Title:
MODULATION OF BACTERIAL MEMBRANE PERMEABILITY
Document Type and Number:
WIPO Patent Application WO2003092587
Kind Code:
A3
Abstract:
Nucleic acids and polypeptides involved in regulation of membrane permeability in bacteria are disclosed. Also disclosed are methods of increasing sensitivity to antibiotics in multi-drug resistant bacteria by increasing expression of PprA or PprB proteins in bacterial cells, and methods for identifying compounds that modulate PprA/PprB expression.
Inventors:
JIN SHOUGUANG
HA UNHWAN
HA UNHWAN
Application Number:
PCT/US2003/013092
Publication Date:
July 22, 2004
Filing Date:
April 29, 2003
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
C07K14/21; C12N1/21; (IPC1-7): C12N15/74; C12N1/20; C12N15/70
Other References:
POOLE K. ET AL.: "Expression of hte multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 40, no. 9, September 1996 (1996-09-01), pages 2021 - 2028, XP002977853
NICAS T.I. ET AL.: "Pseudomonas aeruginosa outer membrane permeability: isolation of a porin protein F-deficient mutant", J. OF BACTERIOLOGY, vol. 153, no. 1, January 1983 (1983-01-01), pages 281 - 285
SAMPSON B.A. ET AL.: "Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability", GENETICS, vol. 122, no. 3, July 1989 (1989-07-01), pages 491 - 501, XP000569629
NICAS T.I. ET AL.: "Pseudomonas aeruginosa outer membrane permeability: isolation of a porin protein F-deficient mutant", J. OF BACTERIOLOGY, vol. 153, no. 1, January 1983 (1983-01-01), pages 281 - 285
SAMPSON B.A. ET AL.: "Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability", GENETICS, vol. 122, no. 3, July 1989 (1989-07-01), pages 491 - 501, XP000569629
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