Title:
MITOCHONDRIA-TARGETED POSITRON EMISSION OR FLUORESCENT PROBE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104009
Kind Code:
A1
Abstract:
The present invention relates to a mitochondria-targeted positron emission or fluorescent probe, and a preparation method therefor and the use thereof. The probe has the structure as shown in formula (I), and is a 18F or 19F substituted indole vinyl quinoline salt (F16) compound. The compound has the advantages of simple preparation, good chemical stability, high radiochemical purity, fluorescence, etc., and can be used as a mitochondrial imaging related myocardial perfusion and tumor PET imaging agent or a fluorescent imaging agent in the technical field of radiopharmaceutical chemistry and fluorescence molecular images.
More Like This:
| WO/1984/001948 | BENZO ADf BD QUINOLINE DERIVATIVES |
| JP4871866 | Oxopiperidine derivative, its manufacture and therapeutic use |
| WO/2006/097175 | DPP-IV INHIBITORS |
Inventors:
CHENG ZHEN (CN)
CHEN HAO (CN)
WANG ZHIMING (CN)
CHEN HAO (CN)
WANG ZHIMING (CN)
Application Number:
PCT/CN2022/136793
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D401/06; A61K49/00; A61K51/00; A61K51/04; C07B59/00; C07D401/00; C07D401/02; C09K11/00; C09K11/04; C09K11/06; A61K101/02
Domestic Patent References:
| WO2020150103A1 | 2020-07-23 |
Foreign References:
| CN109293633A | 2019-02-01 | |||
| CN109867591A | 2019-06-11 | |||
| CN110577478A | 2019-12-17 | |||
| CN112028815A | 2020-12-04 | |||
| CN112375027A | 2021-02-19 | |||
| US20150336993A1 | 2015-11-26 |
Other References:
ZHENG LINGLING, WANG ZHIMING, ZHANG XIAOQING, ZHOU YUJING, JI AIYAN, LOU HONGYUE, LIU XINGDANG, CHEN HAO, CHENG ZHEN: "Development of Mitochondria-Targeted Small-Molecule Dyes for Myocardial PET and Fluorescence Bimodal Imaging", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 1, 13 January 2022 (2022-01-13), US , pages 497 - 506, XP093072195, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01660
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
Download PDF:
Previous Patent: DATA ERROR CORRECTION METHOD AND DEVICE, MEMORY CONTROLLER, AND SYSTEM
Next Patent: COMMUNICATION METHOD AND APPARATUS
Next Patent: COMMUNICATION METHOD AND APPARATUS