Title:
MICRORNA MEDIATED NEURONAL CELL INDUCTION
Document Type and Number:
WIPO Patent Application WO/2013/089819
Kind Code:
A3
Abstract:
Methods of converting non-neuronal somatic cells into induced neuronal cells are provided. Aspects of the methods include contacting a non-neuronal somatic cell with a microRNA mediated neuronal cell induction agent. Aspects of the invention further include compositions produced by methods of the invention as well as compositions that find use in practicing embodiments of methods of invention. The methods and compositions find use in a variety of different applications.
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Inventors:
CRABTREE GERALD R (US)
YOO ANDREW (US)
YOO ANDREW (US)
Application Number:
PCT/US2012/032606
Publication Date:
August 22, 2013
Filing Date:
April 06, 2012
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
CRABTREE GERALD R (US)
YOO ANDREW (US)
CRABTREE GERALD R (US)
YOO ANDREW (US)
International Classes:
C12N5/079; C12N15/113; G01N33/15
Foreign References:
| US20100021437A1 | 2010-01-28 |
Other References:
VIERBUCHEN, THOMAS ET AL.: "Direct conversion of fibroblasts to functional neurons by defined factors", NATURE, vol. 463, 25 February 2010 (2010-02-25), pages 1035 - 1041
YOO, ANDREW S. ET AL.: "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development", NATURE, vol. 460, 30 July 2009 (2009-07-30), pages 642 - 646
MAKEYEV, EUGENE V. ET AL.: "The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing", MOLECULAR CELL, vol. 27, no. 3, 3 August 2007 (2007-08-03), pages 435 - 448
YOO, ANDREW S. ET AL.: "MicroRNA-mediated conversion of human fibroblasts to neurons", NATURE, vol. 476, 11 August 2011 (2011-08-11), pages 228 - 231
YOO, ANDREW S. ET AL.: "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development", NATURE, vol. 460, 30 July 2009 (2009-07-30), pages 642 - 646
MAKEYEV, EUGENE V. ET AL.: "The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing", MOLECULAR CELL, vol. 27, no. 3, 3 August 2007 (2007-08-03), pages 435 - 448
YOO, ANDREW S. ET AL.: "MicroRNA-mediated conversion of human fibroblasts to neurons", NATURE, vol. 476, 11 August 2011 (2011-08-11), pages 228 - 231
Attorney, Agent or Firm:
FIELD, Bret E. (Field & Francis LLP1900 University Avenue, Suite 20, East Palo Alto California, US)
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