MICROFLUIDIC MIXING AND DISPENSING

WIPO Patent Application WO2003016832

A3

A micro fluidic dispensing tap (20), such as for use in screening assays, includes a 5 dispensing tube (11) translatable within a sealed reservoir housing (32), The tube has an outer surface and defines an inner cavity (25) open at a lower end of the tube, and a metering aperture (27) extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal (24) at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed 10 below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir (21) for entraining a discrete dose of a sample liquid (30) within the aperture. An injector (130) is configured to inject a known quantity ofa diluent (53) into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete 15 mixture for dispensing from an open end of the tube.

KARG JEFFREY A (US)
KRONCKE DOUGLAS W (US)

PCT/US2002/025653

May 30, 2003

August 13, 2002

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BOSTON INNOVATION INC (US)
KARG JEFFREY A (US)
KRONCKE DOUGLAS W (US)

B01F5/06; B01F11/00; B01J19/00; B01L3/02; G01N1/38; G01N35/10; B01F13/00; C40B60/14; (IPC1-7): B01L3/02; B01F13/00; B01J19/00; G01N35/10; G01N1/38

WO1990008075A1	1990-07-26
WO2001064345A2	2001-09-07

DE3115568A1	1982-04-15
US6165417A	2000-12-26
US4844868A	1989-07-04
EP0971235A1	2000-01-12

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