Title:
NEURON PROLIFERATION PROMOTING AGENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/068176
Kind Code:
A1
Abstract:
Provided are: a neuron proliferation promoting agent containing, as an active ingredient, an inhibitor of miR-191-5p or an expression inhibitor of miR-191-5p; a prophylactic or therapeutic agent for Alzheimer's disease or depression, the agent containing the neuron proliferation promoting agent; a pharmaceutical composition for promoting neuron proliferation, the composition comprising the neuron proliferation promoting agent and a pharmaceutically acceptable carrier; and a food composition for promoting neuron proliferation, the composition comprising the neuron proliferation promoting agent.
Inventors:
TACHIBANA HIROFUMI (JP)
Application Number:
PCT/JP2022/038303
Publication Date:
April 27, 2023
Filing Date:
October 14, 2022
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K45/00; A23L33/10; A61K31/7024; A61K31/7028; A61K47/62; A61P25/28
Foreign References:
| JP2020150942A | 2020-09-24 |
Other References:
ZHOU HENG, YANG CEN, BAI FUHAI, MA ZHI, WANG JINGYI, WANG FENG, LI FENG, WANG QIANG, XIONG LIZE: "Electroacupuncture Alleviates Brain Damage Through Targeting of Neuronal Calcium Sensor 1 by miR-191a-5p After Ischemic Stroke", REJUVENATION RESEARCH, vol. 20, no. 6, 1 December 2017 (2017-12-01), US , pages 492 - 505, XP093059147, ISSN: 1549-1684, DOI: 10.1089/rej.2017.1920
MOHAMMADIPOOR-GHASEMABAD LILY; SANGTARASH MOHAMMAD HOSSEIN; SHEIBANI VAHID; SASAN HOSEIN ALI; ESMAEILI-MAHANI SAEED: "Hippocampal microRNA-191a-5p Regulates BDNF Expression and Shows Correlation with Cognitive Impairment Induced by Paradoxical Sleep Deprivation", NEUROSCIENCE, vol. 414, 4 July 2019 (2019-07-04), US , pages 49 - 59, XP085755497, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2019.06.037
FUJIWARA HIRONORI, TABUCHI MASAHIRO, YAMAGUCHI TAKUJI, IWASAKI KOH, FURUKAWA KATSUTOSHI, SEKIGUCHI KYOJI, IKARASHI YASUSHI, KUDO Y: "A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta- O -galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteins in vitro and in vivo", JOURNAL OF NEUROCHEMISTRY, vol. 109, no. 6, 1 June 2009 (2009-06-01), GB , pages 1648 - 1657, XP093059156, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2009.06069.x
MORI T; REZAI-ZADEH K; KOYAMA N; ARENDASH G W; YAMAGUCHI H; KAKUDA N; HORIKOSHI-SAKURABA Y; TAN J; TOWN T: "Tannic acid is a natural [beta]-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 9, 24 February 2012 (2012-02-24), US , pages 6912 - 6927, XP009519228, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.294025
LUDUVICO KARINA PEREIRA; SPOHR LUIZA; SOARES MAYARA SANDRIELLY PEREIRA; TEIXEIRA FERNANDA CARDOSO; DE FARIAS ALANA SEIXAS; BONA NA: "Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice", NEUROCHEMICAL RESEARCH, vol. 45, no. 9, 5 June 2020 (2020-06-05), New York, pages 2032 - 2043, XP037217614, ISSN: 0364-3190, DOI: 10.1007/s11064-020-03064-5
METZGER JEANETTE M., LOPEZ MARY S., SCHMIDT JENNA K., MURPHY MEGAN E., VEMUGANTI RAGHU, EMBORG MARINA E.: "Effects of Cardiac Sympathetic Neurodegeneration and PPAR γ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2020, 2 May 2020 (2020-05-02), pages 1 - 13, XP093059157, ISSN: 2314-6133, DOI: 10.1155/2020/9426204
LEE, KWANWOO ET AL.: "The effect of pentagalloyl glucose on hippocampal neurogenesis in old mice", JSNFS DATABASE OF PROCEEDINGS OF ANNUAL MEETINGS, 12 June 2022 (2022-06-12), XP009546972, Retrieved from the Internet> [retrieved on 20221129]
MOHAMMADIPOOR-GHASEMABAD LILY; SANGTARASH MOHAMMAD HOSSEIN; SHEIBANI VAHID; SASAN HOSEIN ALI; ESMAEILI-MAHANI SAEED: "Hippocampal microRNA-191a-5p Regulates BDNF Expression and Shows Correlation with Cognitive Impairment Induced by Paradoxical Sleep Deprivation", NEUROSCIENCE, vol. 414, 4 July 2019 (2019-07-04), US , pages 49 - 59, XP085755497, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2019.06.037
FUJIWARA HIRONORI, TABUCHI MASAHIRO, YAMAGUCHI TAKUJI, IWASAKI KOH, FURUKAWA KATSUTOSHI, SEKIGUCHI KYOJI, IKARASHI YASUSHI, KUDO Y: "A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta- O -galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteins in vitro and in vivo", JOURNAL OF NEUROCHEMISTRY, vol. 109, no. 6, 1 June 2009 (2009-06-01), GB , pages 1648 - 1657, XP093059156, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2009.06069.x
MORI T; REZAI-ZADEH K; KOYAMA N; ARENDASH G W; YAMAGUCHI H; KAKUDA N; HORIKOSHI-SAKURABA Y; TAN J; TOWN T: "Tannic acid is a natural [beta]-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 9, 24 February 2012 (2012-02-24), US , pages 6912 - 6927, XP009519228, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.294025
LUDUVICO KARINA PEREIRA; SPOHR LUIZA; SOARES MAYARA SANDRIELLY PEREIRA; TEIXEIRA FERNANDA CARDOSO; DE FARIAS ALANA SEIXAS; BONA NA: "Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice", NEUROCHEMICAL RESEARCH, vol. 45, no. 9, 5 June 2020 (2020-06-05), New York, pages 2032 - 2043, XP037217614, ISSN: 0364-3190, DOI: 10.1007/s11064-020-03064-5
METZGER JEANETTE M., LOPEZ MARY S., SCHMIDT JENNA K., MURPHY MEGAN E., VEMUGANTI RAGHU, EMBORG MARINA E.: "Effects of Cardiac Sympathetic Neurodegeneration and PPAR γ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2020, 2 May 2020 (2020-05-02), pages 1 - 13, XP093059157, ISSN: 2314-6133, DOI: 10.1155/2020/9426204
LEE, KWANWOO ET AL.: "The effect of pentagalloyl glucose on hippocampal neurogenesis in old mice", JSNFS DATABASE OF PROCEEDINGS OF ANNUAL MEETINGS, 12 June 2022 (2022-06-12), XP009546972, Retrieved from the Internet
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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