MODIFIED NUCLEOSIDE AND SYNTHESIS METHOD THEREFOR

Title:

MODIFIED NUCLEOSIDE AND SYNTHESIS METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2021/027614

Kind Code:

A1

Abstract:

A modified cytidine compound, that is, an aminooxy group is modified at the 4-position of a cytidine pyrimidine ring to produce derivative cytidine and nucleic acid containing the derivative cytidine, such as RNA. The expression level of the nucleic acid containing the modified cytidine, in particular mRNA, in the body is significantly improved.

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Inventors:

CAI YUNSONG (CN)
LI HANGWEN (CN)
LIU LIANXIAO (CN)
LI NING (CN)

Application Number:

PCT/CN2020/106696

Publication Date:

February 18, 2021

Filing Date:

August 04, 2020

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Assignee:

STEMIRNA THERAPEUTICS CO LTD (CN)

International Classes:

A61K31/7068; C07H19/067; A61K31/7105; A61K31/711; A61P35/00; C07H1/00; C07H19/073; C07H19/10; C07H21/02; C07H21/04

Domestic Patent References:

WO2017156380A1	2017-09-14
WO2007024708A2	2007-03-01

Foreign References:

CN107427529A	2017-12-01
CN102695525A	2012-09-26

Other References:

KOCHETKOV, N.K. ET AL.: "Selective Modification of Uridine and Guanosine", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 87, no. 3, 31 December 1964 (1964-12-31), XP025828603, ISSN: 0926-6550, DOI: 20200909155350A

Attorney, Agent or Firm:

HANGZHOU TIANHAO PATENT AGENCY CO., LTD (CN)

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