Title:
MINERALIZED DRUG-LOADED YEAST BIONIC MICRO-NANO ROBOT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104024
Kind Code:
A1
Abstract:
Provided are a mineralized drug-loaded yeast bionic micro-nano robot, and a preparation method therefor and the use thereof. The mineralized drug-loaded yeast bionic micro-nano robot comprises a yeast cell, a biological mineralized nano scaffold located in the yeast cell, a drug trapped in the nano scaffold and a carbonate crystal outside the yeast cell. The internal biological mineralized nano scaffold greatly increases the loading capacity of a drug, under the condition of gastric acid, calcium carbonate is decomposed to generate carbon dioxide gas, the robot is pushed to be rapidly attached to the gastric mucus part, and the administration efficiency of the stomach is greatly improved.
More Like This:
Inventors:
CAI LINTAO (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
MA AIQING (CN)
ZHANG LISHAN (CN)
HUANG GUOJUN (CN)
PAN HONG (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
MA AIQING (CN)
ZHANG LISHAN (CN)
HUANG GUOJUN (CN)
PAN HONG (CN)
Application Number:
PCT/CN2022/136889
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K47/69; A61K45/00; A61K47/46; A61K47/52; A61P1/00
Foreign References:
| CN114470227A | 2022-05-13 | |||
| CN111135339A | 2020-05-12 |
Other References:
MA, XIAOMING ET AL.: "Construction and Potential Applications of a Functionalized Cell with an Intracellular Mineral Scaffold", ANGEW. CHEM. INT. ED., vol. 50, 28 June 2011 (2011-06-28), pages 7414 - 7417, XP072074967, DOI: 10.1002/anie.201100126
MARIA GUIX, ANNE K. MEYER, BRITTA KOCH, OLIVER G. SCHMIDT: "Carbonate-based Janus micromotors moving in ultra-light acidic environment generated by HeLa cells in situ", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 April 2016 (2016-04-01), XP055717546, DOI: 10.1038/srep21701
YAO, CHENGLI ET AL.: "Preparation of Inorganic Shell on Yeast Cell Surface", JIANGSU AGRICULTURAL SCIENCES, vol. 43, no. 4, 31 December 2015 (2015-12-31), pages 44 - 46, XP093072256, DOI: 10.15889/j.issn.1002-1302.2015.04.014
CHEN, HUIFENG: "The Preparation, Characterization and Application of Functionalized Yeast Cell Containing Calcium Carbonate Supporter", BASIC SCIENCES, CHINA MASTER'S THESES FULL-TEXT DATABASE, 1 May 2011 (2011-05-01), CN, pages 1 - 63, XP009546297
MARIA GUIX, ANNE K. MEYER, BRITTA KOCH, OLIVER G. SCHMIDT: "Carbonate-based Janus micromotors moving in ultra-light acidic environment generated by HeLa cells in situ", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 April 2016 (2016-04-01), XP055717546, DOI: 10.1038/srep21701
YAO, CHENGLI ET AL.: "Preparation of Inorganic Shell on Yeast Cell Surface", JIANGSU AGRICULTURAL SCIENCES, vol. 43, no. 4, 31 December 2015 (2015-12-31), pages 44 - 46, XP093072256, DOI: 10.15889/j.issn.1002-1302.2015.04.014
CHEN, HUIFENG: "The Preparation, Characterization and Application of Functionalized Yeast Cell Containing Calcium Carbonate Supporter", BASIC SCIENCES, CHINA MASTER'S THESES FULL-TEXT DATABASE, 1 May 2011 (2011-05-01), CN, pages 1 - 63, XP009546297
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: