Title:
MICROCHANNEL CHIP FOR MICROPARTICLE SEPARATION, MICROPARTICLE SEPARATION METHOD AND SYSTEM FOR MICROPARTICLE SEPARATION USING CHIP
Document Type and Number:
WIPO Patent Application WO/2014/061631
Kind Code:
A1
Abstract:
Provided is a microchannel chip, for microparticle separation, which can continuously separate microparticles, from a solution in which microparticles of different particle diameter are mixed, without needing to use an antibody or similar, and without causing clogging. Also provided are a microparticle separation method and a system for microparticle separation using the chip. Microparticles can be captured by using the microchannel chip for microparticle separation, the microchannel chip being characterised by being provided with a plurality of main channels and capture portions that are wider than the main channels and at least one of which is provided to each main channel.
Inventors:
ARAI FUMIHITO (JP)
MASUDA TAISUKE (JP)
NIIMI MIYAKO (JP)
DOUKE HARUKI (JP)
NAKANISHI HAYAO (JP)
ITO SEIJI (JP)
MASUDA TAISUKE (JP)
NIIMI MIYAKO (JP)
DOUKE HARUKI (JP)
NAKANISHI HAYAO (JP)
ITO SEIJI (JP)
Application Number:
PCT/JP2013/077905
Publication Date:
April 24, 2014
Filing Date:
October 15, 2013
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
AICHI PREFECTURE (JP)
AICHI PREFECTURE (JP)
International Classes:
G01N35/08; C12M1/00; G01N1/04; G01N1/28; G01N15/14; G01N33/50; G01N37/00
Domestic Patent References:
| WO2012037030A2 | 2012-03-22 | |||
| WO2010142954A1 | 2010-12-16 | |||
| WO2010144745A2 | 2010-12-16 |
Foreign References:
| JP2008539711A | 2008-11-20 | |||
| JP2008136475A | 2008-06-19 | |||
| JP2007186456A | 2007-07-26 | |||
| JP2008116211A | 2008-05-22 | |||
| US20110303586A1 | 2011-12-15 | |||
| JP2011163830A | 2011-08-25 |
Other References:
ALLARD WJ; MATERA J; MILLER MC; REPOLLET M; CONNELLY MC; RAO C; TIBBE AG; UHR JW; TERSTAPPEN LW: "Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.", CLIN CANCER RES, vol. 10, no. 20, 2004, pages 6897 - 904
RIETHDORF S; FRITSCHE H; MULLER V; RAU T; SCHINDLBECK C; RACK B; JANNI W; COITH C; BECK K, JANICKE F: "Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system", CLIN CANCER RES, vol. 13, no. 3, 2007, pages 920 - 8
TAN SJ; YOBAS L; LEE GY; ONG CN; LIM CT.: "Microdevice for the isolation and enumeration of cancer cells from blood.", BIOMED MICRODEVICES, vol. 11, no. 4, 2009, pages 883 - 92
MOHAMED H; MURRAY M; TURNER JN; CAGGANA M.: "Isolation of tumor cells using size and deformation", J CHROMATOGR A, vol. 1216, no. 47, 2009, pages 8289 - 95
See also references of EP 2908140A4
RIETHDORF S; FRITSCHE H; MULLER V; RAU T; SCHINDLBECK C; RACK B; JANNI W; COITH C; BECK K, JANICKE F: "Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system", CLIN CANCER RES, vol. 13, no. 3, 2007, pages 920 - 8
TAN SJ; YOBAS L; LEE GY; ONG CN; LIM CT.: "Microdevice for the isolation and enumeration of cancer cells from blood.", BIOMED MICRODEVICES, vol. 11, no. 4, 2009, pages 883 - 92
MOHAMED H; MURRAY M; TURNER JN; CAGGANA M.: "Isolation of tumor cells using size and deformation", J CHROMATOGR A, vol. 1216, no. 47, 2009, pages 8289 - 95
See also references of EP 2908140A4
Attorney, Agent or Firm:
MATSUMOTO SEIJI (JP)
Seiji Matsumoto (JP)
Seiji Matsumoto (JP)
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