Title:
MILK-DERIVED POLYPEPTIDE DERIVATIVE AND APPLICATIONS THEREOF IN PREPARATION OF DRUG, HEALTH PRODUCT AND FOOD ADDITIVE FOR PREVENTION AND TREATMENT OF OBESITY
Document Type and Number:
WIPO Patent Application WO/2023/284684
Kind Code:
A1
Abstract:
A milk-derived polypeptide derivative and applications thereof in the preparation of a drug, a health product and a food additive for the prevention and treatment of obesity, belonging to the technical field of biomedicine. The present milk-derived polypeptide and a penetrating peptide derivative thereof can slow down the weight gain of mice induced by a high-fat diet, reduce blood sugar, blood lipid and insulin levels, and improve insulin sensitivity and glucose tolerance; in addition, they can achieve weight loss and blood sugar reduction in obese model mice. Therefore, they have the potential to prepare a drug, a health product and a food additive for the prevention and treatment of obesity, its complications and other related diseases.
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Inventors:
JI CHENBO (CN)
CUI XIANWEI (CN)
CUI XIANWEI (CN)
Application Number:
PCT/CN2022/104946
Publication Date:
January 19, 2023
Filing Date:
July 11, 2022
Export Citation:
Assignee:
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL (CN)
International Classes:
C07K19/00; A23L33/18; A61K38/17; A61K47/64; A61P3/04; A61P3/06; A61P3/10
Domestic Patent References:
| WO2017179824A2 | 2017-10-19 | |||
| WO2016175362A1 | 2016-11-03 |
Foreign References:
| CN113248628A | 2021-08-13 | |||
| CN110511267A | 2019-11-29 | |||
| CN111138552A | 2020-05-12 | |||
| CN110038114A | 2019-07-23 |
Other References:
FARDET ANTHONY, ROCK EDMOND: "In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence", NUTRITION RESEARCH REVIEWS, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 31, no. 1, 1 June 2018 (2018-06-01), GB , pages 52 - 70, XP093024627, ISSN: 0954-4224, DOI: 10.1017/S0954422417000191
"Cell Penetrating Peptide Research Methods and Experiment Guide", 30 September 2016, WORLD BOOK PUBLISHING COMPANY, CN, ISBN: 978-7-5192-0093-0, article URO LANGER: "Passage; Cell Penetrating Peptide Research Methods and Experiment Guide", pages: 303, XP009542619
"Applied Molecular Pharmacology", 30 September 2015, PEKING UNION MEDICAL COLLEGE PRESS, CN, ISBN: 978-7-5679-0411-8, article WANG XIAOLIANG: "Passage; Applied Molecular Pharmacology", pages: 530, XP009542620
ZHIWEI YE, XIAN YINGXIN, CHEN ZONGLAN; LIN BEISI; XU FEN; YAO BIN: "Study of mechanism of exenatide in the treatment of obesity", NEW MEDICINE, ZHONGSHAN YIKE DAXUE, CN, vol. 51, no. 10, 1 October 2020 (2020-10-01), CN , pages 780 - 785, XP093024644, ISSN: 0253-9802, DOI: 10.3969/j.issn.0253-9802.2020.10.010
SANDRINE G. RIVAL, CARMEN G. BOERIU, HARRY J. WICHERS: "Caseins and Casein Hydrolysates. 2. Antioxidative Properties and Relevance to Lipoxygenase Inhibition", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 49, no. 1, 1 January 2001 (2001-01-01), US , pages 295 - 302, XP055674969, ISSN: 0021-8561, DOI: 10.1021/jf0003911
"Cell Penetrating Peptide Research Methods and Experiment Guide", 30 September 2016, WORLD BOOK PUBLISHING COMPANY, CN, ISBN: 978-7-5192-0093-0, article URO LANGER: "Passage; Cell Penetrating Peptide Research Methods and Experiment Guide", pages: 303, XP009542619
"Applied Molecular Pharmacology", 30 September 2015, PEKING UNION MEDICAL COLLEGE PRESS, CN, ISBN: 978-7-5679-0411-8, article WANG XIAOLIANG: "Passage; Applied Molecular Pharmacology", pages: 530, XP009542620
ZHIWEI YE, XIAN YINGXIN, CHEN ZONGLAN; LIN BEISI; XU FEN; YAO BIN: "Study of mechanism of exenatide in the treatment of obesity", NEW MEDICINE, ZHONGSHAN YIKE DAXUE, CN, vol. 51, no. 10, 1 October 2020 (2020-10-01), CN , pages 780 - 785, XP093024644, ISSN: 0253-9802, DOI: 10.3969/j.issn.0253-9802.2020.10.010
SANDRINE G. RIVAL, CARMEN G. BOERIU, HARRY J. WICHERS: "Caseins and Casein Hydrolysates. 2. Antioxidative Properties and Relevance to Lipoxygenase Inhibition", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 49, no. 1, 1 January 2001 (2001-01-01), US , pages 295 - 302, XP055674969, ISSN: 0021-8561, DOI: 10.1021/jf0003911
Attorney, Agent or Firm:
HANGZHOU YUYANG UNION PATENT AGENCY CO., LTD. (CN)
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