2- chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 482 (MH ⁺, 100%), 356, 302.

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.84 (br.s, 1 H, -NH); 8.96 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 9.0, 3.2, 1 H); 7.37 (ddd, J = 9.1 , 8.3, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 4.50 (br.s, 1 H, - OH); 4.25-4.03 (m, 2H); 4.13 (br.s, 2H); 3.87 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.55 (m, 1 H); 1.42 (m, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F24: 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5/-/-pyrro lo[3,2- c(]pyrimidine-7-carboxylic acid [1 -((S)-2-hydroxy-propionyl)-piperidin-4-yl]-amide Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo [3,2-d]pyrimidine-7- carboxylic acid piperidirM-ylamide hydrochloride (example D.f12) and commercially available (2S)- 1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%), 356, 302.

1H-NMR (300 MHz, DMSO-d ₆): 11.84 (br.s, 1 H, -NH); 8.97 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 9.0, 3.2, 1 H); 7.37 (ddd, J = 9.1 , 8.3, 3.2, 1 H); 7.19 (dd, J = 9.1 , 4.4, 1 H); 5.01-4.58 (s, 1 H, -OH); 4.28-4.07 (m, 2H); 3.95 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.29 (m, 1 H); 3.01 (m, 1 H); 2.79 (s, 3H); 1.98 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 1.22 (br.s, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F25: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[trans-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f13) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.81 (s, 1 H, -NH); 8.97 (s, 1 H); 8.64 (d, J = 7.9, 1 H, -NH); 7.47 (d, j = 8.4, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H); 7.36 (ddd, J = 9.1 , 8.2, 3.3, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 5.40 (t, J = 5.7, 1 H, -OH); 3.87 (d, J = 6.8, 2H); 3.82 (m, 1 H); 3.79 (d, J = 5.7, 2H); 3.68 (m, 1 H); 2.79 (s, 3H); 2.01 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F26: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(trans-4-{[(2S)- 2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo rophenyl]-6-methyl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f13) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.81 (s, 1 H, -NH); 8.97 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.42 (dd, J = 8.9, 3.3, 1 H & d, J = 8.4, 1 H, -NH); 7.36 (ddd, J = 9.1 , 8.4, 3.3, 1 H); 7.18 (dd, J = 9.1 , 4.4, 1 H); 5.40 (d, J = 5.3, 1 H, -OH); 3.94 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.63 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.21 (d, J = 6.7, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example F27: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-fluorop henyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f14) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.82 (s, 1 H, -NH); 9.00 (s, 1 H); 8.94 (d, J = 7.7, 1 H, -NH); 7.48 (d, J = 7.9, 1 H, -NH); 7.43 (dd, J = 9.1 , 3.3, 1 H); 7.38 (ddd, J = 8.9, 8.4, 3.3, 1 H); 7.19 (dd, J = 8.9, 4.4, 1 H); 5.37 (d, J = 5.5, 1 H, -OH); 4.05 (m, 1 H); 3.99 (td, J = 6.8, 5.5, 1 H); 3.88 (d, J = 6.8, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.81-1.58 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.94 (m, 1 H); 0.37 (m, 2H); 0.23 (m, 2H).

Example F28: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R)-1 - (hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f15) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 468.2039 ([MH] ⁺, C ₂₄H ₂₆FN ₅O ₄+, calc. 468.2042).

Example F29: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{(3R)-1 -[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[(3R)-p yrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f15) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 482.2199 ([MH] ⁺, C ₂₄H ₂₆FN ₅O ₄ ⁺, calc. 482.2198). Example F30: 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxy-1 -

(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- d]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f16) and

commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 498.2142 ([MH] ⁺, C ₂₅H ₂₉FN ₅O ₅ ⁺, calc. 498.2147).

Example F31 : Diastereomeric mixture of 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N- {(3R,4R)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2- cf]pyπmidine-7-carboxamide and 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-{(3S,4S)-3-hydro xy- 1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-N-[(3R*,4R*)-3-hyd roxypiperidin^4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f16) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 512.2298 ([MH] ⁺, C ₂₆H _3IFN ₅O ₅ ⁺, calc. 512.2304). Example F32: 4-(2-Ethoxy-5-fluorophenyl)-N-[1-(hydroxyacetyl)piperidin-4- yl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5H-p yrrolo[3,2-cy]pyrimidine-7- carboxamide hydrochloride (example D.f17) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 456 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.95 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.42 (ddd, J = 9.1 , 8.9, 3.2, 1 H); 7.38 (dd, J = 8.3, 3.2, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.50 (t, J = 5.5, 1 H, -OH); 4.23^.06 (m, 2H); 4.13 (d, J = 5.5, 2H); 4.08 (qu, J = 6.9, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H); 2.78 (s, 3H); 1.97 (m, 2H); 1.53 (m, 1 H); 1.42 (m, 1 H); 1.11 (t, J = 6.9, 3H).

Example F33: 4-(2-Ethoxy-5-fluorophenyl)-N-{1-[(2S)-2-hydroxypropanoyl]pi peridin-4-yl}-6- methyl-5H-pyrrolo[3,2-d]pyrimidine-7 -carboxamide

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5/-/ -pyrrolo[3,2-c(]pyrimidine-7- carboxamide hydrochloride (example D.f17) and commercially available (2S)-1-chloro-1- oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 470 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.96 (s, 1 H); 8.79 (d, J = 6.7, 1 H, -NH); 7.42 (ddd, J = 9.1 , 8.9, 3.3, 1 H); 7.38 (dd, J = 8.3, 3.3, 1 H); 7.22 (dd, J = 9.1 , 4.4, 1 H); 4.86 (d, J = 6.7, 1 H, -OH); 4.47 (m, 1 H); 4.26-4.11 (m, 2H); 4.08 (qu, J = 6.9, 2H); 3.95 (m, 1 H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.98 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 1.21 (br.s, 3H); 1.11 (t, J = 6.9, 3H).

Example F34: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-(1 -glycoloylpiperidin-4-yl)-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide hydrochloride (example D.f18) and commercially available

2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.68 (s, 1 H, -NH); 8.90 (s, 1 H); 8.84 (d, J = 7.7, 1 H, -NH); 7.58 (d,

J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 2H); 6.69 (d, J = 2.2, 1 H); 4.50 (t, J = 5.5, 1 H, -OH); 4.24-4.02 (m, 2H); 4.13 (m, 2H); 3.90 (d, J = 6.9, 2H); 3.86 (s, 3H); 3.67 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H);

2.78 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example F35: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide (example D.f18) and commercially available (2S)-1 -chloro- 1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.68 (s, 1 H, -NH); 8.91 (s, 1 H); 8.84 (d, J = 7.5, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 6.79 (d, J = 2.2, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 4.86 (t, J = 6.9, 1 H, -OH); 4.46 (m, 1 H); 4.28-4.06 (m, 2H); 3.96 (m, 1 H); 3.90 (d, J = 6.9, 2H); 3.86 (s, 3H); 3.26 (m, 1 H); 3.00 (m, 1 H); 2.78 (s, 3H); 1.97 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 1.21 (br.s, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H).

Example F36: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-(trans^-{[(2S)- 2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f19) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid. MS (ESI): m/z = 522 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.65 (s, 1 H, -NH); 8.91 (s, 1 H); 8.67 (d, J = 7.9, 1 H, -NH); 7.59 (d, J = 8.4, 1 H); 7.42 (d, J = 8.4, 1 H, -NH); 6.72 (dd, J = 8.4, 2.2, 2H); 6.68 (d, J = 2.2, 1 H ); 5.40 (d, J = 5.3, 1 H, -OH); 3.94 (m, 1 H); 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.80 (m, 1 H); 3.63 (m, 1 H); 2.77 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.42 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.26 (m, 2H). Example F37: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R)-1 -glycoloylpyrrolidin-

3-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamid e

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f21 ) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 480 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.71 (br.s, 1 H, -NH); [8.95 (d, J = 7.6), 8.93 (d, J = 7.6), 1 H, -NH]; 8.90 (s, 1 H); 7.59 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); [4.59 (m), 4.49 (m), 1 H]; 4.55 (t, J = 5.8, 1 H, -OH); [4.06 (d, J = 5.8), 4.01 (d, J = 5.8), 1 H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H); 3.79-3.68 (m, 1 H); 3.62-3.43 (m, 1 H); 3.39-3.27 (m, 1 H); 2.78 (s, 3H); 2.34-2.15 (m 1 H); 2.09-1.86 (m, 1 H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.26 (m, 2H).

Example F38: 4-[2-(CyclopropylmethoxyH-methoxyphenyl]-N-{(3R)-1 -[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f21 ) and commercially available

(2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 494.2402 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₅ ⁺, calc. 494.2389).

Example F39: 4-[2-(Cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-1 -glycoloyl-4- hydroxypyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f22) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (br.s, 1 H, -NH); [8.90 (d, J = 7.1 ), 8.85 (d, J = 6.6), 1 H, -NH];

[8.89 (s), 8.88 (s), 1 H]; 7.58 (d, J = 8.4, 1 H); 6.72 (dd, J = 8.4, 2.2, 1 H); 6.69 (d, J = 2.2, 1 H ); [5.56 (d, J = 4.0), 5.50 (d, J = 4.2), 1 H, -OH]; [4.63 (t, J = 5.7), 4.60 (t, J = 5.7), 1 H, -OH]; [4.37 (m), 4.19

(m), 1 H]; 4.28 (m, 1 H); [4.05 (d, J = 5.7), 4.04 [d, J = 5.7), 2H]; 3.90 (d , J = 6.9, 2H); 3.86 (s, 3H);

3.84-3.69 (m, 1 H); 3.68-3.59 (m, 1 H); 3.46-3.32 (m, 2H); 2.78 (s, 3H); 0.95 (m, 1 H); 0.37 (m, 2H);

0.26 (m, 2H). Example F40: Diastereomeric mixture of 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-

{(3R,4R)-4-hydroxy-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyr rolo[3,2- cf]pyπmidine-7-carboxamide and 4-[2-(cyclopropylmethoxy)^4-methoxyphenyl]-N-{(3S,4S)-4- hydroxy-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrro lo[3,2-c^pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-N-[(3R*,4R*)-4-hy droxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f22) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 510.2352 ([MH]+, C ₂₆H ₃₂N ₅O ₅ ⁺, calc. 510.2347).

Example F41: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(1 -glycoloylpiperidin-4-yl)-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f23) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.95 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 4.50 (t, J = 5.5, 1 H, -OH); 4.24^.04 (m, 2H); 4.13 (m, 2H); 3.82 (d, J = 6.9, 2H); 3.77 (s, 3H); 3.68 (m, 1 H); 3.19 (m, 1 H); 3.02 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.55 (m, 1 H); 1.42 (m, 1 H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example F42: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-piperi din-4-yl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f23) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.96 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.11 (d, J = 1.8, 2H); 4.86 (d, J = 6.9, 1 H, -OH); 4.47 (m, 1 H); 4.27-4.06 (m, 2H); 3.95 (m, 1 H); 3.82 (d, J = 6.9, 2H); 3.77 (s, 3H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.99 (m, 2H); 1.63-1.31 (m, 2H); 1.22 (br.s, 3H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H). Example F43: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[trans-4-

(glycoloylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c^pyr imidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f24) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 508 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (d, J = 7.8, 1 H, -NH); 7.47 (d, J = 8.2, 1 H, -NH); 7.17 (t, J = 1.8, 1 H); 7.10 (d, J = 1.8, 2H); 5.50 (t, J = 5.8, 1 H, -OH); 3.82 (d, J = 6.9, 2H); 3.79 (d, J = 5.8, 2H); 3.77 (s, 3H & m, 1 H); 3.69 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example F44: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-(trans^4-{[(2S) -2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth oxyphenyl]-6-methyl- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f24) and commercially available (2S)-1 -chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid. MS (ESI): m/z = 522 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.96 (s, 1 H); 8.65 (d, J = 7.9, 1 H, -NH); 7.42 (d, J = 8.2, 1 H, -NH); 7.18 (t, J = 1.8, 1 H); 7.10 (d, J = 1.8, 2H); 5.40 (d, J = 5.1 , 1 H, -OH); 3.94(m, 1 H); 3.82 (d, J = 6.9, 2H & m, 1 H); 3.77 (s, 3H); 3.63 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.92 (m, 1 H); 0.34 (m, 2H); 0.19 (m, 2H).

Example F45: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[cis-4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-methoxy phenyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f25) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 508.2558 ([MH] ⁺, C ₂₇H ₃₄N ₅O ₅ ⁺, calc. 508.2554).

Example F46: 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-(cis-4-{[(2S)-2 - hydroxypropanoyllaminoJcyclohexyO-θ-methyl-SH-pyrrolop^-dlp yrimidine-y-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methox yphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f25) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 522.2710 ([MH] ⁺, C ₂₈H ₃₆N ₅O ₅ ⁺, calc. 522.271 1 ).

Example F47: 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R)-1 -glycoloylpyrrolidin-3- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f26) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 480.2243 ([MH] ⁺, C ₂₅H ₃₀N ₅O ₅ ⁺, calc. 480.2241 ). Example F48: 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3R)-1 -[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[(3R)- pyrrolidin-3-yl]-5H- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f26) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 494.2399 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₅ ⁺, calc. 494.2398).

Example F49: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxy-1 - (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxypiperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f27) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 510.2349 ([MH] ⁺, C ₂₆H ₃₂N ₅O ₆ ⁺, calc. 510.2347). Example F50: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-

{(3R,4R)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2- cf]pyπmidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3S,4S)-3- hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin^4-yl}-6-methyl-5/-/-pyrr olo[3,2-c(]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-3-hy droxypiperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f27) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 524.2495 ([MH] ⁺, C ₂₇H ₃₄N ₅O ₆ ⁺, calc. 514.2504).

Example F51: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1-(hydroxyacety l)piperidin-4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide hydrochloride (example D.f28) and commercially available 2-chloro-2- oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 478 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.74 (br.s, 1 H, -NH); 8.93 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 1.8, 1 H); 7.33 (dd, J = 8.4, 1.8, 1 H); 7.06 (d, J = 8.4, 1 H); 4.51 (t, J = 5.3, 1 H, -OH); 4.24- 4.05 (m, 2H); 4.13 (m, 2H); 3.86 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.03 (m, 1 H); 2.78 (s, 3H); 2.33 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F52: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrolo[3,2-c^p yrimidine-7 -carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide hydrochloride (example D.f28) and commercially available (2S)-1- chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (br.s, 1 H, -NH); 8.94 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 1.8, 1 H); 7.33 (dd, J = 8.6, 1.8, 1 H); 7.06 (d, J = 8.6, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.47 (m, 1 H); 4.24-4.08 (m, 2H); 4.95 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.78 (s, 3H); 2.33 (s, 3H); 1.98 (m, 2H); 1.63-1.32 (m, 2H); 1.21 (br.s, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F53: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7 -carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7 -carboxamide hydrochloride (example D.f29) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.94 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 8.4, 1 H, -NH); 7.43 (d, J = 2.1 , 1 H); 7.32 (dd, J = 8.4, 2.1 , 1 H); 7.06 (d, J = 8.4, 1 H); 5.40 (t, J = 5.9, 1 H, -OH); 3.86 (d, J = 6.8, 2H); 3.79 (d, J = 5.9, 2H & m, 1 H); 3.68 (m, 1 H); 2.77 (s, 3H); 2.33 (s, 3H); 2.01 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example F54: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(trans^-{[(2S)-2 - hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-meth ylphenyl]-6-methyl-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f29) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.71 (s, 1 H, -NH); 8.94 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.43 (d, J = 2.0, 1 H); 7.42 (d, J = 7.8, 1 H, -NH); 7.33 (dd, J = 8.4, 2.0, 1 H); 7.06 (d, J = 8.4, 1 H); 5.40 (d, J = 5.3, 1 H, -OH); 3.94 (m, 1 H); 3.86 (d, J = 6.8, 2H); 3.80 (m, 1 H); 3.63 (m, 1 H); 2.77 (s, 3H); 2.33 (s, 3H); 2.01 (m, 2H); 1.83 (m, 2H); 1.43 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.94 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example F55: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{cis-4-

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methyl phenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f30) and commercially available

2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.97 (s, 1 H & d, J = 7.5, 1 H, -NH); 7.53 (d, J = 7.7, 1 H, -NH); 7.44 (d, J = 2.0, 1 H); 7.33 (dd, J = 8.4, 2.0, 1 H); 7.06 (d, J = 8.4, 1 H); 5.33 (t, J = 5.8,

1 H, -OH); 4.06 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.83 (d, J = 5.8, 3H); 3.80 (m, 1 H); 2.76 (s, 3H); 2.33

