Title:
MODIFIED CELLS AND USES THEREOF FOR DELIVERING AGENTS
Document Type and Number:
WIPO Patent Application WO/2023/103963
Kind Code:
A1
Abstract:
A cell linker and a cell modified by an agent linked thereto, wherein the agent is conjugated to a phospholipid via a sortase recognition motif, and the phospholipid with the conjugated agent is incorporated into the cell membrane of the cell. A method for obtaining the modified cell, as well as the use of the modified cells for delivering agents such as drugs and probes.
Inventors:
GAO XIAOFEI (CN)
HUANG YANJIE (CN)
HUANG YANJIE (CN)
Application Number:
PCT/CN2022/136600
Publication Date:
June 15, 2023
Filing Date:
December 05, 2022
Export Citation:
Assignee:
WESTLAKE THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
A61K35/12; C12N5/00; A61K39/00; A61K45/00; A61K47/51; A61K48/00; A61P35/00; C12N1/00; C12N9/10; C12Q1/02
Domestic Patent References:
| WO2022089605A1 | 2022-05-05 | |||
| WO2021185359A1 | 2021-09-23 |
Foreign References:
| CN103204911A | 2013-07-17 | |||
| US20170183380A1 | 2017-06-29 |
Other References:
HUANG J; JIANG H; HE Z
MA J
ZHANG X
HUANG J; WU Z; WU X
WU Y
WANG Y: "Preparation and biocompatibility evaluation of PEG-PLL/RGD-PEG-DSPE/phospholipid/CaP nanoparticles", JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, AMERICAN SCIENTIFIC PUBLISHERS, US, vol. 14, no. 1, 1 January 2018 (2018-01-01), US , pages 98 - 113, XP009533759, ISSN: 1550-7033, DOI: 10.1166/jbn.2018.2460
AKHTER AFSANA; HAYASHI YASUHIRO; SAKURAI YU; OHGA NORITAKA; HIDA KYOKO; HARASHIMA HIDEYOSHI: "A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 456, no. 1, 7 August 2013 (2013-08-07), NL , pages 195 - 201, XP028717494, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2013.07.068
J. SHI, L. KUNDRAT, N. PISHESHA, A. BILATE, C. THEILE, T. MARUYAMA, S. K. DOUGAN, H. L. PLOEGH, H. F. LODISH: "Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 28, 15 July 2014 (2014-07-15), pages 10131 - 10136, XP055189994, ISSN: 00278424, DOI: 10.1073/pnas.1409861111
AKHTER AFSANA; HAYASHI YASUHIRO; SAKURAI YU; OHGA NORITAKA; HIDA KYOKO; HARASHIMA HIDEYOSHI: "A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 456, no. 1, 7 August 2013 (2013-08-07), NL , pages 195 - 201, XP028717494, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2013.07.068
J. SHI, L. KUNDRAT, N. PISHESHA, A. BILATE, C. THEILE, T. MARUYAMA, S. K. DOUGAN, H. L. PLOEGH, H. F. LODISH: "Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 28, 15 July 2014 (2014-07-15), pages 10131 - 10136, XP055189994, ISSN: 00278424, DOI: 10.1073/pnas.1409861111
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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