Title:
MODIFIED PRODUCT OF FC DOMAIN OF ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2020/116560
Kind Code:
A1
Abstract:
The present invention is a modified product of a parent polypeptide including the Fc domain of a canine or feline IgG, wherein the activity of the modified product for binding to a canine or feline neonate Fc receptor (FcRn) is higher than the activity of the parent polypeptide for binding to the canine or feline FcRn, and the modified product includes at least one amino acid modification in the Fc domain. The modified product has an enhanced FcRn-binding activity under acidic-range conditions, and therefore, the use of the modified product allows providing an antibody (IgG) and a Fc fusion protein that have the ability to be retained in blood plasma for a longer period of time.
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Inventors:
NAKAO RYOTA (JP)
IZUMI YOSHIKATSU (JP)
HATTORI KUNIHIRO (JP)
IZUMI YOSHIKATSU (JP)
HATTORI KUNIHIRO (JP)
Application Number:
PCT/JP2019/047620
Publication Date:
June 11, 2020
Filing Date:
December 05, 2019
Export Citation:
Assignee:
BICA THERAPEUTICS INC (JP)
International Classes:
C07K16/18; C12N15/13
Domestic Patent References:
| WO2018073185A1 | 2018-04-26 | |||
| WO2013081143A1 | 2013-06-06 | |||
| WO2002060919A2 | 2002-08-08 | |||
| WO2012083370A1 | 2012-06-28 | |||
| WO2000042072A2 | 2000-07-20 | |||
| WO2006020114A2 | 2006-02-23 | |||
| WO2006031370A2 | 2006-03-23 | |||
| WO2010033279A2 | 2010-03-25 | |||
| WO2006053301A2 | 2006-05-18 | |||
| WO2009086320A1 | 2009-07-09 |
Foreign References:
| JP2012521784A | 2012-09-20 | |||
| JP2017517745A | 2017-06-29 | |||
| EP2154157A2 | 2010-02-17 | |||
| US20070141052A1 | 2007-06-21 | |||
| JP2018228448A | 2018-12-05 |
Other References:
STRIETZEL, C. J. ET AL.: "In vitro functional characterization of feline IgGs", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 158, no. 3, 2014, pages 214 - 223, XP028604528
YEUNG YA ET AL., J. IMMUNOL., vol. 182, 2009, pages 7663 - 71
DATTA-MANNAN A ET AL., J. BIOL. CHEM., vol. 282, 2007, pages 1709 - 17
DALL'ACQUA WF ET AL., J. IMMUNOL., vol. 169, 2002, pages 5171 - 80
GHETIE ET AL., IMMUNOL. TODAY, vol. 18, no. 12, 1997, pages 592 - 598
RAGHAVAN ET AL., IMMUNITY, vol. 1, 1994, pages 303 - 315
TANG ET AL., VET. IMMUNOL. IMMUNOPATHOL., vol. 80, no. 3-4, 2001, pages 259 - 270
KANAI, T.H. ET AL.: "Identification of two allelic IgG1 C(H)coding regions (Cgammal) of cat", VET. IMMUNOL. IMMUNOPATHOL., vol. 73, no. 1, 2000, pages 53 - 62
STRIETZEL, C.J. ET AL.: "In Vitro functional characterization of feline IgGs", VET. IMMUNOL. IMMUNOPATHOL., vol. 158, no. 3-4, 2014, pages 214 - 233
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol. 17, 2016, pages 1298 - 1314
PROC NATL ACSD SCI USA, vol. 81, 1984, pages 5662 - 5666
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. U.S.A., vol. 100, no. 11, 2003, pages 6353 - 6357
DRUG METAB DISPOS., vol. 35, no. 1, January 2007 (2007-01-01), pages 86 - 94
INT IMMUNOL., vol. 18, no. 12, December 2006 (2006-12-01), pages 1759 - 69
