Title:
MULTI-CORE-SHELL NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2011/136500
Kind Code:
A3
Abstract:
The present invention relates to core-shell nanoparticles comprising: a manganese-containing magnetic nanoparticle (Mn-MNP) multi-core; and a silica shell coating the multi-core. Since the core-shell nanoparticles used in the present invention have high saturation magnetization (Ms) value and transverse relaxivity (R2), a sensor of the present invention using the same can detect analytes with remarkably improved sensitivity. It is possible to detect a trace amount of analytes, for example, a protein or a nucleic acid molecule as an anti-cancer marker in the blood, a chemical material, and the like with the improved sensitivity. Therefore, the core-shell nanoparticles of the present invention can be useful in an effective and practical magnetic nanoparticle system and a magnetic sensing method or a contrast medium using the same due to excellent magnetic characteristics, in vivo non-toxicity, high solubility and easy surface modification.
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Inventors:
YOON TAE JONG (KR)
CHUNG KWANG-HOE (KR)
KO JUNG-JAE (KR)
CHUNG KWANG-HOE (KR)
KO JUNG-JAE (KR)
Application Number:
PCT/KR2011/002870
Publication Date:
April 05, 2012
Filing Date:
April 21, 2011
Export Citation:
Assignee:
CHABIOMED CO LTD (KR)
YOON TAE JONG (KR)
CHUNG KWANG-HOE (KR)
KO JUNG-JAE (KR)
YOON TAE JONG (KR)
CHUNG KWANG-HOE (KR)
KO JUNG-JAE (KR)
International Classes:
B82B3/00; A61K49/06; B82B1/00
Foreign References:
| KR20100006080A | 2010-01-18 | |||
| KR20070029030A | 2007-03-13 | |||
| KR20090085435A | 2009-08-07 | |||
| KR20090077159A | 2009-07-15 |
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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