(s, 3H); 1.81-1.61 (m, 8H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example F56: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-methyl phenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f30) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.97 (s, 1 H); 8.96 (d, J = 6.4, 1 H, -NH); 7.48 (d, J = 7.9, 1 H, -NH); 7.44 (d, J = 1.8, 1 H); 7.33 (dd, J = 8.6, 1.8, 1 H); 7.06 (d, J = 8.6, 1 H); 5.37 (d, J = 5.5, 1 H, -OH); 4.05 (m, 1 H); 3.99 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.33 (s, 3H); 1.81-1.57 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example F57: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-[1 - (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methy l-N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f31 ) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 532 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.80 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.51 (t, J = 5.5, 1 H, -OH); 4.25-4.06 (m, 2H); 4.13 (m, 2H); 4.00 (d, J = 6.9, 2H); 3.69 (m, 1 H); 3.20 (m, 1 H); 3.03 (m, 1 H); 2.79 (s, 3H);

1.97 (m, 2H); 1.55 (m, 1 H); 1.43 (m, 1 H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example F58: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{1-[( 2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifiuoromethyl)phenyl]-6-methy l-N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f31 ) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 546 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.90 (s, 1 H, -NH); 8.99 (s, 1 H); 8.80 (d, J = 7.5, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.38 (d, J = 8.8, 1 H); 4.87 (d, J = 6.9, 1 H, -OH); 4.47 (m,

1 H); 4.28-4.07 (m, 2H); 3.99 (d, J = 6.9, 2H); 3.93 (m, 1 H); 3.28 (m, 1 H); 3.01 (m, 1 H); 2.80 (s, 3H);

1.98 (m, 2H); 1.64-1.31 (m, 2H); 1.22 (br.s, 3H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example F59: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{tran s^4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(tri fluoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f32) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 546 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.63 (d, J = 7.7, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.48 (d, J = 8.2, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 5.40 (t, J = 5.9, 1 H, -OH); 3.99 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.79 (d, J = 5.9, 2H); 3.69 (m, 1 H); 2.79 (s, 3H); 2.02 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example F60: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(tran s^-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(tri fluoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f32) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 560 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.87 (s, 1 H, -NH); 8.99 (s, 1 H); 8.64 (d, J = 7.8, 1 H, -NH); 7.91 (d, J = 2.0, 1 H); 7.89 (dd, J = 8.8, 2.0, 1 H); 7.42 (d, J = 8.2, 1 H, -NH); 7.38 (d, J = 8.8, 1 H); 5.40 (d, J = 5.1 , 1 H, -OH); 4.00 (d, J = 6.9, 2H); 3.94 (m, 1 H); 3.81 (m, 1 H); 3.63 (m, 1 H); 2.79 (s, 3H); 2.02 (m, 2H); 1.83 (m, 2H); 1.43 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.98 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H).

Example F61 : 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis- 4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(trifl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f33) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 546 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.91 (s, 1 H, -NH); 9.03 (s, 1 H); 8.96 (d, J = 7.3, 1 H, -NH); 7.91 (s, 1 H); 7.90 (d, J = 8.8, 1 H); 7.58 (d, J = 7.8, 1 H, -NH); 7.39 (d, J = 8.8, 1 H); 5.37 (t, J = 5.9, 1 H, - OH); 4.07 (m, 1 H); 4.00 (d, J = 7.0, 2H); 3.83 (d, J = 5.9, 2H); 3.80 (m, 1 H); 2.80 (s, 3H); 1.83-1.59 (m, 8H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H).

Example F62: 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(cis^ -{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(trifl uoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f33) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 560 (MH ⁺, 100%).

1 H-NMR (400 MHz, DMSO-d ₆): 1 1.91 (s, 1 H, -NH); 9.03 (s, 1 H); 8.95 (d, J = 7.3, 1 H, -NH); 7.91 (s, 1 H); 7.90 (d, J = 8.8, 1 H); 7.52 (d, J = 7.6, 1 H, -NH); 7.39 (d, J = 8.8, 1 H); 5.40 (d, J = 5.5, 1 H, - OH); 4.06 (m, 1 H); 4.00 (d, J = 7.0, 2H & m, 1 H); 3.75 (m, 1 H); 2.80 (s, 3H); 1.83-1.57 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.98 (m, 1 H); 0.40 (m, 2H); 0.28 (m, 2H). Example F63: 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-[1 -(hydroxyacetyl)piperidin-4-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/-pyrrolo[3,2- cflpyπmidine-7-carboxamide hydrochloride (example D.f34) and commercially available 2-chloro-2- oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

1H-NMR (400 MHz, DMSO-d ₆): 11.93 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.79 (d, J = 7.7, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.91 (dd, J = 9.4, 2.2, 1 H); 7.42 (d, J = 9.4, 1 H); 4.50 (t, J = 5.4, 1 H, -OH); 4.21 (qu, J = 7.0, 2H); 4.18-4.07 (m, 4H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.03 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.55 (m, 1 H); 1.42 (m, 1 H); 1.16 (t, J = 7.0, 3H). Example F64: 4-[2-Ethoxy-5-(trifluoromethyl)phenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrolo[3,2-d]p yrimidine-7-carboxamide

Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin -4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f34) and commercially available (2S)-1- chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.93 (br.s, 1 H, -NH); 8.98 (s, 1 H); 8.79 (d, J = 7.8, 1 H, -NH); 7.92 (d, J = 2.2, 1 H); 7.91 (dd, J = 9.5, 2.2, 1 H); 7.42 (d, J = 9.5, 1 H); 4.86 (d, J = 6.6, 1 H, -OH); 4.46 (m, 1 H); 4.21 (qu, J = 7.0, 2H); 4.18-4.09 (m, 2H); 3.95 (m, 1 H); 3.28 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.98 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 1.21 (br.s, 3H); 1.16 (t, J = 7.0, 3H).

Example F65: 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-N-(1- glycoloylpiperidin-4-yl)-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimi dine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5H- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f35) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 512 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.77 (s, 1 H, -NH); 8.96 (s, 1 H); 8.81 (d, J = 7.5, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.50 (t, J = 5.5, 1 H, -OH); 4.24 - 4.04 (m, 2H); 4.13 (m, 2H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H); 2.79 (s, 3H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example F66: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{1-[(2 S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c (]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f35) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100 %). ¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.96 (s, 1 H); 8.81 (d, J = 7.5, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.47 (m, 1 H); 4.27 - 4.06 (m, 2H); 3.95 (m. 1 H); 3.84 (s, 3H & d, J = 6.9, 2H); 3.28 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.98 (m, 2H); 1.53 (m, 1 H); 1.42 (m, 1 H); 1.21 (br.s, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example F67: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[trans -4- (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyr imidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.64 (s, J = 7.7, 1 H, -NH); 7.47 (d, J = 8.2, 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 5.40 (t, J = 5.8, 1 H, -OH); 3.84 (s, 3H & d, J = 6.8, 2H); 3.79 (d, J = 5.8, 2H & m, 1 H); 3.68 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.83 (m, 2H); 1.44 (m, 4H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example F68: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(trans -4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluo ro-5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f36) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100 %).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.64 (d, J = 7.7, 1 H, -NH); 7.42 (d, J = 8.1 , 1 H, -NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 5.40 (d, J = 5.1 , 1 H, -OH); 3.94 (m, 1 H); 3.84 (s, 3H & d, J = 6.8, 2H); 3.79 (d, J = 5.8, 2H & m, 1 H); 3.63 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1 .43 (m, 4H); 1.21 (d, J = 6.7, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H). Example F69: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[cis^4 -

(glycoloylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c^pyr imidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f37) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100 %).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.74 (s, 1 H, -NH); 8.99 (s, 1 H); 8.95 (d, J = 7.5, 1 H, -NH); 7.52 (d,

J = 7.7, 1 H, -NH); 7.43 (d, J = 9.9, 1 H); 7.19 (d, J = 13.3, 1 H); 5.33 (t, J = 5.1 , 1 H, -OH); 4.06 (m, 1 H); 3.85 (s, 3H & d, J = 6.9, 2H); 3.82 (d, J = 5.1 , 2H & m, 1 H); 2.79 (s, 3H); 1.72 (m, 8H); 0.93 (m, 1 H); 0.37 (m, 2H); 0.22 (m, 2H).

Example F70: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-(cis^4 -{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-4-fluoro- 5-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f37) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100 %).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.99 (s, 1 H); 8.94 (d, J = 7.5, 1 H, -NH); 7.47 (d, J = 7.8, 1 H, -NH); 7.40 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); 5.36 (d, J = 5.5, 1 H, -OH); 4.04 (m, 1 H); 3.99 (m, 1 H); 3.85 (s, 3H & d, J = 6.9, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.71 (m, 8H); 1.22 (d, J = 6.7, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example F71 : 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-1 - glycoloyl-S-hydroxypiperidin^-yll-e-methyl-SH-pyrrolop^-dlpy rimidine^-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f38) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 528.2258 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₆ ⁺, calc. 528.2253).

Example F72: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-{(rac.-3R,4R)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-

N-{(rac.-3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5H-pyrrol o[3,2- cf]pyπmidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride (example

D.f38) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 542.2410 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409). Example F73: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-1 - glycoloyl-4-hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f39) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 528.2252 ([MH] ⁺, C ₂₆H _3IFN ₅O ₆ ⁺, calc. 528.2253). Example F74: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methoxyphenyl]-N-{(rac.-3S,4S)^4-hydroxy-1-[(2S)-2-hydroxypr opanoyl]piperidin-3-yl}-6-methyl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]- N-{(rac.-3R,4R)-4-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2- cf]pynmidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3S*, 4S*)-4- hydroxypiperidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f39) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 542.2393 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409).

Example F75: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[1- (hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]p yrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f40) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 496 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.93 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.53 (d, J = 9.0, 1 H); 7.03 (d, J = 12.0, 1 H); 4.50 (t, J = 5.5, 1 H, -OH); 4.25-4.05 (m, 2H & m, 2H); 3.87 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.02 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.3, 3H); 1.97 (m, 2H); 1.53 (m, 1 H); 1.42 (m, 1 H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example F76: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{1-[(2S )-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl- N-(piperidin-4-yl)-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f40) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.93 (s, 1 H); 8.81 (d, J = 7.7, 1 H, -NH); 7.54 (dd, J = 9.1 , 0.6, 1 H); 7.03 (d, J = 12.0, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.46 (m, 1 H); 4.27-4.07 (m, 2H); 3.95 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 1.3, 3H); 1.98 (m, 2H); 1.62-1.31 (m, 2H); 1.22 (br.s, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H). Example F77: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans^ 4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c^ pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)^4-fluo ro-5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f41 ) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.93 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.53 (d, J = 9.1 , 1 H); 7.47 (d, J = 8.2, 1 H, -NH); 7.03 (d, J = 12.2, 1 H); 5.40 (t, J = 5.7, 1 H, -OH); 3.87 (d, J = 6.9, 2H); 3.79 (m, 1 H & d, J = 5.7, 2H); 3.68 (m, 1 H); 2.77 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.44 (m, 4H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example F78: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-(trans- 4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f41 ) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.72 (s, 1 H, -NH); 8.94 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.42 (d, J = 8.4, 1 H, -NH); 7.03 (d, J = 12.2, 1 H); 5.40 (d, J = 5.2, 1 H, -OH); 3.94 (dt, J = 6.8, 5.2, 2H); 3.87 (d, J = 6.9, 2H); 3.80 (m, 1 H); 3.63 (m, 1 H); 2.77 (s, 3H); 2.25 (d, J = 1.1 , 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.42 (m, 4H); 1.21 (d, J = 6.8, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example F79: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{cis^4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-4-fluoro -5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f42) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 510 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.97 (s, 1 H); 8.96 (d, J = 7.3, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H & d, J = 7.5, 1 H, -NH); 7.04 (d, J = 12.2, 1 H); 5.33 (t, J = 5.8, 1 H, -OH); 4.06 (m, 1 H); 3.88 (d, J = 6.9, 2H); 3.82 (d, J = 5.8, 2H); 3.80 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 0.9, 3H); 1.81- 1.59 (m, 8H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H). Example F80: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-(cis^-{ [(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-4-fluoro- 5-methylphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f42) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 524 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.97 (s, 1 H); 8.95 (d, J = 7.8, 1 H, -NH); 7.54 (d, J = 9.1 , 1 H); 7.48 (d, J = 7.8, 1 H, -NH); 7.04 (d, J = 12.2, 1 H); 5.36 (d, J = 5.5, 1 H, -OH); 4.05 (m, 1 H); 3.99 (dt, J = 6.8, 5.5, 1 H); 3.88 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.25 (d, J = 0.9, 3H); 1.80-1.59 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.95 (m, 1 H); 0.37 (m, 2H); 0.24 (m, 2H).

Example F81: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3- hydroxy-1 -(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxypiperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f43) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 512.2324 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₅ ⁺, calc. 512.2304).

Example F82: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-4-fluoro-5- methylphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropanoy l]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)^4-fluoro-5-methylphenyl]-N- {(3S,4S)-3-hydroxy-1 -[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrr olo[3,2- c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-[(3R*,4 R*)-3-hydroxypiperidin- 4-yl]-6-methyl-5/-/-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f43) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 526.2470 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₅ ⁺, calc. 526.2460).

Example F83: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-(1- glycoloylpiperidin-4-yl)-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimi dine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f44) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 512 (MH ⁺, 100%). ¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H ₁ -NH); 8.92 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.92 (d, J = 7.3, 1 H); 4.50 (t, J = 5.3, 1 H, -OH); 4.22 - 4.06 (m, 2H & d, J = 5.3, 2H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.19 (m, 1 H); 3.02 (m, 1 H); 2.79 (s, 3H); 1.96 (m, 2H); 1.54 (m, 1 H); 1.41 (m, 1 H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F84: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-{1-[(2S )-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl -N-piperidin-4-yl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f44) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (br.s, 1 H, -NH); 8.92 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.92 (d, J = 7.3, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.46 (m, 1 H); 4.28 - 4.07 (m, 2H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.30 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 1.98 (m, 2H); 1.53 (m, 1 H); 1.41 (m, 1 H); 1.21 (br.s, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F85: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[trans -4-

(glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f45) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.92 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 8.2, 1 H, -NH & d, J = 11.7, 1 H); 6.93 (d, J = 7.3, 1 H); 5.40 (t, J = 5.8, 1 H, -OH); 3.97 (s, 3H);

3.94 (d, J = 6.9, 2H); 3.79 (m, 1 H & d, J = 5.8, 2H); 3.69 (m, 1 H); 2.78 (s, 3H); 2.01 (m, 2H); 1.82

(m, 2H); 1.44 (m, 4H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F86: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-(trans -4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluo ro-4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f45) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.92 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 7.42 (d, J = 8.2, 1 H, -NH); 6.92 (d, J = 7.3, 1 H); 5.40 (d, J = 5.1 , 1 H, -OH); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H & m, 1 H); 3.80 (m, 1 H); 3.63 (m, 1 H); 2.78 (s, 3H); 2.00 (m, 2H); 1.82 (m, 2H); 1.42 (m, 4H); 1.21 (d, J = 6.7, 3H); 0.96 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F87: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-[cis^4 - (glycoloylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-d]pyri midine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^-[2-(cyclopropylmethoxy)-5-fluoro- 4-methoxyphenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.97 (d, J = 7.7, 1 H, -NH); 8.95 (s, 1 H); 7.53 (d, J = 7.8, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 6.93 (d, J = 7.3, 1 H); 5.33 (t, J = 5.8, 1 H, -OH); 4.06 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 7.1 , 2H); 3.82 (d, J = 5.8, 1 H); 3.80 (m,1 H); 2.79 (s, 3H); 1.82 - 1.59 (m, 8H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example F88: 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-N-(cis^4 -{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-fluoro -4-methoxyphenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f46) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.70 (s, 1 H, -NH); 8.96 (s, 1 H & d, J = 7.3, 1 H, -NH); 7.47 (d, J = 11.9, 1 H); 7.46 (d, J = 7.7, 1 H, -NH); 6.93 (d, J = 7.3, 1 H); 5.36 (d, J = 5.5, 1 H, -OH); 4.05 (m, 1 H); 4.00 (m, 1 H); 3.97 (s, 3H); 3.94 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.79 (s, 3H); 1.80 - 1.58 (m, 8H); 1.22 (d, J = 6.8, 3H); 0.96 (m, 1 H); 0.39 (m, 2H); 0.25 (m, 2H).

Example F89: 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxy-1 -(hydroxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy ]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide hydrochloride (example D.f47) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 528.2267 ([MH] ⁺, C ₂₆H ₃₁FN ₅O ₆ ⁺, calc. 528.2253).

