Title:
NEUROTRIMIN FUNCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/024565
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an agent that suppresses cell aging and a drug that prevents or treats diseases and the like caused by cell aging. More specifically, the present invention is a cell aging suppressor that contains a neurotrimin (NTM) function inhibitor as an active ingredient and a drug or the like that contains the cell aging suppressor. The present invention is also an antibody that suppresses aging. The present invention is also a screening method for substances that suppress cell aging.
Inventors:
AKIYAMA TETSU (JP)
KAMOSHIDA YUKI (JP)
HAYASHI TOMOATSU (JP)
YAMAZUMI YUSUKE (JP)
ODA TAKEAKI (JP)
SHIKANAI MIMA (JP)
KAMOSHIDA YUKI (JP)
HAYASHI TOMOATSU (JP)
YAMAZUMI YUSUKE (JP)
ODA TAKEAKI (JP)
SHIKANAI MIMA (JP)
Application Number:
PCT/JP2023/026213
Publication Date:
February 01, 2024
Filing Date:
July 18, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K39/395; A23L33/00; A61K31/7088; A61K38/02; A61K45/00; A61P1/14; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/00; A61P17/14; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/04; A61P27/06; A61P27/10; A61P27/12; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07K2/00; C12N15/113; C12N15/115; G01N33/15; G01N33/50
Foreign References:
| JP2010133705A | 2010-06-17 | |||
| US20220003787A1 | 2022-01-06 |
Other References:
YOON, I.K. ET AL.: "Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology.", EXPERIM. GERONTOL., vol. 39, no. 9, September 2004 (2004-09-01), pages 1369 - 1378, XP004601743, DOI: 10.1016/j.exger.2004.07.002
VENKANNAGARI, H. ET AL.: "Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes", J. MOL. BIOL., vol. 432, no. 19, 4 July 2020 (2020-07-04), pages 5287 - 5303, XP086267322, DOI: 10.1016/j.jmb.2020.07.014
VENKANNAGARI, H. ET AL.: "Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes", J. MOL. BIOL., vol. 432, no. 19, 4 July 2020 (2020-07-04), pages 5287 - 5303, XP086267322, DOI: 10.1016/j.jmb.2020.07.014
Attorney, Agent or Firm:
OKUHARA Koji (JP)
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