Title:
MODIFIED α-ISOPROPYLMALATE SYNTHASE
Document Type and Number:
WIPO Patent Application WO/2022/210228
Kind Code:
A1
Abstract:
The present disclosure provides a novel IPMS mutant which can impart, to various microorganisms, the ability to produce a derivative including L-leucine or a precursor thereof. The IPMS mutant contains at least two amino acid substitutions selected from the following (a') to (c') on the basis of the amino acid sequence set forth in SEQ ID NO: 2: (a') substitution of the amino acid residue corresponding to the glycine residue at position 530 with an amino acid residue other than a glycine residue; (b') substitution of the amino acid residue corresponding to the glycine residue at position 532 with an amino acid residue other than a glycine residue; and (c') substitution of the amino acid residue corresponding to the alanine residue at position 535 with an amino acid residue other than an alanine residue.
Inventors:
NAKANE SHUHEI (JP)
Application Number:
PCT/JP2022/013788
Publication Date:
October 06, 2022
Filing Date:
March 24, 2022
Export Citation:
Assignee:
GREEN EARTH INST CO LTD (JP)
ITOCHU CHEMICAL FRONTIER CORP (JP)
ITOCHU CHEMICAL FRONTIER CORP (JP)
International Classes:
C12N15/54; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12P13/06
Foreign References:
| JP2015514431A | 2015-05-21 | |||
| JP2020503045A | 2020-01-30 | |||
| CN109456987A | 2019-03-12 | |||
| JP2015529459A | 2015-10-08 | |||
| JP2001037494A | 2001-02-13 |
Attorney, Agent or Firm:
YAGAMI Ayanobu (JP)
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