Title:
MIXTURE OF PEPTIDES ORIGINATING FROM A NEF PROTEIN AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO2002062834
Kind Code:
A3
Abstract:
The invention relates to a mixture of peptides originating from a Nef protein and the applications thereof as a medicine (in immunogenic compositions which stimulate the production in vivo of anti-HIV T CD4+ lymphocytes and are therefore useful for vaccinating against AIDS) or as a reactive diagnosis agent for T lymphocytes particular to HIV, particularly to assess the immune status of HIV-positive patients or patients undergoing anti-retroviral therapy. Each of said peptides in the mixture is linked to at least three HLA-DR molecules encoded by the alleles selected from the group comprising alleles HLA DRB1*0101, DRB1*0301, DRB1*0401, DRB1*0701, DRB1*1101, DRB1*1301 and DRB1*1501 (molecules DR1, DR3, DR4, DR7, DR11, DR13 and DR15) and to at least one HLA-DR molecule encoded by the alleles selected from the group comprising alleles HLA DRB3*0101, DRB4*0101 and DRB5*0101 (B3, B4 and B5), with a binding capacity of <1000 nM, said mixture of peptides linking all of the aforementioned alleles.
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Inventors:
MAILLERE BERNARD (FR)
POUVELLE-MORATILLE SANDRA (FR)
GUILLET JEAN-GERARD (FR)
GAHERY-SEGARD HANNE (FR)
POUVELLE-MORATILLE SANDRA (FR)
GUILLET JEAN-GERARD (FR)
GAHERY-SEGARD HANNE (FR)
Application Number:
PCT/FR2002/000471
Publication Date:
July 01, 2004
Filing Date:
February 07, 2002
Export Citation:
Assignee:
COMMISSARIAT ENERGIE ATOMIQUE (FR)
INST NAT SANTE RECH MED (FR)
MAILLERE BERNARD (FR)
POUVELLE-MORATILLE SANDRA (FR)
GUILLET JEAN-GERARD (FR)
GAHERY-SEGARD HANNE (FR)
INST NAT SANTE RECH MED (FR)
MAILLERE BERNARD (FR)
POUVELLE-MORATILLE SANDRA (FR)
GUILLET JEAN-GERARD (FR)
GAHERY-SEGARD HANNE (FR)
International Classes:
G01N33/49; A61K35/76; A61K39/00; A61K48/00; A61P31/18; A61P37/04; C07K14/155; C07K14/16; C12N15/09; C12Q1/02; G01N33/53; G01N33/543; (IPC1-7): C07K14/16; G01N33/68; A61K39/21
Domestic Patent References:
| WO1999027954A2 | 1999-06-10 | |||
| WO2000075181A1 | 2000-12-14 |
Other References:
MICHEL F ET AL: "HIV-1 ENV, NEF, AND GAG-SPECIFIC T-CELL IMMUNITY IN MICE: CONSERVED EPITOPES IN NEF P27 AND GAG P25 PROTEINS", AIDS RESEARCH AND HUMAN RETROVIRUSES, NEW YORK, NY, US, vol. 8, no. 4, April 1992 (1992-04-01), pages 469 - 478, XP008023996, ISSN: 0889-2229
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