Example F90: Diastereomeric mixture of 4-[2-(Cyclopropylmethoxy)-5-fluoro^4- methoxyphenyl]-N-{(3R,4R)-3-hydroxy-1-[(2S)-2-hydroxypropano yl]piperidin-4-yl}-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide and 4-[2-(Cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]- N-{(3S,4S)-3-hydroxy-1-[(2S)-2-hydroxypropanoyl]piperidin-4- yl}-6-methyl-5/-/-pyrrolo[3,2- cf]pynmidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R*, 4R*)-3- hydroxypiperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidi ne-7-carboxamide hydrochloride (example D.f47) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 542.2406 ([MH] ⁺, C ₂₇H ₃₃FN ₅O ₆ ⁺, calc. 542.2409).

Example F91: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[1-(hydroxyacetyl )piperidin-4- yl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f48) and commercially available 2-chloro-2- oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺, 100%).

1H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.94 (s, 1 H); 8.83 (d, J = 7.7, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.36 (dd, J = 8.4, 2.2, 1 H); 7.08 (d, J = 8.4, 1 H); 4.49 (br.s, 1 H, -OH); 4.24-4.03 (m, 2H); 4.13 (d, J = 4.6, 2H); 3.87 (d, J = 6.9, 2H); 3.68 (m, 1 H); 3.22 (m, 1 H); 3.03 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 1.97 (m, 2H); 1.54 (m, 1 H); 1.42 (m, 1 H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example F92: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-(piperid in-4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f48) and commercially available (2S)-1- chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 505 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.75 (s, 1 H, -NH); 8.95 (s, 1 H); 8.83 (d, J = 7.5, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.47 (m, 1 H); 4.25-4.11 (m, 2H); 3.95 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.6, 2H); 1.98 (m, 2H); 1.53 (m, 1 H); 1.42 (m, 1 H); 1.21 (br.s, 3H); 1.18 (t, J = 7.6, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example F93: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-ethy lphenyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f49) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%). ¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (br.s, 1 H ₁ -NH); 8.95 (s, 1 H); 8.66 (d, J = 7.9, 1 H, -NH); 7.48 (d, J = 8.4, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.35 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 5.40 (t, J = 5.7, 1 H, -OH); 3.87 (d, J = 6.9, 2H); 3.79 (d, J = 5.7, 2H & m, 1 H); 3.68 (m, 1 H); 2.77 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.02 (m, 2H); 1 .83 (m, 2H); 1.44 (m, 4H); 1.18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F94: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(trans-4-{[(2S)-2 - hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-ethy lphenyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f49) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.72 (s, 1 H, -NH); 8.95 (s, 1 H); 8.66 (d, J = 7.8, 1 H, -NH); 7.45 (d, J = 2.4, 1 H); 7.42 (d, J = 8.4, 1 H, -NH); 7.36 (dd, J = 8.6, 2.4, 1 H); 7.08 (d, J = 8.6, 1 H); 5.40 (t, J = 5.1 , 1 H, -OH); 3.94 (m, 1 H); 3.86 (d, J = 6.9, 2H); 3.82 (m, 1 H); 3.63 (m, 1 H); 2.77 (s, 3H); 2.64 (qu, J = 7.5, 2H); 2.00 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.21 (d, J = 6.8, 3H); 1 .18 (t, J = 7.5, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F95: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-ethylp henyl]-6-methyl-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f50) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

1 H-NMR (300 MHz, DMSO-d ₆): 1 1.73 (s, 1 H, -NH); 8.98 (s, 1 H); 8.97 (d, J = 7.5, 1 H, -NH); 7.53 (d, J = 7.8, 1 H, -NH); 7.45 (d, J = 2.3, 1 H); 7.36 (dd, J = 8.6, 2.3, 1 H); 7.08 (d, J = 8.6, 1 H); 5.33 (br.s, 1 H, -OH); 4.06 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.83 (s, 2H); 3.80 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.5, 2H); 1 .85-1.55 (m, 8H); 1 .19 (t, J = 7.6, 53H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H). Example F96: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-(cis-4-{[(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-ethylp henyl]-6-methyl-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f50) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹ H-NMR (300 MHz, DMSO-d ₆): 1 1.73 (s, 1 H, -NH); 8.98 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 7.48 (d, J = 7.8, 1 H, -NH); 7.45 (d, J = 2.2, 1 H); 7.36 (dd, J = 8.4, 2.2, 1 H); 7.08 (d, J = 8.4, 1 H); 5.37 (d, J = 5.3, 1 H, -OH); 4.06 (m, 1 H); 3.99 (m, 1 H); 3.87 (d, J = 6.8, 2H); 3.75 (m, 1 H); 2.78 (s, 3H); 2.64 (qu, J = 7.6, 2H); 1.83-1.56 (m, 8H); 1.21 (t, J = 7.6, 3H); 1.17 (d, J = 7.7, 1 H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example F97: 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxy-1- (hydroxyacetyl)pyrrolidin-3-yl]-6-methyl-5/-/-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxypyrrolidin-3-yl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f51 ) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 494 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.80 (s, 1 H, -NH); 8.92 (s, 1 H); [8.88 (d, J = 7.1 ), 8.84 (d, J = 6.6), 1 H, -NH]; 7.44 (d, J = 2.4, 1 H); 7.36 (dd, J = 8.4, 2.4, 1 H); 7.08 (d, J = 8.4, 1 H); [5.57 (d, J = 3.8), 5.51 (d, J = 4.0), 1 H, -OH]; [4.64 (t, J = 5.6), 4.60 (t, J = 5.6), 1 H, -OH]; [4.38 (m), 4.20 (m, 1 H]; 4.28 (m, 1 H); [4.06 (br.s), 4.04 (br.s), 2H]; 3.86 (d, J = 6.9, 2H); 3.84-3.60 (m, 2H); 3.46-3.27 (m, 2H); 2.78 (s, 3H); 2.63 (qu, J = 7.5, 2H); 1.18 (t, J = 7.5, 3H); 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F98: Diastereomeric mixture of 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N- {(3R,4R)-4-hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-y l}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide and 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-{(3S,4S)-4-hydrox y-1 - [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-N-[(3R*,4R*)-4-hydr oxypyrrolidin-3-yl]-6- methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f51 ) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

HR-MS (ESI): m/z = 508.2548 ([MH] ⁺, C ₂₇H ₃₄N ₅O ₅ ⁺, calc. 508.2554).

Example F99: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{1-[(2S)- 2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-N- (piperidin-4-yl)-5/-/- pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f52) and commercially available

(2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.76 (s, 1 H, -NH); 8.95 (s, 1 H); 8.83 (d, J = 7.1 , 1 H, -NH); 7.46 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 4.86 (d, J = 6.9, 1 H, -OH); 4.47 (m,

1 H); 4.27-4.08 (m, 2H); 3.95 (m, 1 H); 3.87 (d, J = 6.9, 2H); 3.27 (m, 1 H); 3.09-2.87 (m, 1 H & sept, J = 6.9, 1 H); 2.78 (s, 3H); 1.98 (m, 2H); 1.53 (m, 1 H); 1.42 (m, 1 H); 1.22 (d, J = 6.9, 6H & br.s, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example F100: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-(trans^-{ [(2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(pro pan-2-yl)phenyl]-6- methyl-5H-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f53) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.73 (s, 1 H, -NH); 8.96 (s, 1 H); 8.66 (d, J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.42 (d, J = 7.9, 1 H, -NH); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.08 (d; J = 8.6, 1 H); 5.40 (d, J =

5.3, 1 H, -OH); 3.94 (td, J = 6.8, 5.3, 1 H); 3.87 (d, J = 6.9, 2H); 3.81 (m, 1 H); 3.64 (m, 1 H); 2.94 (sept, J = 6.9, 1 H); 2.77 (s, 3H); 2.01 (m, 2H); 1.82 (m, 2H); 1.43 (m, 4H); 1.22 (d, J = 6.9, 6H); 1.21 (d, J = 6.8, 3H); 0.94 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H). Example F101: 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-(cis-4-{[ (2S)-2- hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-c ^pyrimidine-7-carboxamide Starting from N-(cis-4-aminocyclohexyl)^4-[2-(cyclopropylmethoxy)-5-(propa n-2-yl)phenyl]-6- methyl-5H-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f54) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.74 (s, 1 H, -NH); 8.99 (s, 1 H); 8.96 (d, J = 7.5, 1 H, -NH); 7.48 (d,

J = 7.7, 1 H, -NH); 7.47 (d, J = 2.4, 1 H); 7.39 (dd, J = 8.6, 2.4, 1 H); 7.09 (d; J = 8.6, 1 H); 5.37 (d, J =

5.4, 1 H, -OH); 4.05 (m, 1 H); 3.99 (td, J = 6.8, 5.4, 1 H); 3.87 (d, J = 6.9, 2H); 3.75 (m, 1 H); 2.95 (sept, J = 6.9, 1 H); 2.78 (s, 3H); 1.81 -1.59 (m, 8H); 1.22 (d, J = 6.9, 6H & d, J = 6.9, 3H); 0.94 (m,

1 H); 0.36 (m, 2H); 0.23 (m, 2H).

Example F102: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-[1-(hydroxyacety l)piperidin-4- yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5/-/-pyrrolo[3,2- cf]pyπmidine-7-carboxamide hydrochloride (example D.f55) and commercially available 2-chloro-2- oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺, 100%).

¹H-NMR (400 MHz, DMSO-d ₆): 11.88 (s, 1 H, -NH); 8.99 (s, 1 H); 8.82 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.15 (dd, J = 8.8, 2.3, 1 H); 7.30 (d, J = 8.8, 1 H); 4.51 (t, J = 5.5, 1 H, -OH); 4.24-4.06

(m, 4H); 4.01 (d, J = 7.0, 2H); 3.68 (m, 1 H); 3.20 (m, 1 H); 3.03 (m, 1 H); 2.79 (s, 3H); 2.58 (s, 3H);

1.97 (m, 2H); 1.55 (m, 1 H); 1.44 (m, 1 H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H). Example F103: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin-4-yl}-6-methyl-5/-/-pyrrolo[3,2-c y]pyrimidine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-(piperi din-4-yl)-5H-pyrrolo[3,2- c(]pyrimidine-7-carboxamide hydrochloride (example D.f55) and commercially available (2S)-1 - chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.88 (s, 1 H, -NH); 9.00 (s, 1 H); 8.81 (d, J = 6.7, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.15 (dd, J = 8.8, 2.3, 1 H); 7.30 (d, J = 8.8, 1 H); 4.47 (br.s, 1 H, -OH); 4.27-4.10 (m, 2H); 4.01 (d, J = 7.1 , 2H); 3.95 (m, 1 H); 3.27 (m, 1 H); 3.00 (m, 1 H); 2.79 (s, 3H); 2.58 (s, 3H); 1 .99 (m, 2H); 1.55 (m, 1 H); 1 .41 (m, 1 H); 1.21 (br.s, 3H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example F104: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4- [(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-aminocy clohexyl)-6-methyl-5f-/- pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f56) and commercially available 2-chloro-2-oxoethyl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 520 (MH ⁺, 100%).

¹ H-NMR (400 MHz, DMSO-d ₆): 1 1.85 (s, 1 H, -NH); 9.00 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.3, 1 H); 8.15 (dd, J = 8.8, 2.3, 1 H); 7.48 (d, J = 8.3, 1 H, -NH); 7.30 (d, J = 8.8, 1 H); 5.40 (t, J = 5.8, 1 H, -OH); 4.01 (d, J = 7.0, 2H); 3.82 (m, 1 H); 3.79 (d, J = 5.8, 2H); 3.69 (m, 1 H); 2.79 (s, 3H); 2.58 (s, 3H); 2.01 (m, 2H); 1 .83 (m, 2H); 1.45 (m, 4H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.28 (m, 2H).

Example F105: 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^-{[(2S)-2 - hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d ]pyrimidine-7-carboxamide Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans^4-aminocy clohexyl)-6-methyl-5f-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f56) and commercially available (2S)-1 -chloro-1 -oxopropan-2-yl acetate the title compound is cbtained as colorless solid.

MS (ESI): m/z = 534 (MH ⁺, 100%).

1 H-NMR (400 MHz, DMSO-d ₆): 1 1.85 (s, 1 H, -NH); 9.00 (s, 1 H); 8.65 (d, J = 7.7, 1 H, -NH); 8.21 (d, J = 2.2, 1 H); 8.15 (dd, J = 8.9, 2.2, 1 H); 7.42 (d, J = 8.3, 1 H, -NH); 7.30 (d, J = 8.9, 1 H); 5.40 (d, J = 5.1 , 1 H, -OH); 4.01 (d, J = 7.0, 2H); 3.94 (td, J = 6.8, 5.1 , 1 H); 3.82 (m, 1 H); 3.64 (m, 1 H); 2.78 (s, 3H); 2.58 (s, 3H); 2.01 (m, 2H); 1 .84 (m, 2H); 1.44 (m, 4H); 1 .21 (d, J = 6.8, 3H); 0.99 (m, 1 H); 0.39 (m, 2H); 0.27 (m, 2H). Example F106: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[1 -(hydroxyacetyl)piperidin-

4-yl]-2,6-dimethyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxam ide Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4-yl)-5/-/- pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f57) and commercially available 2-chloro-2-oxoethyl acetate the title compound is obtained as colorless solid.

MS (ESI): m/z = 492 (MH ⁺ , 100%)

1H-NMR (300 MHz, DMSO-d ₆): 11.60 (s, 1 H ₁ -NH); 9.05 (d, J = 7.5, 1 H, -NH); 7.39 (d, J = 2.0, 1 H);

7.31 (dd, J = 8.6, 2.0, 1 H); 7.04 (d, J = 8.6, 1 H); 4.52 (t, J = 5.3, 1 H, -OH); 4.24-4.04 (m, 2H); 4.13 (m, 2H); 3.85 (d, J = 6.9, 2H); 3.67 (m, 1 H); 3.24 (m, 1 H); 3.12 (m, 1 H); 2.75 (s, 3H); 2.72 (s, 3H);

2.32 (s, 3H); 1.96 (m, 2H); 1.69-1.36 (m, 2H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H). Example F107: 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{1-[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-methylphenyl]-2,6-dimethyl-N-(pi peridin-4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f57) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is obtained as colorless solid.

MS (ESI): m/z = 506 (MH ⁺ , 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 11.58 (s, 1 H, -NH); 9.05 (br.s, 1 H, -NH); 7.39 (d, J = 1.8, 1 H); 7.31 (dd, J = 8.4, 1.8, 1 H); 7.04 (d, J = 8.4, 1 H); 4.86 (m, 1 H, -OH); 4.47 (m, 1 H); 4.21-3.99 (m,2H); 3.99-3.80 (m, 1 H); 3.84 (d, J = 6.9, 2H); 3.43-3.24 (m, 1 H); 3.24-2.98 (m, 1 H); 2.75 (s, 3H); 2.72 (s, 3H); 2.33 (s, 3H); 2.05-1.89 (m, 2H); 1.63-1.36 (m, 2H); 1.21 (d, J = 6.0, 3H); 0.93 (m, 1 H); 0.35 (m, 2H); 0.22 (m, 2H).

Example F108: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-fluoro^4-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f58) and commercially available (2S)-1 -chloro-1-oxopropan-2-yl acetate the title compound is obtained as colorless solid. MS (ESI) : 540 (MH ⁺, 100%)

¹H-NMR (300 MHz, DMSO-d ₆): 11.56 (s, 1 H, -NH); 9.04 (m, 1 H, -NH); 7.43 (d, J = 11.9, 1 H); 6.91 (d, J = 7.3, 1 H); 4.91 ^.80 (m, 1 H, -OH); 4.47 (m, 1 H); 4.21-4.07 (m, 2H); 3.96 (s, 3H); 3.93 (d, J = 6.9, 2H); 3.89 (m, 1 H); 3.44-3.25 (m, 1 H); 3.38-3.25 (m, 1 H); 3.25-2.99 (m, 1 H); 2.76 (s, 3H); 2.71 (s, 3H); 2.04-1.89 (m, 2H); 1.64-1.34 (m, 2H); 1.21 (d, J = 6.2, 3H); 0.95 (m, 1 H); 0.38 (m, 2H); 0.25 (m, 2H).

Example F109: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[1- (hydroxyacetyl)piperidin-4-yl]-2,6-dimethyl-5/-/-pyrrolo[3,2 -cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-cf]pyπmidine-7-carboxamide hydrochloride (example D.f59) and commercially 2- chloro-2-oxoethyl acetate the title compound is obtained as colorless solid. MS (ESI): m/z = 526 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.61 (s, 1 H, -NH); 9.02 (d, J = 7.7, 1 H, -NH); 7.34 (d, J = 9.9, 1 H); 7.16 (d, J = 13.3, 1 H); 4.50 (t, J = 5.5, 1 H, -OH); 4.21-4.05 (m, 2H); 4.13 (s, 2H); 3.84 (s, 3H); 3.82 (d, J = 6.8, 2H); 3.66 (m, 1 H); 3.24 (m, 1 H); 3.11 (m, 1 H); 2.75 (s, 3H); 2.73 (s, 3H); 1.96 (m, 2H); 1.64-1.37 (m, 2H); 0.92 (m, 1 H); 0.35 (m, 2H); 0.19 (m, 2H).