J BIOL CHEM., vol. 276, no. 9, 2 March 2001 (2001-03-02), pages 6591 - 604
J BIOL CHEM., vol. 282, no. 3, 2007, pages 1709 - 17
J IMMUNOL., vol. 169, no. 9, 2002, pages 5171 - 80
J IMMUNOL., vol. 182, no. 12, 2009, pages 7663 - 71
MOLECULAR CELL, vol. 7, April 2001 (2001-04-01), pages 867 - 877
NAT BIOTECHNOL., vol. 15, no. 7, July 1997 (1997-07-01), pages 637 - 40
NAT BIOTECHNOL., vol. 23, no. 10, October 2005 (2005-10-01), pages 1283 - 8
PROC NATL ACAD SCI U S A., vol. 103, no. 49, 5 December 2006 (2006-12-05), pages 18709 - 14
MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
J. EXP. MED., vol. 108, 1995
VALLE ET AL., NATURE, vol. 291, 1981, pages 338 - 340
PACE ET AL., PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
"GenBank", Database accession no. XP 023100998.1
ZELEVSKY, J ET AL., NAT TECHNOL, vol. 28, 2010, pages 157 - 159
See also references of EP 3892632A4
YEUNG YA ET AL., J. IMMUNOL., vol. 182, 2009, pages 7663 - 71
DATTA-MANNAN A ET AL., J. BIOL. CHEM., vol. 282, 2007, pages 1709 - 17
DALL'ACQUA WF ET AL., J. IMMUNOL., vol. 169, 2002, pages 5171 - 80
GHETIE ET AL., IMMUNOL. TODAY, vol. 18, no. 12, 1997, pages 592 - 598
RAGHAVAN ET AL., IMMUNITY, vol. 1, 1994, pages 303 - 315
TANG ET AL., VET. IMMUNOL. IMMUNOPATHOL., vol. 80, no. 3-4, 2001, pages 259 - 270
KANAI, T.H. ET AL.: "Identification of two allelic IgG1 C(H)coding regions (Cgammal) of cat", VET. IMMUNOL. IMMUNOPATHOL., vol. 73, no. 1, 2000, pages 53 - 62
STRIETZEL, C.J. ET AL.: "In Vitro functional characterization of feline IgGs", VET. IMMUNOL. IMMUNOPATHOL., vol. 158, no. 3-4, 2014, pages 214 - 233
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol. 17, 2016, pages 1298 - 1314
PROC NATL ACSD SCI USA, vol. 81, 1984, pages 5662 - 5666
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. U.S.A., vol. 100, no. 11, 2003, pages 6353 - 6357
DRUG METAB DISPOS., vol. 35, no. 1, January 2007 (2007-01-01), pages 86 - 94
INT IMMUNOL., vol. 18, no. 12, December 2006 (2006-12-01), pages 1759 - 69
J BIOL CHEM., vol. 276, no. 9, 2 March 2001 (2001-03-02), pages 6591 - 604
J BIOL CHEM., vol. 282, no. 3, 2007, pages 1709 - 17
J IMMUNOL., vol. 169, no. 9, 2002, pages 5171 - 80
J IMMUNOL., vol. 182, no. 12, 2009, pages 7663 - 71
MOLECULAR CELL, vol. 7, April 2001 (2001-04-01), pages 867 - 877
NAT BIOTECHNOL., vol. 15, no. 7, July 1997 (1997-07-01), pages 637 - 40
NAT BIOTECHNOL., vol. 23, no. 10, October 2005 (2005-10-01), pages 1283 - 8
PROC NATL ACAD SCI U S A., vol. 103, no. 49, 5 December 2006 (2006-12-05), pages 18709 - 14
MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
J. EXP. MED., vol. 108, 1995
VALLE ET AL., NATURE, vol. 291, 1981, pages 338 - 340
PACE ET AL., PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
"GenBank", Database accession no. XP 023100998.1
ZELEVSKY, J ET AL., NAT TECHNOL, vol. 28, 2010, pages 157 - 159
See also references of EP 3892632A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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