Title:
NASAL SPRAY OF DEXMEDETOMIDINE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/259440
Kind Code:
A1
Abstract:
Disclosed is a nasal spray of dexmedetomidine. The basic prescription comprises an osmotic pressure regulator, a preservative, a pH regulator, a carrier, and a pharmaceutically effective amount of dexmedetomidine. The nasal spray of dexmedetomidine according to the prescription has a high stability and a broad pH applicability, despite the simple prescription. The nasal spray has a rapid onset, good pharmacokinetic properties, does not cause irritation to the nasal cavity, and also reduces the cost of production.
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Inventors:
WANG WAN (CN)
WANG ZHENYU (CN)
HE GANGMIN (CN)
LI YANGQIANG (CN)
SHI XINYUE (CN)
LI PEI (CN)
HOU SHUGUANG (CN)
WANG ZHENYU (CN)
HE GANGMIN (CN)
LI YANGQIANG (CN)
SHI XINYUE (CN)
LI PEI (CN)
HOU SHUGUANG (CN)
Application Number:
PCT/CN2020/097454
Publication Date:
December 30, 2020
Filing Date:
June 22, 2020
Export Citation:
Assignee:
SICHUAN PURITY PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/12; A61K31/4174; A61K47/02; A61K47/18; A61M11/00; A61M15/00; A61P23/00; A61P25/20; A61P29/00
Domestic Patent References:
| WO2013130577A3 | 2015-03-12 |
Foreign References:
| CN111481506A | 2020-08-04 | |||
| CN104470516A | 2015-03-25 | |||
| US20130143938A1 | 2013-06-06 | |||
| US10682311B2 | 2020-06-16 | |||
| CN106727524A | 2017-05-31 | |||
| CN109620802A | 2019-04-16 |
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