Example F110: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{1 -[(2S)-2- hydroxypropanoyl]piperidin^4-yl}-2,6-dimethyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)^4-fluoro-5-methoxyphenyl]-2,6-dime thyl-N-(piperidin-4-yl)- 5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f59) and commercially 2- chloro-2-oxoethyl acetate the title compound is obtained as colorless solid.

MS (ESI): m/z = 540 (MH ⁺, 100%).

¹H-NMR (300 MHz, DMSO-d ₆): 11.61 (s, 1 H, -NH); 9.03 (br.s, 1 H, -NH); 7.33 (d, J = 9.9, 1 H); 7.16 (d, J = 13.5, 1 H); 4.86 (br.s, 1 H, -OH); 4.47 (m, 1 H); 4.23-4.00 (m, 2H); 3.88 (m, 1 H); 3.84 (s, 3H); 3.82 (d, J = 6.8, 2H); 3.36 (m, 1 H); 3.10 (m, 1 H); 2.75 (s, 3H); 2.73 (s, 3H); 1.97 (m, 2H); 1.62-1.37 (m, 2H); 1.21 (d, J = 6.0, 3H); 0.91 (m, 1 H); 0.35 (m, 2H); 0.19 (m, 2H).

Example F111: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R)- 1 - glycoloylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

MS (ESI): m/z = 498 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.80 (s, 1 H, _NH); 8.95 (s, 1 H); [8.92 (d, J = 7.3), 8.90 (d, J = 7.9), 1 H, -NH]; 7.93 (d, J = 9.8, 1 H); 7.18 (d, J = 13.4, 1 H); 4.67-4.46 (m, 1 H); 4.56 T, J = 5.7, 1 H, - OH); [4.06 (d, J = 5.7), 4.01 (d, J = 5.7), 1 H]; 3.85 (d, J = 6.9, 2H & s, 3H); 3.81-3.69 (m, 1 H); 3.64- 3.46 (m, 2H); 3.38-3.31 (m, 1 H); 2.79 (s, 3H); 2.35-2.17 (m, 1 H); [2.05 (m), 1.93 (m), 1 H]; 0.93 (m, 1 H); 0.36 (m, 2H); 0.22 (m, 2H).

Example F112: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R)- 1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide

MS (ESI): m/z = 512 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.80 (s, 1 H, -NH); [8.95 (s), 8.92 (s), 1 H]; 8.92 (d, J = 7.1 , 1 H, - NH); 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.5, 1 H); [4.91 (d, J = 6.9), 4.84 (d, J = 6.9), 1 H ₁ -OH]; [4.58 (m), 4.51 (m), 1 H]; [4.33 (m), 4.26 (m), 1 H]; 3.84 (d, J = 6.6, 2H & s, 3H); 3.87-3.79 (m, 1 H); 3.87- 3.42 (m, 2H); 3.39-3.27 (m, 1 H); 2.79 (s, 3H); 2.33-2.15 (m, 1 H); [2.05 (m), 1.92 (m), 1 H]; [1.23 (d, J =6.6), 1.20 (d, J = 6.6), 3H]; 0.93 (m, 1 H); 0.36 (m, 2H); 0.21 (m, 2H).

Example F113: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-[(3R*, 4R*)-1- glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide

MS (ESI): m/z = 514 (MH+, 100 %). 1 H-NMR (300 MHz, DMSO-d6): 11.81 (s, 1 H, -NH); [8.94 (s), 8.93 (s), 1 H]; [8.86 (d, J = 7.3), 8.82 (d, J = 6.6), 1 H, -NH]; 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); [5.57 (d, J = 3.8), 5.50 (d, J = 4.0), 1 H, -OH]; [4.64 (t, J = 5.7), 4.60 (t, J = 5.7), 1 H, -OH]; 4.41-4.17 (m, 2H); [4.06 (br.s), 4.04 (br.s), 2H]; 3.84 (d, J = 6.8, 2H & s, 3H); 3.80-3.60 (m, 2H); 3.46-3.27 (m, 2H); 2.79 (s, 3H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example F114: 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{(3R*, 4R*)-4- hydroxy-1-[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl -5H-pyrrolo[3,2-d]pyrimidine-7- carboxamide (mixture of diastereomers)

MS (ESI): m/z = 528 (MH+, 100 %).

1 H-NMR (300 MHz, DMSO-d6): 11.81 (s, 1 H, -NH); [8.93 (s), 8.91 (s), 8.89 (s), 8.88 (s), 1 H]; 8.87- 8.82 (m, 1 H, -NH]; 7.39 (d, J = 9.9, 1 H); 7.18 (d, J = 13.3, 1 H); [5.57 (d, J = 3.7), 5.55 (d, J = 3.7), 5.50 (d, J = 2.0), 5.49 (d, J = 1.8), 1 H, -OH]; [4.64 (t, J = 5.7), 4.60 (t, J = 5.7), 1 H, -OH]; 4.41-4.17 (m, 2H); [4.97 (d, J = 6.8), 4.95 (d, J = 7.1 ), 4.89 (d, J = 3.5), 4.87 (d, J = 3.5), 1 H, -OH]; 4.38-4.17 (m, 3H); 4.03-3.27 (m, 4H); 3.84 (d, J = 6.9, 2H & s, 3H); 2.79 (s, 3H); 1.27-1.21 (m, 3H); 0.92 (m, 1 H); 0.36 (m, 2H); 0.20 (m, 2H).

Example F115: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-[(3R)- 1 - glycoloylpyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidi ne-7-carboxamide

MS (ESI): m/z = 498 (MH+, 100%).

Example F116: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{(3R)- 1-[(2S)-2- hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrolo[3,2-d] pyrimidine-7-carboxamide

MS (ESI): m/z = 512 (MH+, 100%).

Example F117: 4-[2-(Cyclopropylmethoxy)-5-fluoro^-methoxyphenyl]-N-[(3R*,4 R*)-1 - glycoloyl^4-hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-7-carboxamide

MS (ESI): m/z = 514 (MH+, 100%). Example F118: 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{(3R*, 4R*)-4- hydroxy-1 -[(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrro lo[3,2-d]pyrimidine-7- carboxamide (mixture of diastereomeres)

MS (ESI): m/z = 528 (MH+, 100%). Example F119: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-[(3R*,4R*)-1 -glycoloyl-4- hydroxypyrrolidin-3-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine -7-carboxamide

MS (ESI): m/z = 496 (MH+, 100%). Example F120: 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{(3R*,4R*H-hydr oxy-1- [(2S)-2-hydroxypropanoyl]pyrrolidin-3-yl}-6-methyl-5H-pyrrol o[3,2-d]pyrimidine-7-carboxamide (mixture of diastereomeres)

MS (ESI): m/z = 510 (MH+, 100%).

The following compounds in the table would fall within the scope of the genus of formula I as described in claim 1 :

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(^2R* ,4R*)-2-fluoro-4-

P160

(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimi dine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2-fluoro^-

P161

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R^2R^4R>2-fluoro-4-

P162

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-cf ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R*,2R*,4R*)-2-fluoro-4-

P163 {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrr olo[3,2-c(]pyrimidine-7- carboxamide

N-[(1 R*,2R*,4S*)^-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P164

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cf]pyrimid ine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R^2R^4S>2-fluoro-4-

P165

(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R^2R^4S>2-fluoro-4-

P166

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4S*)-2-fluoro-4-

P167

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-cf ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R*,2R*,4S*)-2-fluoro-4-

P168 {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrr olo[3,2-c(]pyrimidine-7- carboxamide

N-[(1 S*,2R*,4S*)^-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P169

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4S*)-2-fluoro-4-

P170

(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4S*)-2-fluoro-4-

P171

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4S*)-2-fluoro-4-

P172

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S ^*,2R ^*,4S ^*)-2-fluoro-4-{[(2S>

P173 2-hydroxypropanoyl]amino}cyclohexyl]-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7- carboxamide

N-[(1 S*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclop ropylmethoxy)-5-

P174

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4R

P175

(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4R*)-2-fluoro-4-

P176

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4R*)-2-fluoro-4-

P177

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4R*)-2-fluoro-4-

P178 {[(2S)-2-hydroxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrr olo[3,2-c(]pyrimidine-7- carboxamide

N-[(1 S*,3R*,4S*)-4-(acetylamino)-3-methylcyclohexyl]^4-[2-(cyclop ropylmethoxy)-5-

P179

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(1 S ^*,3R ^*,4S ^*)-3-

P180

methyl-4-(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3R*,4S*)-4-[(methoxy-

P181

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7 -carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,3R*,4S*)-4-[(hydroxy-

P182

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-cf ]pyrimidine-7 -carboxamide

4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S ^*,3R ^*,4S ^*H-{[(2S)-2-

P183 hydroxypropanoyl]amino}-3-methylcyclohexyl]-6-methyl-5H-pyrr olo[3,2-c/]pyrimidine-7- carboxamide

N-[(1 S*,3R*,4R*)^-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P184

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide

P185 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(1 S*,3R*,4R*)-3- droxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c^p yrimidine-7-carboxamide

N-[(1 S*,2R*,4S*)^-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P572

methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cf]pyrimidine-7-carb oxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S^2R^4S>2-fluoro-4-

P573

(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,2R*,4S*)-2-fluoro^-

P574

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,2R*,4S*)-2-fluoro^-

P575

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-cf ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S*,2R*,4S*)-2-fluoro-4-{[(2S)-2-hy-

P576

droxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

N-[(1 S^2R^4R>4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P577

methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]4\l-[(1 S^2R^4R>2-fluoro^^-

P578

(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyr imidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,2R*,4R*)-2-fluoro-4-

P579

[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,2R*,4R*)-2-fluoro-4-

P580

[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S*,2R*,4R*)-2-fluoro^-{[(2S)-2-hy-

P581

droxypropanoyl]amino}cyclohexyl]-6-methyl-5H-pyrrolo[3,2-c(] pyrimidine-7-carboxamide

N-[(1 S*,3R*,4S*)-4-(acetylamino)-3-methylcyclohexyl]^-[2-(cyclopr opylmethoxy)-5-

P582

methylphenyl]-6-methyl-5H-pyrrolo[3,2-cdpyrimidine-7-carboxa mide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[(1 S*,3R*,4S*)-3-methyl-4-

P583

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,3R*,4S*)-4-[(methoxy-

P584

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,3R*,4S*H-[(hydroxyacetyl)amino]

P585

3-methylcyclohexyl}-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine- 7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S*,3R*,4S*)-4-{[(2S)-2-hydroxypro-

P586

panoyl]amino}-3-methylcyclohexyl]-6-methyl-5/-/-pyrrolo[3,2- c(]pyrimidine-7-carboxamide

N-[(1 S*,3R*,4R*)^-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P587

methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[(1S*,3 R*,4R*)-3-methyl-4-

P588

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cf]pyrimidine-7 -carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,3R*,4R*)-4-[(methoxy-

P589

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 S*,3R*,4R*)-4-[(hydroxy-

P590

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 S*,3R*,4R*)-4-{[(2S)-2-hydroxypro-

P591

panoyl]amino}-3-methylcyclohexyl]-6-methyl-5/-/-pyrrolo[3,2- cf]pyrimidine-7-carboxamide

N-[(1 R*,3R*,4R*)^4-(acetylamino)-3-methylcyclohexyl]-4-[2-(cyclop ropylmethoxy)-5-

P592

methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carb oxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[(1 R*,3R*,4R*)-3-methyl-4-

P593

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-cf]pyrimidine-7 -carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 R*,3R*,4R*)-4-[(methoxy-

P594

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{(1 R*,3R*,4R*)-4-[(hydroxy-

P595

acetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-c( ]pyrimidine-7-carboxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-[(1 R*,3R*,4R*)-4-{[(2S)-2-

P596 hydroxypropanoyl]amino}-3-methylcyclohexyl]-6-methyl-5H-pyrr olo[3,2-cy]pyrimidine-7- carboxamide

N-[(1 R*,3R*,4S*)^-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclopr opylmethoxy)-5-

P597

methylphenyl]-6-methyl-5/-/-pyrrolo[3,2-cf]pyrimidine-7-carb oxamide

4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[(1 R*,3R*,4S*)-3-methyl-4-

P598

(propanoylamino)cyclohexyl]-5/-/-pyrrolo[3,2-c(]pyrimidine-7 -carboxamide

a salt thereof, or a stereoisomer of the compound or a salt thereof.

The following compounds of the above table are prepared analogously to the procedure described in above example E1. Example P1: N-(1-Acetylpiperidin-4-yl)-4-[2-(cyclopropylmethoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-(piperidin^4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.fβO) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 498.2303 ([MH] ⁺, C ₂₆H ₃₀F ₂N ₅O ₃ ⁺, calc. 498.2311 ).

Example P2: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-(1- propanoylpiperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbo xamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-(piperidin^4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f60) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2453 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468). Example P3: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[1-

(methoxyacetyl)piperidin-4-yl]-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-(piperidin^4-yl)-5/-/- pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f60) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 528.2394 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₄ ⁺, calc. 528.2417).

Example P6: N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy )-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(dif luoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f61 ) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2457 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468).

Example P7: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[trans-4- (propanoylamino)cyclohexyl]-5 ^H-pyrrolo[3,2- ^d]pyrimidine-7-carboxamide

Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(dif luoromethyl)phenyl]-6- methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f61 ) and commercially available propionyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 526.2621 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₃ ⁺, calc. 526.2624).

Example P8: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{trans ^4- [(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyrrolo[3,2- cy]pyrimidine-7-carboxamide Starting from N-(trans-4-aminocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-(dif luoromethyl)phenyl]-6- methyl-5H-pyrrolo[3,2-c^pyrimidine-7-carboxamide hydrochloride (example D.f61 ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 542.2571 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₄ ⁺, calc. 542.2573).

Example P24: N-[(3S,5S)-1 -Acetyl-5-methylpyrrolidin-3-yl]-4-[2-(cyclopropylmethoxy)-5 - (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

HR-MS (ESI): m/z = 498.2316 ([MH] ⁺, C ₂₆H ₃₀F ₂N ₅O ₃ ⁺, calc. 498.231 1 ).

Example P25: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(3S,5S)-5- methyl-1 -propanoylpyrrolidin-3-yl]-5/-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(3S*,5S*)-5- methylpyrrolidin-3-yl]-5H-pyrrolo[3,2-c^pyrimidine-7-carboxa mide hydrochloride (example D.f66) and commercially available propionyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 512.2466 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468). Example P26: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(3S,5 S)-1 -

(methoxyacetyl)-5-methylpyrrolidin-3-yl]-6-methyl-5/-/-py rrolo[3,2-cy]pyrimidine-7-carboxamide Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(3S*,5S*)-5- methylpyrrolidin-3-yl]-5H-pyrrolo[3,2-c^pyrimidine-7-carboxa mide hydrochloride (example D.f66) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 528.241 1 ([MH] ⁺, C ₂₇H ₃₁F ₂N ₅O ₄ ⁺, calc. 528.2417).

Example P89: N-[(1 S,3S)-3-(Acetylamino)cyclopentyl]^4-[2-(cyclopropylmethoxy)- 5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide

Starting from N-[(1 S,3S)-3-aminocyclopentyl]^4-[2-(cyclopropylmethoxy)-5-(diflu oromethyl)phenyl]- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f64) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 498.2305 ([MH] ⁺, C ₂₆H ₃₀F ₂N ₅O ₃ ⁺, calc. 498.231 1 ). Example P90: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-[(1 S,3S)-3-

(propanoylamino)cyclopentyl]-5/-/-pyrrolo[3,2-cy]pyrimidi ne-7-carboxamide

Starting from N-[(1 S,3S)-3-aminocyclopentyl]^4-[2-(cyclopropylmethoxy)-5-(diflu oromethyl)phenyl]- 6-methyl-5/-/-pyrrolo[3,2-c(]pyrimidine-7-carboxamide hydrochloride (example D.f64) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 512.2474 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₃ ⁺, calc. 512.2468).

Example P91: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S,3S)-3- [(methoxyacetyl)amino]cyclopentyl}-6-methyl-5/-/-pyrrolo[3,2 -c(]pyrimidine-7-carboxamide

Starting from N-[(1 S,3S)-3-aminocyclopentyl]^4-[2-(cyclopropylmethoxy)-5-(diflu oromethyl)phenyl]- 6-methyl-5/-/-pyrrolo[3,2-cy]pyrimidine-7-carboxamide hydrochloride (example D.f64) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 528.2418 ([MH] ⁺, C ₂₇H ₃₂F ₂N ₅O ₄ ⁺, calc. 528.2417).

