Title:
MULTIBINDING AGENTS THAT MODULATE THE 5-HT TRANSPORTER
Document Type and Number:
WIPO Patent Application WO1999063932
Kind Code:
A3
Abstract:
Disclosed are multibinding compounds are capable of binding to a 5-HT cell membrane transporter. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. the mltibinding compounds of this invention are useful for modulating serotonin levels.
Inventors:
BEATTIE DAVID T (US)
AGGEN JAMES (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
GRIFFIN JOHN H (US)
Application Number:
PCT/US1999/012724
Publication Date:
February 03, 2000
Filing Date:
June 07, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
BEATTIE DAVID T (US)
AGGEN JAMES (US)
GRIFFIN JOHN H (US)
BEATTIE DAVID T (US)
AGGEN JAMES (US)
GRIFFIN JOHN H (US)
International Classes:
A61K45/00; A61K47/48; A61P43/00; C07B61/00; C07C217/16; C07K2/00; C40B20/00; C40B40/02; C40B50/06; G01N33/15; G01N33/566; G01N33/68; G01N33/50; (IPC1-7): A61K31/58; A61K38/00; A61K39/00; A61K39/395; A61K51/00; C07D401/04; C07D401/12; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566
Domestic Patent References:
| WO1998028293A1 | 1998-07-02 | |||
| WO1997035195A1 | 1997-09-25 |
Foreign References:
| GB2044254A | 1980-10-15 | |||
| US5714127A | 1998-02-03 |
Other References:
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LEBOULLUEC K. L., ET AL.: "BIVALENT INDOLES EXHIBITING SEROTONERGIC BINDING AFFINITY.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 05., no. 02., 1 January 1995 (1995-01-01), AMSTERDAM, NL, pages 123 - 126., XP002922909, ISSN: 0960-894X, DOI: 10.1016/0960-894X(94)00470-Z
KROEZE W. K., ROTH B. L.: "THE MOLECULAR BIOLOGY OF SEROTONIN RECEPTORS: THERAPEUTIC IMPLICATIONS FOR THE INTERFACE OF MOOD AND PSYCHOSIS.", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 44., no. 11., 1 December 1998 (1998-12-01), NEW YORK, NY; US, pages 1128 - 1142., XP002922910, ISSN: 0006-3223, DOI: 10.1016/S0006-3223(98)00132-2
MATECKA et al., "Development of Novel, Potent and Selective Dopamine Reuptake Inhibitors Through Alteration of the Piperazine Ring of 1-(2¬Diphenylmethoxy¾ethyl and 1-(2-¬Bis{4-Fluorophenyl}methoxy¾ethyl)-4-( 3-Phenylpropyl) Piperazines (GBR 12935 and GBR 12909)", J. MED. CHEM., 22 November 1996, Vol. 39, No. 24, pages 4704-4716,
DUTTA A. K., XU C., REITH M. E. A.: "STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF NOVEL 4-(2-(BIS(4-FLUOROPHENYL)METHOXY)ETHYL)-1-(3-PHENYLPROPYL) PIPERIDINE ANALOGS: SYNTHESIS AND BIOLOGICAL EVALUATION AT THE DOPAMINE AND SEROTONIN TRANSPORTER SITES.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39., 1 January 1996 (1996-01-01), US, pages 749 - 756., XP002922912, ISSN: 0022-2623, DOI: 10.1021/jm9506581
SHUKER S. B., ET AL.: "DISCOVERING HIGH-AFFINITY LIGANDS FOR PROTEINS: SAR BY NMR.", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 274., 29 November 1996 (1996-11-29), US, pages 1531 - 1534., XP002922913, ISSN: 0036-8075, DOI: 10.1126/science.274.5292.1531
LEBOULLUEC K. L., ET AL.: "BIVALENT INDOLES EXHIBITING SEROTONERGIC BINDING AFFINITY.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 05., no. 02., 1 January 1995 (1995-01-01), AMSTERDAM, NL, pages 123 - 126., XP002922909, ISSN: 0960-894X, DOI: 10.1016/0960-894X(94)00470-Z
KROEZE W. K., ROTH B. L.: "THE MOLECULAR BIOLOGY OF SEROTONIN RECEPTORS: THERAPEUTIC IMPLICATIONS FOR THE INTERFACE OF MOOD AND PSYCHOSIS.", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 44., no. 11., 1 December 1998 (1998-12-01), NEW YORK, NY; US, pages 1128 - 1142., XP002922910, ISSN: 0006-3223, DOI: 10.1016/S0006-3223(98)00132-2
MATECKA et al., "Development of Novel, Potent and Selective Dopamine Reuptake Inhibitors Through Alteration of the Piperazine Ring of 1-(2¬Diphenylmethoxy¾ethyl and 1-(2-¬Bis{4-Fluorophenyl}methoxy¾ethyl)-4-( 3-Phenylpropyl) Piperazines (GBR 12935 and GBR 12909)", J. MED. CHEM., 22 November 1996, Vol. 39, No. 24, pages 4704-4716,
DUTTA A. K., XU C., REITH M. E. A.: "STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF NOVEL 4-(2-(BIS(4-FLUOROPHENYL)METHOXY)ETHYL)-1-(3-PHENYLPROPYL) PIPERIDINE ANALOGS: SYNTHESIS AND BIOLOGICAL EVALUATION AT THE DOPAMINE AND SEROTONIN TRANSPORTER SITES.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39., 1 January 1996 (1996-01-01), US, pages 749 - 756., XP002922912, ISSN: 0022-2623, DOI: 10.1021/jm9506581
SHUKER S. B., ET AL.: "DISCOVERING HIGH-AFFINITY LIGANDS FOR PROTEINS: SAR BY NMR.", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 274., 29 November 1996 (1996-11-29), US, pages 1531 - 1534., XP002922913, ISSN: 0036-8075, DOI: 10.1126/science.274.5292.1531
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