Title:
MODEL ANIMAL HAVING LOW RISK OF HEARING LOSS
Document Type and Number:
WIPO Patent Application WO/2014/042262
Kind Code:
A1
Abstract:
The present invention provides a model animal having a low risk of hearing loss by preparing a fatty acid binding protein 7 gene knockout animal.
Inventors:
SUZUKI JUN (JP)
OSUMI NORIKO (JP)
TAKADA YUSUKE (JP)
OWADA YUJI (JP)
OSUMI NORIKO (JP)
TAKADA YUSUKE (JP)
OWADA YUJI (JP)
Application Number:
PCT/JP2013/074940
Publication Date:
March 20, 2014
Filing Date:
September 13, 2013
Export Citation:
Assignee:
UNIV TOHOKU (JP)
UNIV YAMAGUCHI (JP)
UNIV YAMAGUCHI (JP)
International Classes:
A01K67/027; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/68
Foreign References:
| JP2010207097A | 2010-09-24 | |||
| JP2010169677A | 2010-08-05 |
Other References:
SAINO-SAITO, S. ET AL.: "Localization of fatty acid binding proteins (FABPs) in the cochlea of mice", ANNALS OF ANATOMY, vol. 192, 2010, pages 210 - 214
FURUHASHI, M ET AL.: "Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 489 - 503
TASHIRO, R. ET AL.: "Fatty acid binding protein (Fabp7) is involved in the maintenance of neural stem/progenitor cells, survival of neurons and maturation of astrocytes", NEUROSCIENCE RESEARCH, vol. 71S, 2011, pages E127
MATSUMATA, M. ET AL.: "The Effects of Fabp7 and Fabp5 on Postnatal Hippocampal Neurogenesis in the Mouse", STEM CELLS, vol. 30, 11 May 2012 (2012-05-11), pages 1532 - 1543
SOMEYA, S. ET AL.: "Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis", PNAS, vol. 106, no. 46, 2009, pages 19432 - 19437
ATSUSHI SUZUKI ET AL.: "Fabp7 no Kagyu ni Okeru Kino Kaiseki -Kareisei Nancho ni Narinikui Mouse no Hakken", OTOL. JPN., vol. 22, no. 4, 14 September 2012 (2012-09-14), pages 574
FURUHASHI, M ET AL.: "Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 489 - 503
TASHIRO, R. ET AL.: "Fatty acid binding protein (Fabp7) is involved in the maintenance of neural stem/progenitor cells, survival of neurons and maturation of astrocytes", NEUROSCIENCE RESEARCH, vol. 71S, 2011, pages E127
MATSUMATA, M. ET AL.: "The Effects of Fabp7 and Fabp5 on Postnatal Hippocampal Neurogenesis in the Mouse", STEM CELLS, vol. 30, 11 May 2012 (2012-05-11), pages 1532 - 1543
SOMEYA, S. ET AL.: "Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis", PNAS, vol. 106, no. 46, 2009, pages 19432 - 19437
ATSUSHI SUZUKI ET AL.: "Fabp7 no Kagyu ni Okeru Kino Kaiseki -Kareisei Nancho ni Narinikui Mouse no Hakken", OTOL. JPN., vol. 22, no. 4, 14 September 2012 (2012-09-14), pages 574
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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