Example P99: N-[(1 R*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclopentyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/ -pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from N-[(1 R*,2R*,4R*)^4-amino-2-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f71 ) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 516.2221 ([MH] ⁺, C ₂₆H ₂₉F ₃N ₅O ₃ ⁺, calc. 516.2217).

Example P100: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R*,2R*,4R*)-2- fluoro^4-(propanoylamino)cyclopentyl]-6-methyl-5/-/-pyrrolo[ 3,2-c(]pyrimidine-7-carboxamide Starting from N-[(1 R*,2R*,4R*)^4-amino-2-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f71 ) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2375 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₃ ⁺, calc. 530.2374).

Example P101 : 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R ^*,2R ^*,4R ^*)-2- fluoro^-[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5H-pyrro lo[3,2-c^pyrimidine-7-carboxamide Starting from N-[(1 R*,2R*,4R*)^4-amino-2-fluorocyclopentyl]-4-[2-(cyclopropylme thoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f71 ) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 546.2324 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₄ ⁺, calc. 546.2323).

Example P139: N-[(1 S*,2S*,4S*)-4-(Acetylamino)-2-methylcyclohexyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/ -pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from N-[(1 S*,2S*,4S*)-4-amino-2-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f63) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 526.2625 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₃ ⁺, calc. 526.2624). Example P140: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N-

[(1 S*,2S*,4S*)-2-methyl-4-(propanoylamino)cyclohexyl]-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide Starting from N-[(1 S*,2S*,4S*)-4-amino-2-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f63) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 540.2773 ([MH] ⁺, C ₂₉H ₃₆F ₂N ₅O ₃ ⁺, calc. 540.2781 ).

Example P141: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*, 2S*,4S*)-4- [(methoxyacetyl)amino]-2-methylcyclohexyl}-6-methyl-5H-pyrro lo[3,2-c^pyrimidine-7-carboxamide Starting from N-[(1 S*,2S*,4S*)-4-amino-2-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f63) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 556.2726 ([MH] ⁺, C ₂₉H ₃₆F ₂N ₅O ₄ ⁺, calc. 556.2730).

Example P159: N-[(1 R*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclohexyl]^-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from N-[(1 R*,2R*,4R*)-4-amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide (example D.f67) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2386 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₃ ⁺, calc. 530.2374).

Example P160: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 R*,2R*,4R*)-2- fluoro^4-(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide Starting from N-[(1 R*,2R*,4R*)-4-amino-2-fluorocyclohexylH-[2-(cyclopropylmetho xy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide (example D.f67) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 544.2539 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₃ ⁺, calc. 544.2530).

Example P161: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 R*,2R*,4R*)-2- fluoro^-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrol o[3,2-c^pyrimidine-7-carboxamide Starting from N-[(1 R*,2R*,4R*)-4-amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f67) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 560.2487 ([MH] ⁺, C ₂₈H ₃₂F ₃N ₅O ₄ ⁺, calc. 560.2479).

Example P169: N-[(1 S*,2R*,4S*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-

(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5 /-/-pyrrolo[3,2-c(]pyrimidine-7- carboxamide

Starting from N-[(1 S*,2R*,4S*)^4-amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f73) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2378 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₃ ⁺, calc. 530.2374).

Example P170: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,2R*,4S*)-2- fluoro^4-(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3 ,2-cy]pyrimidine-7-carboxamide Starting from N-[(1 S*,2R*,4S*)^4-amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5-

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyri midine-7-carboxamide (example D.f73) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 544.2528 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₃ ⁺, calc. 544.2530). Example P171 : 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*,2R*,4S*)-2- fluoro^-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrol o[3,2-c^pyrimidine-7-carboxamide Starting from N-[(1 S*,2R*,4S*)^4-amino-2-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide (example D.f73) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid. HR-MS (ESI): m/z = 560.2479 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₄ ⁺, calc. 560.2479).

Example P189: N-[(1 S*,3S*,4S*)-4-(Acetylamino)-3-methylcyclohexyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5/-/ -pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from N-[(1 S*,3S*,4S*)-4-amino-3-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f65) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 540.2788 ([MH] ⁺, C ₂₉H ₃₆F ₂N ₅O ₃ ⁺, calc. 540.2781 ).

Example P190: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl -N- [(1 S*,3S*,4S*)-3-methyl-4-(propanoylamino)cyclohexyl]-5/-/-pyrr olo[3,2-d]pyrimidine-7-carboxamide Starting from N-[(1 S*,3S*,4S*)-4-amino-3-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f65) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 526.2615 ([MH] ⁺, C ₂₈H ₃₄F ₂N ₅O ₃ ⁺, calc. 526.2624).

Example P191: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*, 3S*,4S*)-4- [(methoxyacetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrro lo[3,2-c^pyrimidine-7-carboxamide Starting from N-[(1 S*,3S*,4S*)-4-amino-3-methylcyclohexyl]^4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride

(example D.f65) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 556.2729 ([MH] ⁺, C ₂₉H ₃₆F ₂N ₅O ₄ ⁺, calc. 556.2730). Example P199: N-[(1 S*,3R*,4S*)-4-(Acetylamino)-3-fluorocyclohexyl]-4-[2-

(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5 /-/-pyrrolo[3,2-cy]pyrimidine-7- carboxamide

Starting from N-[(1 S*,3R*,4S*)^4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5-

(difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyri midine-7-carboxamide hydrochloride (example D.f72) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2381 ([MH] ⁺, C ₂₇H ₃₁F ₃N ₅O ₃ ⁺, calc. 530.2374).

Example P200: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*,3R*,4S*)-3- fluoro^4-(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide Starting from N-[(1 S*,3R*,4S*)^4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride (example D.f72) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 544.2525 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₃ ⁺, calc. 544.2530).

Example P201: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*, 3R*,4S*)-3- fluoro^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyr rolo[3,2-c(]pyrimidine-7-carboxamide Starting from N-[(1 S*,3R*,4S*)^4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride

(example D.f72) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 560.2478 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₄ ⁺, calc. 560.2479). Example P209: N-[(1 S ^*,3S ^*,4S ^*)-4-(Acetylamino)-3-fluorocyclohexyl]-4-[2- (cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-p yrrolo[3,2-d]pyrimidine-7- carboxamide

Starting from N-[(1 S*,3S*,4S*)-4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-c(]pyrimid ine-7-carboxamide hydrochloride (example D.f62) and commercially available acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 530.2359 ([MH] ⁺, C ₂₇H _3IF ₃N ₅O ₃ ⁺, calc. 530.2374).

Example P210: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1 S*, 3S*,4S*)-3- fluoro^4-(propanoylamino)cyclohexyl]-6-methyl-5/-/-pyrrolo[3 ,2-c(]pyrimidine-7-carboxamide Starting from N-[(1 S*,3S*,4S*)-4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f62) and commercially available propionyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 544.2536 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₃ ⁺, calc. 544.2530).

Example P211: 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1 S*, 3S*,4S*)-3- fluoro^4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5/-/-pyr rolo[3,2-c(]pyrimidine-7 -carboxamide Starting from N-[(1 S*,3S*,4S*)-4-amino-3-fluorocyclohexyl]-4-[2-(cyclopropylmet hoxy)-5- (difluoromethyl)phenyl]-6-methyl-5/-/-pyrrolo[3,2-cy]pyrimid ine-7-carboxamide hydrochloride (example D.f62) and commercially available methoxy-acetyl chloride the title compound is obtained as colorless solid.

HR-MS (ESI): m/z = 560.2466 ([MH] ⁺, C ₂₈H ₃₃F ₃N ₅O ₄ ⁺, calc. 560.2479).

Commercial utility

The compounds of formula (I), the salts thereof, and the stereoisomers of the compounds and the salts thereof are hereinafter referred to as the compounds of the present subject matter. In particular, the compounds of the present subject matter are pharmaceutically acceptable.

The compounds of the present subject matter have valuable pharmaceutical properties which make them commercially utilizable. In particular, as type 5 phosphodiesterase (PDE5) inhibitors, they are able to influence the physiological and pathophysiological function of various cells, e.g., but not limited to, smooth muscle cells, fibroblasts, myofibroblasts and platelets, which are involved in a great variety of physiological and pathophysiological mechanisms. In particular, the PDE5 inhibiting compounds of the present subject matter can effect relaxation of the vasculature, thus increasing blood flow, improve the spatial balance between blood perfusion and ventilation within the lung ("re-matching" effect) thereby reducing the amount of so-called low V/Q-areas [areas within the lung with high perfusion (Q) but no or reduced ventilation (V)] and high V/Q-areas (areas within the lung with low perfusion but high ventilation), induce neurogenesis, inhibit platelet function, such as aggregation, adhesion and mediator release and, thus, have an anti-inflammatory effect. The compounds of the present subject matter are distinguished by valuable and desirable properties, such as, for example, high efficacy, low toxicity, superior bioavailability in general (e.g. good enteral absorption), superior therapeutic window, superior pharmacokinetics (e.g. half-life), absence of significant side effects, and further beneficial effects related with their therapeutic and

pharmaceutical suitability.

Accordingly, the present subject matter further relates to the compounds of the present subject matter for the treatment or prophylaxis of diseases, especially diseases alleviated by inhibition of the type 5 phosphodiesterase. In particular, the present subject matter relates to the compounds of the present subject matter for the treatment or prophylaxis of the following diseases:

male and female sexual dysfunction, such as, but not limited to, male erectile dysfunction, premature ejaculation, Peyronie ^'s disease;

acute and chronic airway diseases, such as, but not limited to, COPD (chronic obstructive pulmonary disease), bronchitis, emphysema, pulmonary vascular remodeling, pulmonary hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis (IPF), asthma, cystic fibrosis, bronchiectasis, bronchiolitis obliterans, connective tissue diseases, sarcoidosis, kyphoscoliosis, pneumoconiosis, amyotrophic lateral sclerosis, thoracoplasty, extrinsic allergic alveolitis;

inflammatory diseases, such as, but not limited to, vasculature inflammation, acute respiratory distress syndrome, nephritis, mesangial glomerulonephritis, chronic inflammatory bowel disease, disseminated intravascular inflammation, allergic vasculitis, dermatoses (e.g., but not limited to, psoriasis, toxic and allergic contact eczema, atopic eczema, seborrhoeic eczema, Lichen simplex, sunburn, pruritus in the anogenital area, alopecia areata, hypertrophic scars, discoid lupus erythematosus, follicular and widespread pyodermias, endogenous and exogenous acne, acne rosacea), disorders of the arthritis type (e.g., but not limited to, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis), disorders of the immune system [e.g., but not limited to, AIDS (acquired immunodeficiency syndrome), multiple sclerosis], graft versus host reaction, allograft rejections, shock [e.g., but not limited to, septic shock, endotoxin shock, gram-negative sepsis shock, toxic shock syndrome and ARDS (adult respiratory distress syndrome)], gastrointestinal inflammations (e.g., but not limited to, Crohn ^'s disease and ulcerative colitis); disorders which are based on allergic and/or chronic, immunological false reactbns (e.g., but not limited to, allergic rhinitis, allergic sinusitis, chronic rhinitis, chronic sinusitis, allergic conjunctivitis, nasal polyps);

pain, such as, but not limited to, inflammatory pain;

right-heart failure, right heart hypertrophy (cor pulmonale), hypertension, hypercholesterolemia, hypertriglyceridemia;

ischaemic diseases, such as, but not limited to, diabetes mellitus, stroke, coronary artery disease, angina (including, but not limited to, vasospastic angina), myocardial infarction, peripheral artery disease, cerebrovascular obstruction, sleep apnea, macular ischaemia, arterial and venous occlusion, congestive heart failure;

diabetic gastroparesis and diseases with symptoms of gastroparesis;

diseases or conditions in which it is desirable to suppress platelet function, for example, but not limited to, after stent implantations (e.g., but not limited to, coronary stenting), after bypass operations, in pulmonary hypertension, thrombotic diseases, post-angioplasty stenosis, coronary artery disease, infarction (e.g., but not limited to, myocardial infarction), instable angina pectoris, stroke, and arterial and venous occlusion diseases (e.g., but not limited to, claudicatio intermittens); diseases or conditions with an impairment or dysfunction of cerebral vascular reactivity and/or neurovascular coupling, such as, but not limited to, arteriosclerotic dementia, multi-infarct dementia, cerebral senility;

diseases which are based on neuronal damage or degradation, such as but not limited to, stroke, spinal cord injury, brain injury, morbus parkinson, amyotrophic lateral sclerosis, morbus alzheimer, amyloidosis, prion diseases and neuropathy;

peripheral arterial diseases, chronic renal failure, chronic heart failure, sepsis, senile dementia (Alzheimer's disease), Creutzfeld-Jacob disease, septic encephalopathy, arteriosclerotic encephalopathy, diabetes associated encephalopathy, toxic encephalopathy, vascular and neuronal dementia, Huntington ^'s disease, Parkinson's disease, multiple sclerosis and

preeclampsia;

portal hypertension, liver cirrhosis, toxic liver damage (e.g., but not limited to, alcohol-induced liver damage), hepatitis, thrombosis of the portal vein, Budd-Chiari syndrome, malformation of liver veins, compression of liver veins (e.g., but without limitation, due to tumors), arteriovenous fistula, diseases associated with an enlarged spleen, schistosomiasis (bilharziosis), sarcoidosis and other granulomatous diseases, primary biliary cirrhosis, myeloproliferative disorders (e.g., but not limited to, chronic myeloid leukemia, osteomyelofibrosis), lymphatic systemic diseases, collagenosis (e.g., but not limited to, systemic lupus erythematodes, sclerodermia), morbus Osier (congenital arteriovenous malformations, inter alia in the liver), nodular regenerative hyperplasia, tricuspid insuffi- ciency, pericarditis constrictiva, veno-occlusive disease (VOD), non-alcoholic steatohepatitis (NASH), liver fibrosis;

benign prostatic hyperplasia;

insufficient uteroplacental blood flow in pregnancies with fetal growth restriction; insufficient brain skills, such as but not limited to, verbal attainment, attention, concentration, deductive thinking, central auditory processing, cognition, learning, vigilance, apprehension and rea- gibility;

Overactive Bladder; LUTS = lower urinary tract symptoms; Raynauds syndrome/phenomenon.

In this respect, the term "pulmonary hypertension" in particular embraces

- pulmonary arterial hypertension including primary pulmonary hypertension (e.g. sporadic or familial) and pulmonary arterial hypertension related, for example, but without limitation, to collagen vascular disease, congenital systemic-to-pulmonary shunts, portal hypertension, human immunodeficiency virus infection, drugs or toxins (e.g., but not limited to, anorexigens), persistent pulmonary hypertension of the newborn;

- pulmonary venous hypertension due to, for example, but without limitation, left-sided atrial or ventricular heart disease, left-sided valvular heart disease, extrinsic compression of central pulmonary veins (e.g. fibrosing mediastinitis, adenopathy in relation to tumors), pulmonary veno- occlusive disease;

- pulmonary hypertension associated with disorders of the respiratory system or hypoxemia including, for example, but without limitation, chronic obstructive pulmonary disease (COPD), interstitial lung disease, sleep-disordered breathing, alveolar hypoventilation disorders, chronic exposure to high altitude, neonatal lung disease, alveolar-capillary dysplasia;

- pulmonary hypertension caused by chronic thrombotic or embolic diseases including thromboembolic obstruction of proximal pulmonary arteries and obstruction of distal pulmonary arteries, such as pulmonary embolism (due to thrombus, tumor, ova, parasites, or foreign material), in situ thrombosis and sickle-cell disease, in particular chronic thromboembolic pulmonary hypertension (CTEPH);

- pulmonary hypertension caused by disorders directly affecting the pulmonary vasculature including inflammatory disorders (e.g., but not limited to, schistosomiasis, sarcoidosis) and pulmonary capillary hemangiomatosis.

Preferably, the present subject matter further relates to the compounds of the present subject matter for the treatment or prophylaxis of the following diseases, especially diseases alleviated by inhibition of the type 5 phosphodiesterase: acute and chronic airway diseases, such as pulmonary hypertension, in particular chronic thromboembolic pulmonary hypertension, lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease. Beside the inhibition of type 5 phosphodiesterase some of the compounds of the present subject matter have also substantial activity in inhibition of type 4 phosphodiesterase and thus have valuable pharmaceutical properties, which make them commercially utilizable. PDE4 inhibitors are thought to be useful in the treatment or prophylaxis of a variety of diseases and disorders. They are thought to be suitable on the one hand as bronchial therapeutics (for the treatment of airway obstructions on account of their dilating action but also on account of their respiratory rate- or respiratory drive-increasing action) and for the removal of erectile dysfunction on ac- count of their vascular dilating action, but on the other hand especially for the treatment of disorders, in particular of an inflammatory nature, e.g. of the airways, of the skin, of the intestine, of the eyes, of the CNS and of the joints, which are mediated by mediators such as histamine, PAF (platelet-activating factor), arachidonic acid derivatives such as leukotrienes and prostaglandins, cytokines, interleukins, chemokines, alpha-, beta- and gamma-interferon, tumor necrosis factor (TNF) or oxygen free radicals and proteases.

