NOVEL $g(b)-LACTAM COMPOUNDS AND PROCESS FOR PREPARING THE SAME

Title:

NOVEL $g(b)-LACTAM COMPOUNDS AND PROCESS FOR PREPARING THE SAME

Document Type and Number:

WIPO Patent Application WO/1998/009965

Kind Code:

A1

Abstract:

$g(b)-Lactam compounds represented by general formula (1) and salts and esters thereof, wherein R?1� represents a lower alkyl or an OH-substituted lower alkyl; R?2� represents H or a lower alkyl; X represents O, S, or NH; n is 1 to 3; and R?3� represents -C(Ra)=NH (wherein Ra represents H, a lower alkyl, or a substituted lower alkyl). The above compounds have an excellent antimicrobial activity against Gram-positive bacteria, particularly meticillin-resistant staphylococci and meticillin-resistant and coagulase-negative staphylococci.

Inventors:

SUNAGAWA MAKOTO (JP)
YAMAGA HIROSHI (JP)
NOUDA HIROSHI (JP)
SHINAGAWA HISATOSHI (JP)

Application Number:

PCT/JP1997/003078

Publication Date:

March 12, 1998

Filing Date:

September 03, 1997

Export Citation:

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Assignee:

SUMITOMO PHARMA (JP)
SUNAGAWA MAKOTO (JP)
YAMAGA HIROSHI (JP)
NOUDA HIROSHI (JP)
SHINAGAWA HISATOSHI (JP)

International Classes:

C07D477/00; A61K31/397; A61K31/435; A61K31/55; A61P31/04; C07D477/20; (IPC1-7): C07D487/04; A61K31/40

Domestic Patent References:

WO1994029313A1

1994-12-22

Foreign References:

JPH072856A

1995-01-06

Other References: