Title:
NANOPARTICLES AND MICROPARTICLES OF HEXAHYDROXY-CYCLOHEXANE HEXAPHOSPHORIC ESTER SALTS FOR THE TREATMENT OF CALCINOSIS AND AS SUPPLEMENTS FOR DIET FOOD
Document Type and Number:
WIPO Patent Application WO/2018/091133
Kind Code:
A3
Abstract:
Disclosed are nanoparticles and/or microparticles of hexahydroxy-cyclohexane hexaphosphoric ester salts for the treatment of calcinosis, in particular pseudogout and calcinosis cutis, the hexahydroxy-cyclohexane being selected from among the group consisting of eis-, epi-, allo-, neo-, myo-, muco-, chiro- and scyllo-inositol, in particular myo-inositol; pharmaceutical preparations, in particular for topical application, dietary supplements for food and diet food, especially milk and milk products, containing at least one type of nanoparticles and/or at least one type of microparticles of at least one type of hexahydroxy-cyclohexane hexaphosphoric ester salts; process for synthesizing the pharmaceutical preparations and the diet food.
Inventors:
LUTHE GREGOR (DE)
Application Number:
PCT/EP2017/001317
Publication Date:
July 12, 2018
Filing Date:
November 14, 2017
Export Citation:
Assignee:
WIND PLUS SONNE GMBH (DE)
International Classes:
A61K9/14; A23L33/105; A61K9/16; A61K9/51; A61K31/047; A61K31/6615; A61P17/00; A61P19/00
Foreign References:
| US20060034923A1 | 2006-02-16 | |||
| EP3037087A1 | 2016-06-29 |
Other References:
FELIX GRASES ET AL: "Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP6) through the Skin", BIOL. PHARM. BULL., vol. 28, no. 4, 30 April 2005 (2005-04-30), pages 764 - 767, XP055467186
F. GRASES ET AL: "Study of a myo-inositol hexaphosphate-based cream to prevent dystrophic calcinosis cutis", BRITISH JOURNAL OF DERMATOLOGY, vol. 152, no. 5, 1 May 2005 (2005-05-01), UK, pages 1022 - 1025, XP055467179, ISSN: 0007-0963, DOI: 10.1111/j.1365-2133.2005.06382.x
GRASES FELIX ET AL: "Phytate acts as an inhibitor in formation of renalcalculi", FRONTIERS IN BIOSCI, FRONTIERS IN BIOSCIENCE, ALBERTSON, NY, US, vol. 12, 1 January 2007 (2007-01-01), pages 2580 - 2587, XP008176574, ISSN: 1093-9946, DOI: 10.2741/2256
GRAF E ET AL: "Antioxidant functions of phytic acid", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER INC, US, vol. 8, no. 1, 1 January 1990 (1990-01-01), pages 61 - 69, XP023522837, ISSN: 0891-5849, [retrieved on 19900101], DOI: 10.1016/0891-5849(90)90146-A
M. HNASEN ET AL: "The Effect of Casein Phosphopetides on Zinc and Calcium Absorption from High Phytate Infant Diets Assessed in Rat Pups and Caco-2 Cells", PEDIATRIC RESEARCH, 1 October 1996 (1996-10-01), pages 1 - 22, XP055438589, Retrieved from the Internet [retrieved on 20180108]
S.R. PLATT ET AL: "Protective Effect of Milk on Mineral Precipitation by Na Phytate", JOURNAL OF FOOD SCIENCE, vol. 52, no. 1, 31 December 1987 (1987-12-31), pages 240 - 241, XP055472800
F. GRASES ET AL: "Study of a myo-inositol hexaphosphate-based cream to prevent dystrophic calcinosis cutis", BRITISH JOURNAL OF DERMATOLOGY, vol. 152, no. 5, 1 May 2005 (2005-05-01), UK, pages 1022 - 1025, XP055467179, ISSN: 0007-0963, DOI: 10.1111/j.1365-2133.2005.06382.x
GRASES FELIX ET AL: "Phytate acts as an inhibitor in formation of renalcalculi", FRONTIERS IN BIOSCI, FRONTIERS IN BIOSCIENCE, ALBERTSON, NY, US, vol. 12, 1 January 2007 (2007-01-01), pages 2580 - 2587, XP008176574, ISSN: 1093-9946, DOI: 10.2741/2256
GRAF E ET AL: "Antioxidant functions of phytic acid", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER INC, US, vol. 8, no. 1, 1 January 1990 (1990-01-01), pages 61 - 69, XP023522837, ISSN: 0891-5849, [retrieved on 19900101], DOI: 10.1016/0891-5849(90)90146-A
M. HNASEN ET AL: "The Effect of Casein Phosphopetides on Zinc and Calcium Absorption from High Phytate Infant Diets Assessed in Rat Pups and Caco-2 Cells", PEDIATRIC RESEARCH, 1 October 1996 (1996-10-01), pages 1 - 22, XP055438589, Retrieved from the Internet
S.R. PLATT ET AL: "Protective Effect of Milk on Mineral Precipitation by Na Phytate", JOURNAL OF FOOD SCIENCE, vol. 52, no. 1, 31 December 1987 (1987-12-31), pages 240 - 241, XP055472800
Attorney, Agent or Firm:
MÜNCH, Volker (DE)
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