Thus, PDE4 inhibitors are thought to be useful in the treatment or prophylaxis of a variety of diseases and disorders, such as for example:

acute and chronic airway diseases, such as, but not limited to, bronchitis, allergic bronchitis, asthma, emphysema, COPD (chronic obstructive pulmonary disease), sarcoidosis, pulmonary hypertension and lung fibrosis;

diseases which are based on allergic and/or chronic, immunological false reactions in the region of the upper airways (pharynx, nose) and the adjacent regions (paranasal sinuses, eyes), such as, but not limited to, allergic rhinitis/sinusitis, chronic rhinitis/sinusitis, allergic conjunctivitis and also nasal polyps;

dermatological diseases especially of proliferative, inflammatory and allergic type, such as, but not limited to psoriasis (vulgaris), toxic and allergic contact eczema, atopic dermatitis (eczema), sebor- rhoeic eczema, Lichen simplex, sunburn, pruritus in the anogenital area, alopecia areata, hypertrophic scars, discoid lupus erythematosus, follicular and widespread pyodermias, endogenous and exogenous acne, acne rosacea and other proliferative, inflammatory and allergic skin disorders; diseases which are based on an excessive release of TNF and leukotrienes, such as, for example, diseases of the arthritis type like rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic conditions;

fibrotic diseases, such as, but not limited to, cystic fibrosis, pulmonary fibrosis, hepatic fibrosis and renal fibrosis;

viral, alcoholic or drug-induced acute and fulminant hepatitis, hepatic steatosis (alcoholic and nonalcoholic steatio-hepatitis);

diseases of the immune system, such as, but not limited to, AIDS, multiple sclerosis, graft versus host reaction, allograft rejections;

cachexia, cancer cachexia, AIDS cachexia;

types of shock, such as, but not limited to, septic shock, endotoxin shock, gram-negative sepsis, toxic shock syndrome and ARDS (adult respiratory distress syndrome);

diseases in the gastrointestinal region, such as Crohn ^'s disease and ulcerative colitis; diseases of the heart which can be treated by PDE inhibitors, such as cardiac insufficiency;

diseases which can be treated on account of the tissue-relaxant action of the PDE inhibitors, such as, for example, erectile dysfunction, colics of the kidneys and of the ureters in connection with kidney stones or oncolytic action (to treat preterm delivery); glomerulonephritis and other urinary tract infections;

diabetes insipidus, diabetes mellitus (type I and in particular type II); cancer (in particular lymphoid and myeloid leukaemia); osteoporosis;

conditions associated with cerebral metabolic inhibition, such as, but not limited to, cerebral senility, senile dementia (Alzheimer's disease), memory impairment associated with Parkinson's dis- ease or multiinfarct dementia;

and also diseases of the central nervous system, such as, but not limited to, depressions, anxiety states, spinal cord injury, schizophrenia or arteriosclerotic dementia.

Preferably, inhibitors of the type 4 phosphodiesterase are used in the treatment or prophylaxis of the following diseases:

acute and chronic airway diseases, such as bronchitis, allergic bronchitis, asthma, emphysema,

COPD, pulmonary hypertension and lung fibrosis;

allergic rhinitis;

and dermatological diseases, such as psoriasis and atopic dermatitis (eczema);

rheumatoid arthritis;

and inflammations in the gastrointestinal region, such as Crohn ^'s disease and ulcerative colitis.

It is noteworthy that compounds of the present subject matter, which are inhibitors of type 5 phosphodiesterase (PDE5) as well as of type 4 phosphodiesterase (PDE4), mentioned herein as dual type 4/5 phosphodiesterase inhibitors, are thought to be useful in the treatment or prophylaxis of the aboved mentioned diseases like inhibitors of the type 5 phosphodiesterase and/or inhibitors of the type 4 phosphodiesterase. Dual type 4/5 phosphodiesterase inhibitors have the potential to be more effective in treatment of distinct disease identities than compounds inhibiting one of those two enzymes only, since inhibition of PDE4 and PDE5 might address divers and different pathophysiologies occuring within one disease as e.g. lung fibrosis. In respect to lung fibrosis it has been described that inhibitors of type 4 phosphodiesterase inhibit TGF-β induced transition of lung fibroblasts to myofibroblasts (Dunkern et al., Eur. J. Pharmacol., 572(1 ): 12-22, 2007), which is a hallmark of fibrosis progression. They have further been described to inhibit matrix

metalloproteinase production from lung fibroblasts (Martin-Chouly CA et al., Life Sci. 75(7): 823^40, 2004) and to prevent chemotaxis of these cells (Kohyama T et al., Am. J. Respir. Cell MoI. Biol., 26(6): 694-701 , 2002), which are important pathophysiological aspects of lung fibrosis. In addition the selective type 4 phosphodiesterase inhibitor roflumilast have also been shown in-vivo in the bleomycin-induced lung fibrosis model in mice to inhibit fibrosis development (Cortijo J et al., Br. J. Pharmacol., 156(3): 534-44, 2009).

On the other hand it has been shown in respect to lung fibrosis that PDE5 inhibition by means of the selective PDE5 inhibitor sildenafil attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation (Hemnes AR, Zaiman A, Champion HC, Am. J. Physiol. Lung Cell. MoI. Physiol. 2008

Jan;294(1 ):L24-33. Epub 2007 Oct 26) and it has been shown in clinical human open-label trials that sildenafil improves lung hemodynamic (vascular resistance and ventilation/perfusion matching) and increases exercise tolerance in patients with pulmonary fibrosis(Ghofrani et al., Lancet 360, 895-900, 2002; Collard et al., Chest 131 , 897-899, 2007).

As described above the present subject matter covers beside type 5 phosphodiesterase inhibitors also dual type 4/5 phosphodiesterase inhibitors. In connection with this application preferred dual type 4/5 phosphodiesterase inhibitors have a -loglCso (mol/l)] higher than 6.0 for inhibition of PDE4 and a -loglC ₅₀ (mol/l) higher than 8.0 for inhibition of PDE5. More preferred dual type 4/5 phosphodiesterase inhibitors have a -loglC ₅₀ (mol/l) higher than 7.0 for inhibition of PDE4 and a - loglC ₅₀ (mol/l) higher than 8.0 for inhibition of PDE5.

Preferably, the present subject matter relates to the compounds of the present subject matter for use in the treatment or prophylaxis of the following diseases, particularly diseases alleviated by inhibition of the dual type 4/5 phosphodiesterase:

lung fibrosis such as idiopathic pulmonary fibrosis, pulmonary arterial hypertension respectively pulmonary hypertension, COPD, asthma, bronchitis, emphysema, nephritis such as proliferative glomerulonephritis, liver fibrosis, sarcoidosis, fibrotic conditions in general such as myelofibrosis, retroperitoneal fibrosis, endomyocardial fibrosis, mediastinal fibrosis, nephrogenic systemic fibro- sis, hypertrophic scars and toxic liver damage.

The present subject matter also relates to the use of a compound of the present subject matter in the manufacture of a pharmaceutical composition inhibiting the type 5 phosphodiesterase, in particular a pharmaceutical composition for the treatment or prophylaxis of diseases alleviated by inhibition of the type 5 phosphodiesterase, preferably, a pharmaceutical composition for the treatment or prophylaxis of the diseases exemplified above.

The present subject matter also further relates to the use of a compound of the present subject matter in the manufacture of a pharmaceutical composition inhibiting the dual type 4/5 phosphodiesterase, in particular a pharmaceutical composition for the treatment or prophylaxis of diseases alleviated by inhibition of the dual type 4/5 phosphodiesterase, preferably, a

pharmaceutical composition for the treatment or prophylaxis of the diseases exemplified above. Preferably, the present subject matter relates to the use of a compound of the present subject matter in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease, such as, but not limited to, pulmonary hypertension, lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease.

Preferably, the present subject matter relates to the use of a compound of the present subject matter in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease, such as, but not limited to, pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease.

In a particularly preferred embodiment of the present subject matter, the present subject matter relates to the use of a compound of the above examples in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease, such as, but not limited to, pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease. The present subject matter further relates to a method of treating or preventing a disease comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter.

In particular, the present subject matter relates to a method of treating or preventing one of the above mentioned diseases comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter.

Especially, the present subject matter relates to a method of treating or preventing a disease which is alleviated by inhibition of the type 5 phosphodiesterase comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter. The present subject matter further relates to a method of treating or preventing a disease which is alleviated by inhibition of the dual type 4/5 phosphodiesterase comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter.

Preferably, the present subject matter relates to a method of treating or preventing of an acute or chronic airway disease, for example, but not limited to, pulmonary hypertension, lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease, comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter.

Preferably, the present subject matter relates to a method of treating or preventing of an acute or chronic airway disease, for example, but not limited to, pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease, comprising administering to a patient in need thereof a therapeutically effective amount of at least one of the compounds of the present subject matter.

In the above methods, the patient is preferably a mammal, more preferably a human. Furthermore, in the above methods, at least one of the compounds of the present subject matter can be used. Preferably, one or two of the compounds of the present subject matter are used, more preferably, one of the compounds of the present subject matter is used.

In a particularly preferred embodiment of the present subject matter, the above methods of treating or preventing one of the above mentioned diseases comprise administering to a patient in need thereof a therapeutically effective amount of one compound of the examples according to the present present subject matter.

The present subject matter furthermore relates to a pharmaceutical composition which comprises at least one of the compounds of the present subject matter together with at least one

pharmaceutically acceptable auxiliary.

The present subject matter additionally relates to a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease, in particular for the treatment or prophylaxis of pulmonary hypertension, lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease. The present subject matter additionally relates to a pharmaceutical composition for the treatment or prophylaxis of an acute or chronic airway disease, in particular for the treatment or prophylaxis of pulmonary hypertension, pulmonary arterial hypertension, lung fibrosis, idiopathic pulmonary lung fibrosis, sarcoidosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease.

Preferably, the pharmaceutical composition comprises one or two of the compounds of the present subject matter. More preferably, the pharmaceutical composition comprises one of the compounds of the present subject matter. In a particularly preferred embodiment of the present subject matter, the pharmaceutical composition comprises a compound of the examples according to the present subject matter together with at least one pharmaceutically acceptable auxiliary.

The present subject matter additionally relates to a pharmaceutical composition comprising at least one of the compounds of the present subject matter, at least one pharmaceutically acceptable auxiliary and at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase

activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides.

In this respect, the therapeutic agent includes the corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides in form of the free compounds, the pharmaceutically acceptable salts thereof, the pharmaceutically acceptable derivatives thereof (e.g., but not limited to, ester derivatives), the solvates thereof and the stereoisomers of the compounds, salts, derivatives and solvates. Co-administration of at least one of the compounds of the present subject matter with at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta- mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta- blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides can take place in form of a fixed combination, a non-fixed combination or a kit of parts.

A "fixed combination" is defined as a combination wherein the compound of the present subject matter and the therapeutic agent intended for co-administration are present in one dosing unit or in a single entity. One example of a fixed combination is a pharmaceutical composition wherein the compound of the present subject matter and the therapeutic agent are present in admixture for simultaneous administration. Another example of a fixed combination is a pharmaceutical composition wherein the compound of the present subject matter and the therapeutic compound are present in one dosing unit without being in admixture.

A "non-fixed combination" or "kit of parts" is defined as a combination wherein the compound of the present subject matter and the therapeutic agent are present in more than one dosing unit. In a non-fixed combination or a kit of parts the compound of the present subject matter and the therapeutic agent are provided as separate formulations. They might be packaged and presented together as separate components of a combination pack for simultaneous, sequential or separate use in combination therapy. Simultaneous or sequential administration of the compound of the present subject matter and the therapeutic agent are preferred. In case of sequential or separate administration of the compound of the present subject matter and the therapeutic agent, the compound of the present subject matter can be administered before or after administration of the therapeutic agent.

In case of sequential or separate administration of the compound of the present subject matter and the therapeutic agent, the compound of the present subject matter can be administered before or after administration of the therapeutic agent.

Sequential administration encompasses a short time period between the administration of the compound of the present subject matter and the therapeutic agent or vice versa (for example, the time that is needed to swallow one tablet after the other).

Separate administration encompasses longer time periods between the administration of the compound of the present subject matter and the therapeutic agent. In a preferred embodiment of the present subject matter, the compound of the present subject matter is administered while the therapeutic agent (or vice versa) still has an therapeutic effect on the patient being treated.

The type of formulation of the compound of the present subject matter and the therapeutic agent of a non-fixed combination or a kit of parts can be identical, i.e. both, the compound of the present subject matter and the therapeutic agent are formulated, for example, as powder, solution or suspension suitable for inhalative administration, or can be different, i.e. suited for different administration forms, such as e.g. the compound of the present subject matter is formulated as powder, solution or suspension suitable for inhalative administration and the therapeutic agent is formulated as tablet or capsule for oral administration. Accordingly, the present subject matter additionally relates to a pharmaceutical composition presented either as a fixed combination, a non-fixed combination or kit of parts comprising at least one of the compounds of the present subject matter, at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, and at least one pharmaceutically acceptable auxiliary. Examples of corticosteroids include without limitation budesonide, fluticasone such as fluticasone propionate, beclometasone such as beclometasone dipropionate, triamcinolone such as triamcinolone acetonide, mometasone, and ciclesonide. Examples of anticholinergics include without limitation tiotropium such as tiotropium bromide, and ipratropium such as ipratropium bromide, aclinidinium sucg as aclinidinium bromide, glycopyrronium such as glycopyrronium bromide. Examples of beta-mimetics include without limitation indacaterol, formoterol such as formoterol fumarate, and salmeterol such as salmeterol xinafoate, salbutamol, milveterol, carmoterol. Examples of lung surfactants include without limitation lusupultide, poractant alfa, sinapultide, beractant, bovactant, colfosceril auch as colfosceril palmitate, surfactant-TA, and calfactant. Examples of endothelin antagonists include without limitation bosentan, ambrisentan, atrasentan, darusentan, clazosentan, avosentan and sitaxsentan such as sitaxsentan sodium. Examples of prostacyclins include without limitation iloprost such as iloprost tromethamine, epoprostenol such as epoprostenol sodium and treprostinil such as treprostinil sodium. Examples of calcium channel blockers include without limitation amlodipine such as amlodipine besylate and amlodipine maleate, nifedipine, diltiazem such as diltiazem hydrochloride, verapamil such as verapamil hydrochloride, and felodipine. Examples of beta-blockers include without limitation bisoprolol such as bisoprolol fumarate, nebivolol, metoprolol such as metoprolol succinate and metoprolol tartrate, carvedilol, atenolol and nadolol. Examples of type 4 phosphodiesterase inhibitors include without limitation roflumilast, roflumilast N-oxide, cilomilast, tetomilast, apremilast and oglemilast. Examples of antidepressants include without limitation bupropion such as bupropion hydrochloride. Examples of antibiotics include without limitation amoxicillin, ampicillin, levofloxacin, clarithromycin, ciprofloxacin such as ciprofloxacin hydrochloride, telithromycin and azithromycin. Examples of anticoagulants include without limitation clopidogrel, enoxaparin, cilostazol, nadroparin, warfarin and abciximab. Examples of diuretics include without limitation furosemide, bumetanide and torsemide. Examples of digitalis glycosides include without limitation digoxin and digitoxin. Examples of Guanyl-cyclase activator/stimulators include without limitation BAY63-2521 (Riociguat) and Ataciguat. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a corticosteroid and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and budesonide,

a compound of the present subject matter and fluticasone,

a compound of the present subject matter and beclometasone,

a compound of the present subject matter and mometasone,

a compound of the present subject matter and triamcinolone acetonide, or

a compound of the present subject matter and ciclesonide,

and at least one pharmaceutically acceptable auxiliary. In an alternative embodiment, the pharmaceutically acceptable derivative of fluticasone is fluticasone-17-propionate. In another alternative embodiment, the pharmaceutically acceptable derivative of beclometasone is beclometasone 17, 21-dipropionate ester. In an alternative embodiment, the pharmaceutically acceptable derivative of mometasone is mometasone furoate. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an anticholinergic and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combi- nation or kit of parts comprise:

