Title:
MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM
Document Type and Number:
WIPO Patent Application WO/2014/038558
Kind Code:
A1
Abstract:
Provided is a molecular assembly of which the retention time is adjusted per target site in accordance with the type or purpose of the encapsulated drug or labeling agent, or a molecular assembly in which the ABC phenomenon is inhibited and which can be administered multiple times in a short time period. A molecular assembly containing a branched amphiphilic block polymer (A), which has a branched sarcosine-containing hydrophilic block and a hydrophobic block having a polylactic acid chain, and a functional substance (F) having a functional site and a polylactic acid chain, wherein the polylactic acid chain configuring the hydrophobic block of the amphiphilic block polymer (A) is configured from an L-lactic acid unit and the polylactic acid chain contained in the functional substance (F) is configured from a D-lactic acid unit, or the polylactic acid chain configuring the hydrophobic block of the amphiphilic block polymer (A) is configured from the D-lactic acid unit and the polylactic acid chain contained in the functional substance (F) is configured from the L-lactic acid unit.
Inventors:
HARA ISAO (JP)
OZEKI EIICHI (JP)
KIMURA SHUNSAKU (JP)
MAKINO AKIRA (JP)
OZEKI EIICHI (JP)
KIMURA SHUNSAKU (JP)
MAKINO AKIRA (JP)
Application Number:
PCT/JP2013/073707
Publication Date:
March 13, 2014
Filing Date:
September 03, 2013
Export Citation:
Assignee:
SHIMADZU CORP (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
A61K9/51; A61K9/10; A61K47/34; A61K49/00
Domestic Patent References:
| WO2012176885A1 | 2012-12-27 | |||
| WO2013039111A1 | 2013-03-21 | |||
| WO2012128326A1 | 2012-09-27 | |||
| WO2012026316A1 | 2012-03-01 | |||
| WO2009148121A1 | 2009-12-10 | |||
| WO2009148121A1 | 2009-12-10 |
Foreign References:
| JP2008024816A | 2008-02-07 |
Other References:
A.MAKINO ET AL.: "Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides", JOURNAL OF CONTROLLED RELEASE, vol. 161, no. 3, 10 August 2012 (2012-08-10), pages 821 - 825, XP028409065
BIOMATERIALS, vol. 30, 2009, pages 5156 - 5160
JOURNAL OF CONTROLLED RELEASE, vol. 161, no. 3, August 2012 (2012-08-01), pages 821 - 825
YAKUGAKU ZASSHI, vol. 129, no. 12, 2009, pages 1445 - 1451
JOURNAL OF CONTROLLED RELEASE, vol. 161, no. 3, 10 August 2012 (2012-08-10), pages 821 - 825
BIOMATERIALS, vol. 30, 2009, pages 5156 - 5160
JOURNAL OF CONTROLLED RELEASE, vol. 161, no. 3, August 2012 (2012-08-01), pages 821 - 825
YAKUGAKU ZASSHI, vol. 129, no. 12, 2009, pages 1445 - 1451
JOURNAL OF CONTROLLED RELEASE, vol. 161, no. 3, 10 August 2012 (2012-08-10), pages 821 - 825
Attorney, Agent or Firm:
OKADA, MASAHIRO (JP)
Masahiro Okada (JP)
Masahiro Okada (JP)
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