Title:
MICROORGANISM BELONGING TO GENUS AKKERMANSIA
Document Type and Number:
WIPO Patent Application WO/2023/224117
Kind Code:
A1
Abstract:
Provided are: a microorganism belonging to the genus Akkermansia, which has a 16S rRNA gene containing a nucleotide sequence having a homology exceeding 98.0% to the nucleotide sequence represented by SEQ ID NO: 3, etc., has NOD2 agonist activity, is capable of assimilating D-mannitol, is negative in Gram stain, is a spherical to short rod-shaped anaerobic bacterium, and is negative in oxidase test and positive in catalase test; and a microorganism including the aforesaid microorganism for activating NOD2, enhancing immunity, etc.
Inventors:
KOBAYASHI YODAI (JP)
KOUDA NORIYUKI (JP)
INOUE SHOICHIRO (JP)
KAWAHARA TOMOHIRO (JP)
HAMURO KOJI (JP)
IBUKURO CHIKA (JP)
KOUDA NORIYUKI (JP)
INOUE SHOICHIRO (JP)
KAWAHARA TOMOHIRO (JP)
HAMURO KOJI (JP)
IBUKURO CHIKA (JP)
Application Number:
PCT/JP2023/018734
Publication Date:
November 23, 2023
Filing Date:
May 19, 2023
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C12N1/20; A23L33/135; A61K35/741; A61P37/02; C12N15/31
Domestic Patent References:
| WO2021060945A1 | 2021-04-01 |
Foreign References:
| JP2017517569A | 2017-06-29 | |||
| JP2019510520A | 2019-04-18 |
Other References:
BECKEN BRADFORD, DAVEY LAUREN, MIDDLETON DUSTIN R, MUELLER KATHERINE D, SHARMA AGASTYA, HOLMES ZACHARY C, DALLOW ERIC, REMICK BREN: "Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, UNITED STATES, 18 May 2021 (2021-05-18), United States, pages e00478 - 21, XP093110809, [retrieved on 20231211], DOI: 10.1128/mBio.00478-21
KOBAYASHI YODAI, KAWAHARA TOMOHIRO, INOUE SHOICHIRO, KOHDA NORIYUKI: "Akkermansia biwaensis sp. nov., an anaerobic mucin-degrading bacterium isolated from human faeces", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, GB, vol. 73, no. 1, 27 January 2023 (2023-01-27), GB , pages 1 - 9, XP093110816, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.005697
KOBAYASHI YODAI, KAWAHARA TOMOHIRO, INOUE SHOICHIRO, KOHDA NORIYUKI: "Akkermansia biwaensis sp. nov., an anaerobic mucin-degrading bacterium isolated from human faeces", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, GB, vol. 73, no. 1, 27 January 2023 (2023-01-27), GB , pages 1 - 9, XP093110816, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.005697
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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