a compound of the present subject matter and glycopyrronium bromide,

a compound of the present subject matter and aclidinium bromide,

a compound of the present subject matter and tiotropium bromide, or

a compound of the present subject matter and ipratropium bromide,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the stereoisomer of glycopyrronium bromide is (R,R)-glycopyrronium bromide. In an alternative embodiment, tiotropium bromide is used in form of its monohydrate. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a beta-mimetic and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and salbutamol,

a compound of the present subject matter and milveterol,

a compound of the present subject matter and indacaterol,

a compound of the present subject matter and carmoterol,

a compound of the present subject matter and salmeterol,

a compound of the present subject matter and formoterol,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the pharmaceutically acceptable salt of salbutamol is salbutamol sulfate. In an alternative embodiment, the pharmaceutically acceptable salt of milveterol is milveterol hydrochloride. In an alternative embodiment, the pharmaceutically acceptable salt of carmoterol is carmoterol hydrochloride. In an alternative embodiment, the pharmaceutically acceptable salt of salmeterol is salmeterol xinafoate. In another alternative embodiment, the pharmaceutically acceptable salt of formoterol is formoterol hemifumarate monohydrate. In another alternative embodiment, the stereoisomer of formoterol is R,R-formoterol. In another alternative embodiment, the pharmaceutically acceptable salt of R,R-formoterol is R,R-formoterol L-tartrate. Preferably the beta-mimetic is a long-acting beta-mimetic; particularly an alternative in this respect are those beta-mimetics having a therapeutic effect over a 12-24 hours period.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter), a lung surfactant and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and lusupultide,

a compound of the present subject matter and poracant alfa,

a compound of the present subject matter and sinapultide,

a compound of the present subject matter and beracant,

a compound of the present subject matter and bovacant,

a compound of the present subject matter and colfosceril palmitate,

a compound of the present subject matter and surfactant-TA, or

a compound of the present subject matter and calfacant,

and at least one pharmaceutically acceptable auxiliary. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an endothelin antagonist and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non- fixed combination or kit of parts comprise:

a compound of the present subject matter and bosentan,

a compound of the present subject matter and ambrisentan,

a compound of the present subject matter and atrasentan,

a compound of the present subject matter and darusentan,

a compound of the present subject matter and clazosentan, or

a compound of the present subject matter and avosentan,

and at least one pharmaceutically acceptable auxiliary. In another alternative embodiment, bosentan is used in form of its monohydrate. In another alternative embodiment the pharmaceutically acceptable salt of clazosentan is the disodium salt of clazosentan. In another alternative embodiment the pharmaceutically acceptable salts of atrasentan are atrasentan hydrochloride or the sodium salt of atrasentan. In another alternative embodiment the R-enantiomer of atrasentan is used. In another alternative embodiment the S-enantiomer of da- rusentan is used.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a prostacyclin and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and iloprost,

a compound of the present subject matter and epoprostenol,

a compound of the present subject matter and triprostinil,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a calcium channel blocker and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non- fixed combination or kit of parts comprise: a compound of the present subject matter and amlodipine,

a compound of the present subject matter and nifedipine,

a compound of the present subject matter and diltiazem,

a compound of the present subject matter and verapamil, or

a compound of the present subject matter and felodipine,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a beta-blocker and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and bisoprolol,

a compound of the present subject matter and nebivolol,

a compound of the present subject matter and metoprolol,

a compound of the present subject matter and carvedilol,

a compound of the present subject matter and atenolol, or

a compound of the present subject matter and nadolol,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a type 4 phosphodiesterase inhibitor and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and roflumilast,

a compound of the present subject matter and roflumilast N-oxide,

a compound of the present subject matter and cilomilast,

a compound of the present subject matter and tetomilast

a compound of the present subject matter and apremilast, or

a compound of the present subject matter and oglemilast,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an antidepressant and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and bupropion,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an antibiotic and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and amoxicillin,

a compound of the present subject matter and ampicillin,

a compound of the present subject matter and levofloxacin,

a compound of the present subject matter and clarithromycin,

a compound of the present subject matter and ciprofloxacin,

a compound of the present subject matter and telithromycin, or

a compound of the present subject matter and azithromycin,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, amoxicillin is used in form of its trihydrate. In another alternative embodiment, ampicillin is used in form of its trihydrate. In another alternative embodiment, the pharmaceutically acceptable salt of ampicillin is ampicillin natrium. In another alternative embodi- ment levofloxacin is used in form of its hemi hydrate. In another alternative embodiment, the pharmaceutically acceptable salt of ciprofloxacin is ciprofloxacin hydrochloride monohydrate. In another alternative embodiment, azithromycin is used in form of its monohydrate.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an anticoagulant and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and clopidogrel,

a compound of the present subject matter and enoxaparin,

a compound of the present subject matter and cilostazol,

a compound of the present subject matter and nadroparin, a compound of the present subject matter and warfarin, or

a compound of the present subject matter and abciximab,

and at least one pharmaceutically acceptable auxiliary. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a diuretic and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and furosemide,

a compound of the present subject matter and bumetanide, or

a compound of the present subject matter and torsemide,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a digitalis glycoside and at least one pharmaceutically acceptable auxil- iary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and digoxin, or

a compound of the present subject matter and digitoxin,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a corticosteroid, a beta-mimetic and at least one pharmaceutically accept- able auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter, budesonide and salbutamol,

a compound of the present subject matter, budesonide and milveterol,

a compound of the present subject matter, budesonide and indacaterol,

a compound of the present subject matter, budesonide and carmoterol,

a compound of the present subject matter, budesonide and salmeterol,

a compound of the present subject matter, budesonide and formoterol,

a compound of the present subject matter, fluticasone and salbutamol, a compound of the present subject matter, fluticasone and milveterol,

a compound of the present subject matter, fluticasone and indacaterol,

a compound of the present subject matter, fluticasone and carmoterol,

a compound of the present subject matter, fluticasone and salmeterol,

a compound of the present subject matter, fluticasone and formoterol,

a compound of the present subject matter, beclometasone and salbutamol,

a compound of the present subject matter, beclometasone and milveterol,

a compound of the present subject matter, beclometasone and indacaterol,

a compound of the present subject matter, beclometasone and carmoterol,

a compound of the present subject matter, beclometasone and salmeterol,

a compound of the present subject matter, beclometasone and formoterol,

a compound of the present subject matter, mometasone and salbutamol,

a compound of the present subject matter, mometasone and milveterol,

a compound of the present subject matter, mometasone and indacaterol,

a compound of the present subject matter, mometasone and carmoterol,

a compound of the present subject matter, mometasone and salmeterol,

a compound of the present subject matter, mometasone and formoterol,

a compound of the present subject matter, triamcinolone acetonide and salbutamol,

a compound of the present subject matter, triamcinolone acetonide and milveterol,

a compound of the present subject matter, triamcinolone acetonide and indacaterol,

a compound of the present subject matter, triamcinolone acetonide and carmoterol,

a compound of the present subject matter, triamcinolone acetonide and salmeterol,

a compound of the present subject matter, triamcinolone acetonide and formoterol,

a compound of the present subject matter, ciclesonide and salbutamol,

a compound of the present subject matter, ciclesonide and milveterol,

a compound of the present subject matter, ciclesonide and indacaterol,

a compound of the present subject matter, ciclesonide and carmoterol,

a compound of the present subject matter, ciclesonide and salmeterol, or

a compound of the present subject matter, ciclesonide and formoterol,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a beta-mimetic, an anticholinergic and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter, salbutamol and glycopyrronium bromide, a compound of the present subject matter, salbutamol and aclidinium bromide,

a compound of the present subject matter, salbutamol and tiotropium bromide,

a compound of the present subject matter, salbutamol and ipratropium bromide,

a compound of the present subject matter, milveterol and glycopyrronium bromide,

a compound of the present subject matter, milveterol and aclidinium bromide,

a compound of the present subject matter, milveterol and tiotropium bromide,

a compound of the present subject matter, milveterol and ipratropium bromide,

a compound of the present subject matter, salmeterol and glycopyrronium bromide,

a compound of the present subject matter, salmeterol and aclidinium bromide,

a compound of the present subject matter, salmeterol and tiotropium bromide,

a compound of the present subject matter, salmeterol and ipratropium bromide,

a compound of the present subject matter, formoterol and glycopyrronium bromide,

a compound of the present subject matter, formoterol and aclidinium bromide,

a compound of the present subject matter, formoterol and tiotropium bromide,

a compound of the present subject matter, formoterol and ipratropium bromide,

a compound of the present subject matter, indacaterol and glycopyrronium bromide,

a compound of the present subject matter, indacaterol and aclidinium bromide,

a compound of the present subject matter, indacaterol and tiotropium bromide,

a compound of the present subject matter, indacaterol and ipratropium bromide,

a compound of the present subject matter, carmoterol and glycopyrronium bromide,

a compound of the present subject matter, carmoterol and aclidinium bromide,

a compound of the present subject matter, carmoterol and tiotropium bromide, or

a compound of the present subject matter, carmoterol and ipratropium bromide,

and at least one pharmaceutically acceptable auxiliary.

In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), a corticosteroid, an anticholinergic and at least one pharmaceutically ac- ceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter, budesonide and glycopyrronium bromide,

a compound of the present subject matter, budesonide and aclidinium bromide,

a compound of the present subject matter, budesonide and tiotropium bromide,

a compound of the present subject matter, budesonide and ipratropium bromide,

a compound of the present subject matter, fluticasone and glycopyrronium bromide,

a compound of the present subject matter, fluticasone and aclidinium bromide,

a compound of the present subject matter, fluticasone and tiotropium bromide, a compound of the present subject matter, fluticasone and ipratropium bromide,

a compound of the present subject matter, beclometasone and glycopyrronium bromide, a compound of the present subject matter, beclometasone and aclidinium bromide,

a compound of the present subject matter, beclometasone and tiotropium bromide,

a compound of the present subject matter, beclometasone and ipratropium bromide,

a compound of the present subject matter, mometasone and glycopyrronium bromide, a compound of the present subject matter, mometasone and aclidinium bromide,

a compound of the present subject matter, mometasone and tiotropium bromide,

a compound of the present subject matter, mometasone and ipratropium bromide,

a compound of the present subject matter, triamcinolone acetonide and glycopyrronium bromide, a compound of the present subject matter, triamcinolone acetonide and aclidinium bromide, a compound of the present subject matter, triamcinolone acetonide and tiotropium bromide, a compound of the present subject matter, triamcinolone acetonide and ipratropium bromide, a compound of the present subject matter, ciclesonide and glycopyrronium bromide,

a compound of the present subject matter, ciclesonide and aclidinium bromide,

a compound of the present subject matter, ciclesonide and tiotropium bromide, or

a compound of the present subject matter, ciclesonide and ipratropium bromide,

and at least one pharmaceutically acceptable auxiliary. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), an guanyl-cyclase activator/stimulator and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combina- tion, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and BAY63-2521 (Riociguat),

a compound of the present subject matter and Ataciguat,

and at least one pharmaceutically acceptable auxiliary. In an alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise a compound of the present subject matter (in particular the compound of the present subject matter is one of the examples of the present subject matter or a pharmaceutically acceptable salt thereof), pirfenidone and at least one pharmaceutically acceptable auxiliary. In a particularly alternative embodiment, the above-mentioned fixed combination, non-fixed combination or kit of parts comprise:

a compound of the present subject matter and pirfenidone,

and at least one pharmaceutically acceptable auxiliary. The above mentioned compound of the present subject matter is preferably a compound according to the examples.

The present subject matter furthermore relates to pharmaceutical compositions according to the present subject matter, as defined above, inhibiting the type 5 phosphodiesterase, especially for the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterase, in particular for the treatment or prophylaxis of the diseases exemplified above.

The present subject matter even furthermore relates to pharmaceutical compositions according to the present subject matter, as defined above, inhibiting the dual type 4/5 phosphodiesterase, especially for the treatment or prophylaxis of diseases alleviated by inhibition of dual type 4/5 phosphodiesterase, in particular for the treatment or prophylaxis of the diseases exemplified above.

The present subject matter also encompasses pharmaceutical compositions according to the present subject matter, as defined above, for the treatment or prophylaxis of the following diseases: acute and chronic airway diseases, such as pulmonary hypertension, lung fibrosis, asthma, bronchitis, emphysema and chronic obstructive pulmonary disease.

The pharmaceutical compositions according to the present subject matter preferably contain the compound or compounds of the present subject matter in a total amount of from 0.1 to 99.9 wt%, more preferably 5 to 95 wt%, in particular 20 to 80 wt%. In case at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides is present in the pharmaceutical compositions of the present subject matter, the total amount of said therapeutic agent or therapeutic agents in the pharmaceutical compositions is preferably in the range of from 0.1 to 99.9 wt%, more preferably 5 to 95 wt%, in particular 20 to 80 wt%, under the provision that the total amount of the compound or compounds of the present subject matter and the therapeutic agent or therapeutic agents is less than 100 wt%. Preferably, the at least one compound of the present subject matter and the at least one therapeutic agent are present in the pharmaceutical composition in a weight ratio of from 1000 : 1 to 1 : 1000, more preferably 500 : 1 to 1 : 500.

As pharmaceutically acceptable auxiliaries, any auxiliaries known to be suitable for preparing pharmaceutical compositions can be used. Examples thereof include, but are not limited to, solvents, excipients, dispersants, emulsifiers, solubilizers, gel formers, ointment bases, antioxidants, preservatives, stabilizers, carriers, fillers, binders, thickeners, complexing agents, disintegrating agents, buffers, permeation promoters, polymers, lubricants, coating agents, propellants, tonicity adjusting agents, surfactants, colorants, flavorings, sweeteners and dyes. In particular, auxiliaries of a type appropriate to the desired formulation and the desired mode of administration are used. The pharmaceutical compositions can be formulated, for example, into tablets, coated tablets

(dragees), pills, cachets, capsules (caplets), granules, powders, suppositories, solutions (e.g., but not limited to, sterile solutions), emulsions, suspensions, ointments, creams, lotions, pastes, oils, gels, sprays and patches (e.g., but not limited to, transdermal therapeutic systems). Additionally, the pharmaceutical compositions can be prepared as e.g. liposome delivery systems, systems in which the compound of the present subject matter is coupled to monoclonal antibodies and systems in which the compound of the present subject matter is coupled to polymers (e.g., but not limited to, soluble or biodegradable polymers).

In case of pharmaceutical compositions comprising at least one of the compounds of the present subject matter and at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, the compound of the present subject matter and the therapeutic agent may be formulated together into the same dosage form (e.g., but not limited to, tablets), separately into the same dosage form (e.g., but not limited to, tablets), or into different dosage forms (without limitation e.g. the compound of the present subject matter may be formulated as tablet and the therapeutic agent may be formulated as powder, solution or suspension). The pharmaceutical compositions can be manufactured in a manner known to a person skilled in the art, e.g. by dissolving, mixing, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes.

The selected formulation depends inter alia on the route of administering the pharmaceutical composition. The pharmaceutical compositions of the present subject matter can be administered by any suitable route, for example, by the oral, sublingual, buccal, intravenous, intraarterial, intramuscular, subcutaneous, intracutaneous, topical, transdermal, intranasal, intraocular, intraperitoneal, intrasternal, intracoronary, transurethral, rectal or vaginal route, by inhalation or by insufflation. Oral administration is preferred.

In case of pharmaceutical compositions comprising at least one of the compounds of the present subject matter and at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, the compound of the present subject matter and the therapeutic agent may be administered by the same route, e.g., without limitation, orally, or by different routes, e.g., without limitation, the compound of the present subject matter can be administered orally and the therapeutic agent can be administered by inhalation or instillation.

Tablets, coated tablets (dragees), pills, cachets, capsules (caplets), granules, solutions, emulsions and suspensions are e.g. suitable for oral administration. In particular, said formulations can be adapted so as to represent, for example, an enteric form, an immediate release form, a delayed release form, a repeated dose release form, a prolonged release form or a sustained release form. Said forms can be obtained, for example, by coating tablets, by dividing tablets into several compartments separated by layers disintegrating under different conditions (e.g. pH conditions) or by coupling the compound of the present subject matter to a biodegradable polymer.

Administration by inhalation or instillation is preferably made by using an aerosol. The aerosol is a liquid-gaseous dispersion, a solid-gaseous dispersion or a mixed liquid/solid-gaseous dispersion.

