TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title:

TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Document Type and Number:

WIPO Patent Application WO2003092586

Kind Code:

A3

Abstract:

The present invention is directed to compounds of the formula (I): (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

Inventors:

JIAO RICHARD (US)
MORRIELLO GREGORI (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
ZHOU CHANGYOU (US)
BUTORA GABOR (US)
KOTHANDARAMAN SHANKARAN (US)
GUIADEEN DEODIALSINGH (US)
TANG CHENG (US)
MOYES CHRISTOPHER (GB)

Application Number:

PCT/US2003/012929

Publication Date:

September 16, 2004

Filing Date:

April 25, 2003

Export Citation:

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Assignee:

MERCK & CO INC (US)
MERCK SHARP & DOHME (GB)
JIAO RICHARD (US)
MORRIELLO GREGORI (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
ZHOU CHANGYOU (US)
BUTORA GABOR (US)
KOTHANDARAMAN SHANKARAN (US)
GUIADEEN DEODIALSINGH (US)
TANG CHENG (US)
MOYES CHRISTOPHER (GB)

International Classes:

A61K31/4375; A61K31/4745; A61P29/00; A61P37/02; C07D471/02; C07D471/04; C07D519/00; (IPC1-7): A61K31/4375; C07D471/04

Foreign References:

JPH09291034A

1997-11-11

Other References: