Title:
MUCOADHESIVE-PLGA NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2024/025059
Kind Code:
A1
Abstract:
The present invention relates to a non-injectable drug delivery system using mucoadhesive nanoparticles, and to mucoadhesive nanoparticles and a preparation method therefor, the nanoparticles having a mucoadhesive polymer bound to the surface thereof, so that the deformation of nanoparticles caused by mucosal moisture and the like is prevented and adhesion to mucous membranes is strengthened, and thus the loss of nanoparticles is prevented. In addition, the present invention relates to a composition for maturing antigen-presenting cells, a composition for treating infectious disease and a composition for treating cancer, all of the compositions containing the mucoadhesive nanoparticles. Moreover, the present invention relates to mucoadhesive nanoparticles and an anticancer immunotherapy composition comprising same, the nanoparticles having immunoactive materials (such as antigens and adjuvants) for cancer treatment immunotherapy, based on antigen-presenting cells including dendritic cells (DC), loaded thereon.
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Inventors:
HAN HEE DONG (KR)
WI TAE IN (KR)
WI TAE IN (KR)
Application Number:
PCT/KR2023/001159
Publication Date:
February 01, 2024
Filing Date:
January 26, 2023
Export Citation:
Assignee:
PRESTIGE BIOPHARMA KOREA CO LTD (KR)
International Classes:
A61K9/51; A61K9/00; A61K39/00; A61P31/00; A61P35/00
Foreign References:
| KR20140133738A | 2014-11-20 | |||
| KR101912757B1 | 2018-10-29 |
Other References:
ZHANG KERU; TANG XING; ZHANG JUAN; LU WEI; LIN XIA; ZHANG YU; TIAN BIN; YANG HUA; HE HAIBING: "PEG-PLGA copolymers: Their structure and structure-influenced drug delivery applications", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 183, 24 March 2014 (2014-03-24), AMSTERDAM, NL , pages 77 - 86, XP028658411, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2014.03.026
LEE HONG JAE; KOO AHN NA; LEE SUK WON; LEE MYUNG HYUN; LEE SANG CHEON: "Catechol-functionalized adhesive polymer nanoparticles for controlled local release of bone morphogenetic protein-2 from titanium surface", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 170, no. 2, 30 May 2013 (2013-05-30), AMSTERDAM, NL , pages 198 - 208, XP028676588, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2013.05.017
WANG HUI, ZHANG SONG, LV JIA, CHENG YIYUN: "Design of polymers for siRNA delivery: Recent progress and challenges", VIEW, vol. 2, no. 3, 1 June 2021 (2021-06-01), XP093133009, ISSN: 2688-268X, DOI: 10.1002/VIW.20200026
"Doctoral Dissertation", 1 February 2022, GRADUATE SCHOOL OF KONKUK UNIVERSITY, Korea, article WI, T. I.: "Tumor-specific antigen delivery using sprayable catechol-labeled poly(lactide-co-glycolic acid) nanoparticles induce dendritic cell-based anticancer immune response for oral cancer", pages: 1 - 56, XP009553145
LEE HONG JAE; KOO AHN NA; LEE SUK WON; LEE MYUNG HYUN; LEE SANG CHEON: "Catechol-functionalized adhesive polymer nanoparticles for controlled local release of bone morphogenetic protein-2 from titanium surface", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 170, no. 2, 30 May 2013 (2013-05-30), AMSTERDAM, NL , pages 198 - 208, XP028676588, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2013.05.017
WANG HUI, ZHANG SONG, LV JIA, CHENG YIYUN: "Design of polymers for siRNA delivery: Recent progress and challenges", VIEW, vol. 2, no. 3, 1 June 2021 (2021-06-01), XP093133009, ISSN: 2688-268X, DOI: 10.1002/VIW.20200026
"Doctoral Dissertation", 1 February 2022, GRADUATE SCHOOL OF KONKUK UNIVERSITY, Korea, article WI, T. I.: "Tumor-specific antigen delivery using sprayable catechol-labeled poly(lactide-co-glycolic acid) nanoparticles induce dendritic cell-based anticancer immune response for oral cancer", pages: 1 - 56, XP009553145
Attorney, Agent or Firm:
KWAK, Jai Gun et al. (KR)
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