Title:
DC-89 DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/009966
Kind Code:
A1
Abstract:
DC-89 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein (a) represents (b) or (c); Y represents hydrogen, halogeno, optionally substituted lower alkyl, COR?1�, CH=NR?8� or (d); Z represents hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted aryl, optionally substituted heterocycle or COR?9� (wherein R represents hydrogen, COR?12� or R?16�R?17�R?18�Si; and V represents hydrogen, halogeno, nitro or COR?11�); W represents hydrogen, (e), (f), (g) or (h); and X represents Cl or Br, provided that when Y is hydrogen or CO�2?R?2� (wherein R?2� is hydrogen, linear or branched C�1-4? alkyl, aryl or benzyl), then Z and V do not represent hydrogen at the same time. These compounds have excellent antitumor activities, which makes them useful as antitumor agents.
Inventors:
AMISHIRO NOBUYOSHI (JP)
SAITO HIROMITSU (JP)
OKAMOTO AKIHIKO (JP)
OKABE MASAMI (JP)
SAITO HIROMITSU (JP)
OKAMOTO AKIHIKO (JP)
OKABE MASAMI (JP)
Application Number:
PCT/JP1997/003089
Publication Date:
March 12, 1998
Filing Date:
September 03, 1997
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
AMISHIRO NOBUYOSHI (JP)
SAITO HIROMITSU (JP)
OKAMOTO AKIHIKO (JP)
OKABE MASAMI (JP)
AMISHIRO NOBUYOSHI (JP)
SAITO HIROMITSU (JP)
OKAMOTO AKIHIKO (JP)
OKABE MASAMI (JP)
International Classes:
C07D487/04; (IPC1-7): C07D487/04; A61K31/40
Domestic Patent References:
| WO1995029179A1 | 1995-11-02 | |||
| WO1995026964A1 | 1995-10-12 |
Foreign References:
| JPH05178858A | 1993-07-20 | |||
| JPH05208979A | 1993-08-20 |
Other References:
TETRAHEDRON LETTERS, Vol. 29, No. 18, (1988), THOMAS A. BRYSON et al., "Cyclopropane Chemistry Related to the Alkaloid CC-1065", pages 2167-2170.
NUCLEIC ACID RESEARCH, Vol. 22, No. 1, (1994), ASAI AKIRA et al., "The Reversible DNA-Alkylating Activity of Duocarmycin and its Analogs", pages 88-93.
NUCLEIC ACID RESEARCH, Vol. 22, No. 1, (1994), ASAI AKIRA et al., "The Reversible DNA-Alkylating Activity of Duocarmycin and its Analogs", pages 88-93.
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