Title:
Netrin-1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/244460
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a substance for making skin normal; and a method for screening for a substance having an activity to make skin normal. Provided are: a Netrin-1 inhibitor; and an agent which comprises the Netrin-1 inhibitor and is effective for making skin normal through the inhibition of the disarrangement of a vascular structure by the inhibition of Netrin-1. A Netrin-1 inhibitor comprising one or a plurality selected from the group consisting of Yuzu (Citrus junos) extract, a citrus unshiu peel extract and lactobiotyl is effective for making skin normal through the inhibition of the disarrangement of a vascular structure. The screening method according to the present invention makes it possible to select a substance having an activity to make skin normal.
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Inventors:
KAJIYA MIKA (JP)
KAMI RYOTA (JP)
TSUTSUI TAIKI (JP)
KAMI RYOTA (JP)
TSUTSUI TAIKI (JP)
Application Number:
PCT/JP2022/013694
Publication Date:
November 24, 2022
Filing Date:
March 23, 2022
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61P17/00; A61K8/96; A61K8/9789; A61K8/99; A61K36/752; A61Q19/00; A61Q19/08; C12Q1/02; C12Q1/6851; C12Q1/686; G01N33/15; G01N33/50
Foreign References:
| JP2008506703A | 2008-03-06 | |||
| JP2014533959A | 2014-12-18 |
Other References:
DATABASE GNPD [https://www.portal.mintel.com] "Skin Conditioning Facial Lotion. ID 7496449", Database accession no. 7496449
WU PENG, CAO YONGQIAN, ZHAO RAN, WANG YIBING: "Netrin-1 plays a critical role in regulating capacities of epidermal stem cells upon ultraviolet-B(UV-B) irradiation", ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY, vol. 47, no. 1, 2019, pages 1416 - 1422, XP093008561
BOUSSOUAR AMINA, TORTEREAU ANTONIN, MANCEAU AMBROISE, PARADISI ANDREA, GADOT NICOLAS, VIAL JONATHAN, NEVES DAVID, LARUE LIONEL, BA: "Netrin-1 and its receptor DCC are causally implicated in Melanoma progression", CANCER RESEARCH, vol. 80, no. 4, 2020, pages 747 - 756, XP093008564
WU PENG, CAO YONGQIAN, ZHAO RAN, WANG YIBING: "Netrin-1 plays a critical role in regulating capacities of epidermal stem cells upon ultraviolet-B(UV-B) irradiation", ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY, vol. 47, no. 1, 2019, pages 1416 - 1422, XP093008561
BOUSSOUAR AMINA, TORTEREAU ANTONIN, MANCEAU AMBROISE, PARADISI ANDREA, GADOT NICOLAS, VIAL JONATHAN, NEVES DAVID, LARUE LIONEL, BA: "Netrin-1 and its receptor DCC are causally implicated in Melanoma progression", CANCER RESEARCH, vol. 80, no. 4, 2020, pages 747 - 756, XP093008564
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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