Title:
NEURAL DIFFERENTIATION INDUCER
Document Type and Number:
WIPO Patent Application WO/1997/032579
Kind Code:
A1
Abstract:
Pyrrolidone derivatives represented by general formula (I), having a neural differentiation induction effect, and hence being useful as remedies for nervous diseases, especially as an antitumor agent, a nootropic agent, an immunosuppressive agent, and an apoptosis inhibitor, and a tissue recovery agent for postoperative medication, etc., wherein R1 represents C1-3 alkyl or is bonded to R2 to thereby form methylidene; R2 represents hydroxy, C1-20 alkoxy, or C1-10 alkoxy substituted by nitrooxy or phenyl; R3 represents hydrogen or C1-20 alkyl; and R4 represents cyano, C1-3 alkoxycarbonyl, or C2-10 alkanoyl optionally substituted by hydroxy.
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Inventors:
ARAI KOSHI (JP)
SATO MASAKAZU (JP)
KAKEYA HIDEAKI (JP)
OSADA HIROYUKI (JP)
SATO MASAKAZU (JP)
KAKEYA HIDEAKI (JP)
OSADA HIROYUKI (JP)
Application Number:
PCT/JP1997/000628
Publication Date:
September 12, 1997
Filing Date:
March 03, 1997
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
RIKAGAKU KENKYUSHO (JP)
ARAI KOSHI (JP)
SATO MASAKAZU (JP)
KAKEYA HIDEAKI (JP)
OSADA HIROYUKI (JP)
RIKAGAKU KENKYUSHO (JP)
ARAI KOSHI (JP)
SATO MASAKAZU (JP)
KAKEYA HIDEAKI (JP)
OSADA HIROYUKI (JP)
International Classes:
A61K31/40; C07D207/38; C07D207/44; (IPC1-7): A61K31/40
Foreign References:
| JPH02247166A | 1990-10-02 | |||
| JPH01279885A | 1989-11-10 | |||
| JPH0317057A | 1991-01-25 |
Other References:
ARCH. PHURM., (WEINHEIM), Vol. 314, No. 2, (1981), SARANTAUS-ZIMMERMANN, RIITTA LIISA et al., "Untersuchungen zur Stabilitat Heterocyclischer alpha-Enaminonitrile", p. 127-133.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Zur Reaktion von 1,2-Diketonen mit Malononitril unter Piperidin-Katalyse", p. 3247-3255.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Zur Reaktion von Biacetyl mit Malononitril unter Alkoholat-Katalyse", p. 3256-3261.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Kondensation von 1,2-Diketonen mit 2-Cyanacetamid", p. 3262-3270.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Zur Reaktion von 1,2-Diketonen mit Malononitril unter Piperidin-Katalyse", p. 3247-3255.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Zur Reaktion von Biacetyl mit Malononitril unter Alkoholat-Katalyse", p. 3256-3261.
CHEM. BER., Vol. 108, No. 10, (1975), ROEBER, HUBERT et al., "Kondensation von 1,2-Diketonen mit 2-Cyanacetamid", p. 3262-3270.
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