Title:
NEUROMUSCULAR-BLOCKING DRUG AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/115413
Kind Code:
A1
Abstract:
A neuromuscular-blocking drug and a preparation method therefor. Specifically, provided are a compound represented by formula I, a preparation method therefor, and a use thereof in neuromuscular blocking. The definition of each group of formula I is the same as in the specification.
Inventors:
YOU QIDONG (CN)
JIANG ZHENGYU (CN)
CHEN XUETAO (CN)
ZHANG ZIJIAN (CN)
WU XUEXUAN (CN)
LUO HAN (CN)
XU DAPING (CN)
JIANG ZHENGYU (CN)
CHEN XUETAO (CN)
ZHANG ZIJIAN (CN)
WU XUEXUAN (CN)
LUO HAN (CN)
XU DAPING (CN)
Application Number:
PCT/CN2020/135612
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D217/04; A61K31/47; A61P21/00
Domestic Patent References:
| WO2014005122A2 | 2014-01-03 |
Foreign References:
| CN101588803A | 2009-11-25 | |||
| CN1257483A | 2000-06-21 |
Other References:
SAMANO VICENTE, RAY JOHN A., THOMPSON JAMES B., MOOK ROBERT A., JUNG DAVID K., KOBLE CECILIA S., MARTIN MICHAEL T., BIGHAM ERIC C.: "Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 1, no. 12, 1 December 1999 (1999-12-01), US, pages 1993 - 1996, XP055821126, ISSN: 1523-7060, DOI: 10.1021/ol9911573
BOROS E E, ET AL: "Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 46, 1 June 2003 (2003-06-01), pages 2502 - 2515, XP002324146, ISSN: 0022-2623, DOI: 10.1021/jm020574+
BOROS E E, ET AL: "Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 46, 1 June 2003 (2003-06-01), pages 2502 - 2515, XP002324146, ISSN: 0022-2623, DOI: 10.1021/jm020574+
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
Download PDF: