Title:
MODIFIED MSCL PROTEIN CHANNEL
Document Type and Number:
WIPO Patent Application WO2005051902
Kind Code:
A8
Abstract:
The invention relates to the field of drug delivery, in particular to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/ or localised release of therapeutic molecules (e.g. small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E.coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
Inventors:
KOCER ARMAGAN (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
Application Number:
PCT/NL2004/000812
Publication Date:
August 11, 2005
Filing Date:
November 25, 2004
Export Citation:
Assignee:
APPLIED NANOSYSTEMS BV (NL)
KOCER ARMAGAN (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
KOCER ARMAGAN (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
International Classes:
A61K9/127; A61K47/48; C07C381/04; (IPC1-7): C07C381/00
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