Title:
NERVE CELL DEATH INHIBITOR, ANTI-ALZHEIMER'S DISEASE AGENT, BRAIN HYPOFUNCTION INHIBITOR, DRUG OR FOOD HAVING ANTI-ALZHEIMER'S DISEASE EFFECT OR BRAIN HYPOFUNCTION-INHIBITING EFFECT, AND METHOD FOR PRODUCING NERVE CELL DEATH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/006407
Kind Code:
A1
Abstract:
A nerve cell death inhibitor, an anti-Alzheimer's disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimer's disease effect or a brain hypofunction-inhibiting effect, each containing as an active ingredient "a preset partitioned portion that is a portion partitioned in methylene dichloride when an ethanol extract of Rhinacanthus nasuta (L.) Kurz is liquid-liquid partitioned with hexane and methanol and then the portion partitioned in methanol is liquid-liquid partitioned with methylene dichloride and water", "a preset fraction that is a fraction eluted from a silica gel column with an elution solvent, said elution solvent consisting of n-hexane, ethyl acetate and anhydrous methanol, when the preset partitioned portion is subjected to silica gel column chromatography using the elution solvent" or Rhinacanthin C.
According to the present invention, a nerve cell death inhibitor having an excellent effect of inhibiting nerve cell death, an anti-Alzheimer's disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimer's disease effect or a brain hypofunction-inhibiting effect can be provided.
Inventors:
TAKAHASHI TOMOYA (JP)
PAN I-HORNG (TW)
WEN SHU-FANG (TW)
LU I-HUANG (TW)
CHUANG KAI-AN (TW)
PAN I-HORNG (TW)
WEN SHU-FANG (TW)
LU I-HUANG (TW)
CHUANG KAI-AN (TW)
Application Number:
PCT/JP2015/069363
Publication Date:
January 12, 2017
Filing Date:
July 04, 2015
Export Citation:
Assignee:
AOB KEIOH GROUP CORP (JP)
International Classes:
A61K36/19; A61K31/222; A61P25/00; A61P25/28
Foreign References:
| JP2011190250A | 2011-09-29 | |||
| JP2011190251A | 2011-09-29 | |||
| CN102391277A | 2012-03-28 |
Other References:
BRIMSON, J.M. ET AL.: "Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-beta Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and beta-Sitosterol", INT. J. MOL. SCI., vol. 13, 2012, pages 5074 - 5097, XP055342327
BRIMSON, J.M. ET AL.: "Rhinacanthus nasutus Protects Cultured Neuronal Cells against Hypoxia Induced Cell Death", MOLECULES, vol. 16, no. 8, 2011, pages 6322 - 6338, XP055342328
SIRIPONG, P. ET AL.: "Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ", BIOL. PHARM. BULL., vol. 29, no. 10, 2006, pages 2070 - 2076, XP055342335
BRIMSON, J.M. ET AL.: "Rhinacanthus nasutus Protects Cultured Neuronal Cells against Hypoxia Induced Cell Death", MOLECULES, vol. 16, no. 8, 2011, pages 6322 - 6338, XP055342328
SIRIPONG, P. ET AL.: "Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ", BIOL. PHARM. BULL., vol. 29, no. 10, 2006, pages 2070 - 2076, XP055342335
Attorney, Agent or Firm:
MATSUO, Nobutaka (JP)
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