Title:
MULTIPLE BIOMARKER FOR CANCER DIAGNOSIS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/035230
Kind Code:
A1
Abstract:
The present invention pertains to a multiple biomarker for cancer diagnosis and a use thereof and, specifically, to a composition for cancer diagnosis, comprising an agent for measuring the protein or mRNA expression levels of IGFI, KLK2, PKCα, and TRPM8. The present inventors confirmed that rapid and accurate cancer diagnosis can be performed by detecting the unique marker combination of IGFI, KLK2, PKCα, and TRPM8 of the present invention in serum samples from actual cancer patients and one or more cancers can be simultaneously detected. Thus, the combination of IGFI, KLK2, PKCα, and TRPM8 is expected to allow for the rapid and accurate diagnosis of various cancers including prostate cancer.
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Inventors:
PARK TAE JUNG (KR)
HUR CHEOL-GOO (KR)
HUR CHEOL-GOO (KR)
Application Number:
PCT/KR2023/011992
Publication Date:
February 15, 2024
Filing Date:
August 11, 2023
Export Citation:
Assignee:
MAXION CORP (KR)
International Classes:
G01N33/574; C12Q1/6886; G01N33/543; G01N33/58
Domestic Patent References:
| WO2016145308A2 | 2016-09-15 |
Foreign References:
| KR20130054311A | 2013-05-24 | |||
| KR20170008729A | 2017-01-24 |
Other References:
AIDOO-BROWN JOSEPHINE, MOSCHOU DESPINA, ESTRELA PEDRO: "Multiplexed Prostate Cancer Companion Diagnostic Devices", SENSORS, MDPI, CH, vol. 21, no. 15, 24 July 2021 (2021-07-24), CH , pages 5023, XP093137605, ISSN: 1424-8220, DOI: 10.3390/s21155023
KANG JEONG-HUN, ASAI DAISUKE, TOITA RIKI, KITAZAKI HIROTARO, KATAYAMA YOSHIKI: "Plasma protein kinase C (PKC)α as a biomarker for the diagnosis of cancers", CARCINOGENESIS, OXFORD UNIVERSITY PRESS, GB, vol. 30, no. 11, 1 November 2009 (2009-11-01), GB , pages 1927 - 1931, XP093103300, ISSN: 0143-3334, DOI: 10.1093/carcin/bgp210
KANG JEONG-HUN, ASAI DAISUKE, TOITA RIKI, KITAZAKI HIROTARO, KATAYAMA YOSHIKI: "Plasma protein kinase C (PKC)α as a biomarker for the diagnosis of cancers", CARCINOGENESIS, OXFORD UNIVERSITY PRESS, GB, vol. 30, no. 11, 1 November 2009 (2009-11-01), GB , pages 1927 - 1931, XP093103300, ISSN: 0143-3334, DOI: 10.1093/carcin/bgp210
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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