Title:
MODIFIED SMALL INTERFERING RNA MOLECULES WITH REDUCED OFF-TARGET EFFECTS
Document Type and Number:
WIPO Patent Application WO/2023/001234
Kind Code:
A9
Abstract:
A modified small interfering RNA (siRNA) molecule comprising phosphorothioate (PS) intemucleotide linkages in the antisense strand for reducing off-target effects and methods and uses thereof. The siRNAs targeting Hypoxia Inducible Factor 1 Subunit Alpha (HIFla) with high specificity and silencing efficiency.
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Inventors:
CHANG YI-CHUNG (CN)
YANG CHI-FAN (CN)
CHEN HUI-YU (CN)
YANG CHIA-CHUN (CN)
YANG CHI-FAN (CN)
CHEN HUI-YU (CN)
YANG CHIA-CHUN (CN)
Application Number:
PCT/CN2022/107028
Publication Date:
March 02, 2023
Filing Date:
July 21, 2022
Export Citation:
Assignee:
MICROBIO SHANGHAI CO LTD (CN)
International Classes:
C12N15/11; A61K31/70; A61K38/00; A61P43/00; C07H21/00; C12N15/115
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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