Title:
MULTI-DRUG-LOADING, HIGH DRUG-LOADING LIGAND-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2018/177287
Kind Code:
A1
Abstract:
The present invention provides a multi-drug-loading and high drug-loading ligand-drug conjugate. The ligand-drug conjugate has a structure of general formula (I). The ligand-drug conjugate has the characteristics of high loading capacity, high drug efficacy, low toxicity, and low risks. The ligand-drug conjugate can be used particularly to connect to a low toxicity chemical molecule, thereby extending a therapeutic window. Furthermore, the present invention provides an antibody-drug conjugate molecule. The antibody-drug conjugate molecule has the characteristics of multiple drug-loading ability and high drug-loading capacity, such that the antibody-drug conjugate can carry a large amount of a low toxicity chemical molecule and achieve a therapeutic effect without depending on antibody targeting or high toxicity chemicals. TM-{R2-PEG1-[R1-PEG2-(R3-A'-D)n]m}l (Ⅰ)
Inventors:
SONG YANPING (CN)
DU JINGHUI (CN)
WANG LEIMIN (CN)
WANG JINLIANG (CN)
LIN MEINA (CN)
FENG ZEWANG (CN)
ZHAO XUAN (CN)
DU JINGHUI (CN)
WANG LEIMIN (CN)
WANG JINLIANG (CN)
LIN MEINA (CN)
FENG ZEWANG (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2018/080680
Publication Date:
October 04, 2018
Filing Date:
March 27, 2018
Export Citation:
Assignee:
JENKEM TECH CO LTD BEIJING (CN)
International Classes:
A61K47/60; A61K47/68; A61K47/65; A61P31/18; A61P35/00; A61P37/02
Foreign References:
| CN107469089A | 2017-12-15 | |||
| CN102145176A | 2011-08-10 | |||
| CN101724144A | 2010-06-09 | |||
| CN104758946A | 2015-07-08 | |||
| CN104371098A | 2015-02-25 | |||
| CN104448296A | 2015-03-25 |
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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