Title:
MULTIMERIC PROTEIN-ALBUMIN CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/164291
Kind Code:
A2
Abstract:
Disclosed herein is a multimeric protein-albumin conjugate. The multimeric protein-albumin conjugate has a multimeric protein variant conjugated with albumin via a linker. In the multimeric protein-albumin conjugate, a predetermined number of albumins are conjugated via a linker to a multimeric protein variant that has an amino acid sequence properly modified to form a conjugate in a site-specific manner. The multimeric protein variant results from substitution of a non-natural amino acid for one or more amino acids in the amino acid sequence of the corresponding wild-type multimeric protein, wherein the linker and albumin is linked to the non-natural amino acid residue.
Inventors:
CHO JEONG HAENG (KR)
SHIN SUN OH (KR)
KIM HYUN WOO (KR)
YANG BYUNGSEOP (KR)
KIM MIN HYUNG (KR)
PARK SEONG JU (KR)
SHIN SUN OH (KR)
KIM HYUN WOO (KR)
YANG BYUNGSEOP (KR)
KIM MIN HYUNG (KR)
PARK SEONG JU (KR)
Application Number:
PCT/KR2022/001675
Publication Date:
August 04, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
PROABTECH INC (KR)
International Classes:
C07C255/50
Attorney, Agent or Firm:
IPLAY PATENT LAW FIRM (KR)
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