Title:
MICROORGANISM HAVING IMPROVED 3'-SIALYLLACTOSE PRODUCTIVITY AND PRODUCTION METHOD OF 3'-SIALYLLACTOSE
Document Type and Number:
WIPO Patent Application WO/2023/238843
Kind Code:
A1
Abstract:
The present invention relates to a microorganism which has an enhanced activity of a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion of 20-37 amino acid residues on the N-terminal side, and which has an improved productivity of 3'-sialyllactose compared to the parent strain.
Inventors:
NAOE TAIKI (JP)
UJIHARA TETSURO (JP)
AOKI YURIKO (JP)
UJIHARA TETSURO (JP)
AOKI YURIKO (JP)
Application Number:
PCT/JP2023/020924
Publication Date:
December 14, 2023
Filing Date:
June 06, 2023
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C12N1/21; C12N15/54; C12P19/18; C12N9/10
Foreign References:
| JP2020528280A | 2020-09-24 |
Other References:
DATABASE Protein 3 November 2016 (2016-11-03), ANONYMOUS : "CMP-N-acetylneuraminate-beta-galactosamide-alph a-2,3-sialyltransferase [Neisseria lactamica 020-06]", XP093113673, retrieved from NCBI Database accession no. CBN87560.1
GILBERT M., ET AL.: "CLONING OF THE LIPOOLIGOSACCHARIDE ALPHA-2,3-SIALYLTRANSFERASE FROMTHE BACTERIAL PATHOGENS NEISSERIA MENINGITIDIS AND NEISSERIA GONORRHOEAE.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 271., no. 45., 8 November 1996 (1996-11-08), US , pages 28271 - 28276., XP002044220, ISSN: 0021-9258, DOI: 10.1074/jbc.271.45.28271
GILBERT M., ET AL.: "CLONING OF THE LIPOOLIGOSACCHARIDE ALPHA-2,3-SIALYLTRANSFERASE FROMTHE BACTERIAL PATHOGENS NEISSERIA MENINGITIDIS AND NEISSERIA GONORRHOEAE.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 271., no. 45., 8 November 1996 (1996-11-08), US , pages 28271 - 28276., XP002044220, ISSN: 0021-9258, DOI: 10.1074/jbc.271.45.28271
Attorney, Agent or Firm:
EIKOH, P.C. (JP)
Download PDF: