Title:
MONOCLONAL ANTIBODY THAT RECOGNIZES INTERSTITIAL CELL SURFACE ANTIGEN
Document Type and Number:
WIPO Patent Application WO/1995/006747
Kind Code:
A1
Abstract:
A novel monoclonal antibody that inhibits the take of hematopoietic stem cells and recognizes the surface antigen of a pancreatic interstitial cell having the ability to support the take of hematopoietic stem cells; and a hybridoma that produces the above antibody. The antibody is useful as, for example, an agent for enhancing the potency of anticancer drugs in the treatment of leukemia.
Inventors:
FUKUSHIMA NAOSHI (JP)
Application Number:
PCT/JP1994/001452
Publication Date:
March 09, 1995
Filing Date:
September 02, 1994
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
FUKUSHIMA NAOSHI (JP)
FUKUSHIMA NAOSHI (JP)
International Classes:
C07K16/28; C12N5/00; C12N5/20; C12N15/00; C12P21/08; A61K38/00; C12R1/93; (IPC1-7): C12P21/08; C12N5/20; C07K16/28
Other References:
BLOOD, Vol. 80, No. 8, (15 October 1992), N. FUKUSHIMA et al., "Enhanced hematopoiesis in vivo and invitro by splenic stromal cells derived from the mouse with recombinant granulocyte colony-stimulating factor", p. 1914-1922.
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