Title:
A MURINE GENOMIC POLYNUCLEOTIDE SEQUENCE ENCODING A G-PROTEIN COUPLED RECEPTOR AND METHODS OF USE THEREFOR
Document Type and Number:
WIPO Patent Application WO2003018066
Kind Code:
A3
Abstract:
The present invention particularly relates to a newly identified murine genomic polynucleotide that encodes an ortholog of the human P2T receptor which is expressed at high levels in the central nervous system, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of P2T, and therefore potentially useful in therapy.
Inventors:
PAUSCH MARK HENRY
Application Number:
PCT/US2002/026005
Publication Date:
May 22, 2003
Filing Date:
August 15, 2002
Export Citation:
Assignee:
WYETH CORP (US)
International Classes:
C07K14/705; C12Q1/68; C12Q1/6883; G01N33/68; (IPC1-7): A61K48/00; A01K67/00; C07H21/04; C07K16/00; C12N5/00; C12N15/00; C12Q1/02; C12Q1/68; G01N33/00
Other References:
LEON C. ET AL.: "Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1", JOURNAL OF CLINICAL INVESTIGATION, vol. 104, no. 12, December 1999 (1999-12-01), pages 1731 - 1737, XP002959919
ENJYOJI K. ET AL.: "Targeted disruption of cd39/ATP diphosphorylase results in disordered hemostasis and thromboregulation", NATURE MEDICINE, vol. 5, no. 9, September 1999 (1999-09-01), pages 1010 - 1017, XP002959920
LEON C. ET AL.: "P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation", THROMBOSIS AND HEMOSTASIS, vol. 81, no. 5, 1999, pages 775 - 781, XP002959921
SUN B. ET AL.: "P2X1 purinoceptor in human platelets", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 19, 8 May 1998 (1998-05-08), pages 11544 - 11547, XP002959922
JIN J. ET AL.: "Molecular basis for ADP-induced platelet achivation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 4, 23 January 1998 (1998-01-23), pages 2030 - 2034, XP002959923
CATTANEO M. ET AL.: "ADP receptors and clinical bleeding disorders", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 19, October 1999 (1999-10-01), pages 2281 - 2285, XP002959924
ENJYOJI K. ET AL.: "Targeted disruption of cd39/ATP diphosphorylase results in disordered hemostasis and thromboregulation", NATURE MEDICINE, vol. 5, no. 9, September 1999 (1999-09-01), pages 1010 - 1017, XP002959920
LEON C. ET AL.: "P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation", THROMBOSIS AND HEMOSTASIS, vol. 81, no. 5, 1999, pages 775 - 781, XP002959921
SUN B. ET AL.: "P2X1 purinoceptor in human platelets", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 19, 8 May 1998 (1998-05-08), pages 11544 - 11547, XP002959922
JIN J. ET AL.: "Molecular basis for ADP-induced platelet achivation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 4, 23 January 1998 (1998-01-23), pages 2030 - 2034, XP002959923
CATTANEO M. ET AL.: "ADP receptors and clinical bleeding disorders", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 19, October 1999 (1999-10-01), pages 2281 - 2285, XP002959924
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