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Title:
MICROORGANISM COMPRISING GENETIC MODIFICATION THAT INCREASES ACTIVITY OF MULTIDRUG TRANSPORTER, AND METHOD FOR PRODUCING TRYPTOPHAN METABOLITES BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/125493
Kind Code:
A1
Abstract:
Disclosed is a recombinant microorganism comprising a genetic modification that increases the activity of a multidrug transporter A (multidrug efflux system subunit A: MdtA). A recombinant microorganism comprising genetic modification that increases the activity of a multidrug transporter and a method for producing tryptophan metabolites by using same enable mass-production of tryptophan metabolites.

Inventors:
RYU GYU RI (KR)
JEON AE JI (KR)
BAE HYUN AE (KR)
JANG JAE WOO (KR)
Application Number:
PCT/KR2020/011315
Publication Date:
June 24, 2021
Filing Date:
August 25, 2020
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Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C07K14/31; C12N9/02; C12N15/70; C12P17/16
Domestic Patent References:
WO2013096475A12013-06-27
Foreign References:
KR20190005707A2019-01-16
JP2011527183A2011-10-27
CN105543155A2016-05-04
Other References:
DATABASE Protein GenPept; ANONYMOUS: "MULTISPECIES: multidrug efflux RND transporter subunit MdtA [Enterobaceae]", XP055824462, retrieved from NCBI
HIRAKAWA HIDETADA ET AL: "Indole induces the expression of multidrug exporter genes in Escherichia coli", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 55, no. 4, 1 February 2005 (2005-02-01), GB, pages 1113 - 1126, XP002426859, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.2004.04449.x
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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