MODIFIED LEPTIN WITH REDUCED IMMUNOGENICITY

WIPO Patent Application WO2002062833

A3

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human obesity protein (leptin) to result in leptin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

CARR FRANCIS J (GB)
CARTER GRAHAM (GB)
JONES TIM (GB)
WILLIAMS STEPHEN (GB)
HAMILTON ANITA (GB)

PCT/EP2002/001188

October 30, 2003

February 05, 2002

Click for automatic bibliography generation  

MERCK PATENT GMBH (DE)
CARR FRANCIS J (GB)
CARTER GRAHAM (GB)
JONES TIM (GB)
WILLIAMS STEPHEN (GB)
HAMILTON ANITA (GB)

A61K9/70; A61K38/00; C12N15/09; A61K38/22; A61K47/02; A61K47/12; A61P3/04; A61P43/00; C07K7/08; C07K14/47; C07K14/54; C07K14/575; C07K16/18; C07K16/28; C07K16/30; C07K16/46; C12N15/16; C12P21/02; G16B15/20; G16B20/00; (IPC1-7): C07K14/575; A61K38/22

WO1998028414A1	1998-07-02
WO2001059130A2	2001-08-16
WO1998052976A1	1998-11-26
WO1999053038A2	1999-10-21
WO2000034317A2	2000-06-15
WO2002062832A2	2002-08-15

US6225446B1	2001-05-01
EP0699755A2	1996-03-06

ALTUVIA Y ET AL: "RANKING POTENTIAL BINDING PEPTIDES TO MHC MOLECULES BY A COMPUTATIONAL THREADING APPROACH", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 249, no. 1, 1995, pages 244 - 250, XP000925520, ISSN: 0022-2836

View/Download PDF      PDF Help

Previous Patent: MODIFIED HUMAN BRAIN-DERIVED NEUTROPHIC FACTOR (BDNF) WITH REDUCED IMMUNOGENICITY

Next Patent: MIXTURE OF PEPTIDES ORIGINATING FROM A NEF PROTEIN AND APPLICATIONS THEREOF