Title:
MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT>3< RECEPTORS
Document Type and Number:
WIPO Patent Application WO1999064046
Kind Code:
A9
Abstract:
Disclosed are novel multi-binding compounds (agents) which bind 5-HT>3< receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the 5-HT>3< receptor.
Inventors:
YANG GUANG (US)
MEIER-DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
MEIER-DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
Application Number:
PCT/US1999/012768
Publication Date:
April 20, 2000
Filing Date:
June 08, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
YANG GUANG (US)
MEIER DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
YANG GUANG (US)
MEIER DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
International Classes:
A61K31/00; A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566; (IPC1-7): A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566
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