Title:
MULTIVALENT AGONISTS, PARTIAL AGONISTS AND ANTAGONISTS OF THE GABA RECEPTORS
Document Type and Number:
WIPO Patent Application WO1999063933
Kind Code:
A9
Abstract:
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists, partial inverse agonist or antagonists of the GABA receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist, partial inverse agonist or antagonist of the GABA receptors. The multibinding compounds of this invention are useful in the treatment of neurological disorders such as anxiety, depression, sleep and seizure disorders, emesis and overdoses of benzodiazepine-type drugs, and producing sedation, hypnosis, retrograde amnesia, and enhancing alertness and the like.
Inventors:
BEATTIE DAVID T (US)
GRIFFIN JOHN H (US)
MORAN EDMUND J (US)
GRIFFIN JOHN H (US)
MORAN EDMUND J (US)
Application Number:
PCT/US1999/012730
Publication Date:
April 27, 2000
Filing Date:
June 07, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
BEATTIE DAVID T (US)
GRIFFIN JOHN H (US)
MORAN EDMUND J (US)
BEATTIE DAVID T (US)
GRIFFIN JOHN H (US)
MORAN EDMUND J (US)
International Classes:
A61K31/13; A61K31/136; A61K31/137; A61K31/155; A61K31/16; A61K31/18; A61K31/27; A61K31/40; A61K31/4015; A61K31/403; A61K31/404; A61K31/41; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/435; G01N33/50; A61K31/437; A61K31/44; A61K31/4402; A61K31/4427; A61K31/4439; A61K31/445; A61K31/454; A61K31/4545; A61K31/47; A61K31/4706; A61K31/4709; A61K31/485; A61K31/495; A61K31/496; A61K31/498; A61K31/506; A61K31/517; A61K31/519; A61K31/55; A61K31/551; A61K31/5517; A61K31/662; A61K38/00; A61K45/00; A61K47/48; A61P9/02; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/02; A61P13/08; A61P15/06; A61P17/04; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/16; A61P43/00; C07B61/00; C07C211/00; C07C213/00; C07C215/00; C07C215/34; C07C215/60; C07C217/00; C07C217/08; C07C217/10; C07C217/48; C07C217/58; C07C217/90; C07C237/08; C07C271/12; C07C311/37; C07C323/44; C07C323/62; C07D207/06; C07D207/08; C07D207/26; C07D209/08; C07D211/14; C07D211/18; C07D211/42; C07D211/52; C07D211/56; C07D211/60; C07D211/72; C07D211/84; C07D213/30; C07D213/38; C07D213/56; C07D213/74; C07D213/75; C07D213/80; C07D215/22; C07D215/48; C07D221/26; C07D221/28; C07D223/04; C07D235/18; C07D235/30; C07D239/95; C07D241/44; C07D249/12; C07D257/04; C07D263/32; C07D263/34; C07D265/32; C07D277/24; C07D277/28; C07D277/34; C07D295/02; C07D295/06; C07D295/08; C07D295/18; C07D295/20; C07D401/04; C07D401/12; C07D401/14; C07D403/02; C07D403/14; C07D413/06; C07D413/14; C07D417/12; C07D471/04; C07D471/08; C07D487/04; C07D495/04; C07D519/00; C07K1/04; C07K2/00; C07K4/00; C07K7/14; C07K16/28; C40B20/00; G01N33/15; G01N33/53; G01N33/543; G01N33/566; G01N33/94; G01N37/00; (IPC1-7): A61K31/495; A61K31/505; A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07D401/14; C07D403/06; C07D403/14; C07D487/04; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566
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