Title:
NANOPARTICLES FOR TUMOR-TARGETING AND PROCESSES FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/062420
Kind Code:
A2
Abstract:
The present invention provides a pharmaceutical composition for tumor-targeting in the form of a nano-dispersion comprising nanoparticles having a mean particle size of 10 to 1,000 nm in an aqueous medium, wherein the nanoparticles comprise a therapeutically effective amount of an anticancer agent; a divalent or trivalent transition metal ion or alkali earth metal ion; and an oil, and wherein hyaluronic acid or its salt is bound on a surface of the nanoparticles. And also, the present invention provides nanoparticles for tumor-targeting obtained by drying the pharmaceutical composition in the form of a nano-dispersion. And also, the present invention provides a process for preparing the pharmaceutical composition in the form of a nano-dispersion and a process for preparing the nanoparticles.
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Inventors:
PARK SEONG-BAE (KR)
KIM JOO-EUN (KR)
YANG JUN-MO (KR)
MIN MI-HONG (KR)
CHOI HYUN-HO (KR)
WOO MIN-NA (KR)
AHN BYUNG-NAK (KR)
KIM JOO-EUN (KR)
YANG JUN-MO (KR)
MIN MI-HONG (KR)
CHOI HYUN-HO (KR)
WOO MIN-NA (KR)
AHN BYUNG-NAK (KR)
Application Number:
PCT/KR2010/008149
Publication Date:
May 26, 2011
Filing Date:
November 18, 2010
Export Citation:
Assignee:
YUHAN CORP (KR)
PARK SEONG-BAE (KR)
KIM JOO-EUN (KR)
YANG JUN-MO (KR)
MIN MI-HONG (KR)
CHOI HYUN-HO (KR)
WOO MIN-NA (KR)
AHN BYUNG-NAK (KR)
PARK SEONG-BAE (KR)
KIM JOO-EUN (KR)
YANG JUN-MO (KR)
MIN MI-HONG (KR)
CHOI HYUN-HO (KR)
WOO MIN-NA (KR)
AHN BYUNG-NAK (KR)
International Classes:
A61K47/30; A61K9/51; A61K47/02; A61P35/00
Domestic Patent References:
| WO2009121069A2 | 2009-10-01 | |||
| WO2009123595A1 | 2009-10-08 | |||
| WO2000041730A1 | 2000-07-20 | |||
| WO2009087678A2 | 2009-07-16 | |||
| WO2001003670A1 | 2001-01-18 |
Foreign References:
| KR20090040979A | 2009-04-28 | |||
| US6593308B2 | 2003-07-15 | |||
| US6699471B2 | 2004-03-02 |
Attorney, Agent or Firm:
OH, Kook-Jin (1708-6 Seocho-dong, Seocho-gu, Seoul 137-884, KR)
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