Title:
MITOTIC KINESIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005092011
Kind Code:
A3
Abstract:
The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Inventors:
GARBACCIO ROBERT M (US)
OLSON CHRISTY M (US)
TASBER EDWARD S (US)
TORRENT MARICEL (US)
OLSON CHRISTY M (US)
TASBER EDWARD S (US)
TORRENT MARICEL (US)
Application Number:
PCT/US2005/009198
Publication Date:
November 24, 2005
Filing Date:
March 18, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
GARBACCIO ROBERT M (US)
OLSON CHRISTY M (US)
TASBER EDWARD S (US)
TORRENT MARICEL (US)
GARBACCIO ROBERT M (US)
OLSON CHRISTY M (US)
TASBER EDWARD S (US)
TORRENT MARICEL (US)
International Classes:
C07C211/00; C07C211/53; C07C215/16; C07C215/20; C07C215/24; C07C215/50; C07C229/18; C07C229/30; C07C237/06; C07C237/10; C07C237/12; C07D211/26; C07D231/12; C07D261/08; C07D295/04; (IPC1-7): C07C211/00
Other References:
FOX ET AL: "A Mechanistic Study of the Reaction of Lithium Aluminum Hydride with N-Methylbenzanilides", JOURNAL OF ORGANIC CHEMISTRY, vol. 38, no. 6, 23 March 1973 (1973-03-23), pages 1136 - 1140, XP008092407
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