Title:
MORPHOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/153182
Kind Code:
A1
Abstract:
Disclosed is a morpholine derivative represented by the formula [I] below, which is useful as a renin inhibitor, or a pharmacologically acceptable salt thereof. (In the formula, R1 represents (A) an alkyl group substituted with a group selected from optionally substituted alkoxy groups or the like, (B) an optionally substituted aryl group, (C) an optionally substituted heterocyclic group, (D) a cycloalkyl group or (E) an alkyl group; R2 represents (A) an alkyl group substituted with a group selected from optionally substituted alkoxy groups or the like, (B) an optionally substituted aryl group, (C) an optionally substituted heterocyclic group, (D) an optionally substituted alkylcarbonyl group, (E) an optionally substituted arylcarbonyl group, (F) an optionally substituted heterocyclic group-substituted carbonyl group or (G) a cycloalkylcarbonyl group; T represents a methylene group or a carbonyl group; and R3, R4, R5 and R6 may be the same or different, and each represents a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group.)
Inventors:
AKATSUKA HIDENORI (JP)
SUGAMA HIROSHI (JP)
AWAI NOBUMASA (JP)
KAWAGUCHI TAKAYUKI (JP)
TAKAHASHI YOICHI (JP)
IIJIMA TORU (JP)
SHEN JINGKANG (CN)
XIA GUANGXIN (CN)
XIE JIANSHU (CN)
SUGAMA HIROSHI (JP)
AWAI NOBUMASA (JP)
KAWAGUCHI TAKAYUKI (JP)
TAKAHASHI YOICHI (JP)
IIJIMA TORU (JP)
SHEN JINGKANG (CN)
XIA GUANGXIN (CN)
XIE JIANSHU (CN)
Application Number:
PCT/JP2008/061004
Publication Date:
December 18, 2008
Filing Date:
June 16, 2008
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
SHANGHAI PHARMACEUTICAL GROUP (CN)
AKATSUKA HIDENORI (JP)
SUGAMA HIROSHI (JP)
AWAI NOBUMASA (JP)
KAWAGUCHI TAKAYUKI (JP)
TAKAHASHI YOICHI (JP)
IIJIMA TORU (JP)
SHEN JINGKANG (CN)
XIA GUANGXIN (CN)
XIE JIANSHU (CN)
SHANGHAI PHARMACEUTICAL GROUP (CN)
AKATSUKA HIDENORI (JP)
SUGAMA HIROSHI (JP)
AWAI NOBUMASA (JP)
KAWAGUCHI TAKAYUKI (JP)
TAKAHASHI YOICHI (JP)
IIJIMA TORU (JP)
SHEN JINGKANG (CN)
XIA GUANGXIN (CN)
XIE JIANSHU (CN)
International Classes:
A61K31/5375; C07D265/30; A61K31/538; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D265/36; C07D413/12
Domestic Patent References:
| WO2003097618A1 | 2003-11-27 | |||
| WO2005042516A2 | 2005-05-12 | |||
| WO2006005741A2 | 2006-01-19 | |||
| WO2005089731A2 | 2005-09-29 |
Foreign References:
| JPS49124079A | 1974-11-27 | |||
| JP2007055940A | 2007-03-08 | |||
| JPS5390275A | 1978-08-08 | |||
| JP2007145828A | 2007-06-14 | |||
| JP2005336168A | 2005-12-08 | |||
| JP2006517563A | 2006-07-27 | |||
| JP2003500392A | 2003-01-07 | |||
| JPH03188030A | 1991-08-16 | |||
| JPH02115182A | 1990-04-27 | |||
| JPS63301821A | 1988-12-08 | |||
| JP2006522796A | 2006-10-05 |
Other References:
KATO S. ET AL.: "Novel Benzamides as Selective and Potent Gastric Prokinetic Agents. 1. Synthesis and Structure-Activity Relationships of N-[(2-Morpholinyl)alkyl]benzamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, 1990, pages 1406 - 1413, XP001037844
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome, Chuo-ku,Osaka-sh, Osaka 01, JP)
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