Title:
USE OF NITRIC OXIDE SYNTHASE PATHWAY INHIBITOR IN PREPARATION OF MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/115412
Kind Code:
A1
Abstract:
The present application relates to a use of a nitric oxide synthase pathway inhibitor in preparation of a medicine, wherein the medicine is used for preventing, relieving and/or treating gastrointestinal ischemia-reperfusion related distal injury in a subject. The present application further relates to a use of nitric oxide synthase for screening a medicine, wherein the medicine is used for preventing, relieving and/or treating gastrointestinal ischemia-reperfusion related distal injury in a subject. The present application further relates to a pharmaceutical composition containing the nitric oxide synthase pathway inhibitor and a method for preventing, relieving and/or treating gastrointestinal ischemia-reperfusion related distal injury in a subject.
Inventors:
ZHOU HONGWEI (CN)
XU KAIYU (CN)
GAO XUXUAN (CN)
YIN JIA (CN)
XU KAIYU (CN)
GAO XUXUAN (CN)
YIN JIA (CN)
Application Number:
PCT/CN2020/135595
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV (CN)
International Classes:
A61K45/00; A61K31/155; A61P9/10
Foreign References:
| CN108484431A | 2018-09-04 | |||
| CN103405408A | 2013-11-27 | |||
| CN102579510A | 2012-07-18 |
Other References:
HUANG, BIN: "Nitric Oxide Synthase and Its Inhibitors and Cerebral Ischemia", FOREIGN MEDICAL SCIENCES (SECTION ON NEUROLOGY & NEUROSURGERY, 30 April 2005 (2005-04-30), pages 1 - 3, XP055821130, [retrieved on 20210705]
VIERA DANIELISOVA; JOZEF BURDA; MIROSLAVA NEMETHOVA; MIROSLAV GOTTLIEB: "Aminoguanidine Administration Ameliorates Hippocampal Damage After Middle Cerebral Artery Occlusion in Rat", NEUROCHEMICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 36, no. 3, 4 January 2011 (2011-01-04), Ne, pages 476 - 486, XP019880072, ISSN: 1573-6903, DOI: 10.1007/s11064-010-0366-1
WILLIAMS LSYILMAZ EYLOPEZ-YUNEZ AM: "Retrospective Assessment of Initial Stroke Severity with The NIH Stroke Scale", STROKE, vol. 31, 2000, pages 858 - 862
See also references of EP 4074341A4
VIERA DANIELISOVA; JOZEF BURDA; MIROSLAVA NEMETHOVA; MIROSLAV GOTTLIEB: "Aminoguanidine Administration Ameliorates Hippocampal Damage After Middle Cerebral Artery Occlusion in Rat", NEUROCHEMICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 36, no. 3, 4 January 2011 (2011-01-04), Ne, pages 476 - 486, XP019880072, ISSN: 1573-6903, DOI: 10.1007/s11064-010-0366-1
WILLIAMS LSYILMAZ EYLOPEZ-YUNEZ AM: "Retrospective Assessment of Initial Stroke Severity with The NIH Stroke Scale", STROKE, vol. 31, 2000, pages 858 - 862
See also references of EP 4074341A4
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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