The aerosol may be generated by means of aerosol-producing devices such as dry powder inhalers (DPIs), pressurized metered dose inhalers (PMDIs) and nebulizers. Depending on the kind of the compound of the present subject matter, and optionally the therapeutic agent, to be administered, the aerosol-producing device can contain the compound and, optionally, the therapeutic agent in form of a powder, a solution or a dispersion. The powder may contain, for example, one or more of the following auxiliaries: carriers, stabilizers and fillers. The solution may contain in addition to the solvent, for example, one or more of the following auxiliaries: propellants, solubilizers (co-solvents), surfactants, stabilizers, buffers, tonicity adjusting agents, preservatives and flavorings. The dispersion may contain in addition to the dispersant, for example, one or more of the following auxiliaries: propellants, surfactants, stabilizers, buffers, preservatives and flavorings. Examples of carriers include, but are not limited to, saccharides, e.g. lactose and glucose. Examples of propellants include, but are not limited to, fluorohydrocarbons, e.g. 1 ,1 ,1 ,2- tetrafluoroethane and 1 ,1 ,1 ,2,3,3,3-heptafluoropropane.

The particle size of the aerosol particles (solid, liquid or solid/liquid particles) is preferably less than 100 μm, more preferably it is in the range of from 0.5 to 10 μm, in particular in the range of from 2 to 6 μm (D50 value, measured by laser diffraction).

Specific aerosol-producing devices which may be used for inhaled administration include, but are not limited to, Cyclohaler®, Diskhaler®, Rotadisk®, Turbohaler®, Autohaler®, Turbohaler®, Novolizer®, Easyhaler®, Aerolizer®, Jethaler®, Diskus®, Ultrahaler® and Mystic® inhalers. The aerosol-producing devices may be combined with spacers or expanders, e.g. Aerochamber®, Nebulator®, Volumatic® and Rondo®, for improving inhalation efficiency. In case of topical administration, suitable pharmaceutical formulations are, for example, ointments, creams, lotions, pastes, gels, powders, solutions, emulsions, suspensions, oils, sprays and patches (e.g., but not limited to, transdermal therapeutic systems).

For parenteral modes of administration such as, for example, intravenous, intraarterial, intramuscular, subcutaneous, intracutaneous, intraperitoneal and intrasternal administration, preferably solutions (e.g., but not limited to, sterile solutions, isotonic solutions) are used. They are preferably administered by injection or infusion techniques.

In case of intranasal administration, for example, sprays and solutions to be applied in drop form are preferred formulations.

For intraocular administration, solutions to be applied in drop form, gels and ointments are exemplified formulations. Generally, the pharmaceutical compositions according to the present subject matter can be administered such that the dose of the compound of the present subject matter is in the range customary for type 5 phosphodiesterase inhibitors or dual type 4/5 phosphodiesterase inhibitors. In particular, a dose in the range of from 0.01 to 4000 mg of the compound of the present subject matter per day is preferred. In this respect, it is to be noted that the dose is dependent, for example, on the specific compound used, the species treated, age, body weight, general health, sex and diet of the subject treated, mode and time of administration, rate of excretion, severity of the disease to be treated and drug combination. In case the pharmaceutical composition of the present subject matter comprises at least one of the compounds of the present subject matter and at least one therapeutic agent selected from the group consisting of corticosteroids,

anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase

activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, the same dose ranges apply to the therapeutic agent. The pharmaceutical compositions according to the present subject matter can be administered in a single dose per day or in multiple subdoses, for example, 2 to 4 doses per day. A single dose unit of the pharmaceutical composition can contain e.g. from 0.01 mg to 4000 mg, preferably 0.1 mg to 2000 mg, more preferably 0.5 to 1000 mg, most preferably 1 to 500 mg, of the compound of the present subject matter. In case the pharmaceutical composition of the present subject matter comprises at least one of the compounds of the present subject matter and at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, a single dose unit of the

pharmaceutical composition can contain e.g. from 0.01 mg to 4000 mg, preferably 0.1 mg to 2000 mg, more preferably 0.5 to 1000 mg, most preferably 1 to 500 mg, of the therapeutic agent.

Furthermore, the pharmaceutical composition can be adapted to weekly, monthly or even more infrequent administration, for example by using an implant, e.g. a subcutaneous or intramuscular implant, by using the compound of the present subject matter in form of a sparingly soluble salt or by using the compound of the present subject matter coupled to a polymer. Administration of the pharmaceutical composition in a single dose per day is preferred. In case the pharmaceutical composition of the present subject matter comprises at least one of the compounds of the present subject matter and at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, beta-mimetics, lung surfactants, endothelin antagonists, prostacyclins, calcium channel blockers, beta-blockers, type 4 phosphodiesterase inhibitors, guanyl-cyclase activators/stimulators, pirfenidone, antidepressants, antibiotics, anticoagulants, diuretics and digitalis glycosides, administration of the compound of the present subject matter and administration of the therapeutic agent can be made simultaneously or sequentially. In case of sequential administration, the compound of the present subject matter can be administered before or after administration of the therapeutic agent.

Biological investigations

Method for measuring inhibition of the type 5 phosphodiesterase (PDE5) activity: As a source for human PDE5, platelets are used. For that purpose, 150 ml fresh blood from human donors anticoagulated with citrate [final concentration 0.3% (w/v)] is centrifuged at 200 g for 10 min to obtain the so-called platelet-rich-plasma (PRP) as a supernatant. 1/10 volume of ACD solution (85 mM Na ₃-citrate, 11 1 mM D-glucose, 71 mM citric acid, pH 4.4) is added to 9/10 volume of PRP. After centrifugation (1 ,400 g, 10 min) the cell pellet is resuspended in 3 ml homogenization buffer (NaCI 140 mM, KCI 3.8 mM, EGTA (ethylene glycol tetraacetic acid) 1 mM, MgCb 1 mM, Tris-HCI 20 mM, beta-mercaptoethanol 1 mM, pH 8.2) plus protease-inhibitor mix giving rise to the final concentrations of 0.5 mM Pefablock (Roche), 10 μM Leupeptin, 5 μM Trypsininhibitor, 2 mM Benzamidin and 10 μM Pepstatin A. The suspension is sonified and thereafter centrifuged for 15 min at 10,000 g. The resulting supernatant (platelet lysate) is used for enzymatic testings.

PDE5A1 activity is inhibited by the compounds of the present subject matter in a modified SPA (scintillation proximity assay) test, supplied byAmersham Biosciences (see procedural instructions "phosphodiesterase [3H]cAMP SPA enzyme assay, code TRKQ 7090"), carried out in 96-well mi- crotitre plates (MTP's). The test volume is 100 μl and contains 20 mM Tris buffer (pH 7.4), 0.1 mg of BSA (bovine serum albumin)/ml, 5 mM Mg ²⁺, 1 μM motapizone, 10 nM PDE2 inhibitor 2-(3,4- dimethoxybenzyl)-7-[(1R,2R)-2-hydroxy-1-(2-phenylethyl)propy l]-5-methylimidazo[5,1- /][1 ,2,4]triazin-4(3/-/)-one, 0.5 μM cGMP (cyclic guanosine monophosphate) (including about 50,000 cpm of [3H]cGMP as a tracer), 1 μl of the respective compound dilution in dimethylsulfoxide (DMSO) and sufficient PDE5-containing platelet lysat (10,000χg supernatant, see above) to ensure that 10-20 wt% of the cGMP is converted under the said experimental conditions. The final concentration of DMSO in the assay (1 % v/v) does not substantially affect the activity of the PDE investigated. After a preincubation of 5 min at 37°C, the reaction is started by adding the substrate (cGMP) and the assay is incubated for a further 15 min; after that, it is stopped by adding SPA beads (50 μl). In accordance with the manufacturer's instructions, the SPA beads had previously been resuspended in water, but are then diluted 1 :3 (v/v) in water; the diluted solution also contains 3 mM 8-methoxymethyl-3-isobutyl-1-methylxanthine (IBMX) to ensure a complete PDE activity stop. After the beads have been sedimented (> 30 min), the MTP's are analyzed in commercially available luminescence detection devices. The corresponding IC ₅₀ values of the compounds for the inhibition of PDE activity are determined from the concentration-effect curves by means of non- linear regression. For the following compounds PDE5A1 inhibitory values [measured as -1OgIC ₅₀ (mol/l)] between 8.0 and 9.0 have been determined. The numbers of the compounds correspond to the numbers of the examples.

Compounds: E28, E31 -E33, E36, E39, E45-E54, E80, E154, E156, E158, E162, E177, E192-E194, F17, F19-F23, F27-F33, F97-F98, F119-F120, P3, P24-P26.

For the following compounds PDE5A1 inhibitory values [measured as -1OgIC ₅₀ (mol/l)] higher than 9.0 have been determined. The numbers of the compounds correspond to the numbers of the examples.

Compounds: E1-E27, E29-E30, E34-E35, E37-E38, E40-E44, E55-E79, E81-E153, E155, E157, E159-E161 , E163-E176, E178-E191 , E-195-E203, F1-F16, F18, F24-F26, F34-F74, F76-F96, F99-F118, P1 -P2, P6-P8, P89-P91 , P139-P141 , P159-P161 , P169-P171 , P189-P191 , P199-201 , P209-P211.

Method for measuring inhibition of the type 4 phosphodiesterase (PDE4) activity:

The PDE4B1 (GB no. L20966) was a gift of Prof. M. Conti (Stanford University, USA). It was amplified from the original plasmid (pCMV5) via PCR with primers Rb18 (5'- CAGACATCCTAA- GAGGGGAT -3') and Rb10 (5'- AGAGGGGGATTATGTATCCAC -3') and cloned into the pCR- Bac vector (Invitrogen, Groningen, NL).

The recombinant baculovirus was prepared by means of homologous recombination in SF9 insect cells. The expression plasmids were cotransfected with Baculo-Gold DNA (Pharmingen, Hamburg) using a standard protocol (Pharmingen, Hamburg). Wt virus-free recombinant virus supernatants were selected using plaque assay methods. After that, high-titre virus supernatants were prepared by amplifying 3 times. PDE4B1 was expressed in SF21 cells by infecting 2 x 10 ⁶ cells/ml with an MOI (multiplicity of infection) between 1 and 10 in the serum-free medium Insect Express Sf9-S2 (PAA, Pasching, Austria). The cells were cultured at 28°C for 48 - 72 hours, after which they were pelleted for 5-10 min at 10OOxg and 4°C.

The SF21 insect cells were resuspended, at a concentration of approx. 10 ⁷ cells/ml, in ice-cold (4°C) homogenization buffer (20 mM Tris, pH 8.2, containing the following additions: 140 mM NaCI, 3.8 mM KCI, 1 mM EGTA, 1 mM MgCI ₂, 10 mM β-mercaptoethanol, 2 mM benzamidine, 0.4 mM Pefablock, 10 μM leupeptin, 10 μM pepstatin A, 5 μM trypsin inhibitor) and disrupted by ultrasoni- cation. The homogenate was then centrifuged for 10 min at 1000χg and the supernatant was stored at -80 ⁰C until subsequent use (see below). The protein content was determined by the Bradford method (BioRad, Munich) using BSA as the standard. PDE4B1 activity was inhibited by the compounds according to the present subject matter in a modified SPA (scintillation proximity assay) test, supplied by Amersham Biosciences (see procedural instructions "phosphodiesterase [3H]cAMP SPA enzyme assay, code TRKQ 7090"), carried out in 96-well microtitre plates (MTP's). The test volume is 100 μl and contains 20 mM Tris buffer

(pH 7.4), 0.1 mg /ml of BSA, 5 mM Mg ²⁺, 0.5 μM cAMP (including about 50,000 cpm of [3H]cAMP), 1 μl of the respective substance dilution in DMSO and sufficient recombinant PDE (1000χg supernatant, see above) to ensure that 10-20% of the cAMP is converted under the said experimental conditions. The final concentration of DMSO in the assays (1 % v/v) does not substantially affect the activity of the PDE investigated. After a preincubation of 5 min at 37°C, the reaction is started by adding the substrate (cAMP) and the assays are incubated for a further 15 min; after that, they are stopped by adding SPA beads (50 μl). In accordance with the manufacturer's instructions, the SPA beads had previously been resuspended in water, but were then diluted 1 :3 (v/v) in water; the diluted solution also contains 3 mM IBMX to ensure a complete PDE activity stop. After the beads have been sedimented (> 30 min), the MTP's are analyzed in commercially available luminescence detection devices. The corresponding IC ₅₀ values of the compounds for the inhibition of PDE4B1 activity are determined from the concentration-effect curves by means of non-linear regression.

For the following compounds PDE4B1 inhibitory values [measured as -loglCso (mol/l)] between 6.0 and 7.0 have been determined. The numbers of the compounds correspond to the numbers of the examples.

Compounds: E37-E40, E45, E66-E74, E96, E145-E147, E151-E157, E159-E160, E169-E171 , E177-E178, F23-F24, F27, F41 -F46, F58, F97, F99-F101 , F106. For the following compounds PDE4B1 inhibitory values [measured as -1OgIC ₅₀ (mol/l)] higher than 7.0 have been determined. The numbers of the compounds correspond to the numbers of the examples.

Compounds: E41-E44, E81-E95, E97-E98, E148-E150, E176, E-195-E203, F25-F26, F51-F57, F59-F62, F93-F96, P1-P3 , P6-P8, P24-P26, P89-P91 , P99-P101 , P139-P141 , P159-P161 , P169- P171 , P189-P191 , P199-201 , P209-P21 1. Animal pharmacological testing of PDE5 inhibitory action of compounds

Nitric oxide regulates smooth muscle tone by elevation of cGMP via activation of guanylate cyclase and subsequent activation of cyclic GMP-dependent protein kinase. The amplitude and duration of the cGMP signal in smooth muscle is largely regulated by cGMP-specific cyclic nucleotide phosphodiesterase 5 (PDE5). Therefore, inhibition of PDE5 or activation of guanylate cyclase causes altered arterial blood pressure response, which is more pronounced under conditions of acute arterial hypertension, which can be easily induced by continuous intravenous (i.v.) phenylephrine(PE)- infusion. The aim of the study was to evaluate the effects of the selective PDE5 inhibitors described in this present subject matter on phenylephrine-induced acute arterial hypertension and sodium- nitroprusside (SNP) induced blood pressure response in anaesthetised male Spraque Dawley rats.

Method

The test compound (suspended in a 4% w/v aqueous methylcellulose solution either 3 or 10 mg/kg) or placebo (i.e. 4% aqueous methylcellulose solution) is administered orally to conscious Spraque Dawley rats 90 min prior to SNP administration. 40 min later, rats are anaesthetised by intramuscular administration of 80 mg/kg ketamine-HCI + 4 mg/kg xylazin-HCI and ventilated with ~1.5% isoflurane in a mixture of ambient air and 40% oxygen. Catheters for i.v. PE- and SNP- administration and recording of mean arterial blood pressure (MAP) are inserted. One hour after compound or placebo administration, a continuous i.v. (V. femoralis) PE-infusion (3 μg/kg/min at an infusion rate of 0.06 ml/min) is started and maintained till the end of the experiment. 30 min after start of the PE-infusion, an i.v.-bolus of the NO-donor sodium nitroprusside (SNP, 30 μg/kg at a volume of 1.0 ml/kg) is administered. To assess the effect of test compounds (PDE5 inhibitory activity) in comparison to placebo, MAP response is analysed. MAP prior to SNP-administration and area under the curve of MAP within 180 s following SNP-administration, corrected for initial MAP (corr. AUC _MAP _O-I _8OS) is used, to describe altered arterial vascular response and thus in vivo PDE5-inhibitory activity. The efficacy (% change vs. control) achievable in this model is approximately between -1 1 % and -40% effect for the examples E1 , E94, E102, E131 , F24, F65, F69, F84 and F112.

Animal pharmacological testing of PDE4 inhibitory action of compounds

The PDE4 inhibitory activity of compounds is well described to result in anti-inflammatory effects. Therefore compounds of the present subject matter have been tested for inhibition of

lipopolysaccharide induced tumor necrosis facfor α (TNFα) release in male Sprague Daley rats. The inhibition of LPS-induced TNFα production obtained by testing of compounds in this model is between 7% and 99% for the examples E84, E86, E87, E89, E93, E94, E95, F12, F53, F55, F56, P7, P8, P89, P90, P140, P141 , P160, P161 , P170, P171 , P189-P191 , P199-P201 , P210 and P211. Method

Compounds were administered at different doses to male Sprague Daley rats (n = 6-8 animals per dose group). A LPS and placebo treated control group (n = 6 to 8 animals) was enclosed.

Compound and placebo were administered per os (p.o.) by gavage (administration volume: 10 ml/kg) one hour before LPS challenge.

LPS was injected intravenously (i.v.) at a dose of 1 mg/kg (administration volume: 10 ml/kg). 1.5 h after LPS-challenge animals were sacrificed by i.v. injection of sodium pentobarbital (120 mg/kg). Heparinized blood was obtained by heart puncture. Blood was centrifuged (21 ,000 x g, 4 ⁰C, 15 min), and plasma samples were kept frozen at -80 ⁰C until determination of TNFα levels by ELISA.

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