Title:
MHC GENE GROUP HUMANIZED ANIMAL
Document Type and Number:
WIPO Patent Application WO/2023/176982
Kind Code:
A1
Abstract:
A vector set including a combination of the following vectors (A), (B), and (D) or (C) and (D): (A) a targeting vector 1 incorporated at any position P1 distal to a human MHC region, (B) a targeting vector 2 incorporated at a position p1 corresponding to the P1 of a non-human MHC region, (C) a targeting vector 3 that triggers a recombination between a region from the P1 to the distal end and a region from the p1 to the distal end, and (D) a targeting vector 4 that triggers in the chromosome after recombination a recombination between a region from any position P2 proximal to a human MHC region to the distal end and a region from a position p2 corresponding to the P2 in a chromosome in which a non-human MHC is present to the distal end.
Inventors:
SUZUKI TERUHIKO (JP)
HARA TAKAHIKO (JP)
HARA TAKAHIKO (JP)
Application Number:
PCT/JP2023/010779
Publication Date:
September 21, 2023
Filing Date:
March 14, 2023
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
C12N15/85; A01K67/027; C12N5/0735; C12N5/10; C12N15/09; C12N15/12
Domestic Patent References:
| WO2021139799A1 | 2021-07-15 | |||
| WO2000010383A1 | 2000-03-02 | |||
| WO2020257545A1 | 2020-12-24 |
Foreign References:
| US20220033781A1 | 2022-02-03 | |||
| US20090328240A1 | 2009-12-31 |
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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